Patents Examined by Anant A Gupta
  • Patent number: 12337181
    Abstract: Systems and techniques are disclosed to establish programming of an implantable electrical neurostimulation device for treating pain of a human subject, through the use and adjustment of analgesic stimulation parameters based on trust dynamics and trust measurements. In an example, the system to establish programming of the neurostimulation device performs operations that: determine a trust measurement value that is derived from results of at least one commitment made with a human subject, via observable interactions; determine a modification of at least one neurostimulation programming parameter, based on the trust measurement value; and to cause the implantable neurostimulation device to implement the modification of the at least one neurostimulation programming parameter. Further examples are provided to produce and track the trust measurement value, as well as identify a pain susceptibility value and determine a receptiveness to analgesic effects based on these and other trust dynamics.
    Type: Grant
    Filed: April 25, 2024
    Date of Patent: June 24, 2025
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: James R. Kozloski, Anup Kalia, Jeffrey Rogers, Sara E. Berger
  • Patent number: 12329531
    Abstract: A medical probe includes an insertion tube for insertion into a patient body, at least an arm, which is attached to a distal end of the insertion tube, at least a reference electrode coupled to the arm, and multiple electrodes, which are coupled to the arm, surround the reference electrode and are configured to sense electrical signals of body tissues that, when measured relatively to the reference electrode, are indicative of anatomical signals in the patient body.
    Type: Grant
    Filed: November 24, 2021
    Date of Patent: June 17, 2025
    Assignee: Biosense Webster (Israel) Ltd.
    Inventors: Alexander David Squires, Christopher Thomas Beeckler
  • Patent number: 12329976
    Abstract: Implementations provide a method that includes: placing a controller device over a surface region of the patient where the implantable wireless stimulation device has been implanted; configuring the controller device to (i) monitor a return loss representing electrical power reflected from the implantable wireless stimulation device to the controller device; (ii) compute a first path loss metric based on a first monitored return loss when the controller device is place over a first location within the surface region; (iii) compute a second path loss metric based on a second monitored return loss when the controller device is over a second location within the surface region; and (iv) generate a feedback to an operator to indicate whether the second path loss is smaller than the first path loss such that the controller device is placed at a location with more electrical energy non-inductively transferred to the implantable wireless stimulation device.
    Type: Grant
    Filed: August 28, 2023
    Date of Patent: June 17, 2025
    Assignee: CURONIX LLC
    Inventors: Laura Tyler Perryman, Patrick Larson, Richard LeBaron
  • Patent number: 12311165
    Abstract: Disclosed are various configurations of electrodes with accompanying extensions and wires configured to be attached at or near the left atrium of a heart to allow the device to be held snug against the endocardium and out of the blood flow for low energy defibrillation of the atria in response to atrial fibrillation or other atrial arrhythmias. The portion of the lead internal to the atrium (e.g., the left atrium) is restrained against the endocardium of the left atrium by way of a restraint mechanism. In one example, the electrode is configured to attach to the atrial septum, with wires containing memory-shaped metal to keep the wires against the heart wall. In yet another example, the electrode is configured to be part of a mitral valve device.
    Type: Grant
    Filed: May 30, 2024
    Date of Patent: May 27, 2025
    Assignee: Wolf Cardio, LLC
    Inventor: Randall K. Wolf
  • Patent number: 12311174
    Abstract: Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, are used to modify the secretion of insulin and glucagon from the pancreas, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating are used to control sensitivity of the liver to plasma insulin and glucagon to treat impaired glucose regulation.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: May 27, 2025
    Assignee: RESHAPE LIFESCIENCES INC.
    Inventors: Jonathan James Waataja, Raj Nihalani
  • Patent number: 12290685
    Abstract: An illustrative insertion management system may be configured to identify one or more attributes of a lead insertion procedure in which an electrode lead having a plurality of electrodes is inserted into a cochlea of a recipient of a cochlear implant; dynamically select, based on the one or more attributes of the lead insertion procedure, a first subset of electrodes included in the plurality of electrodes for inclusion in a monitoring electrode set, the monitoring electrode set configured to have less electrodes than a total number of the plurality of electrodes; monitor, during the lead insertion procedure, impedance values for electrodes included in the monitoring electrode set; and determine, during the lead insertion procedure and based on the monitoring, a positioning state of the electrode lead.
    Type: Grant
    Filed: August 22, 2020
    Date of Patent: May 6, 2025
    Assignee: Advanced Bionics AG
    Inventor: Patrick J. Boyle
  • Patent number: 12279887
    Abstract: The present disclosure provides a stretchable and flexible sweat-activated graphene-coated Ni foam-based Mg—O2 battery capable of powering an intelligent and flexible electronics for health monitoring purposes with different biosensors.
