Abstract: An analgesic and sleep-aid composition containing an analgesic (e.g. aspirin, APAP or combinations thereof) and diphenhydramine dihydrogencitrate. Discloses several dosage forms including a two layer tablet in which aspirin is contained in one layer and APAP contained in the other layer; the preferred form being such that the diphenhydramine dihydrogencitrate is contained in the APAP layer.

Abstract: There are disclosed derivatives of five-membered nitrogen-containing heterocycles substituted on the nitrogen atom in position 1 by polyfunctional alkenyl groups. Said compounds are endowed with phytogrowth-regulating activity and, in higher doses, with herbicidal activity. A process for synthesizing the compounds and their use in agriculture are also disclosed.

Abstract: Compounds of the formula ##STR1## a pharmaceutically or agriculturally acceptable salt thereof, wherein R is 5-chloro-2-pyridyl or phenyl optionally substituted by one to three substituents, each independently selected from F, Cl, Br, I, CF.sub.3, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy; R.sup.1 is CONR.sup.2 R.sup.3 where either(a) R.sup.2 is H or C.sub.1 -C.sub.4 alkyl and R.sup.3 is C.sub.2 -C.sub.4 alkanoyl or optionally substituted benzoyl; or(b) R.sup.2 and R.sup.3 are each (C.sub.1 -C.sub.4 alkoxy)carbonyl; and R.sup.4 and R.sup.5 are each H or CH.sub.3 ; methods for their use in combating fungal infections in plants, seeds and animals, including humans, and pharmaceutical and agricultural compositions containing them.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each hydrogen, halogen, alkyl of 1 to 6 carbon atoms or alkoxy of 1 to 6 carbon atoms;R.sub.5 is hydrogen, alkyl of 1 to 6 carbon atoms or alkenyl of 3 to 6 carbon atoms;R.sub.6 is alkyl of 1 to 6 carbon atoms, alkenyl of 3 to 6 carbon atoms, phenyl, halo-phenyl, lower alkyl-phenyl, or lower alkoxy-phenyl or ##STR2## R.sub.7 and R.sub.8 are each hydrogen, halogen, alkyl of 1 to 6 carbon atoms or alkoxy or 1 to 6 carbon atoms;n is an integer from 0 to 4, inclusive;x is --O--, --S--, or --CH.sub.2 --; and the broken line between the 10 and 13b-positions indicates a single or double bond;and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as antiallergics and antithrombotics.

Abstract: This invention relates to novel alicyclic alcohol compounds of the formula ##STR1## wherein Az is imidazole or 1,2,4-triazole, R.sup.6 is optionally substituted phenyl and A is an alicyclic ring optionally benzo-fused, which compounds possess pharmaceutical, veterinary, agricultural and horticultural antifungal properties; together with a process for their manufacture, compositions containing them, and a method of combatting plant fungal diseases.

Abstract: A process for the preparation of E-isomers of 1-cyclohexyl-2-(1,2,4-triazol-1-yl)-1-penten-3-one derivatives of the formula ##STR1## in which X and Y independently of one another represent hydrogen or halogen by contacting isomers of 1-cyclohexyl-2-(1,2,4-triazol-1-yl)-1-penten-3-one derivatives of the formula ##STR2## in which X and Y have the previously indicated meaning with at least one secondary amine, if desired in the presence of water and/or in the presence of a water immiscible solvent.

Abstract: A process is provided for converting 1-hydrogen-triazolo[4,3-a]-[1,4]benzodiazepines, e.g., estazolam, to 1-(hydroxymethyl)-triazolo-[4,3-a][1,4]benzodiazepines, and, if desired, these 1-(hydroxymethyl)-compounds to 1-aminomethyl compounds, e.g., to adinazolam, without the need for column chromatography or sealed tube procedures, and while minimizing 1,4-bis-(hydroxymethyl)- group formation.

Abstract: Phenoxycarboxylic acid amide compound of the formula ##STR1## wherein R.sup.1 and R.sup.2 are individually selected from hydrogen and methyl,R.sup.3 is hydrogen or alkyl with from 1 to 5 carbon atomsR.sup.4 is optionally substituted alkoxycarbonylalkyl, aminocarbonylalkyl or dialkylaminocarbonylalkyl, phenyl, or substituted phenyl wherein the substituent is at least one of the group consisting of alkyl, alkoxy or alkylthio of from 1 to 4 carbon atoms, carbalkoxy of from 2 to 4 carbon atoms, halogen, and nitro; orR.sup.3 and R.sup.

Abstract: A triazolyl-vinyl ketone or carbinol of the formula ##STR1## in which A represents the keto group or a CH(OH) grouping,R.sup.1 represents alkyl or halogenoalkyl andR.sup.2 represents a primary or tertiary alkyl radical, halogenoalkyl, alkoxyalkyl, alkylmercaptoalkyl, dialkylaminoalkyl, hydroxyalkyl, an optionally substituted alkenyl, alkynyl or alkenynyl radical, phenylalkyl which is optionally substituted in the alkyl part and/or in the phenyl part, an optionally substituted indenyl or fluorenyl radical, or an optionally substituted diphenylmethyl or triphenylmethyl radical,or an addition product thereof with a physiologically acceptable acid or a metal salt, which possesses fungicidal activity.

Abstract: The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. Two compounds of this invention are N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea and N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-N"-cyanoguanidine.

