Abstract: A medical system for monitoring a left atrial pressure in a heart of a patient may include an implantable device including an expandable framework and a first sensor secured to the expandable framework and an external component configured to communicate wirelessly with the implantable device. The first sensor may be configured to detect a first measurement. The first sensor may be a pressure sensor and the first measurement may be the left atrial pressure. The implantable device or the external component may include a processor configured to create a first trend for the first measurement. The processor may be configured to use the first trend to modify the first measurement prior to outputting a corrected result.

Abstract: A surgical robotic system includes a sensor unit, a controller, and a robotic subsystem. The robotic subsystem is in communication with the sensor unit and the controller. Additionally, the robotic subsystem includes a plurality of robotic arms that each have an end effort at a distal end thereof. The robotic subsystem also includes a camera assembly that has at least two cameras and an autofocus unit that automatically focuses a lens of each of the cameras.

Abstract: Systems, interfaces, and methods are described herein for evaluation and adjustment cardiac therapy. The systems, interfaces, and methods may utilize, or include, a graphical user interface to display various information with respect to a plurality of external electrodes and electrical activity monitored using such external electrodes and to allow a user to adjust what information to display.

Abstract: Certain aspects of the present disclosure provide methods, apparatus, and computer-readable media for determining hemodynamic stability in a subject. In one example method, an optical signal is transmitted via at least one optical fiber in a set of one or more optical fibers partially disposed in a heart of the subject, wherein the at least one optical fiber in the set is configured to bend with the mechanical movement of the heart. A reflected portion of the optical signal is received via the at least one optical fiber, wherein changes in at least one parameter of the received reflected portion of the optical signal are indicative of the mechanical movement of the heart. A hemodynamic stability of the heart is determined based on the received reflected portion. Hemodynamic stability of the subject may further be determined based on thermal, ultrasound, and/or impedance signals measured in or near the heart.

Abstract: Systems and techniques are disclosed to establish programming of an implantable electrical neurostimulation device for treating pain of a human subject, through the use and adjustment of analgesic stimulation parameters based on trust dynamics and trust measurements. In an example, the system to establish programming of the neurostimulation device performs operations that: determine a trust measurement value that is derived from results of at least one commitment made with a human subject, via observable interactions; determine a modification of at least one neurostimulation programming parameter, based on the trust measurement value; and to cause the implantable neurostimulation device to implement the modification of the at least one neurostimulation programming parameter. Further examples are provided to produce and track the trust measurement value, as well as identify a pain susceptibility value and determine a receptiveness to analgesic effects based on these and other trust dynamics.

Abstract: A medical probe includes an insertion tube for insertion into a patient body, at least an arm, which is attached to a distal end of the insertion tube, at least a reference electrode coupled to the arm, and multiple electrodes, which are coupled to the arm, surround the reference electrode and are configured to sense electrical signals of body tissues that, when measured relatively to the reference electrode, are indicative of anatomical signals in the patient body.

Abstract: Implementations provide a method that includes: placing a controller device over a surface region of the patient where the implantable wireless stimulation device has been implanted; configuring the controller device to (i) monitor a return loss representing electrical power reflected from the implantable wireless stimulation device to the controller device; (ii) compute a first path loss metric based on a first monitored return loss when the controller device is place over a first location within the surface region; (iii) compute a second path loss metric based on a second monitored return loss when the controller device is over a second location within the surface region; and (iv) generate a feedback to an operator to indicate whether the second path loss is smaller than the first path loss such that the controller device is placed at a location with more electrical energy non-inductively transferred to the implantable wireless stimulation device.

Abstract: Disclosed are various configurations of electrodes with accompanying extensions and wires configured to be attached at or near the left atrium of a heart to allow the device to be held snug against the endocardium and out of the blood flow for low energy defibrillation of the atria in response to atrial fibrillation or other atrial arrhythmias. The portion of the lead internal to the atrium (e.g., the left atrium) is restrained against the endocardium of the left atrium by way of a restraint mechanism. In one example, the electrode is configured to attach to the atrial septum, with wires containing memory-shaped metal to keep the wires against the heart wall. In yet another example, the electrode is configured to be part of a mitral valve device.

Abstract: Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, are used to modify the secretion of insulin and glucagon from the pancreas, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating are used to control sensitivity of the liver to plasma insulin and glucagon to treat impaired glucose regulation.

Abstract: An illustrative insertion management system may be configured to identify one or more attributes of a lead insertion procedure in which an electrode lead having a plurality of electrodes is inserted into a cochlea of a recipient of a cochlear implant; dynamically select, based on the one or more attributes of the lead insertion procedure, a first subset of electrodes included in the plurality of electrodes for inclusion in a monitoring electrode set, the monitoring electrode set configured to have less electrodes than a total number of the plurality of electrodes; monitor, during the lead insertion procedure, impedance values for electrodes included in the monitoring electrode set; and determine, during the lead insertion procedure and based on the monitoring, a positioning state of the electrode lead.