    Type: Grant
    Filed: November 2, 2021
    Date of Patent: April 22, 2025
    Assignee: City University of Hong Kong
    Inventors: Xinge Yu, Xingcan Huang, Yiming Liu
  • Patent number: 12274852
    Abstract: A hermetic seal tester for medical devices and a process for testing medical device integrity with a hermetic seal tester are disclosed. The hermetic seal tester for medical devices detects internal seal leaks, if any, by performing the process for testing medical device integrity with a hermetic seal tester prior to every use of a medical device, instrument or medical power tool. A leak can cause medical device or power tool failure during surgery. Leaks within the fluid pathway also compromise the ability to clean and sterilize the medical device or power tool, resulting in the potential for cross-contamination. Preventive maintenance is far superior to waiting until the medical device or power tool fails.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: April 15, 2025
    Inventors: John Dawoodjee, William Shane Manor
  • Patent number: 12239497
    Abstract: A medical instrument includes an instrument shaft with exit holes near a distal end of the shaft, a tool coupled to the distal end of the shaft, and a backend. The backend may include a mechanism that manipulates a drive element that extends through the shaft and couples to the tool, a fluid inlet, and a fluid channel assembly providing fluid communication between the fluid inlet and the proximal end of the shaft. Cleaning fluid is directed into the fluid inlet, through the fluid channel assembly, and into the shaft. A chassis or other structural piece of the backend may form part of the fluid channel assembly.
    Type: Grant
    Filed: October 4, 2023
    Date of Patent: March 4, 2025
    Assignee: Intuitive Surgical Operations, Inc.
    Inventors: Bram Gilbert Antoon Lambrecht, S. Christopher Anderson, Thomas G. Cooper
  • Patent number: 12226628
    Abstract: A method of manufacturing an implantable lead including a cuff is disclosed. The method includes partially curing a first silicone electrode cover, embedding electrodes within the first silicone electrode cover, partially curing a second silicone electrode cover, placing the first silicone electrode in a face-to-face relationship with the second silicone electrode cover to form an assembly, forming the assembly into a desired shape against a shim, placing an assembly within a canister to control an outer expansion, and curing the assembly.
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: February 18, 2025
    Assignee: Oscor Inc.
    Inventors: Timothy Searfoss, Brian Walguarnery, Thomas P. Osypka
  • Patent number: 12214186
    Abstract: A neuroprosthetic system for substituting a sensory modality of a mammal by electrical stimulation of a region of the cerebral cortex corresponding to the neural modality to be substituted. The system includes at least one sensor for generating a sensed data feed by sensing a neural modality to be substituted, an electrode unit including a plurality of three-dimensional arrays of flexible electrode shafts for implantation of a region of the cerebral cortex, a rigid electrode support structure for guiding the flexible electrode shafts into the region of the cerebral cortex and for retraction after implantation, a driving unit for electrically driving the electrode, a recording unit, and a processing unit for analysing sensed data feed for providing stimulation patterns for electrically driving groups of electrical contacts of the electrode unit corresponding to subsets of locations in the region of the cerebral cortex, for substituting the sensory modality.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: February 4, 2025
    Assignee: NEDERLANDS HERSENINSTITUUT
    Inventors: Pieter R. Roelfsema, Xing Chen
  • Patent number: 12201846
    Abstract: An implantable medical device includes an electrode and an insulative material secured to the electrode via an adhesive. The electrode includes a metal substrate and a metal coating. The metal substrate includes a connection segment and an active segment along a length of the metal substrate. The metal coating is disposed on an outer surface of the metal substrate along the connection segment and the active segment. The insulative material surrounds the connection segment of the metal substrate without surrounding the active segment, and the adhesive adheres to the metal coating on the connection segment.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: January 21, 2025
    Assignee: Pacesetter, Inc.
    Inventors: Wesley Alleman, Keith Victorine, Tyler Strang, Nicole Cooper, Steve Chantasirivisal, Traci Chang
  • Patent number: 12201826
    Abstract: The embodiment discloses an electrode array including a housing; a plurality of first contact electrodes exposed to an outside of the housing; a plurality of second contact electrodes exposed to the outside of the housing; a first wire group disposed inside the housing and electrically connected to the first contact electrodes; and a second wire group disposed inside the housing and electrically connected to the second contact electrodes, the plurality of first contact electrodes and the first wire group being disposed on different planes within the housing.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: January 21, 2025
    Assignee: TODOC Co., Ltd.
    Inventors: Kyou Sik Min, Soo Won Shin, June Woo Hyun, Sang Woo Kim, Yoon Hee Ha, Gwang Jin Choi
  • Patent number: 12201404
    Abstract: Systems, methods, devices, and techniques for estimating a heart disease prediction of a mammal. An electrocardiogram (ECG) procedure is performed on a mammal, and a computer system obtains ECG data that describes results of the ECG over a period of time. The system provides a predictive input that is based on the ECG data to a predictive model, such as a neural network or other machine-learning model. In response, the predictive model processes the input to generate an estimated heart disease predictive characteristic of the mammal. The system outputs the estimated heart disease prediction of the mammal for presentation to a user.
