Patents Examined by Anish Gupta
  • Method and carrier complexes for delivering molecules to cells
    Patent number: 7704954
    Abstract: The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
    Type: Grant
    Filed: May 3, 2004
    Date of Patent: April 27, 2010
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Hazel H. Szeto, Kesheng Zhao, Hugh D. Robertson, Alex V. Birk
  • Beta sheet tapes ribbons in tissue engineering
    Patent number: 7700721
    Abstract: There is described a material comprising ribbons, fibrils or fibres characterised in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a beta-sheet-tape-like substructure.
    Type: Grant
    Filed: July 15, 2003
    Date of Patent: April 20, 2010
    Assignee: University of Leeds
    Inventors: Neville Boden, Amalia Agelli, Eileen Ingham, Jennifer Kirkham
  • Method of treating chronic ulcers
    Patent number: 7700660
    Abstract: The invention provides a method of treating a chronic ulcer, such as a diabetic ulcer, comprising administering a therapeutic amount of a hydrogel matrix to the ulcer, the matrix composition comprising gelatin and a long chain carbohydrate. The matrix may further include polar amino acids, nitric oxide inhibitors and super oxide inhibitors. Injection is a preferred method of administration. The matrix may be injected into one or more locations within the ulcer, underneath the ulcer and/or around the periphery of the ulcer.
    Type: Grant
    Filed: May 30, 2001
    Date of Patent: April 20, 2010
    Assignee: Encelle, Inc.
    Inventor: Anton-Lewis Usala
  • Gonadotropin releasing hormone analogues conjugates with steroid hormones
    Patent number: 7700559
    Abstract: A compound comprising a gonadotrophin releasing hormone analogue conjugated to a hormone moiety, or a derivative thereof, which is able to bind to a plasma hormone binding protein. The compounds may be used to treat hormone-dependent disorders such as cancer, or as a contraceptive.
    Type: Grant
    Filed: April 5, 2004
    Date of Patent: April 20, 2010
    Assignee: Medical Research Council
    Inventor: Robert Peter Millar
  • DNA minor groove binding compounds
    Patent number: 7700765
    Abstract: There is provided an oligopeptide compound comprising: (a) at least one nitrogen-containing basic group attached to at least one end of the oligopeptide; and (b) two or more heterocyclic monomers, at least one of which is substituted in the heterocyclic part by a branched, cyclic or part cyclic C3-5 alkyl group, or a pharmaceutically acceptable salt or solvate thereof; which compound, salt or solvate binds to the minor groove of DNA.
    Type: Grant
    Filed: December 24, 2002
    Date of Patent: April 20, 2010
    Assignee: University of Strathclyde
    Inventors: Abedawn Khalaf, Roger Waigh, Colin Suckling
  • Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
    Patent number: 7696165
    Abstract: The present invention relates to methods of preventing or treating a mammal with a viral-induced disorder. The method involves administering to the mammal a therapeutically effective amount of a compound represented by Formula I, as shown below: or a pharmaceutically acceptable salt thereof, with X, R0, and R1 defined herein, under conditions effective to prevent or treat the viral-induced disorder.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: April 13, 2010
    Assignee: Albany Molecular Research, Inc.
    Inventor: Bruce F. Molino
  • Process and systems for recovery of peptides
    Patent number: 7696311
    Abstract: The invention provides methods of obtaining a peptide that include steps of synthesizing a peptide intermediate having one or more side chain protecting groups; providing a solvent to the peptide intermediate to form a peptide intermediate composition; and providing a precipitating agent in an amount sufficient to precipitate the peptide intermediate from the peptide intermediate composition, wherein the precipitating agent is an alcohol having three or more carbon atoms. Also provided are methods for precipitating peptides, methods for concentration peptides, and methods for filtering peptides.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: April 13, 2010
    Assignee: Roche Colorado Corporation
    Inventors: Yeun-Kwei Han, Hiralal N. Khatri, Robert J. Topping
  • Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
    Patent number: 7696166
    Abstract: The present invention relates to methods of preventing or treating a mammal with a viral-induced disorder. The method involves administering to the mammal a therapeutically effective amount of a compound represented by Formula I, as shown below: or a pharmaceutically acceptable salt thereof, with X, R0, R1, and R2 defined herein, under conditions effective to prevent or treat the viral-induced disorder.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: April 13, 2010
    Assignee: Albany Molecular Research, Inc.
    Inventor: Bruce F. Molino
  • Helical synthetic peptides that stimulate cellular cholesterol efflux
    Patent number: 7691965
    Abstract: The present invention provides peptides comprising at least one amphipathic alpha helix and having an cholesterol mediating activity and a ABCA stabilization activity. The invention further provides methods of using such peptides.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: April 6, 2010
    Assignee: The Regents of the University of California
    Inventors: John K. Bielicki, Pradeep Natarajan
  • Intracellular formation of peptide conjugates
    Patent number: 7691603
    Abstract: The invention includes methods and compositions for forming peptide conjugates intracellularly having a covalent linkage between a modifying group and a glycosylated or non-glycosylated peptide. The modifying group is conjugated to the peptide via a glycosyl linking group interposed between and covalently linked to both the peptide and the modifying group.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: April 6, 2010
    Assignee: Novo Nordisk A/S
    Inventor: Shawn DeFrees
  • Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue
    Patent number: 7687230
    Abstract: The invention relates to a method of treatment of collagenous connective tissue removed from a donor for implant into a recipient which is re-habited or re-colonized by host cells without an immune rejection and inflammatory reaction. After removal from the donor, the tissue is trimmed and thereafter soaked in a cold stabilizing solution having a temperature range of 4 to 10 degrees centigrade. The tissue is then soaked at a predetermined temperature in a polyglycol, salt, hydrogen peroxide, and phosphate buffer first solution of predetermined quantities and concentrations and of sufficient ionic strength to permit ground substances to dissociate such that the collagen fibers remain stable. The tissue is then soaked in an alcohol and water solution at a predetermined temperature for a sufficient period of time to remove the residue of the first solution.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: March 30, 2010
    Inventor: David T. Cheung
  • Antigen delivery vectors and constructs
    Patent number: 7687455
    Abstract: The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: March 30, 2010
    Assignee: Immune Targeting Systems Ltd.
