Patents Examined by Andrew S Rosenthal
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Patent number: 9198871Abstract: An enteric-coated oral dosage form comprising an acid labile active pharmaceutical ingredient where the composition is substantially free of monomeric phthalic acid esters and synthetic oils is described herein. Also provided are methods for making and using the enteric-coated oral dosage form. The disclosed pharmaceutical compositions comprise an enteric coating which includes at least one plasticizer, at least one film-forming agent and optionally at least one anti-sticking agent.Type: GrantFiled: August 15, 2006Date of Patent: December 1, 2015Assignee: Abbott Products GmbHInventors: George Shlieout, Claus-Juergen Koelln, Frithjof Sczesny, Jens Onken, Andreas Koerner
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Patent number: 9174378Abstract: The present invention describes a polyamide textile fiber comprising conjugated nanoparticles homogeneously dispersed in the fiber, selected from polyethylene glycol-conjugated platinum nanoparticles, hyaluronic acid-conjugated gold nanoparticles and mixtures thereof. The invention also describes how to obtain it as well as its use in a cosmetic skin treatment as a system for the release of said conjugated nanoparticles.Type: GrantFiled: July 28, 2011Date of Patent: November 3, 2015Assignee: NYLSTAR, S.A.Inventors: Alfonso Cirera Santasusana, Esteve Soy Fabra
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Patent number: 9161539Abstract: A plant disease control composition comprising a carboxamide compound represented by following formula (I), wherein R1 represents a hydrogen atom or a methyl group, and R2 represents a methyl group, a difluoromethyl group or a trifluoromethyl group, and fludioxonil is provided by this invention, and this composition has an excellent effect for controlling plant disease.Type: GrantFiled: April 25, 2011Date of Patent: October 20, 2015Assignee: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Yuichi Matsuzaki
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Patent number: 9161943Abstract: A sustained release composition comprising a polymer and manufacturing method thereof. The sustained release composition comprises a polymer, a bioactive agent, and a release rate determined agent, wherein the release rate determined agent is dispersed in the sustained release composition to control the release rate of the bioactive agent. The method comprises providing an oil phase comprising a bioactive agent, a polymer, and a release rate determined agent; providing an aqueous phase comprising a surfactant; mixing the oil phase with the aqueous phase to form the sustained release composition having a controlled release effect.Type: GrantFiled: December 31, 2007Date of Patent: October 20, 2015Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jui-Mei Lu, Chia-Wen Liu, Po Hong Lai, John Jianghann Lin, Chiao Pin Li, Sung En Chen, Yo Wen Lo, Ming-Thau Sheu, Min-Ying Lin
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Patent number: 9155719Abstract: The invention relates to a medicament, the active principle of which is a leucine and, for example, a N-ACETYL-DL-LEUCINE. It can be applied to the prevention and/or treatment of eye diseases or disorders and especially of hereditary dystrophies of the retina, glaucomatous neuropathy, glaucoma, macular degeneration, myopia, presbyopia, hypermetropia, astigmatism, all the ophtalmologic diseases or disorders inducing a decrease of visual function and/or age-related physiological vision decline.Type: GrantFiled: May 6, 2011Date of Patent: October 13, 2015Inventor: Raouf Rekik
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Patent number: 9149426Abstract: The present invention provides a novel nanoparticle drug delivery system generated from poly(ortho ester) polymers with sustained drug release capability and can be functionalized to allow for systemic delivery to various organ systems throughout the body. One important aspect of this invention is that the nanoparticle drug delivery system generated from poly(ortho ester) polymers encapsulate several types of drugs in poly(ortho ester) nanoparticles, including but not limited to lipophilic, hydrophilic small and large molecules and also hydrophilic and lipophilic dyes by adopting appropriate emulsion techniques. These poly(ortho ester) nanoparticles are biodegradable, biocompatible and controlled release drug delivery system with zero order kinetics, which can be used in various biomedical applications such as eye-related diseases, cancer, arthritis, etc.Type: GrantFiled: February 14, 2013Date of Patent: October 6, 2015Assignee: University of Tennessee Research FoundationInventors: Monica Jablonski, Mallika Palamoor
