Patents Examined by Ann Y. Lam
  • Patent number: 10761092
    Abstract: Provided is a multi-flux micro-fluidic chip including a chip body. The chip body includes a fluid inflow cavity communicated with an external air path, reaction-quantification cavities, waste liquid cavities, and a fluid path distribution cavity disposed at a middle position of the chip body. The two or more reaction-quantification cavities are distributed on two sides of the fluid path distribution cavity in rows to form the first and second row of reaction-quantification cavities respectively; and they are communicated with a fluid outlet of the fluid path distribution cavity through fluid path branches, and a fluid inlet of the fluid path distribution cavity through fluid path branches, and a fluid inlet of the fluid path distribution cavity is communicated with a fluid outlet of the fluid inflow cavity and an external fluid path, which making it possible to detect multiple items simultaneously and greatly improving the flux of the micro-fluidic chip.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: September 1, 2020
    Assignee: LANSION BIOTECHNOLOGY CO., LTD.
    Inventors: Xingshang Xu, Jeffery Chen, Long Wang, Weiyan Sun, Qilu Wan, Shen Yang
  • Patent number: 10751072
    Abstract: A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: August 25, 2020
    Assignee: VAXXAS PTY LIMITED
    Inventor: Mark Anthony Fernance Kendall
  • Patent number: 10725032
    Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: July 28, 2020
    Assignee: Quanterix Corporation
    Inventors: David C. Duffy, David M. Rissin, David R. Walt, David Fournier, Cheuk Kan
  • Patent number: 10718764
    Abstract: The present invention is directed to a luminescent immunoassay method for detecting an analyte in a liquid sample with high sensitivity. The invention provides a unique combination of (i) using a probe having a small sensing surface area for binding analyte molecules, (ii) using a high molecular weight branched polymer conjugated with multiple binding molecules and multiple luminescent labels, and (iii) cycling the probe having immunocomplex formed back to the reagent vessel and amplification vessel 1-10 times and repeating the reaction with the reagent and the amplification polymer, to improve the sensitivity of detection level. For each cycling, the luminescent signal is increased significantly over the noise. The present invention is also directed to an electrochemiluminescent detection system for measuring a chemiluminescent signal on a probe tip.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: July 21, 2020
    Assignee: Access Medical Systems, LTD.
    Inventors: Robert F. Zuk, Hong Tan
  • Patent number: 10697868
    Abstract: Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate. Each slide support element may support a microscope slide. Each microscope slide can be enclosed within an individual pressurizable reaction compartment. Pressures exceeding 1 atm or below 1 atm can be created and maintained in the reaction compartment prior to, during or after heating of the slide begins.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: June 30, 2020
    Inventor: Lee H. Angros
  • Patent number: 10670588
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: June 2, 2020
    Assignee: Theranos IP Company, LLC
    Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
  • Patent number: 10656079
    Abstract: Devices, systems and methods for detecting molecules in a solid state using UV lights in a dry condition are provided. Interaction between a plurality of molecules, a conformational change of a molecule, a size difference between a plurality of molecules and a presence of a molecule can be detected in a dry environment by measuring a light absorption in at least one of light transmission mode and light reflection mode. In a preferred embodiment, the measurement of a light absorption is performed at a wavelength of ultraviolet light between 260 nm and 285 nm.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: May 19, 2020
    Assignee: MICRO DETECT, INC.
    Inventor: Mehdi Alem
  • Patent number: 10648975
    Abstract: Provided is a single-channel chemiluminescent micro-fluidic chip, including a chip body with a quantification-reaction cavity and a waste liquid cavity. The quantification-reaction cavity is composed of a quantification-reaction pool on a lower portion and a reaction pool cover plate, the quantification-reaction pool is equally divided into three cavities by two partition plates, a labeled antibody is placed in the middle cavity, coated antibodies are placed in the others, a surface, facing the quantification-reaction pool, of the reaction pool cover plate is equally divided into two parts. In result, the coated antibodies and the labeled antibodies are physically separated to effectively avoid nonspecific binding. Due to a special structure of the reaction tank, wavy fluid flow is generated to fully mix the coated antibodies and the labeled antibodies, which improves testing efficiency and sensitivity.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: May 12, 2020
    Assignee: LANSION BIOTECHNOLOGY CO., LTD.
