Patents Examined by Allison M Fox
  • Patent number: 10874699
    Abstract: The invention relates to cell-free compositions obtained by culturing adult-derived human liver stem/progenitor cells (ADHLSC) in cell culture medium and isolating the resulting conditioned medium (ADHLSC-CM) that has advantageous properties, such as anti-fibrotic effects. ADHLSC-CM, compositions based on ADHLSC-CM, and other related and derived products, can be used in cell culture processes or as a medicament, more particularly for the treatment of diseases involving organ injury, organ failure, in organ or cell transplantation or the pathological disruption, inflammation, degeneration, and/or proliferation of cells within a tissue or an organ, in particular within liver.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: December 29, 2020
    Assignee: UNIVERSITÉ CATHOLIQUE DE LOUVAIN
    Inventors: Mustapha Najimi, Etienne Sokal, Silvia Berardis
  • Patent number: 10874697
    Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: December 29, 2020
    Assignee: MiMedx Group, Inc.
    Inventors: John Daniel, Randall Spencer, John Russo, Robert Tofe
  • Patent number: 10876728
    Abstract: There is provided a process for growing a phototrophic biomass in a reaction zone, wherein the reaction zone includes a reaction mixture that is operative for effecting photosynthesis upon exposure to photosynthetically active light radiation, wherein the reaction mixture includes phototrophic biomass that is operative for growth within the reaction zone. The process includes supplying at least a fraction of gaseous exhaust material, being discharged from an industrial process, to the reaction zone, exposing the reaction mixture to photosynthetically active light radiation and effecting growth of the phototrophic biomass in the reaction zone, wherein the effected growth includes growth effected by photosynthesis, and modulating distribution of a molar rate of supply of carbon dioxide, being exhausted from the reaction zone, as between a smokestack and at least another point of discharge.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: December 29, 2020
    Assignee: Pond Technologies Inc.
    Inventors: Jaime A. Gonzalez, Steven C. Martin, Max Kolesnik
  • Patent number: 10870733
    Abstract: A process for preparing an algal powder containing a reduced content of proteins, a bioplastic composition formed from such a powder, a process for manufacturing a plastic product obtained from such an algal powder and also the plastic product obtained in this way. Process for preparing an algal powder, especially intended for the manufacture of a plastic product, including the successive steps of: culturing and/or harvesting an algal biomass; reducing by at least 10% the intrinsic amount of proteins of the algae, by weight relative to the weight of proteins of the harvested biomass; drying; and reducing to give powder or granules.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: December 22, 2020
    Assignee: ERANOVA
    Inventors: Philippe Lavoisier, Ronan Pierre, Maud Benoit
  • Patent number: 10869952
    Abstract: Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of amnion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. The presence of the cross-linking agent present on the graft also enhances adhesion to the biological tissue of interest. Also described herein are methods for making and using the tissue grafts.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: December 22, 2020
    Assignee: MiMedx Group, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, John Daniel
  • Patent number: 10869951
    Abstract: Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of amnion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. The presence of the cross-linking agent present on the graft also enhances adhesion to the biological tissue of interest. Also described herein are methods for making and using the tissue grafts.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: December 22, 2020
    Assignee: MiMedx Group, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, John Daniel
  • Patent number: 10869899
    Abstract: An isolated human cell and populations thereof is provided comprising at least one astrocytic phenotype and at least one mesenchymal stem cell phenotype, wherein the mesenchymal stem cell phenotype is not an astrocytic phenotype.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: December 22, 2020
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Daniel Offen, Merav Bahat-Stromza, Eldad Melamed
  • Patent number: 10864299
    Abstract: In some embodiments, the present invention provides tissue compositions including a first silk scaffold comprising a plurality of epithelial cells, a second silk scaffold comprising a plurality of stromal cells, and a plurality of neurons. In some embodiments, provided compositions can function as physiologically relevant corneal model systems for, inter alia, testing of therapeutics for corneal disease and/or injury and production of functional corneal tissue (e.g., for transplant, etc). The present invention also provides methods for making and using provided compositions.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: December 15, 2020
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Siran Wang, Rachel Gomes, Chiara Ghezzi, Dana Cairns
  • Patent number: 10864457
    Abstract: The present invention relates to an improved method for preservation of e.g. microorganisms, especially lactic acid bacteria, said method includes spray freezing.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: December 15, 2020
    Assignee: CHR. HANSEN A/S
    Inventors: Michelle Madsen, Allan Jensen, Hans Bisgaard-Frantzen
  • Patent number: 10857215
    Abstract: Methods of using botulinum toxin based pharmaceuticals are disclosed. The methods cause vasodilatation and decreased flow resistance of certain vascular beds for the purpose of increasing blood flow to a region in order to positively impact deterioration from a number of diseases.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: December 8, 2020
    Assignee: Revance Therapeutics, Inc.
    Inventors: Gary E. Borodic, Martin A Acquadro
  • Patent number: 10849932
    Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: December 1, 2020
    Assignee: MESOBLAST, INC.