Abstract: The present disclosure provides a stretchable and flexible sweat-activated graphene-coated Ni foam-based Mg—O2 battery capable of powering an intelligent and flexible electronics for health monitoring purposes with different biosensors.

Abstract: A hermetic seal tester for medical devices and a process for testing medical device integrity with a hermetic seal tester are disclosed. The hermetic seal tester for medical devices detects internal seal leaks, if any, by performing the process for testing medical device integrity with a hermetic seal tester prior to every use of a medical device, instrument or medical power tool. A leak can cause medical device or power tool failure during surgery. Leaks within the fluid pathway also compromise the ability to clean and sterilize the medical device or power tool, resulting in the potential for cross-contamination. Preventive maintenance is far superior to waiting until the medical device or power tool fails.

Abstract: A medical instrument includes an instrument shaft with exit holes near a distal end of the shaft, a tool coupled to the distal end of the shaft, and a backend. The backend may include a mechanism that manipulates a drive element that extends through the shaft and couples to the tool, a fluid inlet, and a fluid channel assembly providing fluid communication between the fluid inlet and the proximal end of the shaft. Cleaning fluid is directed into the fluid inlet, through the fluid channel assembly, and into the shaft. A chassis or other structural piece of the backend may form part of the fluid channel assembly.

Abstract: A method of manufacturing an implantable lead including a cuff is disclosed. The method includes partially curing a first silicone electrode cover, embedding electrodes within the first silicone electrode cover, partially curing a second silicone electrode cover, placing the first silicone electrode in a face-to-face relationship with the second silicone electrode cover to form an assembly, forming the assembly into a desired shape against a shim, placing an assembly within a canister to control an outer expansion, and curing the assembly.

Abstract: A neuroprosthetic system for substituting a sensory modality of a mammal by electrical stimulation of a region of the cerebral cortex corresponding to the neural modality to be substituted. The system includes at least one sensor for generating a sensed data feed by sensing a neural modality to be substituted, an electrode unit including a plurality of three-dimensional arrays of flexible electrode shafts for implantation of a region of the cerebral cortex, a rigid electrode support structure for guiding the flexible electrode shafts into the region of the cerebral cortex and for retraction after implantation, a driving unit for electrically driving the electrode, a recording unit, and a processing unit for analysing sensed data feed for providing stimulation patterns for electrically driving groups of electrical contacts of the electrode unit corresponding to subsets of locations in the region of the cerebral cortex, for substituting the sensory modality.

Abstract: An implantable medical device includes an electrode and an insulative material secured to the electrode via an adhesive. The electrode includes a metal substrate and a metal coating. The metal substrate includes a connection segment and an active segment along a length of the metal substrate. The metal coating is disposed on an outer surface of the metal substrate along the connection segment and the active segment. The insulative material surrounds the connection segment of the metal substrate without surrounding the active segment, and the adhesive adheres to the metal coating on the connection segment.

Abstract: The embodiment discloses an electrode array including a housing; a plurality of first contact electrodes exposed to an outside of the housing; a plurality of second contact electrodes exposed to the outside of the housing; a first wire group disposed inside the housing and electrically connected to the first contact electrodes; and a second wire group disposed inside the housing and electrically connected to the second contact electrodes, the plurality of first contact electrodes and the first wire group being disposed on different planes within the housing.

Abstract: Systems, methods, devices, and techniques for estimating a heart disease prediction of a mammal. An electrocardiogram (ECG) procedure is performed on a mammal, and a computer system obtains ECG data that describes results of the ECG over a period of time. The system provides a predictive input that is based on the ECG data to a predictive model, such as a neural network or other machine-learning model. In response, the predictive model processes the input to generate an estimated heart disease predictive characteristic of the mammal. The system outputs the estimated heart disease prediction of the mammal for presentation to a user.

Abstract: Methods and systems for facilitating the determining and setting of stimulation parameters for programming an electrical stimulation system are disclosed. The disclosed systems and methods use algorithms to identify patient-specific metrics to use as feedback variables for optimizing stimulation parameters for a patient. The patient-specific metric(s) are determined by ranking a plurality of clinical indicators for the patient with and without the presence of a medical intervention to determine which clinical indicators respond most strongly to the medical intervention. The clinical indicators that respond most strongly can be used as the patient-specific metric for optimizing stimulation, or a composite patient-specific metric may be derived as a mathematical combination of a plurality of clinical indicators that respond well to the intervention.

Abstract: The present invention is directed to a method for inducing an immune response in a subject, including a step of activating neurons in the mesolimbic network of the subject by applying a neurofeedback.