Abstract: Pharmaceutical compositions, containing a 4,4'-dihydroxy-3,3'-triphenylmethanedicarboxylic acid (or an oxidized derivative) as active ingredient, are described and are prepared conventionally in a form suitable for topical administration e.g. ointment. The compositions are useful for the treatment of inflammatory diseases and inflammatory conditions of the skin. Many of the active ingredients are novel compounds. A representative novel active ingredient is 4"-cyano-4,4'-dihydroxy-5,5'-dimethyl-3,3'-triphenylmethanedicarboxylic acid.
Abstract: 1-Alkylamino-3-(3- or 4-[2-(endobicyclo[3.1.0]-hex-6-yl)ethylaminocarbonyl]-1-phenoxy)-2-propano l and substituted derivatives thereof and methods for preparing such compounds are disclosed. 5-(3- Or 4-[2-(endobicyclo[3.1.0]hex-6-yl)ethylaminocarbonyl]-phenoxy)methyl 3-alkyl-2-optionally substituted oxazolidine and derivatives thereof, and methods for preparing such compounds are also disclosed. These compounds exhibit cardiovascular acitivity and are useful in the treatment of abnormal heart condition as well as hypertension in mammals. The former compounds are prepared by treatment of the corresponding 1,2-epoxy-3-(3- or 4-[2-(endobicyclo[3.1.0]hex-6-yl)-ethylaminocarbonyl]phenoxy)propane with the desired alkylamine or by base or acid hydrolysis of the corresponding 5-(3- or 4-[2-(endobicyclo[3.1.0]hex-6-yl)-ethylaminocarbonyl)-3-alkyl oxazolidine. The latter compounds are prepared from the corresponding 1-alkylamino-3-(3- or 4-[2-(endobicyclo[3.1.
Type:
Grant
Filed:
October 31, 1977
Date of Patent:
April 24, 1979
Assignee:
Syntex (U.S.A.) Inc.
Inventors:
Karl G. Untch, Stefan H. Unger, Brian Lewis
Abstract: The invention relates to a process for the production of anthraquinone by catalytic oxidation of indans or diphenylmethane derivatives with oxygen in the presence of a vanadium (V) compound with or without one or more than one compund of potassium, boron, thallium, antimony and/or caesium. Anthraquinone which can be prepared by the process according to this invention is a valuable starting material for the production of dyes and pesticides.
Abstract: Process for the preparation of a p-arylaminophenol by reacting hydroquinone with a primary arylamino in the presence of a catalytic amount of aluminum sulfate or an aluminum lower carboxylate.
Abstract: This invention relates to color-changing styryl-like compounds and the preparing of the same. A compound according to the present invention has, as its principal ring, an indoline ring of 2nd position, and has, at stimulation reversible or irreversible change(s) between a closed ring structure of a non-plane molecular structure indicated by the following chemical formula(1) showing white or pale color, and an open ring structure of a plane molecular structure indicated by the following chemical formula(2) showing vivid visible color: ##STR1## wherein Q, R.sub.1, R.sub.2, R.sub.3, Y, Z, A and X are defined in the detailed specification.
Type:
Grant
Filed:
October 21, 1976
Date of Patent:
April 3, 1979
Assignee:
Matsushita Electric Industrial Co., Ltd.
Abstract: Novel cephalosporin derivatives having a (1-alkyl-1H-tetrazol-5-yl)vinyl group at the 3-position of the cephem nucleus and showing an excellent antibacterial activity are disclosed. A process for preparing the cephalosporin derivatives is also disclosed.
Abstract: Novel compounds having the following structure ##STR1## wherein X represents O, S or NR and R is benzyl or butyl;G.sup.1 and G.sup.2 represent cyano or taken together with the carbon atom to which they are attached represent sufficient atoms to complete an ethyl substituted barbituric acid nucleus;R.sup.1 and R.sup.2, which may be the same or different represent phenyl, (--CH.dbd..sub.n A.sup.1, --CH.dbd.CH--A.sup.2 ; and R.sup.3, R.sup.4, A.sup.1, A.sup.2 and n are as stated in the detailed disclosure.
