Abstract: The invention provides pharmaceutical compositions and methods of treating immunological disorders. The invention also provides pharmaceutical compositions and methods of inducing eosinophil apoptosis, and methods for treating eosinophil-associated disorders comprising inducing eosinophil apoptosis in an individual in need thereof.
Type:
Grant
Filed:
May 12, 2006
Date of Patent:
August 26, 2008
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
James S. Malter, Stephane Esnault, Zhong-Jian Shen
Abstract: Linear and cyclic peptides are provided specific to one or melanocortin receptors, and which exhibit agonist, antagonist, or mixed agonist-antagonist activity.
Type:
Grant
Filed:
January 12, 2004
Date of Patent:
August 26, 2008
Assignee:
Palatin Technologies, Inc.
Inventors:
Shubh D. Sharma, Annette M. Shadiack, Wei Yang, Ramesh Rajpurohit
Abstract: The present invention is directed to the use of a class of peptide compounds for treating primary or/and secondary dyskinesias such as tardive dyskinesia.
Abstract: The invention relates to the use of a peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, said peptide comprising a B epitope of a poly-?2,8 sialic acid attached to NCAM, which is recognized by an anti-poly-?2,8 sialic acid (PSA) antibody, for the preparation of a medicament for modulating NCAM functions, to be administered for the prevention and/or the treatment of neurodegenerative diseases, brain and spine lesions, age-related learning and memory problems, and cancer.
Type:
Grant
Filed:
October 16, 2003
Date of Patent:
August 26, 2008
Assignees:
Centre National de la Recherche Scientifique, Universite de la Mediterranee AIX-Marseille, Schafer-N, Universitaetsklinikum Hamburg-Eppendorf
Abstract: Disclosed herein is a new method for the solid phase peptide synthesis (SPPS) of C-terminal peptide ? thioesters using Fmoc/t-Bu chemistry. This method is based on the use of an aryl hydrazine linker, which is totally stable to conditions required for Fmoc-SPPS. When the peptide synthesis has been completed, activation of the linker is achieved by mild oxidation. The oxidation step converts the acyl-hydrazine group into a highly reactive acyl-diazene intermediate which reacts with an ?-amino acid alkylthioester (H-AA-SR) to yield the corresponding peptide ?-thioester in good yield. A variety of peptide thioesters, cyclic peptides and a fully functional Src homology 3 (SH3) protein domain have been successfully prepared.
Type:
Grant
Filed:
June 18, 2004
Date of Patent:
August 19, 2008
Assignee:
Lawrence Livermore National Security, LLC
Inventors:
Julio A. Camarero, Alexander R. Mitchell, James J. De Yoreo
Abstract: Antagonistic peptides of prostaglandin E2 receptor subtype EP4 and their use in the treatment or prevention of medical conditions associated with oligouric nephropathy, bone resorption, abnormal intestinal crypt cell proliferation or patency of the ductus arteriosus and the like are provided herein. The antagonistic peptides of the present invention can include the following formula: X-A-RnYm wherein “X” is a hydrogen atom or an amine protecting group producing a carbamate or an amide when reacting with the amine; “A” is L-(4,4?)-biphenylalanine or D-(4,4?)-biphenylalanine; “R” is an amino acid selected from the group consisting of threonine, serine, tyrosine, glutamic acid, alanine, leucine and glycine; “Y” is lysine; “n” is an integer ranging from 5 to 7; and “m” is an integer ranging from 0 to 2.
Type:
Grant
Filed:
October 19, 2004
Date of Patent:
August 19, 2008
Assignee:
Theratechnologies, Inc.
Inventors:
Krishna G. Peri, Serge Moffett, Daniel Abran, Annie Bergeron
Abstract: The present invention relates to peptides of CaV2.2 and their use in the treatment of pain. The sequence of the peptides is derived from the C-terminus of CaV2.2. and is believed to inhibit the interaction of CaV2.2 with Mint1-PDZ1. The invention is related to use of this peptide to treat pain and to use of this peptide in binding reaction with int-PDZ to screen for small molecules that can inhibit pain.
Type:
Grant
Filed:
March 31, 2005
Date of Patent:
August 12, 2008
Assignee:
Board of Regents, The University of Texas System
Abstract: The present invention relates to novel human glucagon-like peptide-2 (GLP-2) peptides and human glucagon-like peptide-2 derivatives which have a protracted profile of action as well as polynucleotide constructs encoding such peptides, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.
Type:
Grant
Filed:
October 14, 2003
Date of Patent:
August 12, 2008
Assignee:
Novo Nordisk A/S
Inventors:
Lars Thim, Susanne Bang, Niels Christian Kaarsholm, Anette Sams Nielsen, Nils Langeland Johansen, Kjeld Madsen, Magali Zundel, Peter Thygesen, Birgitte Michelsen
Abstract: The present invention relates to a method for measuring a ceruloplasmin concentration, and more particularly, to a method for measuring a ceruloplasmin in a blood spot based on a standard concentration curve obtained through an enzyme-linked immunosorbent assay (ELISA) or a dissociation-enhanced time-resolved fluoroimmunoassay using a ceruloplasmin-specific polyclonal antibody or a ceruloplasmin-specific monoclonal antibody.
