Patents Examined by Albert T. Meyers
  • Patent number: 4820736
    Abstract: The invention relates to the use of clomiphene and its citrate salt in predicting fertility in a human female.
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: April 11, 1989
    Assignee: Yale University
    Inventors: Pamela S. Jensen, Florence Comite
  • Patent number: 4820698
    Abstract: Disclosed are tetraalkyl enthenylidenebisphosphonates and a method for their manufacture. These compounds are suitable for use as antimicrobial agents in combating a number of pathogenic microorganisms, such as bacteria, yeasts, viruses, fungi and protozoa, when used together with a pharmaceutically-acceptable carrier. Also disclosed is a method for treating infectious diseases by administering a safe and effective amount of these tetraalkyl ethenylidenebisphosphonates.
    Type: Grant
    Filed: April 23, 1986
    Date of Patent: April 11, 1989
    Assignee: The Procter & Gamble Company
    Inventors: Charles R. Degenhardt, Duane L. Charbonneau
  • Patent number: 4818751
    Abstract: The present invention relates to a cosmetic comprising a neutral polysaccharide obtained from an acid-fast bacterium. This cosmetic smoothly spreads on the skin without sticking to the skin to give moistness to the skin. Furthermore, the cosmetic covers the skin and shows an excellent moisture-retaining action, and exerts an effect of preventing or moderating the rough skin.
    Type: Grant
    Filed: December 11, 1986
    Date of Patent: April 4, 1989
    Assignee: ZEria Shinyaku Kogyo Kabushiki Kaisha
    Inventor: Sachiaki Ibe
  • Patent number: 4818526
    Abstract: Described are the uses of dimethyl disulfide having the structure: ##STR1## and dibutyl succinate having the structure: ##STR2## taken alone or taken in combination as attractants for mosquitos (Culicidae). The dibutyl succinate and dimethyl disulfide taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: April 4, 1989
    Assignees: International Flavors & Fragrances Inc., The University of Florida
    Inventors: Richard A. Wilson, Jerry F. Butler, Donald Withycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
  • Patent number: 4816485
    Abstract: N-phenylbenzamide derivatives of the general formula I ##STR1## wherein the radicals R.sup.1, R.sup.2, and R.sup.3, which can be the same or different, are a hydrogen atom or a methyl radical, as well as the pharmacologically acceptable salts thereof for controlling malignant, proliferative and auto-immune diseases and for immunosuppressive therapy upon grafting are described.
    Type: Grant
    Filed: March 30, 1987
    Date of Patent: March 28, 1989
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Manfred Herrmann, Edgar Fritschi, Ute Weiershausen
  • Patent number: 4816248
    Abstract: Described are the uses of N,N-diethyl-m-toluamide having the structure: ##STR1## and the ethyl ester of 2-methyl-3-pentenoic acid having the structure: ##STR2## taken alone or in combination as attractions for mosquitos (Culicidae). The N,N-diethyl-m-toluamide and the ethyl ester of 2-methyl-3-pentenoic acid taken along or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.
    Type: Grant
    Filed: March 17, 1987
    Date of Patent: March 28, 1989
    Assignees: International Flavors & Fragrances Inc., The University of Florida
    Inventors: Richard A. Wilson, Jerry F. Butler, Donald Withycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
  • Patent number: 4810707
    Abstract: Method for the effective management of Herpes Simplex including the administration of an effective dosage of phenol, 4,4'-(2-pyridinyl methylene) bis diacetate (ester), in combination with a carrier, vitamins, or other therapeutic agents, and an effective dosage product comprising phenol, 4,4'-(2-pyridinyl methylene) bis,- diacetate (ester) for carrying out the method.
    Type: Grant
    Filed: March 29, 1988
    Date of Patent: March 7, 1989
    Assignee: Meditech Pharmaceuticals, Inc.