    Inventors: Dominique Bonnet, Carlton B. Brown, Bertrand Georges, Philip J. Sizer
  • Cell permeabilization and stabilization reagent and method of use
    Patent number: 7678578
    Abstract: A cell permeabilization and stabilization reagent and method of use are disclosed. The reagent contains a N-acyl sarcosine or a salt thereof, a pH adjusting agent to adjust pH of the reagent in a range from about 4 to about 6; and an aqueous medium; the reagent having a low ionic strength defined by a conductivity of less than 9.0 mS/cm. The reagent further contains bovine serum albumin and glycerol. The reagent may further include an alkyl sulfate surfactant. Upon incubating the cells with the reagent, the reagent permeates the cellular membrane to allow penetration of an intracellular marker, causes intracellular protein aggregation within the cellular membrane, while preserves a cellular constituent for binding with a cellular marker for subsequent analysis by flow cytometry.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: March 16, 2010
    Assignee: Beckman Coulter, Inc.
    Inventors: Andreas Van Agthoven, Fabrice Malergue, Enrique Rabellino
  • Antimicrobial peptides and utilization of the same
    Patent number: 7674771
    Abstract: Antimicrobial peptide provided by present invention is an artificially designed antimicrobial peptide that does not occur naturally, and includes a sequence composed of at least 6 contiguous amino acid residues selected from an amino acid sequence constituting laminin binding site (LBS), or said sequence with one or a plurality of amino acid residue(s) conservatively replaced, and an amino acid sequence that can express antimicrobial activity against at least one kind of bacteria or fungi. It is desirable that the total number of amino acid residues is 100 or less.
    Type: Grant
    Filed: October 25, 2004
    Date of Patent: March 9, 2010
    Assignee: Toagosei Co., Ltd
    Inventors: Tetsuhiko Yoshida, Yoshinao Yamada, Masayoshi Kume, Hiroki Kourai
  • Formulations and methods for delivery of growth factor analogs
    Patent number: 7671012
    Abstract: Formulations, kits and methods for bone or cartilage repair, including treatment of osteogenic defects, including formulations of synthetic heparin-binding growth factor analogs, non-ionic polymers, gelling agents and calcium-containing agents.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: March 2, 2010
    Assignee: BioSurface Engineering Technologies, Inc.
    Inventors: Paul O. Zamora, Sarah Campion
  • Methods of treatment using specific binding agents of human angiopoietin-2
    Patent number: 7666832
    Abstract: Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: February 23, 2010
    Assignee: Amgen Inc.
    Inventors: Jonathan Daniel Oliner, Hosung Min
  • Methods of treatment using specific binding agents of human angiopoietin-2
    Patent number: 7666839
    Abstract: Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: February 23, 2010
    Assignee: Amgen Inc.
    Inventors: Jonathan Daniel Oliner, Hosung Min
  • Methods of treatment using specific binding agents of human angiopoietin-2
    Patent number: 7666831
    Abstract: Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: February 23, 2010
    Assignee: Amgen Inc.
    Inventors: Jonathan Daniel Oliner, Hosung Min
  • Transdermal delivery peptides and method of use thereof
    Patent number: 7659252
    Abstract: Transdermal delivery peptides for the treatment of skin diseases and/or facilitation or enhancement of transdermal delivery of pharmaceutically active agents are provided. Compositions comprising the transdermal delivery peptides and methods of therapeutic use, including the improvement of transdermal delivery of drugs or other pharmaceutically active agents, are also disclosed. Nucleic acids, expression vectors, and methods of their use, which encode the transdermal delivery peptides are disclosed. Methods are also provided for in vivo phage display for identifying further peptides with enhanced transdermal delivery capability.
    Type: Grant
    Filed: September 14, 2006
    Date of Patent: February 9, 2010
    Assignees: Novomed Technologies, Inc. (Shanghai), University of Science & Technology of China
    Inventors: Long-Ping Wen, Yongping Chen, Yuanyuan Shen, Xin Guo, Weiping Wang, Brian Zhang
  • Method of peptide synthesis of peptides containing a proline residue or hydroxyproline residue at or adjacent to the C-terminal end of the peptide
    Patent number: 7645858
    Abstract: A method for synthesizing a given peptide or its derivative which contains a proline residue or a proline derivative, at proximity to, or at, the C-terminal end of said peptide is provided. The method comprises a) synthesizing on a first resin a C-terminal portion of said peptide, or its derivative, comprising at least three successive amino acid residues or their derivatives, by successive coupling of selected amino acids, small peptides or their derivatives; b) cleaving the C-terminal portion from said first resin; c) reattaching said C-terminal portion to a second resin which is generally suitable for the synthesis of peptides but is unsuitable for the formation of peptides having a proline residue positioned at the C-terminal end of said peptide; and d) coupling selected amino acids, small peptides or derivatives to the C-terminal portion.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: January 12, 2010
    Assignee: Almac Sciences (Scotland) Limited
    Inventor: Andrew Smith Johnstone Stewart