Patents Examined by Allen B. Curtis
  • Patent number: 4152341
    Abstract: Pharmaceutical compositions, containing a 4,4'-dihydroxy-3,3'-triphenylmethanedicarboxylic acid (or an oxidized derivative) as active ingredient, are described and are prepared conventionally in a form suitable for topical administration e.g. ointment. The compositions are useful for the treatment of inflammatory diseases and inflammatory conditions of the skin. Many of the active ingredients are novel compounds. A representative novel active ingredient is 4"-cyano-4,4'-dihydroxy-5,5'-dimethyl-3,3'-triphenylmethanedicarboxylic acid.
    Type: Grant
    Filed: May 19, 1978
    Date of Patent: May 1, 1979
    Assignee: Imperial Chemical Industries Limited
    Inventors: Geraint Jones, David S. Thomson
  • Patent number: 4151297
    Abstract: 1-Alkylamino-3-(3- or 4-[2-(endobicyclo[3.1.0]-hex-6-yl)ethylaminocarbonyl]-1-phenoxy)-2-propano l and substituted derivatives thereof and methods for preparing such compounds are disclosed. 5-(3- Or 4-[2-(endobicyclo[3.1.0]hex-6-yl)ethylaminocarbonyl]-phenoxy)methyl 3-alkyl-2-optionally substituted oxazolidine and derivatives thereof, and methods for preparing such compounds are also disclosed. These compounds exhibit cardiovascular acitivity and are useful in the treatment of abnormal heart condition as well as hypertension in mammals. The former compounds are prepared by treatment of the corresponding 1,2-epoxy-3-(3- or 4-[2-(endobicyclo[3.1.0]hex-6-yl)-ethylaminocarbonyl]phenoxy)propane with the desired alkylamine or by base or acid hydrolysis of the corresponding 5-(3- or 4-[2-(endobicyclo[3.1.0]hex-6-yl)-ethylaminocarbonyl)-3-alkyl oxazolidine. The latter compounds are prepared from the corresponding 1-alkylamino-3-(3- or 4-[2-(endobicyclo[3.1.
    Type: Grant
    Filed: October 31, 1977
    Date of Patent: April 24, 1979
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Karl G. Untch, Stefan H. Unger, Brian Lewis
  • Patent number: 4151182
    Abstract: The invention relates to a process for the production of anthraquinone by catalytic oxidation of indans or diphenylmethane derivatives with oxygen in the presence of a vanadium (V) compound with or without one or more than one compund of potassium, boron, thallium, antimony and/or caesium. Anthraquinone which can be prepared by the process according to this invention is a valuable starting material for the production of dyes and pesticides.
    Type: Grant
    Filed: May 9, 1977
    Date of Patent: April 24, 1979
    Assignee: Badische Anilin- & Soda-Fabrik Aktiengesellschaft
    Inventors: Heinz Engelbach, Hermann Wistuba, Michael J. Sprague, Hans-Juergen Sturm, Herbert Armbrust
  • Patent number: 4148823
    Abstract: Process for the preparation of a p-arylaminophenol by reacting hydroquinone with a primary arylamino in the presence of a catalytic amount of aluminum sulfate or an aluminum lower carboxylate.
    Type: Grant
    Filed: June 12, 1978
    Date of Patent: April 10, 1979
    Assignee: Eastman Kodak Company
    Inventor: David R. Dubois
  • Patent number: 4147862
    Abstract: This invention relates to color-changing styryl-like compounds and the preparing of the same. A compound according to the present invention has, as its principal ring, an indoline ring of 2nd position, and has, at stimulation reversible or irreversible change(s) between a closed ring structure of a non-plane molecular structure indicated by the following chemical formula(1) showing white or pale color, and an open ring structure of a plane molecular structure indicated by the following chemical formula(2) showing vivid visible color: ##STR1## wherein Q, R.sub.1, R.sub.2, R.sub.3, Y, Z, A and X are defined in the detailed specification.
    Type: Grant
    Filed: October 21, 1976
    Date of Patent: April 3, 1979
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventors: Masaaki Hayami, Seiko Torikoshi
  • Patent number: 4147863
    Abstract: Novel cephalosporin derivatives having a (1-alkyl-1H-tetrazol-5-yl)vinyl group at the 3-position of the cephem nucleus and showing an excellent antibacterial activity are disclosed. A process for preparing the cephalosporin derivatives is also disclosed.
    Type: Grant
    Filed: August 25, 1975
    Date of Patent: April 3, 1979
    Assignee: Sankyo Company Limited
    Inventors: Tetsuo Miyadera, Mitsuo Nagano, Shinichi Sugawara
  • Patent number: 4146707
    Abstract: Novel compounds having the following structure ##STR1## wherein X represents O, S or NR and R is benzyl or butyl;G.sup.1 and G.sup.2 represent cyano or taken together with the carbon atom to which they are attached represent sufficient atoms to complete an ethyl substituted barbituric acid nucleus;R.sup.1 and R.sup.2, which may be the same or different represent phenyl, (--CH.dbd..sub.n A.sup.1, --CH.dbd.CH--A.sup.2 ; and R.sup.3, R.sup.4, A.sup.1, A.sup.2 and n are as stated in the detailed disclosure.