    Inventors: Xingshang Xu, Jeffery Chen, Long Wang, Weiyan Sun, Qilu Wan, Shen Yang
  • Patent number: 10634667
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: April 28, 2020
    Assignee: Theranos IP Company, LLC
    Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
  • Patent number: 10620192
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: April 14, 2020
    Assignee: Theranos IP Company, LLC
    Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
  • Patent number: 10620120
    Abstract: In one aspect, nanoplasmonic devices are described herein. In some embodiments, a nanoplasmonic device comprises a radiation transmissive substrate, a metal layer positioned on the substrate and at least one aperture extending through the metal layer to the radiation transmissive substrate, wherein width of the aperture decreases with increasing depth of the aperture.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: April 14, 2020
    Assignee: The University of North Carolina at Greensboro
    Inventor: Jianjun Wei
  • Patent number: 10613080
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: April 7, 2020
    Assignee: Theranos IP Company, LLC
    Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
  • Patent number: 10605804
    Abstract: Disclosed is an analysis method including: moving a complex, by means of a magnet unit, in a flow path of a specimen cartridge which includes the flow path and a detection vessel, the complex containing a test substance formed on magnetic particles and a labeled substance binding to the test substance; taking an image of the magnetic particles in the specimen cartridge; and measuring a label of the labeled substance contained in the complex in the detection vessel.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: March 31, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Kosuke Jitsuhara, Jianyin Lu
  • Patent number: 10598654
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: March 24, 2020
    Assignee: Theranos IP Company, LLC
    Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
  • Patent number: 10578613
    Abstract: Disclosed is a solid support suitable for improving the detection of how different species interact with each other. The solid support has multiple defined areas divided by low dividers, and optionally independent containers divided by high dividers, each container having at least two defined areas. The solid support is typically used in measurements where the total amount of liquid is temporarily reduced during measurement. The solid support extends the possibilities of the measurement system.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: March 3, 2020
    Assignee: RIDGEVIEW INSTRUMENTS AB
    Inventors: Karl Andersson, John Strandgard
  • Patent number: 10571465
    Abstract: Techniques for metal enhanced fluorescence include determining a calibration curve that relates concentration of a particular analyte to at least one of intensity or lifetime of fluorescent emissions at a plasmonic substrate in response to incident light, for a plurality of known concentrations of the particular analyte mixed with a reagent. The reagent comprises a detection molecule. A concentration of the particular analyte in a vicinity of a cell in a sample is determined directly from the calibration curve and measurements, in response to the incident light, of at least one of intensity or lifetime of fluorescent emissions at the plasmonic substrate in contact with the cell and reagent.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: February 25, 2020
    Assignee: The University of Maryland, Baltimore
    Inventors: Henryk Szmacinski, Joseph R. Lakowicz
  • Patent number: 10571464
    Abstract: The invention relates to methods, reagents and devices for detecting an analyte in a sample.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: February 25, 2020
    Assignee: Orgentec Diagnostika GmbH
    Inventors: Vinzenz Kirste, Wigbert Berg, Vukic Soskic
  • Patent number: 10551374
    Abstract: According to the invention there is provided a method of detecting an analyte including the steps of: i) providing a sample which contains the analyte and magnetic nanoparticles, in which the magnetic nanoparticles include a magnetic body portion which acts as a signalling vector and at least one receptor moiety attached to the body portion for binding to the analyte; ii) applying a magnetic field across at least a portion of the sample to orient the magnetic nanoparticles with respect to the applied magnetic field; iii) introducing electromagnetic radiation into the sample; iv) detecting a physical property which varies in dependence on the orientation of the magnetic nanoparticles with respect to the applied magnetic field, wherein the physical property is associated with the interaction of the electromagnetic radiation with the magnetic body portion which thereby acts as a signalling vector; and v) correlating the detected physical property with the presence of the analyte.
    Type: Grant
    Filed: September 3, 2012
    Date of Patent: February 4, 2020
    Assignee: COTTON MOUTON DIAGNOSTICS LIMITED
    Inventors: David Newman, Raphael Matelon
  • Patent number: 10539582
    Abstract: A substrate for sample analysis on which transfer of a liquid is to occur with rotational motion includes: a substrate having a rotation axis; a first chamber being located in the substrate and having a first space for retaining a liquid and magnetic particles; a second chamber being located in the substrate and having a second space for retaining the liquid to be discharged from the first chamber; a channel being located in the substrate and having a path connecting the first chamber and the second chamber; and a magnet being located in the substrate and near the first space in the substrate for capturing the magnetic particles in the first chamber.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: January 21, 2020
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Fusatoshi Okamoto, Masahiro Johno
  • Patent number: 10429306
    Abstract: A surface plasmon resonance fluorescence analysis device has a chip holder for holding an analysis chip, a light source for irradiating excitation light, an angle adjustment unit for adjusting the angle of incidence of the excitation light in relation to the interface of a prism and metal film of the analysis chip, an excitation light reflection filter, a first optical sensor for detecting the fluorescence emitted from the analysis chip and transmitted through the excitation light reflection filter, a second optical sensor for detecting the plasmon scattered light emitted from the analysis chip and reflected by the excitation light reflection filter, and a control unit for controlling the angle adjustment unit. The control unit determines an enhancement angle on the basis of the plasmon scattered light detection results of the second optical sensor.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: October 1, 2019
    Assignee: KONICA MINOLTA, INC.
    Inventors: Hideyuki Fujii, Tetsuya Noda, Koji Miyazaki