Type:
Grant
Filed:
February 1, 1978
Date of Patent:
March 27, 1979
Assignee:
Eastman Kodak Company
Inventors:
James A. Van Allan, Frank G. Webster, George A. Reynolds
Abstract: A process for the manufacture of Bz-1-bromobenzanthrone by brominating finely divided benzanthrone in aqueous suspension, wherein the improvement comprises treating benzanthrone having a mean particle size of 30 .mu.m or less with bromine or brominating agent at above 80.degree. C.A product which contains from 91 to 94% by weight of Bz-1-bromobenzanthrone is obtained.
Abstract: This invention relates to hydroxyalkylaminoalkylamides, the N-alkylated derivatives thereof, and the preparaton and uses thereof. This invention also relates to quaternaries of the abovementioned hydroxyalkylaminoalkylamides.
Abstract: 1-Alkylamino-3-(?2-(endobicyclo?3.1.0!-hex-6-yl)ethylaminocarbonyl!naphthyl oxy)-2-propanols and methods for preparing these compounds are disclosed. The compounds are useful in the treatment of hypertension and abnormal heart conditions in mammals. These compounds are prepared by the treatment of the corresponding 1,2-epoxy-3-?2-(endobicyclo?3.1.0!hex-6-yl)ethylaminocarbonyl!naphthyloxy) -propane with an alkylamine having the desired alkyl substituent or by base or acid hydrolysis of the corresponding 2-optionally substituted -3-alkyl-5-(?2-(endobicyclo?3.1.0!hex-6-yl)ethylaminocarbonyl!naphthyloxym ethyl)oxazolidine. These latter compounds can be prepared by condensing a hydroxy-substituted naphthalene with a 3-alkyl-5-tosyloxymethyloxazolidine such substituted or unsubstituted at the 2-position or alternatively, by treating the former aminopropanol compounds of the present invention with an aldehyde having the desired substituent.
Abstract: Pyranthrone pigments of the formula ##STR1## WHEREIN N IS 0 OR 1, WHEREIN WHEN N IS 0, EACH A is hydrogen or chlorine, and when n is 1, each A is chlorine are prepared by crystallizing a finely divided crude pyranthrone pigment in an organic polar solvent, in the presence of from 0.5 to 10% by weight, based on the crude pigment, of an anthraquinone compound of the formula ##STR2## WHEREIN X is chlorine, Y is alkyl of 1 to 4 carbon atoms, hydroxyl, carboxyl, carbo-alkoxy, wherein said alkoxy group has 1 to 4 carbon atoms, or carbophenoxy, p is 0, 1 or 2 and m is 0, 1 or 2.
Abstract: Polymeric colorants comprising a hydrocarbon backbone and attached directly thereto through amine linkages, at least one water-solubilizing group and at least one optically chromophoric group are disclosed. In a preferred embodiment, the backbone is a saturated aliphatic hydrocarbon, the chromophore is an anthraquinone chromophore and the solubilizing group is a sulfonate or sulfamate residue.
Abstract: 1:1-Metal complexes of azomethines of the formula I ##STR1## wherein A and B are isocyclic or heterocyclic aromatic radicals, with however only one of the radicals A and B being a benzene ring, R represents a hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, or an aryl radical, and the complexing metal ions are bivalent cations of the transition metals, zinc ions or cadmium ions which are useful for pigmenting high molecular organic material.
Abstract: This application relates to certain 4'-substituted and to 3',4'-disubstituted anilides, to methods for their preparation and to methods for their use as anti-androgens.
Abstract: Covers compounds of the formula ##STR1## where R" is lower alkyl, R is hydrogen or lower alkyl and Y is selected from the group consisting of CN, CONH.sub.2, CO.sub.2 R', CONR'.sub.2 and COR' where R' independently is hydrogen, lower alkyl or aryl. Also covers a method of producing a polyurethane by utilizing said above compounds as catalysts in reacting an organic polyisocyanate with an organic polyester polyol or polyether polyol in the presence of said catalyst.
