Abstract: The present invention provides an improved process for the production of a compound of formula I ##STR1## wherein R.sub.1 is carboxyl, alkoxy(C.sub.1-5)carbonyl, amido, alkyl(C.sub.1-5)amido, di(alkyl(C.sub.1-5)amido or an amido radical of formula II ##STR2## wherein R.sub.a is alkyl(C.sub.1-4),R.sub.b is alkyl(C.sub.1-4) or benzyl, andR.sub.2 is hydrogen or alkyl(C.sub.1-4), andeitherR.sub.3 is hydrogen and R.sub.4 is hydrogen or alkoxy(C.sub.1-4)orR.sub.3 and R.sub.4 together are a single bond,characterized in that a compound of formula III ##STR3## wherein R.sub.1 to R.sub.4 are as defined above,is brominated with a bromine complex of 3-bromo-6-chloro-2-methyl-imidazo[1,2-b]pyridazine.
Type:
Grant
Filed:
April 18, 1980
Date of Patent:
September 2, 1986
Assignee:
Sandoz Ltd.
Inventors:
Milan Jurgec, Rudolf Rucman, Branko Stanovnik, Miha Tisler
Abstract: The invention provides novel .alpha.-(ethynyl substituted phenyl)-.alpha.-hydrocarbyl-1H-azole-ethanols wherein the azole group is 1,2,4-triazol-1-yl or imidazol-1-yl, the ethynyl group is unsubstituted or substituted and the phenyl group may bear an additional substituent and ethers thereof, which are useful as fungicides.
Abstract: This invention provides compounds of ##STR1## wherein R.sub.1 is benzyl or benzyl substituted by hydroxy, chlorine, fluorine, amino, amido, (C.sub.2-5) alkanoylamino, (C.sub.1-4) alkyl, (C.sub.1-4) alkylamino, (C.sub.1-4) alkoxy, (C.sub.1-4) alkylamido, di[(C.sub.1-4) alkyl]amino, or di[(C.sub.1-4) alkyl]amino,R.sub.2, R.sub.4 and R.sub.5 are each (C.sub.1-4) alkyl, andR.sub.3 is (C.sub.2-4) alkylare prolactin secretion promoters.
Abstract: Azolylmethylcycloacetals of the formula I ##STR1## where R is phenyl which can be substituted by halogen, or is C.sub.1 -C.sub.6 -alkyl, R.sup.1 is hydrogen or C.sub.1 -C.sub.3 -alkyl, Z is CH or N, and m is 0 or 1, and their physiologically tolerated addition salts with acids and their preparation are described.The novel substances have an antimycotic action.
Type:
Grant
Filed:
January 16, 1985
Date of Patent:
August 19, 1986
Assignee:
BASF Aktiengesellschaft
Inventors:
Bernd Janssen, Friedrich-Wilhelm Kohlmann, Walter Wesenberg, Wolfgang Heberle
Abstract: The known E-isomers of compounds of the formula ##STR1## in which X and Y independently of each other represent hydrogen or halogen,are obtained according to a new process, in which triazolylketones of the formula ##STR2## in which X and Y have the above mentioned meaning, are reacted with an excess of cyclohexanecarbaldehyde in the presence of a non-polar organic diluent and in the presence of a catalyst mixture of organic acids and secondary amines in a molar ratio of 1:0.5 to 1:1 at temperatures between 40.degree. and 100.degree. C. by continuously removing the water formed and subsequently working up in the manner that is described in the specification.
Type:
Grant
Filed:
June 22, 1984
Date of Patent:
August 19, 1986
Assignee:
Bayer Aktiengesellschaft
Inventors:
Peter Feyen, Gebhard Rauleder, Wolf Reiser
Abstract: The compounds of the formula (I): ##STR1## wherein R.sub.4 is hydrogen, C.sub.1-6 alkyl, alkenyl or alkynyl having up to 4 carbon atoms, phenylallyl, phenyl, benzyl optionally ring-substituted with for example halogen, C.sub.1-4 alkyl or alkoxy, nitro, trifluoromethyl, cyano or methylene-dioxy, of alpha-(C.sub.1-4 alkyl) benzyl optionally ring-substituted with for example halogen, and R.sub.5 is C.sub.1-6 alkyl or cycloalkyl having up to 6 carbon atoms; and Z is C.dbd.O or a derivative thereof; or salts of such compounds. The compounds have fungicidal and plant growth regulating properties.
