Patents Examined by Ana Z Muresan
  • Method for producing methylmethacrylate
    Patent number: 10766847
    Abstract: The present invention relates to a process for producing methyl methacrylate, comprising the following steps: A) producing methacrolein and B) reacting the methacrolein obtained in step A) in an oxidative esterification reaction to give methyl methacrylate, characterized in that the two steps A) and B) take place in a liquid phase at a pressure of from 2 to 100 bar, and step B) is carried out in the presence of a heterogeneous noble-metal-containing catalyst comprising metals and/or comprising metal oxides.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: September 8, 2020
    Assignee: RÖHM GMBH
    Inventors: Steffen Krill, Torsten Balduf, Martin Koestner, Matthias Groemping, Alexander Lygin, Rudolf Burghardt
  • Cyclic bio-renewable flame retardants
    Patent number: 10752776
    Abstract: A bio-renewable flame-retardant compound is disclosed. The bio-renewable flame-retardant compound includes a cyclic structure formed in a reaction with a bio-renewable diene.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: August 25, 2020
    Assignee: International Business Machines Corporation
    Inventors: Brandon M. Kobilka, Jacob T. Porter, Jason T. Wertz, Joseph Kuczynski
  • Method for the manufacture of fluorinated compounds
    Patent number: 10737997
    Abstract: A method for the manufacture of perfluorinated compounds is herein disclosed. In particular, the method is useful for the manufacture of perfluorooxyalkyl carboxylic acid salts which can be used as surfactants. The method envisages the fluorination or a fluoroformate of an alcohol comprising a —CH2OCH2-moiety at a temperature equal to or higher than 20° C. and allows obtaining high yields and selectivity.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: August 11, 2020
    Assignee: SOLVAY SPECIALTY POLYMERS ITALY S.P.A.
    Inventors: Marco Galimberti, Vito Tortelli, Emanuela Antenucci, Giuseppe Marchionni
  • PdIn alloy catalyst, method for manufacturing PdIn alloy catalyst and application thereof
    Patent number: 10737250
    Abstract: The present disclosure provides a PdIn alloy catalyst including a carrier and Pd metal particles supported by the carrier, the carrier is a nitrogen-doped porous carbon composite material having a plurality of passages, Pd metal particles are distributed in the plurality of passages, the nitrogen-doped porous carbon composite material includes a nitrogen-doped porous carbon material, a plurality of indium oxide particles, and In metal particles. The In metal particles are exposed through the plurality of passages, the plurality of indium oxide particles are uniformly distributed in the nitrogen-doped porous carbon material, and In atoms of the In metal particles migrated to surfaces of Pd particles selectively occupy edge and corner positions of metal lattice of Pd metal particles. The present disclosure further provides a method for manufacturing the PdIn alloy catalyst and application thereof.
    Type: Grant
    Filed: September 1, 2019
    Date of Patent: August 11, 2020
    Assignees: ZHEJIANG NHU COMPANY LTD., ZHEJIANG UNIVERSITY, SHANDONG NHU PHARMACEUTICAL CO., LTD., SHANDONG NHU VITAMIN CO., LTD.
    Inventors: Yong Wang, Lili Yu, Xiao Ma, Jianyong Mao, Zhe Wang, Shanjun Mao, Jianqing Li, Gang Chen, Haoran Li, Zhirong Chen
  • Lipids and lipid compositions for the delivery of active agents
    Patent number: 10729775
    Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: August 4, 2020
    Assignee: NOVARTIS AG
    Inventors: Jeremy Lee Baryza, Rohan Eric John Beckwith, Keith Bowman, Crystal Byers, Tanzina Fazal, Gabriel Grant Gamber, Cameron Chuck-munn Lee, Ritesh Bhanudasji Tichkule, Chandra Vargeese, Shuangxi Wang, Laura Ellen West, Thomas Zabawa, Junping Zhao
  • Solid porous form of trimesic acid and a process for preparation thereof
    Patent number: 10730820
    Abstract: The present invention relates to hexagonal hollow rods and a porous single crystalline structure, namely Form II of trimesic acid of Formula (A) and a process for preparation thereof. The present invention also discloses that the new solid porous single crystalline Form II of trimesic acid shows high adsorption for Rhodamine B (RHB) dye.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: August 4, 2020
    Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
    Inventors: Srinu Tothadi, Rahul Banerjee
  • Dimethoxyphenyl inhibitors of vesicular monoamine transporter 2
    Patent number: 10722479
    Abstract: Described are dimethoxyphenyl inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: July 28, 2020
    Assignee: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Chengzhi Zhang
  • Processes for preparing (R)-1-(5-chloro-[1,1?-biphenyl] -2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1?-biphenyl]-2-yl)-2,2,2-trifluoroethanone
    Patent number: 10710948
    Abstract: The present invention relates to processes for the preparation of (R)-1-(5-chloro-[1,1?-biphenyl]-2-yl)-2,2,2-trifluoroethanol, 1-(5-chloro-[1,1?-biphenyl]-2-yl)-2,2,2-trifluoroethanone, and intermediates thereof, which are useful in the preparation of inhibitors of TPH1 for the treatment of, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, low bone mass diseases, serotonin syndrome, and cancer.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: July 14, 2020
    Assignee: Roivant Sciences GmbH
    Inventors: Stéphane De Lombaert, Daniel R. Goldberg
  • Motuporamine derivatives as antimicrobial agents and antibiotic enhancers against resistant gram-negative bacteria
    Patent number: 10710957
    Abstract: Motuporamine agents having antimicrobial activity and uses thereof.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: July 14, 2020
    Assignees: University of Central Florida Research Foundation, Inc., Inserm Transfert, S.A.
