Abstract: The present invention relates to a medical instrument capable of enhancing the slidability of an operating wire in a lumen. The medical instrument (for example, a catheter (10) of the present invention) includes: a medical instrument body (a sheath (16)) which has a long length and flexibility and is inserted into a body cavity; a lumen (for example, a sub-lumen (30)) which is formed in the medical instrument body along a longitudinal direction of the medical instrument body; and an operating wire (40). The operating wire (40) is accommodated in the lumen, extends along a longitudinal direction of the lumen, and is slidable in the longitudinal direction of the lumen, and the medical instrument body can be bent by an operation of pulling the operating wire (40). A lubricating liquid (45) adheres to at least a surface of the operating wire (40).

Abstract: An inflator comprises a body, a first drive member, and a second drive member. The body defines a reservoir that is configured to hold fluid and includes an outlet. The first drive member is operable to move through the reservoir to drive fluid from the reservoir through the outlet. The second drive member is engaged with the first drive member. The second drive member is movable relative to the body through a first range of motion to actuate the first drive member to drive fluid through the outlet at a first rate. The second drive member is movable relative to the body through a second range of motion following the first range of motion. The first drive member is configured to either drive fluid through the outlet at a second rate or not drive fluid through the outlet as the second drive member moves through the second range of motion.

Abstract: A syringe barrel includes a hollow barrel portion that has a proximal-end opening at a proximal end of the barrel portion and is configured such that a gasket is insertable from the proximal-end opening into the barrel portion. An inner peripheral portion of the barrel portion includes a tapered portion in a main area of the inner peripheral portion in an axial direction, the tapered portion having an inner diameter that gradually increases toward a distal end of the tapered portion from a proximal end of the tapered portion.

Abstract: A handheld injection device includes a housing, a rotatable dose setting member and a power reservoir coupled to the dose setting member. Energy is stored in the power reservoir during rotation of the dose setting member. The injection device also includes a release member for receiving a force from a user and a rotatably arranged drive member engaging with a drive track of a piston rod. The device further includes a release clutch rotationally constrained to the housing and releasably engaging the drive member. The release clutch is positionable in a first axial position when the release member is in a dose setting position and in a second axial position when the release member is in a dose injection position. The axial position of the drive member within the housing remains constant when the release member is in its dose setting position and in its dose injection position.

Abstract: An access port for subcutaneous implantation into a body of a patient is disclosed. The port is typically subcutaneously connected to a catheter, a distal portion of which is disposed within a vein or other vessel of the patient. The port is configured with enhanced fluid handling features to improve fluid flow therethrough while reducing the likelihood of clotting or occlusions in the attached catheter, thus improving system patency. In one embodiment, for instance, an implantable access port is disclosed and comprises a body defining a reservoir, a needle-penetrable septum covering an opening to the reservoir, a stem defining an outlet to the reservoir, and a deformable element included in the reservoir. The deformable element is operably connected to a main portion of the septum and deforms in response to displacement of the septum to counteract a change in volume within the reservoir and prevent blood ingress into the catheter.

Abstract: An injection device includes a housing having an aperture or window, and a dose indicator positioned within the housing. The dose indicator is rotatable with respect to the housing during dose setting and dose dispensing. The device includes a gauge element interposed between the housing and the dose indicator. The gauge element has a second aperture or window, which is positioned with respect to the first aperture or window such that at least a part of the dose indicator is visible through the first and second apertures or windows. The gauge element is axially guided within the housing and is in threaded engagement with the dose indicator such that rotation of the dose indicator causes an axial displacement of the gauge element. A resilient member provides a force necessary for ejecting a dose from the injection device.

Abstract: A drive mechanism of a drug delivery device for dispensing of a dose of a medicament includes a housing extending in an axial direction, a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction, and a drive sleeve extending in the axial direction and being rotatable in a dose incrementing direction against the action of a spring enclosing at least an axial portion of the drive sleeve. The drive mechanism further includes a dose limiting member threadedly engaged with the drive sleeve, rotatably locked to the housing and at least partially extending radially between the drive sleeve and the spring, and at least one stop located on at least one of dose limiting member and drive sleeve for limiting an axial displacement of the dose limiting member relative to the drive sleeve.

Abstract: The wound treatment apparatus combines an internal negative pressure (vacuum) pump and an internal positive pressure (compressor) pump connectable to an external oxygen supply for providing both negative pressure wound therapy and hyperbaric oxygen wound therapy to a wound site. The apparatus also includes a user interface operatively connected to an electronic controller that monitors and actuates the vacuum and compressor pumps. The user interface and controller enables the apparatus to provide multiple modes of operation and the ability to selectively change between negative pressure therapy operational modes and hyperbaric oxygen operational modes.

Abstract: Catheters including those having guidewire lumens that can convert from an Over-the-Wire mode to a Rapid Exchange mode are useful and effective when this conversion happens without adjusting the position of the guidewire in a body lumen.

Abstract: In general, medical sheath systems that can employ retainer devices having a plurality of channels configured to retain a sheath assembly in one or more curved configurations are described. In one embodiment, a retainer device may releasably retain a curvable tube of the sheath assembly in any of multiple curved configurations that range, for example, in selectable increments between 0° to 180°.

Abstract: The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicament, and to a respective drug delivery device, wherein the drive mechanism comprises: —an elongated housing (30) extending in an axial direction (1, 2), —a piston rod (80) to operably engage with a piston (16) of a cartridge (14) to displace the piston (16) in axial distal direction (1), —a drive sleeve (60) extending in axial direction (1, 2) and being rotatably supported in the housing (30), —a dose setting member (40) rotatably supported on a side wall portion (31) of the housing (30) and being rotatable with respect to an axis (41) extending in radial direction (r), —wherein the drive sleeve (60) is operably releasable from the piston rod (80) and rotatably engageable with the dose setting member (40) for setting of the dose.