Abstract: Thiazolidine and pyrrolidine compounds which have the general formula ##STR1## and salts thereof for preventing or relieving diabetic complications and for reducing blood pressure, the processes for their preparation, and the compositions comprising them and pharmaceutically acceptable excipient(s).

Abstract: A substituted triazolylmethyl-oxirane of the formula ##STR1## in which R is optionally substituted alkyl, aryl or cycloalkyl is prepared by reacting a triazolyl-ketone of the formula ##STR2## with (a) dimethyloxosulphonium methylide of the formula ##STR3## or (b) trimethylsulphonium methylsulphate of the formula[(CH.sub.3).sub.3 S].sup..sym. CH.sub.3 SO.sub.4.sup..crclbar.in the presence of a diluent.The end product can then be reacted with a phenol of the formulaR"--OHto produce known fungicidally active compounds of the formula ##STR4## in which R" is optionally substituted phenyl.

Abstract: The invention provides a method of reducing the feeding activity of insects on plants with the aid of 1,2,3-triazoles being unsubstituted in the 4- and 5-positions and bearing a phenyl moiety in the 1-position, fungicidal compositions comprising such triazoles and novel 1,2,3-triazoles.

Abstract: New 2-acylaminomethyl-1H-2,3-dihydro-1,4-benzodiazepine compounds are described having the general formula I ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl or alkenyl radical or the cyclopropylmethyl radical, R.sub.2 is a hydrogen atom, or a lower alkyl or alkenyl radical, n is 0, 1 or 2, R.sub.3 is an optionally substituted furyl, thienyl, pyrrolyl, pyridyl or phenyl radical, R.sub.4 is an optionally substituted furyl, thienyl, pyrrolyl or pyridyl radical, R.sub.5 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy, hydroxyl, lower alkylthio, nitro, trifluoromethyl, cyano, amino, lower mono- or dialkylamino, lower monoalkanoylamino, lower N-alkyl-N-alkanoylamino or lower alkanoyloxy radical, and R.sub.6 is a hydrogen atom, or a lower alkyl or lower alkoxy radical or R.sub.5 and R.sub.6 together denote a methylenedioxy or ethylenedioxy radical. The compounds have pharmacological, for example, analgesic, properties.

Abstract: The invention relates to novel azolyl-olefin derivatives of the general formula I ##STR1## wherein R.sub.1 is an azolyl group,R.sub.2 is C.sub.1 -C.sub.12 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 alkyl substituted by unsubstituted or substituted phenyl, C.sub.1 -C.sub.4 alkoxycarbonyl or C.sub.2 -C.sub.6 alkenyl, or is C.sub.3 -C.sub.8 cycloalkyl which is substituted by 1 to 4 C.sub.1 -C.sub.4 alkyl groups,R.sub.3 is C.sub.1 -C.sub.12 alkyl, C.sub.3 -C.sub.8 cycloalkyl which is substituted by 1 to 4 C.sub.1 -C.sub.4 alkyl groups, or is the --C(R.sub.4)(R.sub.5)--[CH(R.sub.4)].sub.n --X--R.sub.6 group, wherein n is 0 or 1 andR.sub.4 and R.sub.5, each independently of the other, are hydrogen or C.sub.1 -C.sub.4 alkyl,X is oxygen or sulfur,R.sub.6 is a radical selected from the group consisting of C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.

Abstract: 1,2,4-Triazole derivatives of the formula ##STR1## where R.sup.1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, or unsubstituted or substituted aryl, heteroaryl or arylalkyl,R.sup.2 is hydrogen or, independently of R.sup.1, has one of the meanings given for R.sup.1,R.sup.3 and R.sup.4 independently of one another are each hydrogen, halogen, nitro or lower alkyl andZ is hydroxyl or a --O.sup..crclbar. M.sup..sym. radical, where M.sup..sym. is one equivalent of a metal cation or is an unsubstituted or substituted ammonium ion,their preparation, and fungicides containing these compounds.

Abstract: S-(2-Halo-2-propen-l-yl) N-(hexamethyleneimino)thiolcarbamates in which the halo is preferably bromo or chloro. The compounds have biological activity and may be used, for example, as selective pre-emergence herbicides.

Abstract: Compounds, having fungicidal and plant growth regulatory properties, of the formula (I): ##STR1## and stereoisomers thereof, wherein Z is --CH.dbd. or .dbd.N--; R.sup.1 is alkyl, cycloalkyl, alkenyl, alkynyl, optionally substituted aryl especially phenyl, or aralkyl; R.sup.2 is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, optionally-substituted aryl especially phenyl or aralkyl; R.sup.3 and R.sup.4, which may be the same or different, are alkyl, alkenyl, alkynyl, aryl, aralkyl, or together form a bridging group linking X and Y; R.sup.5 is hydrogen, alkyl or aryl; R.sup.6 is hydrogen, alkyl, alkenyl, alkynyl or acyl; and X and Y, which may be the same or different, are oxygen or sulphur; and acid salts and metal complexes thereof.

Abstract: Novel chloroacetic acid cyclohexylamides of the formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 have the meanings given in the description, their preparation and their use as herbicides.

Abstract: A compound of 1,5-disubstituted 1,2,4-triazole-3-carboxamide represented by the general formula; ##STR1## wherein R.sup.1 is alkyl of one to three carbon atoms, chloro, fluoro, iodo, trifluoromethyl or nitro, R.sup.2 is hydrogen, methyl or chloro, R.sup.3 is hydrogen or methyl is provided in the invention, which shows an excellent herbicidal activity.