Type:
Grant
Filed:
August 13, 1985
Date of Patent:
August 12, 1986
Assignee:
Imperial Chemical Industries PLC
Inventors:
Sugavanam Balasubramanyan, Margaret C. Shephard
Abstract: Novel substituted azolylalkyl-t-butyl-ketones and -carbinols of the formula ##STR1## in which Az is imidazol-1-yl or 1,2,4-triazol-1-yl,A is the carbonyl group or the hydroxymethylene group, andR is optionally substituted cycloalkylalkyl or cycloalkenylalkyl,and plant-tolerated addition products thereof with acids and metal salts, which are fungicidally active and are also useful as intermediates in making other fungicides.
Type:
Grant
Filed:
May 22, 1985
Date of Patent:
July 29, 1986
Assignee:
Bayer Aktiengesellschaft
Inventors:
Wolf Reiser, Karl H. Buchel, Wilhelm Brandes, Paul Reinecke
Abstract: Compounds having the general formula (I): ##STR1## and stereoisomers thereof, wherein R.sup.1 and R.sup.2 are each hydrogen, a cation, alkyl, cycloalkyl, aryl or aralkyl optionally substituted with halogen, nitro, alkyl, haloalkyl, alkoxy, haloalkoxy, phenyl, phenoxy, halophenyl or halophenoxy, or together form a ring; R.sup.3 and R.sup.4 are each hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl or aralkyl optionally substituted with halogen, nitro, alkyl, haloalkyl, alkoxy, haloalkoxy, phenyl, phenoxy, halophenyl or halophenoxy; W is N or CH; X is oxygen or sulphur; ester and ether derivatives of the alcohol; and its acid addition salts and metal complexes. The compounds are useful as fungicides and for plant growth regulation.
Type:
Grant
Filed:
March 2, 1984
Date of Patent:
July 29, 1986
Assignee:
Imperial Chemical Industries PLC
Inventors:
John Dalziel, Paul A. Worthington, Balasubramanyan Sugavanam
Abstract: Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles wherein the 1,3-dioxolane ring is substituted in the 4- and in the 5-positions, said compounds having useful antimicrobial properties.
Type:
Grant
Filed:
November 7, 1983
Date of Patent:
July 22, 1986
Assignee:
Janssen Pharmaceutica, N.V.
Inventors:
Jan Heeres, Leo Backx, Willy Van Laerhoven, Elmar Sturm
Abstract: Carbamoylated azolylalkyl-phenoxy-carbinols of the formula ##STR1## in which A is a nitrogen atom or the CH group, andR is optionally substituted phenyl, which possess fungicidal and insecticidal activity.
Type:
Grant
Filed:
April 6, 1984
Date of Patent:
July 8, 1986
Assignee:
Bayer Aktiengesellschaft
Inventors:
Gerhard Heywang, Paul Reinecke, Wilhelm Brandes, Gerd Haenssler, Ingeborg Hammann
Abstract: New thiadiazole ureas are provided for the control of plant growth, especially of undesirable weeds and grasses. Particularly effective are compounds which contain an organic substitutent in the 5-position of the thiadiazole portion.
Abstract: Azolylmethyl-thienyl-carbinols of the formula ##STR1## in which R.sup.1 is optionally substituted phenyl, andR.sup.2 is optionally substituted thienyl,or addition products thereof with acids or metal salts, which possess fungicidal activity.