    Inventor: Joseph B. Michaelson
  • Patent number: 4808403
    Abstract: Described are the N,N-diethyl-m-toluamide having the structure: ##STR1## and the ethyl ester of 2-methyl-3-pentenoic acid having the structure: ##STR2## taken alone or taken in combination as attractants for house flies (Musca domestica L. (Diptera:Muscidae)). The N,N-diethyl-m-toluamide and ethyl ester of 2-methyl-3-pentenoic acid taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.
    Type: Grant
    Filed: March 17, 1987
    Date of Patent: February 28, 1989
    Assignees: International Flavors & Fragrances Inc., The University of Florida
    Inventors: Richard A. Wilson, Jerry F. Butler, Donald Withycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
  • Patent number: 4806529
    Abstract: Methods and products for overcoming bacterial resistance to tetracycline-type antibiotics by inhibiting the plasmid-mediated active efflux system for tetracycline in the resistant bacterial cell by administering with tetracycline efflux system blocking agents, thereby increasing the sensitivity of the resistant cell to tetracycline type antibiotics.
    Type: Grant
    Filed: November 18, 1982
    Date of Patent: February 21, 1989
    Assignee: Trustees of Tufts College, Tufts University
    Inventor: Stuart B. Levy
  • Patent number: 4801446
    Abstract: Described are the uses of methyl-isoeugenol having the structure: ##STR1## n-dodecanol having the structure: ##STR2## and 1-(2-butenoyl)-2,6,6-trimethyl-1,3-cyclohexadiene having the structure: ##STR3## taken alone or taken in combination as attractants house flies (Musca domestica L. (Diptera:Muscidae)) and Stored Products Moths. The methyl-isoeugenol, n-dodecanol and 1-(2-butenoyl)-1,3-cyclohexadiene taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.
    Type: Grant
    Filed: November 14, 1986
    Date of Patent: January 31, 1989
    Assignees: International Flavors & Fragrances Inc., The University of Florida
    Inventors: Richard A. Wilson, Jerry F. Butler, Donald Withycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
  • Patent number: 4801448
    Abstract: Described are the uses of dimethyl disulfide having the structure: ##STR1## and dibutyl succinate having the structure: ##STR2## taken alone or taken in combination as attractants for sand flies (Psychodidae), house flies and beetles (Coleoptera). The dimethyl disulfide itself is specifically useful as an attractant for house flies and the dibutyl succinate is specifically useful as an attractant for Coleoptera and Psychodidae. The dibutyl succinate and dimethyl disulfide taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.
    Type: Grant
    Filed: June 27, 1986
    Date of Patent: January 31, 1989
    Assignees: International Flavors & Fragrances Inc., The University of Florida
    Inventors: Richard A. Wilson, Jerry F. Butler, Donald Whithycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
  • Patent number: 4800080
    Abstract: A capillary cosmetic composition for washing or disentangling hair comprises in an appropriate cosmetic vehicle at least one plant extract, the active principle of which is at least one saponin and at least one cationic polymer.
    Type: Grant
    Filed: August 18, 1986
    Date of Patent: January 24, 1989
    Assignee: Societe Anonyme dite: L'Oreal
    Inventors: Jean-Francois Grollier, Bernard Beauquey
  • Patent number: 4797285
    Abstract: A drug/liposome composition comprising an aqueous suspension of liposomes and, entrapped in the lipid bilayer region of the liposomes, an anthraquinone drug containing quinone and hydroquinone functionalities on adjacent anthracene rings. An iron-specific trihydroxamic chelating agent contained in the bulk aqueous phase of the suspension and a lipophilic free-radical scavenger contained in the bilayer region of the liposome cooperate to reduce chemical modification of both drug and lipid components of the composition. A preferred composition containing doxorubicin and alpha-tocopherol entrapped in the liposomes, and ferrioxamine in the aqueous suspension phase is effective in treating human neoplasms, with significantly reduced side effects over those produced by free-drug administration.
