Patents Examined by Amber R Stiles
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Patent number: 11844919Abstract: The disclosed subject matter relates to a cleavable microneedle for delivery of therapeutic agent, wherein the needle includes a longitudinal body having a detachable portion that comprises at least one therapeutic agent. The microneedle may be configured to administer the therapeutic agent to the inner ear of a subject. Also disclosed is a method for preparing a microneedle using two-photon polymerization lithography.Type: GrantFiled: January 3, 2019Date of Patent: December 19, 2023Assignee: The Trustees of Columbia University in the City of New YorkInventors: Anil K. Lalwani, Jeffrey W. Kysar, Aykut Aksit, Daniel N. Arteaga
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Patent number: 11844920Abstract: A dissoluble microneedle drug delivery system includes a fixation component having an opening window area, and at least two replaceable and/or dissoluble inner matrices fitting into the window area one after another. The fixation component comprises an array of microneedles attached on its base, at least part of the microneedles being configured to fix the delivery system onto skin. The first inner matrix comprises a multitude of microneedles attached on its base, at least part of the microneedles configured to prepare the skin to vaccination by the subsequent second inner matrix. The second inner matrix is a vaccine/immunization matrix configured to replace the first inner matrix and comprising an array of microneedles attached on its base, at least part of the microneedles configured to deliver a vaccination. The system may include a microchannel network within at least one inner matrices for delivery of components regulating dissolution of the microneedles.Type: GrantFiled: July 21, 2021Date of Patent: December 19, 2023Assignee: Microneedles IncInventors: Vasilii Nikolaevich Zvezdin, Andrei Jurievich Pavlov
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Patent number: 11844886Abstract: A syringe with structural features to accomplish one-handed aspiration as well as one-handed injection. The syringe includes one or more breaking points that are configured to break at predetermined locations in response to external forces being applied thereto. To assist in accountability, identification chips and/or codes are included to allow for the traceability of the syringe to potential sources of irresponsible dispensing of medical waste.Type: GrantFiled: July 2, 2021Date of Patent: December 19, 2023Assignee: ALSAHAB MEDICAL COMPANYInventor: Abdulaziz A. Alsuhaibani
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Patent number: 11844933Abstract: An auto-injector operable in a single activation step. The auto-injector is automatically armed when removed from its carrying receptacle. The auto-injector may be prefilled with more than one constituent of a beneficial agent, stored in separated compartments, in such an arrangement that the compartments will automatically merge when the auto-injector is removed from its carrying receptacle.Type: GrantFiled: July 20, 2020Date of Patent: December 19, 2023Assignee: Aktivax, Inc.Inventor: Amir Genosar
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Patent number: 11839749Abstract: Provided is a syringe cap including a projection extending in the circumferential direction of a cap body, wherein the projection includes an apex located radially outward of the cap body from the outer circumferential surface of the cap body, a first inclined surface having a starting end located at the apex and having a terminal end located at a position on the side closer to the proximal end of the cap body than the starting end is, and a second inclined surface having a starting end located at the apex and on the outer circumferential surface of the cap body having a terminal end located at a position on the side closer to the distal end of the cap body than the starting end is, on the outer circumferential surface of the cap body, and the shortest distance from the starting end to the terminal end of the first inclined surface is smaller than the shortest distance from the starting end to the terminal end of the second inclined surface.Type: GrantFiled: June 4, 2015Date of Patent: December 12, 2023Assignees: Taisei Kako Co., Ltd., Chugai Seiyaku Kabushiki KaishaInventors: Rieko Shiozaki, Yuji Yamanaka, Taiji Horita, Ippei Matsumoto, Kensuke Taniguchi
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Patent number: 11826461Abstract: The present invention discloses a nano-armored single cell product, comprising a liposome and probiotics encapsulated by the liposome, wherein the probiotics are fermented to produce gamma-aminobutyric acid (GABA) that alleviates the activation of an inflammatory response in substantia nigra inducedin a MPTP induced PD model, thus mitigating an inflammatory injury to dopaminergic neurons in substantia nigra and having a neuroprotective effect; encapsulation of the probiotics by the liposome can protect the probiotics from strong acids and digestive enzymes in gastric acid.Type: GrantFiled: October 18, 2021Date of Patent: November 28, 2023Assignees: TANGYI HOLDINGS (SHENZHEN) LIMITED, HEALTHINA STEM CELL INDUSTRY PLATFORM (TIANJIN) LIMITEDInventors: Bin Zheng, Yulin Cao, Bowen Li, Wei Sun, Shixiang Cheng
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Patent number: 11819675Abstract: A needle mechanism module for automatically inserting a fluid path into a patient for drug delivery is provided. The needle mechanism module can be a component of a wearable drug delivery device. The needle mechanism module can insert a needle and cannula into the patient responsive to activation of the drug delivery device by a user. After insertion, the needle can be automatically retracted, leaving only the cannula in the patient. As a result, discomfort of the user is reduced.Type: GrantFiled: December 17, 2020Date of Patent: November 21, 2023Assignee: INSULET CORPORATIONInventors: Maureen McCaffrey, Ian McLaughlin