Type:
Grant
Filed:
May 29, 1984
Date of Patent:
June 24, 1986
Assignee:
Bayer Aktiengesellschaft
Inventors:
Udo Kraatz, Graham Holmwood, Karl H. Buchel, Hans-Jurgen Rosslenbroich, Hans Scheinpflug
Abstract: Benzodiazocines corresponding to the formula ##STR1## are converted to benzodiazepines corresponding to the formula ##STR2## of claim 1 by subjecting the benzodiazocine (a) if it is halogen-substituted in the 3-position to a thermal treatment which may also take place in the presence of a nucleophilic agent for the reaction or (b) if the 3-position is hydroxy substituted to treatment with a Lewis acid which is a chlorinating or brominating agent. Whenever the diazepine obtained as the final product has a 2-halogenomethyl group it may then be converted to benzodiazepine which is otherwise substituted in the 2-position.
Type:
Grant
Filed:
April 24, 1984
Date of Patent:
June 17, 1986
Assignee:
Kali-Chemie AG
Inventors:
Wolfgang Milkowski, Renke Budden, Siegfried Funke, Rolf Huschens, Hans-Gunther Liepmann, Werner Stuhmer, Horst Zeugner
Abstract: The triazole compounds have the general formula (I): ##STR1## wherein R.sup.1 is alkyl, cycloalkyl (e.g. cyclopropyl, cyclopentyl or cyclohexyl) or optionally substituted phenyl and R.sup.2 is optionally substituted phenyl or optionally substituted benzyl; or an acid addition salt or metal complex thereof. The compounds have fungicidal and plant growth regulating properties.
Type:
Grant
Filed:
February 10, 1984
Date of Patent:
June 17, 1986
Assignee:
Imperial Chemical Industries PLC
Inventors:
Keith P. Parry, Paul A. Worthington, William G. Rathmell
Abstract: There are disclosed compounds of formula: ##STR1## wherein R is selected from the group consisting of H, an alkyl, and alkenyl, an alkynyl, an alkoxyl, a phenyl, a phenoxy, an alkoxycarbonyl, an alkylcarbonyl, a benzoyl and a cyano group; R.sup.1 and R.sup.2 are each selected from the group consisting of an alkyl, an alkenyl, an alkynyl, a phenyl, an alkoxycarbonyl, an alkylcarbonyl and a cyano group; or R and R.sup.2 together form an orthocondensed benzene ring; X.dbd.CH or N.The compounds of formula I are endowed with fungicide activity against phytopathogenous fungi.
Type:
Grant
Filed:
March 26, 1984
Date of Patent:
June 10, 1986
Assignee:
Montedison S.p.A.
Inventors:
Roberto Colle, Franco Gozzo, Luigi Mirenna
Abstract: (-)-Antipode of (E)-1-cyclohexyl-4,4-dimethyl-3-hydroxy-2-(1,2,4-triazol-1-yl)-pent-1-ene of the formula ##STR1## a plant growth regulant containing the same and a process for regulating the growth of plants are disclosed. Also disclosed is a method for making such antipode.
Type:
Grant
Filed:
January 16, 1984
Date of Patent:
June 3, 1986
Assignee:
Bayer Aktiengesellschaft
Inventors:
Udo Kraatz, Wolf Reiser, Karl H. Buchel, Klaus Lurssen
Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are alkyl or aryl groups, A, B, C and D are non-reactive substituents or two are joined to form an additional ring, and Z is either of the formula Z': ##STR2## wherein R.sup.4 is H, lower alkyl or a cation; or a -6-oxotetrahydropyran-2-yl ring of the formula Z": ##STR3## e.g. 4-hydroxy-6-{2-[2-(methyldiphenylsilyl)phenyl]ethenyl]ethyenyl}-tetrahydro -2H-pyran-2-one, (trans, trans). The compounds inhibit cholesterol biosynthesis and are useful as anti-atherosclerotic agents.
Abstract: Compounds having the general formula (I): ##STR1## wherein Y is --CH.dbd. or .dbd.N--, R.sup.1 is alkyl, cycloalkyl optionally substituted phenyl and R.sup.2 and R.sup.3, which may be the same or different, are hydrogen, alkyl, cycloalkyl, (e.g. cyclopropyl, cyclopentyl or cyclohexyl) optionally substituted phenyl or optionally substituted benzyl, or together form an alkylene bridging group; and acid addition salts; metal complexes; ether and ester derivatives of the hydroxy groups; and stereoisomers thereof. These compounds have fungicidal and plant growth regulating properties.