    Inventors: Otto Phanstiel, IV, Jean-Michel Brunel
  • Organic colorant, coloring composition, and inkjet ink
    Patent number: 10703911
    Abstract: Organic colorant represented by General Formula (1) below: where in the General Formula (1), R1 and R2 each independently represent C1-C20 alkyl group, C1-C20 alkenyl group, phenyl group, naphthyl group, or group represented by —(CH2)n—COO—R3, —(CH2)n—R4, —(CH2)n—CONH—R5, —CR6R7—COO—R8, or —(CH2)n—OCOCH3; R3 represents hydrogen atom or C1-C2 alkyl group; R4 represents hydroxy group, C1-C2 alkoxy group, C2-C5 alkenyloxy group, SO3Na group, OSO3Na group, phenyl group, phenylalkyl group, naphthyl group, or naphthylalkyl group; R5 represents C1-C20 alkyl group, C1-C20 alkenyl group, or C1-C12 hydroxyalkyl group; R6 represents hydrogen atom or methyl group; R7 represents C1-C4 alkyl group; R8 represents C1-C5 alkyl group; and n is integer of from 1 to 12.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: July 7, 2020
    Assignees: Ricoh Company, Ltd., Tokyo University of Science Foundation
    Inventors: Takuya Fujita, Yoshimasa Miyazawa, Tatsuya Tomura, Masahiro Yanagisawa, Kiyofumi Nagai, Yukishige Kondo, Juki Migii
  • Lubricant base oil and method for preparing the same
    Patent number: 10696914
    Abstract: The present invention relates to a lubricant base oil containing an aromatic ester lubricant represented by Chemical Formula 1 and to a method for preparing the aromatic ester lubricant. By containing an aromatic ester lubricant, the lubricant base oil exhibits an excellent dispersibility and fluidity and is ecofriendly due to a high biodegradability. In addition, the method for preparing the aromatic ester lubricant does not generate such toxic substances as S, N, aromatic compounds and heavy metals and enables an easy control of the physical properties of a desired lubricant base oil by selecting a suitable alcohol compound to be introduced for an esterification reaction.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: June 30, 2020
    Assignees: SK Innovation Co., Ltd., SK Lubricants Co., Ltd.
    Inventors: Hee Jung Jeon, Yong Woo Kim
  • Chiral phase-transfer catalyst and method for preparing alpha-amino acid by using the same
    Patent number: 10696621
    Abstract: The present invention relates to a novel chiral phase-transfer catalyst, and a method for preparing an alpha-amino acid by using the same. According to the present invention, an alpha-amino acid of high optical purity could be synthesized in a high yield under an easy industrially applicable reaction condition by using a novel cinchona alkaloid compound as a chiral phase-transfer catalyst, and thus the present invention can be used as a key technique of the asymmetric alpha-amino acid synthesis and preparation field.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: June 30, 2020
    Inventors: Kee Pyung Nahm, Yeon Ji Lee, Bae Geun Lim, Seung A Woo, Ji Inn Oh, Won Gyoung Son
  • PH-sensitive linkers for delivering a therapeutic agent
    Patent number: 10688193
    Abstract: The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target and effect on the cells. The target delivery provided by the linker of the invention can be used for example for disease sensing, imaging, drug delivery, and therapy.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: June 23, 2020
    Assignee: GNT BIOTECH & MEDICALS CORPORATION
    Inventors: Yu-Jung Liao, Wei-Jan Huang, Chia-Nan Chen, Huan-Yu Lin, Ching-Yi Lin, Meng-Ju Tsai, Wan-Yi Hsu, Li-Ling Chi, Ye-Su Chao, Yi-Hong Wu
  • Alpha-aminoamide derivative compound and pharmaceutical composition comprising same
    Patent number: 10676425
    Abstract: The present disclosure relates to an ?-aminoamide derivative compound and a pharmaceutical composition containing the same, for treating a neurodegenerative diseases.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: June 9, 2020
    Assignee: MEGABIOWOOD CO., LTD
    Inventors: Ki Duk Park, ChangJoon Justin Lee, Dong Jin Kim, Ae Nim Pae, Hyun Ah Choo, Sun Joon Min, Yong Koo Kang, Yun Kyung Kim, Hyo Jung Song, Ji Won Choi, Min Ho Nam, Jun Young Heo, Seul Ki Yeon, Bo Ko Jang, Eun Ji Ju, Seon Mi Jo, Jong-Hyun Park
  • Branched amphiphilic lipids