    Type: Grant
    Filed: February 1, 1978
    Date of Patent: March 27, 1979
    Assignee: Eastman Kodak Company
    Inventors: James A. Van Allan, Frank G. Webster, George A. Reynolds
  • Patent number: 4146547
    Abstract: A process for the manufacture of Bz-1-bromobenzanthrone by brominating finely divided benzanthrone in aqueous suspension, wherein the improvement comprises treating benzanthrone having a mean particle size of 30 .mu.m or less with bromine or brominating agent at above 80.degree. C.A product which contains from 91 to 94% by weight of Bz-1-bromobenzanthrone is obtained.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: March 27, 1979
    Assignee: BASF Aktiengesellschaft
    Inventors: Alfred Schuhmacher, Karl-Erich Kling
  • Patent number: 4146556
    Abstract: This invention relates to hydroxyalkylaminoalkylamides, the N-alkylated derivatives thereof, and the preparaton and uses thereof. This invention also relates to quaternaries of the abovementioned hydroxyalkylaminoalkylamides.
    Type: Grant
    Filed: July 11, 1977
    Date of Patent: March 27, 1979
    Assignee: Petrolite Corporation
    Inventors: Derek Redmore, Benjamin T. Outlaw
  • Patent number: 4145443
    Abstract: 1-Alkylamino-3-(?2-(endobicyclo?3.1.0!-hex-6-yl)ethylaminocarbonyl!naphthyl oxy)-2-propanols and methods for preparing these compounds are disclosed. The compounds are useful in the treatment of hypertension and abnormal heart conditions in mammals. These compounds are prepared by the treatment of the corresponding 1,2-epoxy-3-?2-(endobicyclo?3.1.0!hex-6-yl)ethylaminocarbonyl!naphthyloxy) -propane with an alkylamine having the desired alkyl substituent or by base or acid hydrolysis of the corresponding 2-optionally substituted -3-alkyl-5-(?2-(endobicyclo?3.1.0!hex-6-yl)ethylaminocarbonyl!naphthyloxym ethyl)oxazolidine. These latter compounds can be prepared by condensing a hydroxy-substituted naphthalene with a 3-alkyl-5-tosyloxymethyloxazolidine such substituted or unsubstituted at the 2-position or alternatively, by treating the former aminopropanol compounds of the present invention with an aldehyde having the desired substituent.
    Type: Grant
    Filed: October 31, 1977
    Date of Patent: March 20, 1979
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Karl G. Untch, Stefan H. Unger
  • Patent number: 4145356
    Abstract: Pyranthrone pigments of the formula ##STR1## WHEREIN N IS 0 OR 1, WHEREIN WHEN N IS 0, EACH A is hydrogen or chlorine, and when n is 1, each A is chlorine are prepared by crystallizing a finely divided crude pyranthrone pigment in an organic polar solvent, in the presence of from 0.5 to 10% by weight, based on the crude pigment, of an anthraquinone compound of the formula ##STR2## WHEREIN X is chlorine, Y is alkyl of 1 to 4 carbon atoms, hydroxyl, carboxyl, carbo-alkoxy, wherein said alkoxy group has 1 to 4 carbon atoms, or carbophenoxy, p is 0, 1 or 2 and m is 0, 1 or 2.
    Type: Grant
    Filed: January 17, 1978
    Date of Patent: March 20, 1979
    Assignee: BASF Aktiengesellschaft
    Inventor: Fritz Graser
  • Patent number: 4144252
    Abstract: Polymeric colorants comprising a hydrocarbon backbone and attached directly thereto through amine linkages, at least one water-solubilizing group and at least one optically chromophoric group are disclosed. In a preferred embodiment, the backbone is a saturated aliphatic hydrocarbon, the chromophore is an anthraquinone chromophore and the solubilizing group is a sulfonate or sulfamate residue.
    Type: Grant
    Filed: February 7, 1977
    Date of Patent: March 13, 1979
    Assignee: Dynapol
    Inventors: Patricia C. Wang, Robert E. Wingard
  • Patent number: 4144258
    Abstract: 1:1-Metal complexes of azomethines of the formula I ##STR1## wherein A and B are isocyclic or heterocyclic aromatic radicals, with however only one of the radicals A and B being a benzene ring, R represents a hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, or an aryl radical, and the complexing metal ions are bivalent cations of the transition metals, zinc ions or cadmium ions which are useful for pigmenting high molecular organic material.
    Type: Grant
    Filed: October 11, 1977
    Date of Patent: March 13, 1979
    Assignee: Ciba-Geigy Corporation
    Inventors: Francois L'Eplattenier, Laurent Vuitel
  • Patent number: 4144270
    Abstract: This application relates to certain 4'-substituted and to 3',4'-disubstituted anilides, to methods for their preparation and to methods for their use as anti-androgens.
