Abstract: A system for controlled release, site-specific delivery of therapeutic agents, particularly myocardial agents such as antiarrhythmic agents, comprises a biocompatible polymeric matrix with an incorporated therapeutic agent for direct placement at the epicardium. Advantageously, the dosage form can be fabricated in such a manner as to tailor the release characteristics as required by the nature of the physical condition desired to be treated. In a specific illustrative embodiment, lidocaine, an antiarrhythmic depressant, is incorporated in polyurethane by a unique method which permits drug-loading of the polymeric matrix from about 5% up to 40% by weight, with about 25% to 30% in a preferred embodiment. A novel FeCl.sub.3 catalyst causes the polyurethane to polymerize despite the presence of drug in the polymeric matrix mixture.

Abstract: This invention relates to an improved skin care composition for moisturizing and conditioning the skin. In particular, it relates to a cosmetically acceptable, translucent skin conditioning lotion having an emulsified petrolatum base. The emulsions of the present invention are prepared using a crosslinked organopolysiloxane-polyoxyalkylene emulsifier and involve matching the refractive indices for the continuous and discontinuous phases.

Abstract: A readily dissolved carrier material having sufficient rigidity for administration of drugs, nutrients, vitamins, biologically-active materials, foodstuffs and combinations thereof capable of rapid dissolution by saliva, bodily fluids or other liquid comprising an interim skeletal structure of an ammoniated gel or foam forming material, preferably a proteinaceous material, such as gelatin, that has been ammoniated, rigidified such as with maltodextrin, in the ammoniated state and deammoniated to leave spaces in place of the frozen ammonia. On dissolution by saliva, bodily fluids or other liquids, the composition becomes a liquid system. While the oral route is preferred, other routes may be used to administer the compositions of this method.

Abstract: This invention relates to alkylmethylsiloxanes mixtures which are useful for softening and moisturizing skin. The mixtures comprise one or more alkylmethylsiloxane solvents of the structure [MeRSiO].sub.a [Me.sub.2 SiO].sub.b or R'Me.sub.2 SiO(MeRSiO).sub.w (Me.sub.2 SiO).sub.x SiR'Me.sub.2 and one or more alkylmethylsiloxane waxes of the structure R'Me.sub.2 SiO(Me.sub.2 SiO).sub.y (MeRSiO).sub.z SiMe.sub.2 R', wherein each R is independently a hydrocarbon of 6 to 30 carbon atoms, R' is methyl or R, a is 1-6, b is 0-5, w is 0-5 and x is 0-5, provided a+b is 3-6 and w is not 0 if R' is methyl.

Abstract: A directly compressed cholestyramine tablet with a solvent-free coating is disclosed. The inner core of the tablet is made up of cholestyramine agglomerates consisting of numerous small, irregularly-shaped, jagged-edged fragments having relatively few smooth or flat surfaces with a moisture content ranging from about 8 to 14 percent by weight. A process is also disclosed for preparing cholestyramine agglomerates of the invention. The solvent-free coating comprises from about 60 percent to about 95 percent by weight of stearic acid and from about 5 percent to about 40 percent of polyethylene glycol.

Abstract: The invention relates to stable emulsions of perfluoropolyethers having perfluoroalkyl end groups and of fat substances, consisting of:one or more perfluoropolyethers having perfluoroalkyl end groups: 1-50% by weight,one or more polyhydroxylated compounds selected from glycerol and polyalcohols other than glycerol and saccharides, containing at least three hydroxylic groups, said compounds being dissolved in water or in a hydrophilic solvent when they are solid: 10-95% by weight, including water and the hydrophilic solvent, if any,one or more fat substances having a melting temperature not higher than 100.degree. C.: 10-80% by weight,one or more emulsifiers: 0.1-10% by weight.These emulsions are utilized, in particular, in cosmetology and dermatology.

Abstract: A liquid pharmaceutical composition which can be administered as a foam by means of suitable supplying devices, without necessity of gas propeller, said composition consisting of:a) one or more natural or synthetic ionic or non ionic, acid, basic or neutral surfactants;b) a solvent or a solvent mixture;c) an active ingredient or a combination of active ingredients;d) optionally mucoadhesive or thermosetting polymers;e) optional adjuvants or excipients.

Abstract: The present invention relates to a novel waterproof cosmetic composition, useful as a mascara which contains a dimethicone-silica copolymer in an emulsion system.

Abstract: Aqueous ophthalmic compositions containing water-soluble borate-polyol complexes are useful in aqueous ophthalmic compositions containing polyvinyl alcohol. These compositions provide the benefits of a borate buffering system, such as enhanced antimicrobial activity, without the problems associated with the use of borate and pol, such as formation of borate-polyvinyl alcohol complexes which are water-insoluble.

Abstract: A personal care composition is provided, comprising (A) an effective amount of a polyalkylsiloxane copolymer having a melting point of from about -40.degree. C. to about +40.degree. C., and being selected from various specific polyalkylsiloxane copolymer fluids or polyalkylsiloxane copolymer resins; and (B) a cosmetically acceptable carrier medium, wherein the polyalkylsiloxane copolymer contains mixtures of linear lower alkyl side chains and linear higher alkyl side chains or mixtures of linear alkyl side chains and branched alkyl side chains. The polyalkylsiloxane copolymers used in the composition are fluids or soft waxes at body temperature and have improved application and payout and better substantivity and hair conditioning properties.