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Patent number: 9138493Abstract: The present invention provides novel radioiodinated fatty acids. Also provided are methods of preparation of said radioiodinated fatty acids from non-radioactive precursors, as well as radiopharmaceutical compositions comprising such radioiodinated fatty acids. The invention also provides in vivo imaging methods using the radioiodinated fatty acids.Type: GrantFiled: December 15, 2011Date of Patent: September 22, 2015Assignee: GE Healthcare LimitedInventors: Michelle E Avory, Harry John Wadsworth, Robert James Domett Nairne
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Patent number: 9138419Abstract: The problem of the present invention is to provide a patch preparation containing a drug (excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof), which is superior in both the skin permeability of a drug, and adhesiveness in the presence of water. A patch preparation containing a support and an adhesive layer on one surface of the support, wherein the adhesive layer contains a drug excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof, an acrylic polymer, lactic acid and magnesium aluminometasilicate.Type: GrantFiled: February 1, 2012Date of Patent: September 22, 2015Assignee: NITTO DENKO CORPORATIONInventors: Yasuaki Okada, Katsuhiro Okada, Masato Nishimura, Yuji Kawaharada
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Patent number: 9125973Abstract: A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.Type: GrantFiled: April 13, 2010Date of Patent: September 8, 2015Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Tuan Bui, Ton That Hai, Mark Nordhaus, Paul Sanders, Cong Jiang, David Lamb, Ozlem Yardimci
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Patent number: 9095543Abstract: A topical composition comprising at least one ?-cyanodiphenylacrylate and dimethicone silylate.Type: GrantFiled: April 28, 2010Date of Patent: August 4, 2015Assignee: ELC Management LLCInventors: Milanka Susak, Ismail Ahmed Syed, Linda Josephine Najdek, Mirela Cristina Ionita-Manzatu
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Patent number: 9095530Abstract: Described herein are films comprising a zinc-containing compound and a film-stabilizing ingredient, for use in oral and personal care compositions.Type: GrantFiled: December 7, 2010Date of Patent: August 4, 2015Assignee: Colgate-Palmolive CompanyInventors: Betty Won, Paloma Pimenta, Shira Pilch, James Masters, Mahmoud Hassan, Ben Gu
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Patent number: 9084730Abstract: The present invention relates to a solid pharmaceutical composition comprising a solid dispersion containing at least one active principle and a pharmaceutically acceptable polymer matrix, a characterized in that said pharmaceutically acceptable polymer matrix comprises a blend of (i) polydextrose, in the form of a continuous polydextrose phase, in order to promote the disintegration of the composition in an aqueous medium, and (ii) at least one polymer other than polydextrose, in the form of a continuous phase of this polymer, whereby the polydextrose is in a concentration of at least 20 wt % and the at least one polymer other than polydextrose is in a concentration of at least 20 wt % in relation to the total weight of said pharmaceutically acceptable polymer matrix.Type: GrantFiled: March 15, 2007Date of Patent: July 21, 2015Assignee: SANOFIInventors: Michel Bedos, Thierry Breul, Stephen Byard, Isabel Ribeiro Dos Santos
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Patent number: 9073884Abstract: The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.Type: GrantFiled: June 3, 2011Date of Patent: July 7, 2015Assignees: The Regents of the University of California, University of Rhode Island Research FoundationInventors: William Gerwick, Lena Gerwick, Hyuakjae Choi, Francisco Villa, Jennifer Smith, David C Rowley
