Abstract: A drug delivery device which includes a first housing part, a second housing part, a button, a drug expelling mechanism, a graduated plate, a circuit board and a pressing rod. The button is connected to the first housing part. The drug expelling mechanism is disposed inside the second housing part, and includes a dose setting member which is rotatable and configured to set a drug dose to be expelled. The graduated plate is disposed inside the first housing part and connected to the button, and includes a first conductive element and a plurality of second conductive element disposed on a surface thereof. The plurality of second conductive elements are arranged in interval and the first conductive element is electrically connected to the plurality of second conductive elements. The circuit board is disposed inside the first housing part and connected to the dose setting member.

Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.

Abstract: A needle assembly for an injection pen (22) has a sleeve (21) supporting internally a double-ended needle having an injection end and a non-injection end (25). The end of the sleeve surrounding the non-injection end (25) of the needle is divided into deformable segments (28) and is internally threaded for interengagement with a threaded boss (23) of the injection pen (22). A collar (29) is mounted on the sleeve (21) for sliding movement between a first position where the collar (29) overlies the segmented end and maintains interengagement of the threads at that end with those of the injection pen boss (23) and a second position where the segments may expand radially to come free of the injection pen boss (23). The needle may be mounted on a carrier (68) slidable with respect to the sleeve (21), the carrier (68) being coupled to the sleeve (21) for movement thereby.

Abstract: Presented herein are implantable systems and methods for long-term delivery of treatment substance to the ear of a recipient of an implantable auditory prosthesis.

Abstract: A treatment device includes: a balloon; a biologically active agent part applied on an outer surface of the balloon; a protective sleeve encircling the balloon and being displaceable proximally; and an interposed member having a self-expanding function arranged between the balloon and the protective sleeve. When the protective sleeve is moved proximally in order for the balloon to be exposed to the inside of a blood vessel, the presence of the interposed member prevents the biologically active agent part from being scraped and peeled off by the inner surface of the protective sleeve.

Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.

Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.

Abstract: The present invention relates to a single-use syringe comprising a barrel (10) having an internal surface defining a chamber for retaining a fluid, a plunger (1) formed by an elongated body including a plurality of longitudinal fins (2) and optionally a piston (3) connected to the end of the plunger close to the needle, the external surface of the piston or of the end of the plunger in the case of not including a piston being in leak-tight connection with the internal surface of the barrel, where the barrel has a general external shape of a cylinder of revolution with a constant radius circular base and a variable internal shape, forming the wall of the barrel with variable thickness, generating a chamber inside which a plunger incorporating a plurality of fins (2) slides; each of the longitudinal fins (2) of the plunger has a constant height along its entire length but different from that of at least one of the other fins, which height is suitable in each fin so that the plunger (1) can be inserted tightly w

Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.

Abstract: Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on the injector device, or on a portion of the injection device housing, or on a drug reservoir. Some devices may be removably attached to a drug reservoir, for example, through a luer connector. Other devices may comprise internal luer seal for securely connecting a drug conduit of the device to the luer cavity of a drug reservoir. Yet other devices may comprise a priming-enabling element to facilitate the drug priming of a shielded needle. Related methods and systems comprising the devices are also described.

Abstract: Mixing syringes including a valve mechanism are configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for the mixing of one or more substances, and the resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject.

Abstract: Embodiments of the invention provide infusion systems for the intravenous or other delivery of drugs and other therapeutic agents to a patient including a human or mammal. The therapeutic agents may be dissolved in solution or comprise the solution itself. Embodiments of the systems can utilize a chemical reaction to predictably drive a flow of drug(s) through a catheter or other flow path and into the patient. More specifically, the reaction may include an acid-base reaction or any other reaction that produces a gaseous substance. The gas is produced and contained in an expandable drive balloon when the acid-base reactants are combined with a liquid. As the gas is produced, the drive balloon expands to exert pressure on a separately-contained drug reservoir which, in turn, pushes drug(s) from the reservoir into the flow path where the drug is ultimately delivered to the patient in a controlled and predetermined manner.

