Patents Examined by Amy Hulina
  • Percutaneous preparation of tulobuterol
    Patent number: 5571530
    Abstract: A percutaneous preparation of tulobuterol is disclosed, comprising a support having thereon a base layer comprising a pressure-sensitive adhesive containing tulobuterol, the pressure-sensitive adhesive comprising polyisobutylene. The preparation achieves persistent and effective administration of tulobuterol through the skin into the body.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: November 5, 1996
    Assignees: Nitto Denko Corporation, Hokuriku Seiyaku Co., Ltd.
    Inventors: Yoshihisa Nakano, Tetsuo Horiuchi, Sanae Fujiwara, Senji Unozawa
  • Delivery of controlled-release systems(s)
    Patent number: 5567439
    Abstract: The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: October 22, 1996
    Assignee: Fuisz Technologies Ltd.
    Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
  • Liquid skin cleanser composition with reduced skin irritation and improved after-feel
    Patent number: 5562912
    Abstract: An improved liquid skin cleanser composition will have about 0.1-25% by weight of at least one EO/PO/EO tri-block nonionic surfactant having the formula: ##STR1## wherein neither x or z can be 0; the sum of x and z is within the range of about 62 to 535, the value of y is within the range of about 15 to 65. Also present will be about 0.1-25% by weight polyvinylpyrrolidone having the formula: ##STR2## wherein the value of n ranges from about 100 to 30,000.
    Type: Grant
    Filed: December 6, 1995
    Date of Patent: October 8, 1996
    Assignee: BASF Corporation
    Inventors: John J. Burke, Joanne P. Gorczyca
  • 5-methyltetrahydrofolic acid, 5-formyl-tetrahydrofolic acid and their pharmaceutically acceptable salts for use in the therapy of depressive disturbances
    Patent number: 5538734
    Abstract: The present invention refers to the use of 5-methyltetrahydrofolic acid, of 5-formyltetrahydrofolic acid and of their pharmaceutically acceptable salts for the preparation of controlled release pharmaceutical compositions suitable for the use in the therapy of depressive disturbances, in particular major depression, dysthymia or depressive neurosis and not otherwise specified depressive disturbances, independently from folate plasmatic levels, and to the pharmaceutical composition thus prepared.
    Type: Grant
    Filed: February 9, 1995
    Date of Patent: July 23, 1996
    Assignee: Bioresearch S.p.A.
    Inventor: Christina Le Grazie
  • Mascara composition
    Patent number: 5534247
    Abstract: A mascara composition containing at least one curl retention additive to help enhance and sustain a curl along with a hair fixative resin designed to hold the eyelashes in a curled position by preventing the fixed eyelash hairs from being affected by humidity.
    Type: Grant
    Filed: October 3, 1994
    Date of Patent: July 9, 1996
    Assignee: Maybelline Intermediate Co.
    Inventors: David Franjac, John Caradonna
  • Use of borate-polyol complexes in ophthalmic compositions
    Patent number: 5505953
    Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: April 9, 1996
    Assignee: Alcon Laboratories, Inc.
    Inventor: Masood Chowhan
  • Barrier film and method
    Patent number: 5500302
    Abstract: A barrier film comprising a flexible substantially of transparent substrate having first and second surfaces. A substantially colorless barrier coating is formed on at least one of said surfaces of a graphite material having a thickness ranging from 50 to 350 .ANG..
    Type: Grant
    Filed: April 26, 1994
    Date of Patent: March 19, 1996
    Assignee: Flex Products, Inc.
    Inventors: Roger W. Phillips, Paul G. Coombs, Lauren R. Wendt
  • Agent for treating chronically inflammatory intestinal diseases
    Patent number: 5484605
    Abstract: Chronic inflammatory intestinal diseases may be treated enterally pharmacologically active doses of said oxypurinol and or its alkali, alkaline earth, or ammonium salts.