    Inventors: Silviu Itescu, Michael David Schuster
  • Patent number: 10851395
    Abstract: Provided herein are methods of producing oils with reduced saturated fatty acids. The methods include culturing oil-producing microorganisms in a fermentation medium in the presence of one or more antifoaming agents under a controlled carbon consumption rate, wherein the culturing produces oils comprising fatty acids and wherein less than 35% of the fatty acids in the oil are saturated fatty acids.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: December 1, 2020
    Assignee: MARA Renewables Corporation
    Inventors: Zhiyong Sun, Alan Sothern, Kevin Berryman, Mercia Valentine, Michael Milway, Laura Purdue, Roberto E. Armenta
  • Patent number: 10844353
    Abstract: The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: November 24, 2020
    Assignees: GPB Scientific, Inc., The Trustees of Princeton University, University of Maryland, Baltimore
    Inventors: Anthony Ward, Roberto Campos-Gonzalez, Alison Skelley, Khushroo Gandhi, Curt Civin, James C. Sturm, Michael Grisham
  • Patent number: 10829833
    Abstract: The invention provides a process of isolating or enriching a heavy metal present in a liquid medium. The process comprising the following steps: (a) incubating a suspension containing (i) particulate scrap metal, household waste and/or industrial waste containing a heavy metal in elemental form and (ii) biomass comprising a bacterium, or a combination of two or more bacteria, capable of binding the heavy metal; (b) separating the biomass having bound heavy metal from the suspension of step (a); and (c) isolating the heavy metal from the biomass separated in step (b).
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: November 10, 2020
    Assignee: B.R.A.I.N. Biotechnology Research and Information Network AG
    Inventors: Stephen Gos, Andrea Christiansen, Xin Lu, Guido Meurer, Yvonne Tiffert, Esther Gabor, Benedikt Hoffmann, Martin Langer
  • Patent number: 10806139
    Abstract: A method is disclosed for recovering living cells highly efficiently from cryopreserved cells by thawing and a system designed for such a method. The method for recovering living cells from cryopreserved cells includes thawing cryopreserved cells and diluting the thawed cell suspension with a diluent, wherein the dilution is performed in such a way that the maximum load of osmotic pressure at the time of dilution is equal to or less than 250 mOsm/second.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: October 20, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Kouichirou Yori, Ryohei Takeuchi
  • Patent number: 10808214
    Abstract: A photobioreactor system and a process for its use is illustrated, whereby water and nutrients from multiple sources are balanced (mixed using aeration) to the specific requirements of the particular photosynthetic organism strain used, sterilized, further mixed to balance the system and seeded with the photosynthetic microorganism, e.g. microalgae (dilution of a concentrated stock or added to an existing algal biomass). In accordance with such an embodiment, the algal biomass is then grown for a most efficient number of hours in a totally controlled environment where temperature (using aeration, an internal coil cooling system, or a combination thereof), pH (via CO2 delivery) and light delivery (using internal lighting directly inside the algal biomass) are optimized to the algal strain grown.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: October 20, 2020
    Assignee: Avespa Corporation
    Inventors: David Punchard, Philippe Bois, Angela Cortina Burgueno
  • Patent number: 10808224
    Abstract: The present invention provides a method of obtaining aggregates containing a rostral hypothalamus tissue and a rostral head ectodermal tissue, a hypophysis precursor tissue and a hypophysis hormone producing cell, by using a serum-free medium (preferably substantially free of growth factor and insulins), forming homogeneous aggregates of stem cells from pluripotent stem cells such as ES cell and the like, which are plated at a high cell concentration, and subjecting the formed aggregates to floating-culture.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: October 20, 2020
    Assignees: RIKEN, Sumitomo Chemical Company, Limited
    Inventors: Yoshiki Sasai, Hidetaka Suga
  • Patent number: 10799534
    Abstract: The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention relates to a method for stimulating, priming and/or expanding in vivo T cells genetically modified to express a chimeric antigen receptor (CAR) targeted to an antigen, comprising contacting the T cells with the antigen or a variant thereof in vivo. In one embodiment, the antigen or variant thereof is provided by administering a nucleic acid encoding the antigen or variant thereof.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: October 13, 2020
    Assignees: BIONTECH CELL & GENE THERAPIES GMBH, TRON—TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÁTSMEDIZIN DER JOHANNES GUTENBERG—UNIVERSITÄT MAINZ GEMEINNÜTZIGE GMBH
    Inventors: Ugur Sahin, Katharina Reinhard, Petra Simon, Karolina Anna Mroz, Kathleen Hobohm
  • Patent number: 10772916
    Abstract: Systems and methods are provided for deriving a platelet product from a plurality of buffy coats. A plurality of buffy coats are separately collected, for example, using a conventional floor centrifuge. Plasma and/or a platelet additive solution may be added to the buffy coats. The buffy coats are pooled into a container and conveyed into a centrifuge or are sequentially conveyed into the centrifuge without being pooled, where they are continuously processed to separate platelets from the other cellular blood components. The separated platelets are conveyed out of the centrifuge as a platelet product, which may be passed through a leukocyte removal filter to reduce the white blood cell content of the platelet product. By continuously separating the buffy coats, fewer buffy coats are required to produce a single-dose platelet product, while also allowing for the derivation and collection of a plurality of single-dose platelet products.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: September 15, 2020
    Assignee: Fenwal, Inc.
    Inventors: Kyungyoon Min, Benjamin E. Kusters, Richard I. Brown
  • Patent number: 10765704
    Abstract: Disclosed herein are induced hepatocytes from a trophoblast stem cell, methods for inducing the cells, and compositions thereof. Also disclosed herein are methods of treating a disease or disorder (e.g., liver-associated) by utilizing an induced hepatocyte disclosed herein.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: September 8, 2020
    Assignee: ACCELERATED BIOSCIENCES CORP.
    Inventors: Jau-Nan Lee, Tony Tung-Yin Lee, Yuta Lee, Eing-Mei Tsai