Patents Examined by Alton D. Rollins
  • Patent number: 4609731
    Abstract: The present invention provides an improved process for the production of a compound of formula I ##STR1## wherein R.sub.1 is carboxyl, alkoxy(C.sub.1-5)carbonyl, amido, alkyl(C.sub.1-5)amido, di(alkyl(C.sub.1-5)amido or an amido radical of formula II ##STR2## wherein R.sub.a is alkyl(C.sub.1-4),R.sub.b is alkyl(C.sub.1-4) or benzyl, andR.sub.2 is hydrogen or alkyl(C.sub.1-4), andeitherR.sub.3 is hydrogen and R.sub.4 is hydrogen or alkoxy(C.sub.1-4)orR.sub.3 and R.sub.4 together are a single bond,characterized in that a compound of formula III ##STR3## wherein R.sub.1 to R.sub.4 are as defined above,is brominated with a bromine complex of 3-bromo-6-chloro-2-methyl-imidazo[1,2-b]pyridazine.
    Type: Grant
    Filed: April 18, 1980
    Date of Patent: September 2, 1986
    Assignee: Sandoz Ltd.
    Inventors: Milan Jurgec, Rudolf Rucman, Branko Stanovnik, Miha Tisler
  • Patent number: 4609668
    Abstract: The invention provides novel .alpha.-(ethynyl substituted phenyl)-.alpha.-hydrocarbyl-1H-azole-ethanols wherein the azole group is 1,2,4-triazol-1-yl or imidazol-1-yl, the ethynyl group is unsubstituted or substituted and the phenyl group may bear an additional substituent and ethers thereof, which are useful as fungicides.
    Type: Grant
    Filed: August 24, 1984
    Date of Patent: September 2, 1986
    Assignee: Sandoz Ltd.
    Inventors: Fritz Schaub, Rupert Schneider
  • Patent number: 4609657
    Abstract: This invention provides compounds of ##STR1## wherein R.sub.1 is benzyl or benzyl substituted by hydroxy, chlorine, fluorine, amino, amido, (C.sub.2-5) alkanoylamino, (C.sub.1-4) alkyl, (C.sub.1-4) alkylamino, (C.sub.1-4) alkoxy, (C.sub.1-4) alkylamido, di[(C.sub.1-4) alkyl]amino, or di[(C.sub.1-4) alkyl]amino,R.sub.2, R.sub.4 and R.sub.5 are each (C.sub.1-4) alkyl, andR.sub.3 is (C.sub.2-4) alkylare prolactin secretion promoters.
    Type: Grant
    Filed: July 14, 1980
    Date of Patent: September 2, 1986
    Assignee: Sandoz Ltd.
    Inventors: Paul Stadler, Franz Troxler
  • Patent number: 4607045
    Abstract: Azolylmethylcycloacetals of the formula I ##STR1## where R is phenyl which can be substituted by halogen, or is C.sub.1 -C.sub.6 -alkyl, R.sup.1 is hydrogen or C.sub.1 -C.sub.3 -alkyl, Z is CH or N, and m is 0 or 1, and their physiologically tolerated addition salts with acids and their preparation are described.The novel substances have an antimycotic action.
    Type: Grant
    Filed: January 16, 1985
    Date of Patent: August 19, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Janssen, Friedrich-Wilhelm Kohlmann, Walter Wesenberg, Wolfgang Heberle
  • Patent number: 4607108
    Abstract: The known E-isomers of compounds of the formula ##STR1## in which X and Y independently of each other represent hydrogen or halogen,are obtained according to a new process, in which triazolylketones of the formula ##STR2## in which X and Y have the above mentioned meaning, are reacted with an excess of cyclohexanecarbaldehyde in the presence of a non-polar organic diluent and in the presence of a catalyst mixture of organic acids and secondary amines in a molar ratio of 1:0.5 to 1:1 at temperatures between 40.degree. and 100.degree. C. by continuously removing the water formed and subsequently working up in the manner that is described in the specification.
    Type: Grant
    Filed: June 22, 1984
    Date of Patent: August 19, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Feyen, Gebhard Rauleder, Wolf Reiser
  • Patent number: 4605747
    Abstract: The compounds of the formula (I): ##STR1## wherein R.sub.4 is hydrogen, C.sub.1-6 alkyl, alkenyl or alkynyl having up to 4 carbon atoms, phenylallyl, phenyl, benzyl optionally ring-substituted with for example halogen, C.sub.1-4 alkyl or alkoxy, nitro, trifluoromethyl, cyano or methylene-dioxy, of alpha-(C.sub.1-4 alkyl) benzyl optionally ring-substituted with for example halogen, and R.sub.5 is C.sub.1-6 alkyl or cycloalkyl having up to 6 carbon atoms; and Z is C.dbd.O or a derivative thereof; or salts of such compounds. The compounds have fungicidal and plant growth regulating properties.
