Patents Examined by Allison M Fox
  • Patent number: 11452797
    Abstract: The invention provides a method to prepare a graft comprising a recellularized extracellular matrix of a mammalian liver, liver lobe or portion thereof, and a method of using the recellularized extracellular matrix of a mammalian liver, liver lobe or portion thereof.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: September 27, 2022
    Assignee: Miromatrix Medical Inc.
    Inventor: Jeffrey Ross
  • Patent number: 11452745
    Abstract: The present invention generally relates to the field of probiotic bacteria. In particular, it relates to methods for treating or preventing functional GI disorders comprising administering Bifidobacterium longum, such as Bifidobacterium longum ATCC BAA-999.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: September 27, 2022
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Peter McLean, Gabriela Bergonzelli Degonda, Stephen Michael Collins, Premysl Bercik, Elena Verdu de Bercik
  • Patent number: 11446335
    Abstract: A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: September 20, 2022
    Assignee: ViaCyte, Inc.
    Inventors: Alan D. Agulnick, Kevin Allen D'Amour
  • Patent number: 11446331
    Abstract: The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are ABCB5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: September 20, 2022
    Assignees: The Brigham and Women's Hospital, Inc., Children's Medical Center Corporation, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: Markus H. Frank, Natasha Y. Frank, Dennis P. Orgill, George F. Murphy
  • Patent number: 11421256
    Abstract: The invention relates to a process for the preparation of a fermentation product from ligno-cellulosic material, comprising the following steps: a) optionally pre-treatment b) optionally washing; c) enzymatic hydrolysis; d) fermentation; and e) optionally recovery of a fermentation product; wherein in step c) an enzyme composition is used that has a temperature optimum of 55 degrees C. or more, the hydrolysis time is 40 hours or more and the temperature is 50 degrees C. or more.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: August 23, 2022
    Assignee: DSM IP ASSETS B.V.
    Inventors: Johannes Petrus Smits, Elisabeth Maria Gierveld, Fop Van Der Hor
  • Patent number: 11412760
    Abstract: The present invention relates to a Myoviridae bacteriophage ESC-COP-7 (accession number KCTC 13130BP) isolated from nature, and a method for preventing and treating infections from pathogenic Escherichia coli by means of a composition containing the Myoviridae bacteriophage ESC-COP-7 as an active ingredient, the Myoviridae bacteriophage ESC-COP-7 being characterized by having the capability to specifically kill Escherichia coli, and genome expressed by the SEQ ID 1.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: August 16, 2022
    Inventors: Seong Jun Yoon, Soo Youn Jun, Hyoun Rok Paik, Jee Soo Son, SAng Hyeon Kang
  • Patent number: 11415513
    Abstract: A method for determining the degree of sensitivity of a strain of fungus to an antifungal agent by using the possible change in a chitin level in a population of cells of a strain of fungus to an antifungal agent. The change is determined compared to the chitin level of a population of cells of said strain of fungus in the absence of antifungal agent.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: August 16, 2022
    Inventors: Delphine Paule Renee Morin-Aldebert, Murielle Monique Jacqueline Cornet-Gigou
  • Patent number: 11406737
    Abstract: Neurosupportive materials that possess strong tissue adhesion were synthesized by photocrosslinking two polymers, gelatin methacryloyl (GelMA) and methacryloyl-substituted tropoelastin (MeTro). The engineered materials exhibited tunable mechanical properties by varying the GelMA/MeTro ratio. In addition, GelMA/MeTro hydrogels exhibited 15-fold higher adhesive strength to nerve tissue ex vivo compared to traditionally used fibrin-based materials. Furthermore, the composites were shown to support Schwann cell (SC) viability and proliferation, as well as neurite extension and glial cell participation in vitro, which are essential cellular components for nerve regeneration. Finally, subcutaneously implanted GelMA/MeTro hydrogels exhibited slower degradation in vivo compared with pure GelMA, indicating its potential to support the growth of slowly regenerating nerves.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: August 9, 2022
    Assignee: Northeastern University
    Inventors: Jonathan R. Soucy, Ehsan Shirzaei Sani, Abigail N. Koppes, Ryan A. Koppes, Nasim Annabi
  • Patent number: 11408893
    Abstract: A method for selective labelling of necrotic cells including incubating the cells in a solution including a Ln(III)Zn16(HA ligand)16 metallacrown complex, wherein the HA ligand is a hydroximate ligand.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: August 9, 2022
    Assignees: The Regents of the University of Michigan, Centre National De La Recherche Scientifique
    Inventors: Ivana Martinic, Tu Ngoc Nguyen, Svetlana V. Eliseeva, Vincent L. Pecoraro, Stéphane Petoud
  • Patent number: 11391732
    Abstract: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to about 0.5, as determined by X-ray photoelectron spectroscopy (XPS); (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: July 19, 2022
    Assignee: 3MInnovative Properties Company
    Inventors: Manjiri T. Kshirsagar, Tushar A. Kshirsagar, Thomas E. Wood
  • Patent number: 11376347