Abstract: The invention is related to a dispense interface for a drug delivery device for delivering at least two drug agents, wherein the dispense interface is configured to be coupled to a cartridge holder of the drug delivery device, wherein the cartridge holder is configured to hold at least two cartridges, wherein the dispense interface comprises at least two inlet channels, each comprising a fluid inlet opening, wherein each fluid inlet opening is configured to receive fluid from a respective cartridge of the at least two cartridges when the dispense interface is axially coupled to the cartridge holder, an outlet channel comprising a fluid outlet opening, a valve structure configured to be selectively moved into any one of a plurality of positions, wherein in at least one position the valve structure selectively permits or prevents fluid flow from any of the at least two inlet channels to the outlet channel.

Abstract: Mixing syringes including a valve mechanism are configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for the mixing of one or more substances, and the resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject. The repetitive mixing of substances contained in a distal and proximal chamber is also provided, where the plunger rod is configured to releasably engage a locking mechanism to actuate the valve, and can axially displace the distal seal assembly while the fluid passage is open.

Abstract: A system for automatically connecting tubing to a medical fluid machine includes at least one fluid container including a tube having a cap on an end of the tube, a shuttle configured to receive the tube, a driving mechanism configured to translate the shuttle, a cap removal device configured to remove the cap from the end of the tube, and a control unit programmed to cause (i) the driving mechanism to translate the shuttle holding the tube in a first direction towards the cap removal device so that the cap removal device can engage the tube cap, (ii) the driving mechanism to translate in a second direction away from the cap removal device so that the cap removal device removes the cap from the end of the tube, and (iii) the driving mechanism to translate the shuttle in the first direction with the cap removed from the tube so that the tube can be mated with the medical fluid machine.

Abstract: A method of performing peritoneal dialysis includes: (i) locating a supply of fresh dialysis fluid above a patient's peritoneal cavity; (ii) locating a drain or a drain container below the patient's peritoneal cavity; (iii) connecting a supply line to the supply of fresh dialysis fluid and the patient's peritoneal cavity; (iv) connecting a drain line to the patient's peritoneal cavity and the drain or drain container; (v) pneumatically opening a supply line valve during a fill cycle; (vi) gravity filling the patient's peritoneal cavity with the supply line valve open during the fill cycle; (vii) pneumatically opening a drain line valve during a drain cycle; and (viii) draining the patient's peritoneal cavity with the drain line valve open during the drain cycle.

Abstract: Sequential delivery syringes including a valve mechanism are configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for the mixing of one or more substances, and the resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject. The sequential delivery of substances contained in a distal and proximal chamber is also provided, where a second substance from the distal chamber is delivered followed by the delivery of a first substance from the distal chamber after the first substance from the proximal chamber is transferred into the distal chamber involving the actuation of the valve mechanism.

Abstract: The device according to the invention includes a hollow body delimiting an inner passage. It further includes an assembly for maintaining the material in position in the inner passage. The maintaining assembly includes a radially compressible member delimiting, when idle, a through passage aperture of the material, and a radial compression member compressing the compressible member, radially movable relative to an axis of the passage aperture to outwardly compress the compressible member. It includes a member for actuating the or each compression member, radially movable relative to the body to cause the compression member to go from a radially retracted position, in which the section of the passage aperture is maximal, to a position radially deployed in the compressible member, in which the section of the passage aperture is minimal.

Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.

Abstract: A dynamic electroporation appliance comprises an oblong isolating applicator (1) with a rounded front part (4) and with two annular electrodes (3) arranged on its front surface at the sides of an intermediate opening (2). The intermediate opening it linked to at least one duct (9) associated with a central seat for a syringe (6) for dispensing pharmacological or aesthetic products or active ingredients. The electrodes (3) are energizable to produce a dynamic electroporation effect on the treated surface.