Patents Examined by Allen B. Curtis
  • Patent number: 4202873
    Abstract: Novel alkylolamides of iodizable amino acids of the formula ##STR1## wherein, R.sup.1 is hydroxybenzyl, dihydroxybenzyl or imidazol-4-yl-methyl andR.sup.2 is monohydroxy-alkyl of 1 or 2 carbon atoms or dihydroxy-alkyl of up to 4 carbon atoms,and the water-soluble salts thereof are provided; these materials are useful as components of radioiodizable immune test reagents.
    Type: Grant
    Filed: March 30, 1977
    Date of Patent: May 13, 1980
    Assignee: Boehringer Mannheim GmbH
    Inventors: Hans-Georg Batz, Klaus Stellner, Hans-Ralf Linke, Gunter Weimann
  • Patent number: 4179450
    Abstract: The invention relates to a novel process for the preparation of 1-acylamino-5(8)-chloroanthraquinones, which are starting materials for the preparation of vat dyes. It is characterized in that 1,5(8)-dichloroanthraquinones is reacted with ammonia at temperatures of 190.degree. to 240.degree. C., the amino groups in the reaction mixture are completely acylated and the more sparingly soluble diacylaminoanthraquinone is separated off from the more readily soluble monoacylaminochloroanthraquinone.The new process yields reaction products which are purer and cheaper than those which are obtained by conventional methods. Moreover there are smaller waste water problems.
    Type: Grant
    Filed: May 5, 1977
    Date of Patent: December 18, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Detlef-Ingo Schutze, Hans-Samuel Bien, deceased, Petra Bien, heir, Daniel Bien, heir
  • Patent number: 4175096
    Abstract: Alkoxylated perfluoroalkanesulphonamides which are obtained by reacting perfluoroalkanesulphonamidoamines of the formula ##STR1## in which R.sub.f denotes C.sub.1 -C.sub.18 -perfluoroalkyl, it also being possible, for n>1, for the radicals R.sub.f to be different,A denotes C.sub.2 -C.sub.8 -alkylene, which can be straight-chain or branched,R denotes C.sub.1 -C.sub.8 alkyl, it also being possible, for p>1, for the radicals R to be different,m denotes a number from 1 to 10,n denotes a number from 1 to m,p denotes a number from 0 to m+2 andq denotes a number from 0 to m+2,and in whichthe sum of n+p+q is m+3,with alkylene oxides, can be used as wetting agents, emulsifiers and dispersing agents and as agents for rendering paper, leather and textiles oleophobic.
    Type: Grant
    Filed: August 30, 1977
    Date of Patent: November 20, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunther Reitz, Gunther Boehmke
  • Patent number: 4164503
    Abstract: There is provided a novel and efficent method of synthesizing 7,10-dihydro-6,11-dihydroxy-5,9,12(8H)-naphthacenetrione and analogs thereof substituted in the 1,2,3 or 4 positions. The novel method comprises reacting the appropriate quinizarinquinone with a haloprene under Diels-Alder conditions, followed by aromatization and treatment with strong acid under very mild temperature conditions. The products of this process are important intermediates in the synthesis of daunomycin and its analogs which are useful in the therapy of neoplastic ailments.
    Type: Grant
    Filed: October 10, 1978
    Date of Patent: August 14, 1979
    Assignee: Research Corporation
    Inventors: Andrew S. Kende, Yuh-Geng Tsay, Takuya Furuta
  • Patent number: 4163747
    Abstract: Process for the preparation of 1-alkylamino-anthraquinones which comprises reacting 1-nitroanthraquinone with a monoalkylamine in the presence of an ether, a hydrocarbon or a mixture of an ether and a hydrocarbon. The 1-alkylamino-anthraquinones which are obtained can be employed directly as dyestuffs or used, without further purification, for the production of dyestuffs. Process of the invention results in the procurement of 1-alkylamine-anthraquinones of high purity and in high yield and avoids the formation of undesired by-products.
    Type: Grant
    Filed: September 22, 1978
    Date of Patent: August 7, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bernd Schroeder, Rudolf Braden, Wolfgang Auge, Karl-Werner Thiem, Rutger Neeff
  • Patent number: 4161481
    Abstract: A process has now been found for the isolation of purified anthraquinone from the crude anthraquinone which has been obtained by oxidation of naphthalene to give naphthoquinone, reaction of the oxidation product with butadiene to give tetrahydroanthraquinone, oxydehydrogenation of this reaction product with molecular oxygen to give a crude anthraquinone and optionally removal of naphthalene, phthalic anhydride and low-boiling substances from this crude anthraquinone, which is characterized in that the crude anthraquinone is treated with an oxygen compound of the elements of the first and/or second main group of the periodic system at an elevated temperature, optionally in the presence of a solvent, and purified anthraquinone is then isolated by subliming the anthraquinone present at a temperature of about 190.degree. to about 290.degree. C. and a pressure of about 1 to about 90 mm Hg and then desubliming it under the same pressure, or by vaporizing the pretreated anthraquinone at a temperature of about 290.