Abstract: The instant invention is directed to a process of preparing a silyl substituted urea derivative comprising reacting an isocyanate of the formula ##STR1## wherein R represents a C.sub.1 -C.sub.18 alkyl group, a C.sub.4 -C.sub.14 cycloalkyl group or a phenyl group,R' represents an optionally halogenated or cyano-substituted C.sub.1 -C.sub.10 alkyl, C.sub.4 -C.sub.10 cycloalkyl or C.sub.6 -C.sub.10 aryl group,R" represents a hydrogen atom, a methyl group or a phenyl group,R'" represents a hydrogen atom or an optionally halogenated or cyano-substituted C.sub.1 -C.sub.18 alkyl, C.sub.4 -C.sub.14 cycloalkyl or C.sub.6 -C.sub.14 aryl group,Q' represents a divalent alkyl group containing 4 to 12 carbon atoms or a divalent C.sub.4 -C.sub.14 cycloalkyl, C.sub.7 -C.sub.15 aralkyl, C.sub.6 -C.sub.14 aryl or C.sub.8 alkylaryl group,A = 0 or 1,With a compound of the formula: Q (XH).sub.
Type:
Grant
Filed:
December 23, 1974
Date of Patent:
March 6, 1979
Assignee:
Bayer Aktiengesellschaft
Inventors:
Kuno Wagner, Gunter Oertel, Hans D. Golitz, deceased, Bernd Quiring
Abstract: 2,6 Anthraquinonylene cycloalkylcarboxamidines and halobenzamidines that are effective against cecal and hepatic amebic infestations in warm-blooded animals, methods of treatment therewith and therapeutic compositions thereof.
Type:
Grant
Filed:
July 13, 1977
Date of Patent:
February 27, 1979
Assignee:
American Cyanamid Company
Inventors:
Stanley A. Lang, Jr., Yang-I Lin, Thomas L. Fields, Paul F. Fabio, Keith C. Murdock
Abstract: The present invention relates to compounds of formula I, ##STR1## in which R.sub.1 signifies a divalent, mono- or binuclear aromatic radical of the carbocylic or heterocyclic series, R.sub.2 signifies a hydrogen atom or an unsubstituted or substituted (C.sub.1-4)alkyl, phenyl, naphthyl or mono-or fused binuclear heterocyclic radical which is bound through a carbon atom, R.sub.3 signifies an oxygen atom or a group of formula >N--R.sub.5 in which R.sub.5 has one of the significances given above for R.sub.2, and each of the R.sub.4 's independently, signifies a mono- or binuclear aromatic radical of the carbocyclic or heterocyclic series,Or mixtures of such compounds, which compounds and mixtures are useful as colorants.
Abstract: A process is disclosed whereby 5,6-dihydro-6-hydroxy-4,4,6-trimethyl-2-vinyl-1,3(4H)-oxazine sulfate (1:1) is neutralized or alkalized under carefully controlled conditions to produce N-(1,1-dimethyl-3-oxobutyl)acrylamide, a reactive monomer useful for preparing polymeric components of photographic films and adhesives.
Abstract: Fluorescent dyestuffs of the general formula ##STR1## wherein X denotes 0, S or N--R.sub.1,Y and Z denote halogen, hydroxyl, amino, alkoxy, aralkoxy, cycloalkoxy, aryloxy, alkylmercapto, arylmercapto, alkylamino, dialkylamino, acylamino, alkyl or aryl andR.sub.1 denotes hydrogen, alkyl, aralkyl, aryl or acyl, andThe rings A and B and the cyclic and acyclic radicals R.sub.1, Y and Z can carry non-chromophoric substituents which are customary for whiteners. andThe ring A, furthermore, can be fused to 1 or 2 carbocyclic, partially saturated or aromatic rings,Are suitable for the whitening of synthetic, semi-synthetic and natural organic high-molecular materials.