Type:
Grant
Filed:
September 7, 2004
Date of Patent:
August 5, 2008
Assignee:
Zenovac, Inc (KR)
Inventors:
Si Houn Hahn, Young-Ju Jang, Soo-Young Lee, Ha-Cheol Shin, Sun-Young Park, Eun-Sun Yu, Hee-Sung Han
Abstract: The present invention provides small molecules having high affinity to the ATP binding site of protein kinases, which are conjugated to apeptide or peptidomimetic moiety which mimics the substrate of PKB. The chimeric compounds according to the present invention preferably serve as PKB inhibitors with improved activity and selectivity. Novel ATP mimetic compounds, particularly isoquinoline derivatives, conjugated with peptides or peptidomimetics are useful as inhibitors of protein kinases for experimental, medical, and drug design purposes. Furthermore, pharmaceutical compositions comprising these protein kinase inhibitors, and methods of using such compositions for treatment and diagnosis of cancers, diabetes, cardiovascular pathologies, hemorrhagic shock, obesity, inflammatory diseases, diseases of the central nervous system, and autoimmune disease, are disclosed.
Abstract: The invention relates to novel peptidic conjugates containing a Gly-His-Lys sequence and used for dermatology or cosmetology for stimulating hair growth or stopping hair fall.
Type:
Grant
Filed:
July 16, 2004
Date of Patent:
July 29, 2008
Assignee:
Institut Europeen de Biologie Cellulaire
Abstract: A method is provided which allows high yields of acylated insulin. The method comprises expressing a singe-chain insulin precursor, preferably in yeast, cleaving the single-chain insulin precursor with a suitable protease which will open the peptide bond between the C-terminal amino group in the B-chain and a connecting peptide connecting the B chain with the A-chain, acylating the two-chain insulin intermediate in the ?-amino group in LysB29 and subjecting the acylated two-chain insulin intermediate to a proteolytic enzyme which will cleave of the N-terminal extension on the B- and A-chains on the precursor molecule.
Abstract: The invention provides a protocol leading to improved embryo implantation rates and/or decreased miscarriage rates in which hCG or LH, or a bio-analogue thereof, is administered during the follicular phase.
Abstract: The present invention is directed to a composition and method for treating uro-genital conditions. One embodiment disclosed is a pharmaceutical composition for use in the treatment of uro-genital conditions wherein said composition comprises a KPV dimer, a first preservative agent, a solvent, an alkalizer, an acrylic acid-based polymer, a second preservative agent and a gelatinizing agent. Another embodiment of the invention is disclosed wherein the composition comprises CKPV (SEQ ID NO: 5) dimer, API, Carbopol®, NF, propylparaben, NF; methylparaben, NF; propylene glycol, USP; edetic acid (EDTA), USP; 2 M sodium hydroxide solution (NaOH); and sterile water for injection, USP. Also disclosed are methods and indications for use of the disclosed composition.
Abstract: In the US about ? of college women show evidence of HPV infection. The clinical problem may be even larger in developing countries. There are currently no effective therapies for HPV infections, aside from therapeutic cone biopsies, which often are followed by recurrent, progressive lesions. Thus, pharmaceutical compositions and processes for treatment of an HPV infection are detailed. In particular, a pharmaceutical composition for inhibiting growth of a human papilloma virus-infected cell is provided which includes a peptide halomethyl ketone inhibitor of a chymotrypsin or chymotrypsin-like protease and a pharmaceutically acceptable carrier. A preferred inhibitor is AAPFcmk.
Type:
Grant
Filed:
March 9, 2005
Date of Patent:
July 22, 2008
Assignee:
Clawnor, Inc.
Inventors:
Gary Clawson, Craig Meyers, David Drubin, Molly McLaughlin-Drubin
Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
Type:
Grant
Filed:
May 18, 2005
Date of Patent:
July 15, 2008
Assignee:
Schering Corporation
Inventors:
Ashok Arasappan, F. George Njoroge, Viyyoor M. Girijavallabhan
Abstract: The present invention relates to pharmaceutical compositions containing fragments of alpha-1 proteinase inhibitor (API) or chimeric proteins of API and insulin-like growth factor for use in stimulating wound healing.
Abstract: It is intended to provide novel polypeptides which specifically inhibit the activity of a mechano-sensitive channel; and mechano-sensitive channel inhibitors or remedies for atrial fibrillation containing these polypeptides or salts thereof. The above objects can be achieved by using polypeptides having amino acid sequences represented by SEQ ID NO:1 (TVP003), SEQ ID NO:2 (TVP004) and SEQ ID NO:3 (TVP005), salts of these polypeptides, and mechano-sensitive channel inhibitors or remedies for atrial fibrillation containing the same.
Abstract: A cosmetic and/or dermatological and/or pharmaceutical composition includes, as the active ingredient, at least one peptide with sequence X1-Y-Phe-Thr-X2-Ala-Thr-Z-Ile-X3-Leu-X4-Phe-Leu-X5; wherein: X1, X2, X3, X4, X5=Arg, Lys, His; Y=Asp, Glu; Z=Asn, Gln. The invention also relates to the use of said composition in order to treat, inter alia, the signs of cutaneous ageing. Moreover, the invention relates to the cosmetic skin treatment method using the peptide.
Type:
Grant
Filed:
March 14, 2003
Date of Patent:
July 8, 2008
Assignee:
Societe d'Extraction des Principes Actifs S.A.
Abstract: A preferred way of converting insulin precursors into insulin compounds is to perform an enzymatic peptide cleavage in an aqueous medium and, thereafter, without removal of the intermediate product formed, to add an amino acid ester or a peptide ester and an organic solvent so that the desired coupling takes place.
Type:
Grant
Filed:
November 19, 2002
Date of Patent:
July 8, 2008
Assignee:
Novo Nordisk A/S
Inventors:
Are Bogsnes, Ingun Christensen, Per Balschmidt