    Type: Grant
    Filed: November 16, 1977
    Date of Patent: July 17, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Joachim Priemer, Georg Nicklas, Nikolaus Schulz
  • Patent number: 4161591
    Abstract: Substituted 2-(carbamoyl)oxyimino-3-imino-butyramides and 2-(carbamoyl)oxyimino-3-iminobutyrates of the formula ##STR1## where Q is --OR.sub.4 or --NR.sub.5 R.sub.6, and A, R, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are as hereinafter defined are useful as aphicides. The compounds are made by reacting an amine with a substituted 2-hydroxyiminoacetoacetamide (or 2-hydroxyiminopropionylacetamide) or an alkyl 2-hydroxyiminoacetoacetate (or 2-hydroxyiminopropionylacetate), then carbamylating the resulting substituted 2-hydroxyimino-3-iminobutyramide (or 2-hydroxyimino-3-iminovaleramide) or 2-hydroxyimino-3-iminobutyrate (or 2-hydroxyimino-3-iminovalerate).
    Type: Grant
    Filed: October 25, 1977
    Date of Patent: July 17, 1979
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Russell F. Bellina
  • Patent number: 4161480
    Abstract: The present invention encompasses novel intermediates having the following structural formulas: ##STR1## wherein X is hydrogen, methoxy, or hydroxy; ##STR2## wherein X is hydrogen, methoxy, or hydroxy; and ##STR3## wherein X is hydrogen, methoxy, or hydroxy. Compounds of the present invention are useful in synthesizing 4-demethoxydaunorubicin, daunorubicin, adriamycin, and carminomycin which are potent antitumor agents.
    Type: Grant
    Filed: June 5, 1978
    Date of Patent: July 17, 1979
    Assignee: G. D. Searle & Co.
    Inventors: Raphael Pappo, Robert B. Garland
  • Patent number: 4160660
    Abstract: 2-CHLORO-2',6'-DIMETHYL-N-(1-ethoxyprop-2-yl)-acetanilide is disclosed as plant growth regulating and herbicidal agent with improved stability in the soil.
    Type: Grant
    Filed: May 15, 1978
    Date of Patent: July 10, 1979
    Assignee: Ciba-Geigy Corporation
    Inventors: Christian Vogel, Rudolf Aebi
  • Patent number: 4159265
    Abstract: Monoazo dyestuffs of the formula ##STR1## wherein K represents the radical of a couping component K-H of the formula ##STR2## said dyestuff being suitable for the dyeing of synthetic fibre materials especially those from polyamides.
    Type: Grant
    Filed: April 25, 1978
    Date of Patent: June 26, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Richard Sommer, Gerhard Wolfrum, Gerhard Buttner
  • Patent number: 4155921
    Abstract: A process has been invented for the isolation of 1,6- and 1,7-dinitroanthraquinone by treating mixtures containing these isomers with nitrobenzene.
    Type: Grant
    Filed: November 10, 1977
    Date of Patent: May 22, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Walter Hohmann, Klaus Wunderlich
  • Patent number: 4155922
    Abstract: A process has been provided for the purification of crude anthraquinone made by (1) oxidation of naphthalene to naphthoquinone (2) reaction of the oxidation product with butadiene to give tetrahydroanthraquinone and (3) oxide-hydrogenation of this reaction product with molecular oxygen to yield the crude anthraquinone, then optionally separating naphthalene, phthalic anhydride and low-boiling compounds from said crude anthraquinone. The purification of said crude anthraquinone is effected by treatment with an oxygen compound or mixture of oxygen compounds of the elements of the 1st and/or 2nd main group of the periodic system at elevated temperature, if desired in the presence of an inert solvent and the purified anthraquinone is isolated by physical separation methods from the products treated.