    Type: Grant
    Filed: October 31, 2023
    Date of Patent: January 21, 2025
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Itzhak Zachi Attia, Paul A. Friedman, Francisco Lopez-Jimenez, Suraj Kapa
  • Patent number: 12186561
    Abstract: Methods and systems for facilitating the determining and setting of stimulation parameters for programming an electrical stimulation system are disclosed. The disclosed systems and methods use algorithms to identify patient-specific metrics to use as feedback variables for optimizing stimulation parameters for a patient. The patient-specific metric(s) are determined by ranking a plurality of clinical indicators for the patient with and without the presence of a medical intervention to determine which clinical indicators respond most strongly to the medical intervention. The clinical indicators that respond most strongly can be used as the patient-specific metric for optimizing stimulation, or a composite patient-specific metric may be derived as a mathematical combination of a plurality of clinical indicators that respond well to the intervention.
    Type: Grant
    Filed: June 7, 2023
    Date of Patent: January 7, 2025
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: León M. Juárez Paz
  • Patent number: 12171568
    Abstract: The present invention is directed to a method for inducing an immune response in a subject, including a step of activating neurons in the mesolimbic network of the subject by applying a neurofeedback.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: December 24, 2024
    Assignees: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED, ICHILOV TECH LTD., RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Talma Hendler, Asya Rolls, Nitzan Lubianiker, Tamar Koren, Neomi Singer, Tamar Ben Shannan, Shai Shen Orr, Fahed Hakim, Hilla Azulay-Debby, Rani Cohen
  • Patent number: 12138450
    Abstract: A delivery device for delivering a pacing lead to the His bundle of a patient's heart includes an elongated sheath having a distal end, and a plurality of mapping electrodes positioned at the distal end. The distal end of the sheath may have a distal end face, and the mapping electrodes may include two electrodes that diametrically oppose one another at a position exposed on or spaced from the distal end face. The sheath includes a plurality of flexible sections spaced apart from one another, and a pull wire that causes the sheath to deflect from a substantially straight configuration to a dual hinged curved configuration that maneuvers and positions the electrodes in the vicinity of the bundle of His. The sheath may include a PTFE liner having axially oriented, platelet-like fibril features that enable the sheath to be split along its length from a proximal end to the distal end.
    Type: Grant
    Filed: July 5, 2022
    Date of Patent: November 12, 2024
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Xiaoping Guo, Erich W. Stoermer
  • Patent number: 12133980
    Abstract: Embodiments of the invention provide apparatus, systems and methods for stimulating tissue in the urinary tract to initiate or facilitate urination. One embodiment provides an external urinary sphincter stimulation (EUSS) catheter for stimulating the external urinary sphincter (EUS), where the EUSS catheter includes nerve stimulation electrodes (NSES) for delivering current to nerves within or around the EUS in order to relax the EUS prior to urination. Other embodiments provide a system for stimulating the EUS including the EUSS catheter and a controller operatively coupled to the EUSS catheter, where the controller includes a pulse generator for delivering current to the NSES. Other embodiments provide methods for positioning the EUSS catheter in the patient's body including in the EUS using a urethral approach. Embodiments of the invention are particularly useful for initiating and/or controlling urination for patients who have lost the ability to voluntarily urinate due to neurogenic bladder dysfunction.
    Type: Grant
    Filed: August 9, 2023
    Date of Patent: November 5, 2024
    Assignee: InCube Labs, LLC
    Inventor: Mir Imran
  • Patent number: 12128235
    Abstract: This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation therapy. In some examples, a medical device includes stimulation generation circuitry configured to deliver a first stimulation pulse to a patient, sensing circuitry configured to sense the first stimulation pulse, and processing circuitry. The processing circuitry is configured to determine that a value of a characteristic of the sensed first stimulation pulse exceeds a target stimulation pulse value and responsive to determining that the value of the characteristic of the sensed first stimulation pulse exceeds the target stimulation pulse value, change a first value of a parameter to a second value of the parameter that at least partially defines a second stimulation pulse deliverable by the stimulation generation circuitry after the first stimulation pulse was sensed.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: October 29, 2024
    Assignee: Medtronic, Inc.
    Inventor: Jiashu Li
  • Patent number: 12121327
    Abstract: Systems, methods, devices, and techniques for estimating a heart disease prediction of a mammal. An electrocardiogram (ECG) procedure is performed on a mammal, and a computer system obtains ECG data that describes results of the ECG over a period of time. The system provides a predictive input that is based on the ECG data to a predictive model, such as a neural network or other machine-learning model. In response, the predictive model processes the input to generate an estimated heart disease predictive characteristic of the mammal. The system outputs the estimated heart disease prediction of the mammal for presentation to a user.
    Type: Grant
    Filed: November 7, 2022
    Date of Patent: October 22, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Itzhak Zachi Attia, Paul A. Friedman, Francisco Lopez-Jimenez, Suraj Kapa