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Patent number: 11819663Abstract: The invention relates to an automatic injector device comprising a single-use, disposable, drug delivery assembly comprising a housing and a syringe assembly located at least partially within the housing, said syringe assembly including a plunger, a pre-filled unit-dose drug containing chamber, and needle, said plunger, drug containing chamber and needle being configured and dimensioned to function as an injection syringe; a reusable motorized transmission assembly comprising a housing, a motor and transmission assembly located within the housing, said transmission assembly being configured and dimensioned to engage the plunger of said syringe in the drug delivery assembly and expel said unit dose drug from the drug containing chamber, into the needle and out of the drug delivery assembly; said single-use disposable drug delivery assembly and said reusable motorized transmission assembly are in substantial axial alignment along a longitudinal axis defined by the syringe, plunger, pre-filled unit-dose drug conType: GrantFiled: December 19, 2017Date of Patent: November 21, 2023Assignee: BIOCORP PRODUCTION S.A.Inventors: Alain Marcoz, Alexandre Pereira, Mathieu Pollard
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Patent number: 11819677Abstract: The present invention relates to a recording unit arranged to be connected to a medicament delivery device, which recording unit comprises a generally elongated housing having dimensions so as to enclose at least a distal part of the medicament delivery device, the recording unit comprising a recording mechanism provided with an electronic circuit and arranged at a distal end inside said housing, said electronic circuit comprising an activation element operably arranged to activate said electronic circuit when said medicament delivery device is inserted in said housing, said electronic circuit comprising sensor elements capable of sensing status changes of said medicament delivery device during use.Type: GrantFiled: August 26, 2020Date of Patent: November 21, 2023Assignee: SHL MEDICAL AGInventors: Daniel Säll, Daniel Carlsson, Ola Hallström
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Patent number: 11819228Abstract: A large bore catheter has a guiding rail extending therethrough and an advance segment of the rail extends at least about 10 cm beyond the distal end of the catheter. The advance segment is advanced from the vena cava through the tricuspid and pulmonary valves of the heart into the central pulmonary artery while the distal end of the large bore catheter remains in the vena cava. The large bore catheter is thereafter distally advanced over the rail until the large bore catheter distal end is at least as far as the central pulmonary artery. The rail is thereafter proximally removed from the large bore catheter, and at least a portion of a clot is drawn from a pulmonary artery into the large bore catheter.Type: GrantFiled: December 17, 2020Date of Patent: November 21, 2023Assignee: Imperative Care, Inc.Inventors: Michael Buck, Julia Fox, James Jacobs
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Patent number: 11813056Abstract: The present disclosure is directed to microneedle patches for direct sampling and ultrasensitive detection of protein biomarkers in dermal interstitial fluids. The microneedle patches are comprised of polymers with high protein absorption capability (e.g. polystyrene) and are modified with capture biorecognition elements that are specific to target analytes in the interstitial fluid (ISF). Systems and methods are further provided for detection of a target ISF analyte obtained by in vivo sampling of the ISF using a microneedle patch.Type: GrantFiled: July 30, 2020Date of Patent: November 14, 2023Assignee: Washington UniversityInventors: Srikanth Singamaneni, Zheyu Wang, Jingyi Luan
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Patent number: 11813418Abstract: An echogenic balloon dilation catheter and a balloon thereof. The balloon includes a balloon body, a balloon cone at each side of the balloon body, and a balloon tip extending from the balloon cone and fixed to the catheter, the balloon body and the balloon cone being formed of a plurality of polymer layers in a radial direction of the balloon. The balloon may be of enhanced echogenicity using a variety of disclosed techniques.Type: GrantFiled: August 24, 2020Date of Patent: November 14, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Qingqing Fan, Irene Gao, Xin Wen
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Patent number: 11813415Abstract: Some embodiments of a medical device anchor system include an anchor sleeve that receives a catheter (or other medical instrument) though a working channel of the anchor sleeve. The anchor sleeve may include a first actuator that controls the extension of one or more subcutaneous tines into the subcutaneous region under the skin. The anchor sleeve can also include a second actuator that can cause the anchor sleeve to lock onto an outer portion of the catheter (or other medical instrument) arrange in the working channel.Type: GrantFiled: October 23, 2020Date of Patent: November 14, 2023Assignee: INTERRAD Medical, Inc.Inventors: Michael S. Rosenberg, Mark R. Christianson
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Patent number: 11793544Abstract: In some embodiments a PEG feeding device includes a tube sized to bridge a channel between a stomach and an outer abdominal surface; an internal bolster, and an external bolster. Optionally the bolsters are connected to the tube. The internal bolster may be sized to resist movement out of the stomach through the stoma. The external bolster may be sized to resist movement into the stoma from the outer abdominal surface. The external bolster may include an underside which extends from the tube in a radial direction between the external bolster and the outer abdominal surface. The underside of the outer bolster may contact the outer abdominal surface at a distance from an external opening of the stoma. Optionally the distance between the internal bolster and the external bolster is adjustable. Optionally an angle between one or both of the bolsters and the tube is adjustable.Type: GrantFiled: July 6, 2020Date of Patent: October 24, 2023Assignee: Fidmi Medical Ltd.Inventors: Shahar Millis, Ishay Benuri-Silbiger