    Type: Grant
    Filed: November 10, 1977
    Date of Patent: May 22, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rupert Wenzel, Johann Grolig
  • Patent number: 4154580
    Abstract: Stable gasoline-alcohol fuel mixtures are produced by hydration of a gasoline or a fraction thereof high in olefins in the presence of an acid catalyst to form a high alcohol content gasoline mixture, which mixture is blended with a gasoline containing up to about 20 volume percent of methanol. The addition of the catalytically hydrated gasoline or olefinic fraction thereof serves to maintain the methanol in complete solution at low temperatures, particularly in the presence of water contaminant.
    Type: Grant
    Filed: January 9, 1978
    Date of Patent: May 15, 1979
    Assignee: Mobil Oil Corporation
    Inventor: Phillip S. Landis
  • Patent number: 4154746
    Abstract: Anils of 1,4- and 1,8-diaminoanthraquinone with p-alkyl- and p-alkoxybenzaldehyde are found to be pleochroic dyes which form guest-host combinations with dielectrically positive anisotropic nematic liquid crystals. These combinations are of value in electro-optical display devices.
    Type: Grant
    Filed: May 24, 1978
    Date of Patent: May 15, 1979
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: William A. Huffman
  • Patent number: 4154851
    Abstract: This invention relates to novel .omega.-benzylamino alkanoic acids, to their salts with an organic or mineral base or with an organic or mineral acid. These alkanoic acids may be in a racemic form or resolved into their optically-active enantiomers.They are produced by condensing an oxoalkanoic acid with a benzylamine under reducing conditions.This invention also relates to .omega.-benzylamino alkanoic amides and to .omega.-benzylamino alkanoic acid esters.They have therapeutical use, namely in the psychotherapeutical field. They are utilized in the form of pharmaceutical compositions.
    Type: Grant
    Filed: March 11, 1977
    Date of Patent: May 15, 1979
    Assignee: Science Union et Cie, Societe Francaise de Recherche Medicale
    Inventors: Charles Malen, Pierre Roger, Jean-Claude Poignant
  • Patent number: 4154947
    Abstract: This disclosure describes novel substituted benzylideneaminoguanidines useful as anti-hypertensive agents and as diuretics.
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: May 15, 1979
    Assignee: American Cyanamid Company
    Inventors: Leon Goldman, Joseph W. Marsico, Jr.
  • Patent number: 4154747
    Abstract: A process for the preparation of 1-amino-8-nitro-4,5-dihydroxyanthraquinone by partially reducing the corresponding dinitrohydroxyanthraquinone and isolating the reduction product, in which crude 1,8-dinitro-4,5-dihydroxyanthraquinone obtained by nitrating 4,5-dihydroxyanthraquinone is partially reduced in a phenol-water mixture, which contains from 5 to 50% by weight of water, in the presence of an alkali metal phenolate, by means of a reductone, reductonate or a mixture of these. The product is virtually free from by-products and is suitable for use for the synthesis of dyes.
    Type: Grant
    Filed: June 20, 1978
    Date of Patent: May 15, 1979
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerhard Epple, Wolfgang Elser, Walter Himmele
  • Patent number: 4153564
    Abstract: Compounds that act as emulsifiers, detergents and antioxidants when added to a lubricant or a fuel are prepared from (1) an alkenylsuccinic anhydride or acid and an aniline-aldehyde resin or (2) the product of (1) and an aromatic triazole, e.g. benzotriazole, and aldehyde. Also included are lubricant compositions containing the compounds.
    Type: Grant
    Filed: April 24, 1978
    Date of Patent: May 8, 1979
    Assignee: Mobil Oil Corporation
    Inventor: Sheldon Chibnik
  • Patent number: 4152340
    Abstract: A process which comprises reacting 1,4,4a,5,8,8a,9a,10a-octahydro-anthraquinone with nitrobenzene in the presence of a catalytic amount of a basic compound soluble in the reaction medium and of an inhibitor of free radical reactions to produce anthraquinone.
    Type: Grant
    Filed: August 19, 1977
    Date of Patent: May 1, 1979
    Assignee: Produits Chimiques Ugine Kuhlmann
    Inventors: Serge-Yvon Delavarenne, Pierre Tellier
  • Patent number: 4152449
    Abstract: Substituted 2-vinyl-chromones are disclosed wherein the chromone ring has an alkyl or alkenyl substituent at the 3-position. The compounds exhibit anti-allergy activity and can be used to treat allergic conditions.
    Type: Grant
    Filed: June 6, 1977
    Date of Patent: May 1, 1979
    Assignee: Carlo Erba S. p. A.
    Inventors: Gianfederico Doria, Ciriaco Romeo, Francesco Lauria, Maria L. Corno, Piernicola Giraldi, Marcello Tibolla