Abstract: A novel molecular scale device is described which is bactericidal, fungicidal, viricidal and algicidal. The anti-pathogenic properties of the device are attributed to electron activity indigenous to diamagnetic semiconducting crystals of tetrasilver tetroxide (Ag.sub.4 O.sub.4) which contains two monovalent and two trivalent silver ions in each molecular crystal. When the crystals are activated with an oxidizing agent, they release electrons equivalent to 6.4.times.10.sup.-19 watts per molecule which in effect electrocute pathogens. A multitude of these devices are effective at such low concentrations as 0.3 PPM used as preservatives in a variety of formulations ranging from cosmetics to pharmaceuticals. Indeed, they are intended as active ingredients for pharmaceuticals formulated to destroy such pathogens as Staphylococcus aureus, and epidermidis, the latter of which it completely destroys in a nutrient broth culture of about 1 million organisms at 0.

Abstract: Flavorings, seasonings, fragrances, skin texturizers, deodorants, and the like, and methods of making such are disclosed. The method includes melting a water soluble carrier material and dispersing an additive within the melt. The dispersed melt is then sprayed into a chilled gas and the resulting powder is recovered.

Abstract: Antimicrobial metal-based compositions, which are photostable, non-staining, and which are easily absorbed into lipophilic matrices, contain silver cations, complexed by acyclic polyether polymers through the formation of a "host-guest relationship" where the acyclic polyether is the "host" and the silver cation is the "guest," wherein stabilization of this "host-guest relationship" is accomplished through the use of excess halide anions. The compositions are useful for topical treatment of infections caused by bacteria, fungus and viruses in humans and animals and for treating medical devices and adhesives to impart infection-resistance.

Abstract: An implantable structure for incorporation into the tissues of a body is provided which retains therein fluid substances or biological substances which produce, or cause to be produced, biochemicals deliverable to the body. The implantable structure is configured to provide insertion and removal of substances therefrom as needed. The implantable structure generally comprises a porous outer member configured to encourage ingrowth of vascularized tissue therethrough, and an inner member of selectively permeable material providing interior space for inserting substances therein and which is structured to prevent ingrowth of tissue therethrough. The inner member is capable of providing immunoisolation to the substances therein as required.

Abstract: Lactoneotrehalose, a novel saccharide shown by the formula O-.beta.-D-galactopyranosyl-(1.fwdarw.4)-O-.beta.-D-glucopyranosyl .alpha.-D-glucopyranoside, is prepared by allowing a saccharide-transferring enzyme to act on an aqueous solution containing lactose and amylaceous substance. Lactoneotrehalose is a non-reducing oligosaccharide, extremely stable, readily soluble in water, and substantially free of hygroscopicity, as well as having a satisfiable quality and moderate sweetness. These render lactoneotrehalose very useful in the preparations of orally-administrable products, cosmetics and pharmaceuticals.

Abstract: Compositions comprise absorbent gelling materials combined with high levels of odor-controlling agents by means of binders. The preferred particle form of the compositions is easy to handle, and is used in the manufacture of catamenials, diapers, bandages, and the like. The absorbent gelling material enhances the odor-controlling properties of the compositions by helping to control ammonia odors.

Abstract: One component, visible light-cured dental restorative compositions having fluoride release properties for the purpose of reducing the chances of secondary caries are provided. The compositions include inorganic particulate fluoride leachable glass.

Abstract: Described herein is a drug delivery system useful to deliver drugs at low dosage levels to patients in a sustained fashion and at a controlled rate. The system comprises a wettable polymeric matrix in which is dispersed a multiplicity of particles containing a substantially homogeneous blend of osmotically active excipient and not more than about 10% by weight of drug. The system is particularly well suited for delivery of therapeutic macromolecules such as protein drugs. Delivery of epidermal growth factor is exemplified.

Abstract: A tablet that rapidly disintegrates in aqueous solution includes a partially collapsed matrix network that has been vacuum-dried above the collapse temperature of the matrix. The matrix is preferably at least partially dried below the equilibrium freezing point of the matrix. Vacuum drying the tablet above its collapse temperature instead of freeze drying it below its collapse temperature provides a process for producing tablets with enhanced structural integrity, while rapidly disintegrating in normal amounts of saliva. The tablet preferably carries a drug, such as acetaminophen. The matrix network of the tablet preferably includes a gum, a carbohydrate and the drug. Especially preferred embodiments also include a flavoring, a sweetener and surfactant. The gum is preferably acacia, guar, xanthan, carrageenan or tragacanth gum. The carbohydrate is preferably mannitol, dextrose, sucrose, lactose, maltose, maltodextrin or corn syrup solids.

Abstract: An antithrombic medical material, having superposed on the surface of a substrate formed of a polymer material a polymerized protein substantially free at least from erythrocyte and leukocyte, a medical device using the same, and a method for production of the antithrombic medical material.