    Type: Grant
    Filed: December 6, 1985
    Date of Patent: January 10, 1989
    Assignees: Yissum Research and Development Company of the Hebrew University of Jerusalem, Hadassah Medical Organization
    Inventors: Yechezkel Barenholz, Alberto Gabizon
  • Patent number: 4797281
    Abstract: Wood preservative compositions containing as active ingredients compounds of copper, of chromium and of arsenic are produced by mixing copper arsenate and sodium dichromate in an aqueous medium into which is introduced strong acid, for example sulphuric acid, effective to achieve a soluble product. The acid addition is preferably effective to reduce the pH to below 0. The composition so produced is a homogeneous paste which may be dissolved in water to working concentration and used for the preservation of wood by impregnation techniques.
    Type: Grant
    Filed: January 16, 1987
    Date of Patent: January 10, 1989
    Assignee: Laporte Industries Limited
    Inventors: Andrew D. J. Broome, Ian K. Egerton
  • Patent number: 4791136
    Abstract: Use of compounds of formula (I) ##STR1## to provide a more effective delivery of oxygen to the tissues of a mammalian, including human, recipient.In vivo applications include the relief or amelioration of conditions wherein there is tissue hypoxia; in vitro the compounds are of use in the storage of mammalian, including human, red blood cells to maintain their oxygen-delivery capacity and prolong their useful storage life.Also provided is a sterile, sealed vessel containing an anticoagulant, a non-toxic amount of a compound of formula (I) and optionally mammalian, in particular human, red blood cells.
    Type: Grant
    Filed: July 30, 1986
    Date of Patent: December 13, 1988
    Assignee: Burroughs Wellcome Co.
    Inventors: John F. Batchelor, Richard M. Hyde, David J. Livingstone
  • Patent number: 4786639
    Abstract: A method for the treatment and/or prophylaxis of reversible airways obstruction and asthma in mammals, which method comprises administering to the mammal in need of said treatment an effective amount of a compound of formula (I): ##STR1## wherein R.sub.1 -R.sub.8 and X are as set forth herein.
    Type: Grant
    Filed: November 4, 1986
    Date of Patent: November 22, 1988
    Assignee: Beecham Group p.l.c.
    Inventor: John M. Evans
  • Patent number: 4785013
    Abstract: Composition containing:a--from 20 to 40% of iprodione,b--an oil-in-water emulsion containing 50 to 160% by weight, relative to the iprodione, of an oil of which the hydrophilic/lipophilic balance has a value of 9 to 12, andc--from 0.1 to 2% by weight of an emulsifier of the ethylene oxide/fatty alcohol condensate type.Composition for the protection of plants against fungal diseases.
    Type: Grant
    Filed: June 6, 1984
    Date of Patent: November 15, 1988
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: Albert Margossian
  • Patent number: 4784667
    Abstract: This invention is directed to oxidation hair dye compositions and their use in the dyeing of human hair. The compositions consist essentially of precursors comprising 2,3-diamino-6-methoxy-pyridines and aromatic amines or diamines. The combination of oxidation dye precursors according to the invention gives bright, deep blue dye finishes having high stability to heat and light.
    Type: Grant
    Filed: October 7, 1985
    Date of Patent: November 15, 1988
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Norbert Maak, Peter Flemming, Dieter Schrader
  • Patent number: 4783449
    Abstract: Hydrosoluble pharmaceutical compositions containing, as the active principal, salts of (-)cis-1,2-epoxypropylphosphonic acid with aminoacids such as arginine, ornithine, lysine, cysteine, and the like, characterized by containing a hydrophyllic organic base.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: November 8, 1988
    Assignee: Istituto Gentili S.p.A.
    Inventor: Stefania Meola
  • Patent number: 4780311
    Abstract: The compounds of the following general structural formula (I) ##STR1## wherein R is hydrogen or a pharmaceutically acceptable salt thereof, are .beta.-ketoacyl-coenzyme A thiolase inhibitors and are useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: October 25, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Janet Onishi, Michael Greenspan