    Type: Grant
    Filed: August 13, 1985
    Date of Patent: August 12, 1986
    Assignee: Imperial Chemical Industries PLC
    Inventors: Sugavanam Balasubramanyan, Margaret C. Shephard
  • Patent number: 4603140
    Abstract: Novel substituted azolylalkyl-t-butyl-ketones and -carbinols of the formula ##STR1## in which Az is imidazol-1-yl or 1,2,4-triazol-1-yl,A is the carbonyl group or the hydroxymethylene group, andR is optionally substituted cycloalkylalkyl or cycloalkenylalkyl,and plant-tolerated addition products thereof with acids and metal salts, which are fungicidally active and are also useful as intermediates in making other fungicides.
    Type: Grant
    Filed: May 22, 1985
    Date of Patent: July 29, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolf Reiser, Karl H. Buchel, Wilhelm Brandes, Paul Reinecke
  • Patent number: 4602929
    Abstract: Compounds having the general formula (I): ##STR1## and stereoisomers thereof, wherein R.sup.1 and R.sup.2 are each hydrogen, a cation, alkyl, cycloalkyl, aryl or aralkyl optionally substituted with halogen, nitro, alkyl, haloalkyl, alkoxy, haloalkoxy, phenyl, phenoxy, halophenyl or halophenoxy, or together form a ring; R.sup.3 and R.sup.4 are each hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl or aralkyl optionally substituted with halogen, nitro, alkyl, haloalkyl, alkoxy, haloalkoxy, phenyl, phenoxy, halophenyl or halophenoxy; W is N or CH; X is oxygen or sulphur; ester and ether derivatives of the alcohol; and its acid addition salts and metal complexes. The compounds are useful as fungicides and for plant growth regulation.
    Type: Grant
    Filed: March 2, 1984
    Date of Patent: July 29, 1986
    Assignee: Imperial Chemical Industries PLC
    Inventors: John Dalziel, Paul A. Worthington, Balasubramanyan Sugavanam
  • Patent number: 4602010
    Abstract: Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles wherein the 1,3-dioxolane ring is substituted in the 4- and in the 5-positions, said compounds having useful antimicrobial properties.
    Type: Grant
    Filed: November 7, 1983
    Date of Patent: July 22, 1986
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo Backx, Willy Van Laerhoven, Elmar Sturm
  • Patent number: 4599349
    Abstract: Carbamoylated azolylalkyl-phenoxy-carbinols of the formula ##STR1## in which A is a nitrogen atom or the CH group, andR is optionally substituted phenyl, which possess fungicidal and insecticidal activity.
    Type: Grant
    Filed: April 6, 1984
    Date of Patent: July 8, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Heywang, Paul Reinecke, Wilhelm Brandes, Gerd Haenssler, Ingeborg Hammann
  • Patent number: 4599427
    Abstract: The new azolylmethylamines can be prepared by reaction of amines and azoles with formaldehyde. They can be used in microbicidal agents.
    Type: Grant
    Filed: September 28, 1983
    Date of Patent: July 8, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Oeckl, Hans-Georg Schmitt, Wilfried Paulus, Hermann Genth
  • Patent number: 4599424
    Abstract: New thiadiazole ureas are provided for the control of plant growth, especially of undesirable weeds and grasses. Particularly effective are compounds which contain an organic substitutent in the 5-position of the thiadiazole portion.
    Type: Grant
    Filed: October 3, 1979
    Date of Patent: July 8, 1986
    Assignee: Rhone-Poulenc, Inc.
    Inventor: Patrick R. Driscoll
  • Patent number: 4598085
    Abstract: Novel compounds of the class of 1-(2-aryl-2-R-ethyl)-1H-1,2,4-triazoles having fungicidal and plant-growth regulating properties.
    Type: Grant
    Filed: January 21, 1982
    Date of Patent: July 1, 1986
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph A. Mostmans
  • Patent number: 4596815
    Abstract: Azolylmethyl-thienyl-carbinols of the formula ##STR1## in which R.sup.1 is optionally substituted phenyl, andR.sup.2 is optionally substituted thienyl,or addition products thereof with acids or metal salts, which possess fungicidal activity.