    Patent number: 10676492
    Abstract: Disclosed are novel branched amphiphilic lipids, in particular novel branched amphiphilic lipids of general formula (II). Also disclosed is a method of synthesis for the compounds of formula (II), from unsaturated amphiphilic compounds of general formula (I). Further disclosed is the use of the compounds of general formula (II) and of the lipoplexes obtained by formulation of the compounds of general formula (II) for applications, particularly transfection, in which improved fusion properties are desired.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: June 9, 2020
    Assignees: UNIVERSITÉ DE BRETAGNE OCCIDENTALE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST
    Inventors: Paul-Alain Jaffrès, Hélène Couthon-Courvès, Damien Afonso, Tristan Montier, Tony Le Gall
  • Process for hydrogenating toluenediamine (TDA) tar
    Patent number: 10662141
    Abstract: Process for hydrogenating toluenediamine (TDA) tar containing TDA and high boilers relative to TDA, including the step of contacting the toluenediamine tar with a heterogeneous hydrogenation catalyst comprising at least one metal selected from the group consisting of Ni, Co, Ru, Pd, Pt on at least one catalyst support selected from the group consisting of carbon, TiO2 and ZrO2, and with hydrogen under hydrogenating conditions.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: May 26, 2020
    Assignee: BASF SE
    Inventors: Armin Lange De Oliveira, Ines Lottenburger, Christian Bechtold, Thomas Heidemann
  • Phenylhydrazine/anhydride adducts and anaerobic curable compositions using same
    Patent number: 10662147
    Abstract: Phenylhydrazine/anhydride adducts and anaerobic curable compositions using these adducts are provided. The compositions are particularly useful as adhesives and sealants.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: May 26, 2020
    Assignee: Henkel IP & Holding GmbH
    Inventors: Philip T. Klemarczyk, David P. Birkett
  • Method for synthesizing ketoxime
    Patent number: 10654795
    Abstract: A method for synthesizing a ketoxime is provided. In a system of an aqueous carbonate solution, a reaction is performed on a ketone, ammonia and hydrogen peroxide by using a titanium-silicon molecular sieve as a catalyst to obtain the ketoxime. Moreover, a reaction progress is judged and an optimal reaction ratio is determined by a real-time monitoring of a pH value in a reaction system during the reaction. In the present invention, by monitoring the pH value in the reaction system, the progress of the reaction is judged, thereby determining the optimal reaction ratio. The pH of the system is further adjusted by an aqueous carbonate solution to increase the reaction velocity and conversion rate of the ammonia.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: May 19, 2020
    Assignee: CHEMICAL TECHNOLOGY ACADEMY OF SHANDONG PROVINCE
    Inventors: Tao Yue, Xu Yang, Wenguo Xing, Qi Chen, Guijun Chen, Fujun Lu, Weichun Feng, Yunge Zhai
  • Crystal of monovalent cation salt of 3-hydroxyisovaleric acid and process for producing the crystal
    Patent number: 10647653
    Abstract: The present invention provides a crystal of a monovalent cation salt of 3-hydroxyisovaleric acid (hereinafter, referred to as HMB), which is excellent in solubility and easy to handle, and a process for producing the crystal. A crystal of a monovalent cation salt of HMB is precipitated in an aqueous HMB solution containing a monovalent cation-containing compound and having a pH of 4.0 to 9.0, and the crystal of a monovalent cation salt of HMB is thereafter collected from the aqueous solution.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: May 12, 2020
    Assignees: KYOWA HAKKO BIO CO., LTD., OTSUKA PHARMACEUTICAL FACTORY, INC.
    Inventors: Tomoya Yokoi, Hiroshi Nagano, Takayuki Shimizu
  • Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
    Patent number: 10638756
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: May 5, 2020
    Assignee: DOW AGROSCIENCES LLC
    Inventors: Paul R. LePlae, Jr., Thomas Barton, Xin Gao, James E. Hunter, William C. Lo, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert, David A. Demeter, Hemant Joshi