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Patent number: 9066860Abstract: The present invention is an oil-in-water emulsified composition and a sunscreen cosmetic characteristically comprising the following (a)-(j): (a) Octocrylene (b) Bis ethylhexyloxyphenol methoxyphenyl triazine (c) Hexyl diethylaminohydroxybenzoylbenzoate (d) 4-tert-butyl-4?-methoxybenzoylmethane (e) Water soluble polymer (f) Water-swelling clay mineral (g) Oil component having IOB of 0.05 or more (h) Higher fatty acid (i) Surfactant (j) Water The object of the present invention is to provide a sunscreen cosmetic that manifests a superior ultraviolet absorption effect and is superior in terms of the emulsification stability and the sensation during use.Type: GrantFiled: September 29, 2009Date of Patent: June 30, 2015Assignee: SHISEIDO COMPANY, LTD.Inventors: Yuko Nagare, Yosuke Ikebe, Momo Yabu, Kazuhiro Yamaguchi
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Patent number: 9061352Abstract: The present invention is directed toward respirable dry particles for delivery of divalent metal cation salts and/or monovalent cation salts to the respiratory tract and methods for treating a subject having a respiratory disease and/or infection.Type: GrantFiled: August 26, 2011Date of Patent: June 23, 2015Assignee: Pulmatrix, Inc.Inventors: Michael M. Lipp, Jean C. Sung
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Patent number: 9056057Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.Type: GrantFiled: May 3, 2013Date of Patent: June 16, 2015Assignees: Kala Pharmaceuticals, Inc., The John Hopkins UniversityInventors: Alexey Popov, Elizabeth M. Enlow, James Bourassa, Colin R. Gardner, Hongming Chen, Laura M. Ensign, Samuel K. Lai, Tao Yu, Justin Hanes, Ming Yang
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Patent number: 9055757Abstract: Methods of making a high gel strength, water-dispersible, stabilizing colloidal microcrystalline cellulose composition are disclosed. This stabilizer composition is useful in many food and non-food applications.Type: GrantFiled: October 4, 2012Date of Patent: June 16, 2015Assignee: FMC CorporationInventors: Zheng Tan, Maurice Gerard Lynch, Thomas Ruszkay, Michael Sestrick
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Patent number: 9050307Abstract: Levothyroxine, also known as L-thyroxine, synthetic T4, or 3,5,3?,5?-tetraiodo-L-thyronine, CAS number 51-48-9, is a synthetic form of thyroxine, used as a hormone substitute for patients with thyroid conditions. The invention relates to a method for the preparation of an oral levothyroxine composition. The method according to the invention results in liquid levothyroxine formulations that have improved storage stability compared to known liquid levothyroxine formulations.Type: GrantFiled: March 10, 2011Date of Patent: June 9, 2015Assignee: EMP Pharma GmbHInventors: Yannis Psarrakis, Konstantinos I. Lioumis
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Patent number: 9044527Abstract: Methods have been developed for incorporation of a peracid compound into or on wound application matrices, such as bandages or dressings, and other matrices which will favorably impact wound healing and help eliminate microbial infection. The peracid compound comprises a base compound that is metabolically pertinent to wound healing, the oxidized form of the base compound (a peracid), and an appropriate oxidizer, such as hydrogen peroxide. In addition, other excipients with wound healing potential, such as esters of the base compound, may be added to the peracid compound. The combination peracid-wound application matrices can be used to disinfect and heal various wound types with designed time release of the peracid compound.Type: GrantFiled: August 14, 2013Date of Patent: June 2, 2015Assignee: CHD Bioscience, Inc.Inventors: Edwin D. Neas, Michael K. Handley, Kevin S. Marchitto, Stephen T. Flock
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Patent number: 9044416Abstract: A method of photoprotecting a keratinous substrate comprising applying a composition onto the keratinous substrate, the composition comprising at least one phenolic compound chosen environmental at least one ortho-diphenol, at least one phenolic compound having a carboxylic acid moiety, and mixtures thereof, —a compound chosen from at least one pelyarn!ne, at least one water solvable metal salt, and mixtures thereof; and a cosmetically acceptable carrier. The present disclosure also relates to photoprotective compositions for application onto hair and skin, the compositions comprising at least one phenolic compound chosen from at least one ortho-diphenol, at least one phenolic compound having a carboxylic acid moiety, and mixtures thereof; a compound chosen from at least one polyamine, at least one water soluble metal salt, and mixtures thereof; and a cosmetically acceptable carrier.Type: GrantFiled: June 7, 2011Date of Patent: June 2, 2015Assignee: L'OREALInventors: Nghi Van Nguyen, Sawa Hashimoto