    Type: Grant
    Filed: December 15, 1993
    Date of Patent: January 16, 1996
    Assignee: Henning Berlin GmbH Chemie-und Pharmawerk
    Inventors: Ekkehard Scheiffele, Gerhard Gerber, Werner Siems, Andreas Werner
  • Process for the preparation of substantially alcohol free pharmaceutical compositions
    Patent number: 5478571
    Abstract: A novel process for the preparation of pharmaceutical compositions involving the stabilization of the active drug(s) through the reduction of residual alcohol present in a drug/carrier blend. The presence of residual alcohol in dried pharmaceutical compositions adversely affects many drugs which must be initially dissolved therein in order to achieve uniform distributions throughout the excipient carrier materials. Wherein not previously possible, its removal is achieved utilizing precise processing parameters in which water lost during the drying process is replenished during blending in a conventional solids processor.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: December 26, 1995
    Assignee: Warner-Lambert Company
    Inventors: Pankaj B. Gala, Gary D'Alonzo, Jatin J. Shah, Jay Weiss
  • Multilayered controlled release pharmaceutical dosage form
    Patent number: 5474786
    Abstract: This invention is directed to a multilayered controlled release pharmaceutical dosage form. More particularly the dosage form is adapted for water soluble drugs and comprises a plurality of coated particles wherein each has multiple layers about a core containing a drug active whereby the drug containing core and at least one other layer of drug active is overcoated with a controlled release barrier layer and preferably an outer layer of additional drug is adapted for immediate release to preferably provide one immediate releasing layer and at least two controlled releasing layers of a water soluble drug from the multilayered coated particle.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: December 12, 1995
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Pramod M. Kotwal, Stephen A. Howard
  • Process for producing a hair conditioner
    Patent number: 5472688
    Abstract: Patent of invention "process for obtaining an hair conditioner," comprising a process for obtaining an hair conditioner which imparts gloss, softness and elasticity to the hair and augments its tendency to maintain the desired shape of the hairdo; the active ingredients of the conditioner being ascorbic acid and cupric and/or cuprous salts: the conditioner in one version being presented in powder form, containing besides the active ingredients, thickening agents, being mixed with water before use and in another version presented in form of a cream, gel or paste, to be used on hair, in both cases containing, optionally, other ingredients of specific action.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: December 5, 1995
    Inventor: Yaclav Soukup
  • Synergistic skin depigmentation composition
    Patent number: 5470567
    Abstract: There is disclosed a synergistic composition and process for skin depigmentation with reduced irritation which does not employ a corticosteroid and which employs a substituted oxybenzene and a retinoid.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: November 28, 1995
    Assignee: Bristol Myers Squibb Company
    Inventors: Xina Nair, Kenneth M. Tramposch
  • Methods of preventing and reducing the size of Striae distensae lesions
    Patent number: 5468495
    Abstract: Striae distensae lesions may be prevented and/or reduced in size by topically applying to the skin affected with the lesions an effective amount of a retinoid, preferably retinoic acid, preferably by daily application in a dermatologically acceptable vehicle, such as a cream base, at a concentration of about 0.025 to 0.1 weight percent retinoic acid. When applied during the striae rubrae stage, the retinoid may be effective to prevent the formation of striae albae lesions, and when applied in either stage, the retinoid may be effective to reduce the width and depth of the lesions, with improved texture and softness.