Abstract: A system and method for treating atherosclerotic plaque. The system includes a first catheter including an expandable balloon and a second catheter including a lumen in fluid communication with a distal hole. The method includes inserting the first catheter into a body lumen adjacent to a plaque formation, and deploying a balloon from the first catheter adjacent to the plaque formation. In addition, the method includes inserting the second catheter adjacent to the first catheter, and routing the distal end portion of second catheter along at least a portion of the deployed balloon of the first catheter. Further, the method includes routing at least a portion of the second catheter into a subintimal space adjacent to the atherosclerotic plaque. Furthermore, the method includes injecting a therapeutic agent into the subintimal space adjacent to the atherosclerotic plaque.

Abstract: In some embodiments, an apparatus includes a first catheter movably disposed within a first lumen of a second catheter. The first catheter has a first occlusion member disposed at a distal end portion and the second catheter has a second occlusion member disposed at a distal end portion. A third catheter has a third occlusion member disposed at a distal end portion and is moveably disposable within a second lumen of the second catheter. The second catheter has a side port in fluid communication with the second lumen and the third catheter can be extended out of the second lumen through the side port. The first occlusion member, second occlusion member and third occlusion member can collectively isolate a target region including a portion of a first body lumen (e.g., a main vessel) and a portion of a second body lumen (e.g., a branch of the main vessel).

Abstract: An autonomous drug delivery system advantageously utilizes physiological monitor outputs so as to automatically give a bolus of a rescue drug or other necessary medication when certain criteria and confidence levels are met. An emergency button is provided to manually trigger administration of the rescue drug. The rescue drug may be an opioid antagonist in response to an analgesia overdose, a hypotensive drug to avert an excessive drop in blood pressure or an anti-arrhythmia drug to suppress abnormal heartbeats, to name a few.

Abstract: A medical tubing connector includes a first connector portion configured for connecting to a mating second connector. A tube engagement portion is integral with and opposite the first connector portion and configured for connecting to a medical tube. A liquid passage extends through the first connector portion and the tube engagement portion. The first connector portion includes a continuous outer surface for sealing engagement with the mating second connector. An annular portion is integral with and surrounds the male connector portion. A connecting portion connects the first connector portion to the annular portion. The connecting portion is discontinuous permitting liquid to pass through the connecting portion so that liquid is prevented from pooling between the first connector portion and the annular portion.

Abstract: Catheters adapted for use in small body vessels are described. A catheter includes an elongate shaft having a main body that defines first and second lumens. An inner tubular member is disposed in the second lumen and is formed of a material that has a stiffness that is greater than a stiffness of the material forming the main body and that has an elastic modulus greater than or equal to about 400 MPa.

Abstract: Sheath assembly for the insertion of a cord-shaped element (32, 105), comprising an introducer sheath (101) and an auxiliary sheath (104) for insertion into the introducer sheath (101) together with the cord-shaped element (32, 105), with first fastening means (106) for detachably fastening the auxiliary sheath to the introducer sheath, and with second fastening means (107) for detachably fastening the cord-shaped element to the auxiliary sheath, wherein the introducer sheath (101) has a first sheath housing (13, 114) and a distal tubular section (11, 41a) that terminates in the first sheath housing, and a first flushing device (108), wherein the auxiliary sheath (104) has a second sheath inner chamber (111), a distal, tubular part (112) and a second flushing device (109).

Abstract: A drug delivery device adapted to receive a cartridge and comprising a housing, an expelling assembly with a threaded piston rod, a threaded nut and a drive element arranged in non-rotational engagement with the piston rod, a drive coupling actuatable between a resetting state in which the piston rod can be moved proximally, and an operational state in which the drive element can drive the piston rod distally, wherein the drive element and the threaded nut are not moved axially relative to the housing when the drive coupling is actuated.

Abstract: A delivery unit (2) of a drug delivery device (1), the delivery unit (2) comprising a subcutaneous delivery mechanism (9) having a subcutaneous delivery member (92), and a subcutaneous delivery member actuation mechanism (10) being operable to move the subcutaneous delivery member (92) between a retracted position and an extended position. The actuation mechanism (10) comprises a rotary member (102) having an engagement member (104) rotatable relative a support member (14), and an actuator (106) comprising a pivot portion (10A) and an engagement portion (10B) pivotally connected to the support member via the pivot portion. The engagement member (104) and engagement portion (10B) are configured to engage upon rotation of the rotary member to pivot the actuator between first and second positions and to thereby move the subcutaneous delivery member (92) between the corresponding retracted and extended positions. In an embodiment, the needle actuation mechanism may comprise a reuse protection.

Abstract: A drive mechanism for a drug delivery device includes an elongated housing extending in an axial direction and a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction. A drive sleeve is rotatably supported in the housing, operably releasable from the piston rod for setting of a dose, and operably engageable with the piston rod for dispensing of the dose. A dose limiting member is engaged with the drive sleeve and engaged with the piston rod in such a way that it is displaced in axial direction relative to the drive sleeve when the drive sleeve rotates relative to the piston rod during a dose setting procedure. At least one stop is configured to engage with the dose limiting member for limiting the axial displacement of the dose limiting member during the dose setting procedure and to impede further displacement of the drive sleeve relative to the piston rod.