    Type: Grant
    Filed: June 26, 1974
    Date of Patent: March 13, 1979
    Assignee: Schering Corporation
    Inventors: Rudolph O. Neri, John G. Topliss
  • Patent number: 4143071
    Abstract: Covers compounds of the formula ##STR1## where R" is lower alkyl, R is hydrogen or lower alkyl and Y is selected from the group consisting of CN, CONH.sub.2, CO.sub.2 R', CONR'.sub.2 and COR' where R' independently is hydrogen, lower alkyl or aryl. Also covers a method of producing a polyurethane by utilizing said above compounds as catalysts in reacting an organic polyisocyanate with an organic polyester polyol or polyether polyol in the presence of said catalyst.
    Type: Grant
    Filed: September 6, 1977
    Date of Patent: March 6, 1979
    Assignee: Texaco Development Corp.
    Inventors: Edward E. McEntire, George P. Speranza
  • Patent number: 4143060
    Abstract: The instant invention is directed to a process of preparing a silyl substituted urea derivative comprising reacting an isocyanate of the formula ##STR1## wherein R represents a C.sub.1 -C.sub.18 alkyl group, a C.sub.4 -C.sub.14 cycloalkyl group or a phenyl group,R' represents an optionally halogenated or cyano-substituted C.sub.1 -C.sub.10 alkyl, C.sub.4 -C.sub.10 cycloalkyl or C.sub.6 -C.sub.10 aryl group,R" represents a hydrogen atom, a methyl group or a phenyl group,R'" represents a hydrogen atom or an optionally halogenated or cyano-substituted C.sub.1 -C.sub.18 alkyl, C.sub.4 -C.sub.14 cycloalkyl or C.sub.6 -C.sub.14 aryl group,Q' represents a divalent alkyl group containing 4 to 12 carbon atoms or a divalent C.sub.4 -C.sub.14 cycloalkyl, C.sub.7 -C.sub.15 aralkyl, C.sub.6 -C.sub.14 aryl or C.sub.8 alkylaryl group,A = 0 or 1,With a compound of the formula: Q (XH).sub.
    Type: Grant
    Filed: December 23, 1974
    Date of Patent: March 6, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Kuno Wagner, Gunter Oertel, Hans D. Golitz, deceased, Bernd Quiring
  • Patent number: 4141992
    Abstract: 2,6 Anthraquinonylene cycloalkylcarboxamidines and halobenzamidines that are effective against cecal and hepatic amebic infestations in warm-blooded animals, methods of treatment therewith and therapeutic compositions thereof.
    Type: Grant
    Filed: July 13, 1977
    Date of Patent: February 27, 1979
    Assignee: American Cyanamid Company
    Inventors: Stanley A. Lang, Jr., Yang-I Lin, Thomas L. Fields, Paul F. Fabio, Keith C. Murdock
  • Patent number: 4142043
    Abstract: The present invention relates to compounds of formula I, ##STR1## in which R.sub.1 signifies a divalent, mono- or binuclear aromatic radical of the carbocylic or heterocyclic series, R.sub.2 signifies a hydrogen atom or an unsubstituted or substituted (C.sub.1-4)alkyl, phenyl, naphthyl or mono-or fused binuclear heterocyclic radical which is bound through a carbon atom, R.sub.3 signifies an oxygen atom or a group of formula >N--R.sub.5 in which R.sub.5 has one of the significances given above for R.sub.2, and each of the R.sub.4 's independently, signifies a mono- or binuclear aromatic radical of the carbocyclic or heterocyclic series,Or mixtures of such compounds, which compounds and mixtures are useful as colorants.
    Type: Grant
    Filed: June 27, 1977
    Date of Patent: February 27, 1979
    Assignee: Sandoz Ltd.
    Inventor: Werner Koch
  • Patent number: 4140714
    Abstract: A process is disclosed whereby 5,6-dihydro-6-hydroxy-4,4,6-trimethyl-2-vinyl-1,3(4H)-oxazine sulfate (1:1) is neutralized or alkalized under carefully controlled conditions to produce N-(1,1-dimethyl-3-oxobutyl)acrylamide, a reactive monomer useful for preparing polymeric components of photographic films and adhesives.
    Type: Grant
    Filed: June 28, 1978
    Date of Patent: February 20, 1979
    Assignee: American Cyanamid Company
    Inventors: Paul D. Mogolesko, Karel F. Bernady
  • Patent number: 4140852
    Abstract: Fluorescent dyestuffs of the general formula ##STR1## wherein X denotes 0, S or N--R.sub.1,Y and Z denote halogen, hydroxyl, amino, alkoxy, aralkoxy, cycloalkoxy, aryloxy, alkylmercapto, arylmercapto, alkylamino, dialkylamino, acylamino, alkyl or aryl andR.sub.1 denotes hydrogen, alkyl, aralkyl, aryl or acyl, andThe rings A and B and the cyclic and acyclic radicals R.sub.1, Y and Z can carry non-chromophoric substituents which are customary for whiteners. andThe ring A, furthermore, can be fused to 1 or 2 carbocyclic, partially saturated or aromatic rings,Are suitable for the whitening of synthetic, semi-synthetic and natural organic high-molecular materials.
    Type: Grant
    Filed: October 27, 1977
    Date of Patent: February 20, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Udo Eckstein, Horst Harnisch