    Abstract: Provided are elastin-rich bioscaffolds, enhanced via stem cell pre-seeding and flow-based mechanical conditioning followed by subsequent removal of stem cells. The bioscaffolds may accelerate cardiovascular tissue regeneration and can be used in the surgical repair/reconstruction in various cardiovascular and other surgical applications including heart valves, cardiovascular grafts, and patches. The provided acellular, elastin-rich bioscaffold will pose minimal immune risk and reduced FDA regulatory hurdles as a non-living biologic product.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: July 5, 2022
    Inventors: Sharan D. Ramaswamy, Brittany Gonzalez, Ariadna Herrera, Alexander Williams
  • Patent number: 11369714
    Abstract: The present invention resides in a method for producing jellyfish collagen hydrogels and kits for producing the same. The jellyfish collagen hydrogels can be used in the culture of cells. According to the invention, there is a process for producing jellyfish collagen hydrogels comprising jellyfish collagen fibrils, said process comprising the steps of: mixing a solution of purified jellyfish collagen and an aqueous neutralisation buffer; and incubating the mixture for a sufficient time to enable jellyfish collagen fibrils to form, wherein a cross-linking agent is either added during to mixing step or during or after the incubation of the mixture.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: June 28, 2022
    Assignee: JELLAGEN PTY LTD
    Inventor: Andrew Mearns Spragg
  • Patent number: 11369643
    Abstract: Acellular amnion derived therapeutic compositions are described having a number of various compositional embodiments. An acellular amnion derived therapeutic composition has essentially no live or active amniotic cells. The amniotic cells may be destroyed and the cells and cell debris may be removed from the acellular amnion derived therapeutic composition. An acellular amnion derived therapeutic composition may comprise micronized placental tissue particles, and/or amniotic fluid. An acellular amnion derived therapeutic composition may be a dispersion of micronized amniotic membrane combined with a fluid, such as plasma, saline, amniotic fluid, combinations thereof and the like. An acellular amnion derived therapeutic composition may be combined with a matrix component to form a composite. An acellular amnion derived therapeutic composition may be used in conjunction with a composition comprising viable cells, such as stem cells.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: June 28, 2022
    Inventors: Christian Beaudry, Terrell Suddarth, Bruce Werber
  • Patent number: 11364324
    Abstract: Methods of forming a connective tissue-to-bone interface scaffolds (e.g., ligament-to-bone interface scaffolds, tendon-to-bone interface scaffolds, etc.). These scaffolds (grafts) may be formed from in such a way as to provide both a mineralized and demineralized layer in which the entire graft is flexible, compressible and compliant.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: June 21, 2022
    Assignee: Sparta Biopharma Inc.
    Inventors: Ian N. Askill, Dushyanth R. Surakanti, Adam B. Yanke, Adam W. Martinez, Kurt W. S. Klitzke, Travis E. Entrop, Dimitrios J. Angelis
  • Patent number: 11365397
    Abstract: Methods of screening rinse-off personal care compositions can include the use of explant skin in combination with measurements for moisture and/or cell proliferation.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: June 21, 2022
    Assignee: The Procter & Gamble Company
    Inventors: Karl Shiqing Wei, Teresa DiColandrea, Deborah Ruth Finlay
  • Patent number: 11357889
    Abstract: A method is used for preparing a product for use in repairing a lesion or defect at a tissue site in a human or animal patient body. The method includes obtaining tissue from a donor human or animal body and freezing the obtained tissue. The method further includes pulverizing the frozen tissue and suspending the pulverized tissue in a fluid. The method further includes homogenizing the tissue suspension and precipitating tissue particles from the homogenized tissue suspension. The method further includes re-suspending the precipitated tissue particles and lyophilizing the tissue re-suspension to provide the product to be used in repairing the lesion or defect.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: June 14, 2022
    Assignee: Cytex Therapeutics, Inc.
    Inventors: Hani Awad, Bradley T. Estes, Farshid Guilak
  • Patent number: 11352596
    Abstract: The invention relates to a method for producing biogas from lignocellulose-containing biomass, preferably from straw, and to a plant for carrying out said method.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: June 7, 2022
    Inventors: Oliver Ludtke, Michael Schlimbach, Enrico Fichter, Jens Horn, Georg Pollert, Jan Kuhling
  • Patent number: 11345889
    Abstract: The present invention provides an artificial tissue culture comprising a heterogeneous population of cells of at least two different tissue sections, wherein said tissue sections are in a three dimensional structure, method of generating such a tissue and kits suitable for said method or maintain a three dimensional tissue culture.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: May 31, 2022
    Assignee: IMBA-Institut fur Molekulare Biotechnologie GMBH
    Inventors: Juergen Knoblich, Madeline A. Lancaster
  • Patent number: 11331348
    Abstract: A method is provided for preparing an ECM material, including an ECM gel, from regenerative or regenerating tissue. ECM material prepared from regenerative or regenerating materials also is provided.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: May 17, 2022
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Chien-Wen Chen, Yadong Wang
  • Patent number: 11319568
    Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: May 3, 2022
    Assignee: AMGEN INC.
    Inventors: Jian Wu, Sean Davern, Simina Crina Petrovan, Michael Charles Brandenstein, Katherine Rose Lindahl, Shawn Erik Lillie