    Type: Grant
    Filed: May 29, 1984
    Date of Patent: June 24, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Udo Kraatz, Graham Holmwood, Karl H. Buchel, Hans-Jurgen Rosslenbroich, Hans Scheinpflug
  • Patent number: 4595531
    Abstract: Benzodiazocines corresponding to the formula ##STR1## are converted to benzodiazepines corresponding to the formula ##STR2## of claim 1 by subjecting the benzodiazocine (a) if it is halogen-substituted in the 3-position to a thermal treatment which may also take place in the presence of a nucleophilic agent for the reaction or (b) if the 3-position is hydroxy substituted to treatment with a Lewis acid which is a chlorinating or brominating agent. Whenever the diazepine obtained as the final product has a 2-halogenomethyl group it may then be converted to benzodiazepine which is otherwise substituted in the 2-position.
    Type: Grant
    Filed: April 24, 1984
    Date of Patent: June 17, 1986
    Assignee: Kali-Chemie AG
    Inventors: Wolfgang Milkowski, Renke Budden, Siegfried Funke, Rolf Huschens, Hans-Gunther Liepmann, Werner Stuhmer, Horst Zeugner
  • Patent number: 4595406
    Abstract: The triazole compounds have the general formula (I): ##STR1## wherein R.sup.1 is alkyl, cycloalkyl (e.g. cyclopropyl, cyclopentyl or cyclohexyl) or optionally substituted phenyl and R.sup.2 is optionally substituted phenyl or optionally substituted benzyl; or an acid addition salt or metal complex thereof. The compounds have fungicidal and plant growth regulating properties.
    Type: Grant
    Filed: February 10, 1984
    Date of Patent: June 17, 1986
    Assignee: Imperial Chemical Industries PLC
    Inventors: Keith P. Parry, Paul A. Worthington, William G. Rathmell
  • Patent number: 4594353
    Abstract: There are disclosed compounds of formula: ##STR1## wherein R is selected from the group consisting of H, an alkyl, and alkenyl, an alkynyl, an alkoxyl, a phenyl, a phenoxy, an alkoxycarbonyl, an alkylcarbonyl, a benzoyl and a cyano group; R.sup.1 and R.sup.2 are each selected from the group consisting of an alkyl, an alkenyl, an alkynyl, a phenyl, an alkoxycarbonyl, an alkylcarbonyl and a cyano group; or R and R.sup.2 together form an orthocondensed benzene ring; X.dbd.CH or N.The compounds of formula I are endowed with fungicide activity against phytopathogenous fungi.
    Type: Grant
    Filed: March 26, 1984
    Date of Patent: June 10, 1986
    Assignee: Montedison S.p.A.
    Inventors: Roberto Colle, Franco Gozzo, Luigi Mirenna
  • Patent number: 4592772
    Abstract: (-)-Antipode of (E)-1-cyclohexyl-4,4-dimethyl-3-hydroxy-2-(1,2,4-triazol-1-yl)-pent-1-ene of the formula ##STR1## a plant growth regulant containing the same and a process for regulating the growth of plants are disclosed. Also disclosed is a method for making such antipode.
    Type: Grant
    Filed: January 16, 1984
    Date of Patent: June 3, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Udo Kraatz, Wolf Reiser, Karl H. Buchel, Klaus Lurssen
  • Patent number: 4588715
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are alkyl or aryl groups, A, B, C and D are non-reactive substituents or two are joined to form an additional ring, and Z is either of the formula Z': ##STR2## wherein R.sup.4 is H, lower alkyl or a cation; or a -6-oxotetrahydropyran-2-yl ring of the formula Z": ##STR3## e.g. 4-hydroxy-6-{2-[2-(methyldiphenylsilyl)phenyl]ethenyl]ethyenyl}-tetrahydro -2H-pyran-2-one, (trans, trans). The compounds inhibit cholesterol biosynthesis and are useful as anti-atherosclerotic agents.
    Type: Grant
    Filed: June 4, 1984
    Date of Patent: May 13, 1986
    Assignee: Sandoz, Inc.
    Inventor: Robert E. Damon, II
  • Patent number: 4586947
    Abstract: Compounds having the general formula (I): ##STR1## wherein Y is --CH.dbd. or .dbd.N--, R.sup.1 is alkyl, cycloalkyl optionally substituted phenyl and R.sup.2 and R.sup.3, which may be the same or different, are hydrogen, alkyl, cycloalkyl, (e.g. cyclopropyl, cyclopentyl or cyclohexyl) optionally substituted phenyl or optionally substituted benzyl, or together form an alkylene bridging group; and acid addition salts; metal complexes; ether and ester derivatives of the hydroxy groups; and stereoisomers thereof. These compounds have fungicidal and plant growth regulating properties.
    Type: Grant
    Filed: December 21, 1982
    Date of Patent: May 6, 1986
    Assignee: Imperial Chemical Industries PLC
    Inventors: Patrick J. Crowley, John C. Williams