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Patent number: 11793981Abstract: Described is a microneedle device, preferably a controlled release device, for delivery of liothyronine (LT3 or salt thereof) to a patient with hypothyroidism and/or who is not pregnant. The microneedle device contains LT3 or salt thereof in an effective amount to maintain normal, stable levels, in the serum, of free and/or total T3. The microneedle device includes at least two components: multi-dimensional array of microneedle(s) and a substrate to which the base of the microneedle(s) are secured or integrated. The microneedles contain LT3 or salt thereof as well as a biodegradable and/or biodissolvable polymer, such as polyvinyl pyrrolidone for controlled release of LT3 or salt thereof. Also described are methods of making and using the microneedle device.Type: GrantFiled: May 21, 2021Date of Patent: October 24, 2023Assignee: EQUILIBRATE THERAPEUTICS, LLCInventor: Elizabeth A. McAninch
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Patent number: 11793920Abstract: Disclosed herein are methods, systems, and devices for collecting a fluid for use in connection with a fluid pumping device such as a breast pump. A fluid collection receptacle includes a rigid connector attached to the fluid collection receptacle. The rigid connector is connectable to a breast pump manifold. The fluid collection receptacle further includes a liquid tight seal in the fluid collection receptacle. The fluid collection receptacle may be constructed of a flexible plastic.Type: GrantFiled: April 29, 2019Date of Patent: October 24, 2023Assignee: Moxxly, LLCInventors: Jacob Kurzrock, Camille I. Henrot, Gabrielle Guthrie, Santhi Analytis, Cara Delzer
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Patent number: 11793931Abstract: A device for conveying a biological material includes a body including an aperture configured to enable connection with an outside of the body and a chamber configured to store a biological material, a plurality of conveyors accommodated in the body and configured to convey the material, and a driver configured to select one of the plurality of conveyors, align the selected conveyor with the aperture, and move the selected conveyor to the outside of the body through the aperture.Type: GrantFiled: November 24, 2022Date of Patent: October 24, 2023Assignee: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Suk Ho Park, Hyun Chul Choi
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Patent number: 11793935Abstract: A flow control device includes an upper housing, a lower housing, a chamber interposed between and defined by the upper and lower housings, and a valve member. The upper housing includes a primary inlet having an internal surface defining a cavity and a secondary inlet. The lower housing defines an outlet of the flow control device. The chamber fluidly connects the primary and secondary inlets with the outlet. A valve member is reciprocally disposed at least partially in the cavity and partially in the chamber to (i) selectively permit fluid flow in the primary inlet in a first direction when a fluid level in the chamber is below a predetermined level, and (ii) prevent fluid backflow in a second direction opposite to the first direction when the fluid level in the chamber is above the predetermined level.Type: GrantFiled: July 22, 2020Date of Patent: October 24, 2023Assignee: CareFusion 303, Inc.Inventor: Amarsinh Deeliprao Jadhav
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Patent number: 11793982Abstract: Drug delivery devices that have a flexible film, an array of nanoscopic, porous needles attached to a surface of the flexible film, and a therapeutic drug cargo loaded onto the needles. The drug delivery device may be applied to living tissue such that the surface of the flexible film contacts the living tissue and some or all of the needles are inserted into the tissue. The flexible film may then be dissolved while leaving the needles inserted in the tissue. The needles degrade in the living tissue over time causing release of the therapeutic drug cargo loaded onto the needles.Type: GrantFiled: June 10, 2021Date of Patent: October 24, 2023Assignees: Purdue Research Foundation, Industry-University Cooperation Foundation Hanyang UniversityInventors: Chi Hwan Lee, Yoon Yeo, Dong Rip Kim
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Patent number: 11786660Abstract: An injection device is disclosed including a housing assembly defining a pair of ramps and adapted to hold a medicament cartridge. A driver is adapted to advance the piston within the cartridge. A plunger having a pair of arms is moveable between a retracted position and an advanced position. Each of the arms are engageable with a respective one of the ramps as the plunger is advanced. A braking mechanism may include braking members on the arms and braking tracks proximate the ramps. Excessive force exerted on the plunger may flex the arms and engage the braking members with the braking tracks. The plunger arms may be connected together by a material bridge that biases the plunger arms apart from each other. The arms may include detents that engage to prevent the arms from moving due to the biasing force of the material bridge when the arms are in the fully retracted position.Type: GrantFiled: April 25, 2018Date of Patent: October 17, 2023Assignee: Eli Lilly and CompanyInventor: Jared Alden Judson