    Type: Grant
    Filed: March 6, 1992
    Date of Patent: November 21, 1995
    Inventor: Albert M. Kligman
  • Body powder comprising colorant
    Patent number: 5460805
    Abstract: Body powder is provided having microcapsules with a colorant located in or on the shell of said microcapsule. The microcapsules are present in an amount effective to impart color to the body powder when viewed in bulk and to substantially decrease in perceptible color upon rubbing said body powder on the skin.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: October 24, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Robert A. Davis, Sheila M. Nichols, Howard J. Buttery
  • Direct compression cholestyramine tablet and solvent-free coating therefor
    Patent number: 5455047
    Abstract: A directly compressed cholestyramine tablet with a solvent-free coating is disclosed. The inner core of the tablet is made up of cholestyramine agglomerates consisting of numerous small, irregularly-shaped, jagged-edged fragments having relatively few smooth or flat surfaces with a moisture content ranging from about 8 to 14 percent by weight. A process is also disclosed for preparing cholestyramine agglomerates of the invention. The solvent-free coating comprises from about 60 percent to about 95 percent by weight of stearic acid and from about 5 percent to about 40 percent of polyethylene glycol.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: October 3, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert J. Bequette, Bruce A. Bonenberger, Claude E. Gallian, John R. Reckelhoff
  • Pharmaceutical composition for immunoenhancement therapy
    Patent number: 5449522
    Abstract: This invention provides an immunoenhancement or immunepotentiation therapy comprising administration of potassium, insulin, glucose and, optionally, thyroid, a cholinergic agent and bicarbonate. Therapeutic compositions comprising the above components in appropriate dosages are also provided.
    Type: Grant
    Filed: August 24, 1993
    Date of Patent: September 12, 1995
    Inventor: Albert F. Hill
  • Oral formulations of ubidecarenone in form of capsules
    Patent number: 5443842
    Abstract: Pharmaceuticals formulations are described, in form of capsules ad oral use, containing as the active ingredient ubidecarenone, characterized in that the active ingredient is dispersed in a mixture of isopropyl myristate or isopropyl palmitate with polyethoxylated, hydrogenated or non hydrogenated, castor oils.
    Type: Grant
    Filed: March 30, 1994
    Date of Patent: August 22, 1995
    Assignee: Inverni Della Beffa Farmaceutici S.r.l.
    Inventors: Roberto Seghizzi, Giuseppe Furiosi
  • Freeze-dried pad
    Patent number: 5441741
    Abstract: There is disclosed: an absorbent, non-adherent, freeze-dried, fibre-free pad comprising from 2 to 6 parts by weight of a water-soluble biocompatible polymer and from 2 to 15 parts by weight of a liquid humectant, provided that the weight ratio of humectant to polymer is from 0.75:1 to 2.5:1 and; a method for producing the pad.
    Type: Grant
    Filed: March 22, 1993
    Date of Patent: August 15, 1995
    Assignee: Johnson & Johnson Medical, Inc.
    Inventor: Catherine L. Cheong
  • Pharmaceutical composition for the prevention of sexually transmitted diseases
    Patent number: 5439685
    Abstract: A pharmaceutical composition for the prevention of sexually transmitted diseases, intended to be contacted with a mucosa. The composition contains, on the one hand, at least one constituent active against the viruses and bacteria responsible for the said sexually transmitted diseases and, on the other hand, a product inhibiting the penetration of the active constituent across a mucosa, in combination with a pharmaceutically acceptable vehicle adapted to the topical administration of this composition. Advantageously, the product inhibiting penetration is a film-former capable of forming a film with which the active constituent or constituents are associated.
    Type: Grant
    Filed: December 22, 1992
    Date of Patent: August 8, 1995
    Assignee: S S P L Safe Sex Products Licensing Societe Anonyme
    Inventor: Jacques J. Augros
  • Skin cleansing and exfoliant composition and method of treating skin
    Patent number: 5431913
    Abstract: A skin cleansing and exfoliant composition comprising d-alpha tocopheryl acetate (Vitamin E) homogenized in a pharmacologically acceptable oil phase and an emulsion or suspension of retinoic acid or a pharmacologically acceptable derivative thereof in a pharmacologically acceptable fluid adapted for application to human or non-human animal skin, the portion of oil phase being sufficient to provide a concentration of oil phase in the emulsion or suspension of from about 20% to about 40% by weight and the portion of retinoic acid or derivative thereof being sufficient to provide a concentration in the emulsion or suspension of from about 60% to about 80% by weight. A method for using the composition is also disclosed.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: July 11, 1995
    Inventor: Eva J. Phillips