Patents Examined by Ann Y. Lam
  • Patent number: 11273454
    Abstract: There is provided system and a separation substrate device for use with an NLM separator in separating and/or detecting at least one target analyte in a sample, the substrate comprising a micromagnet array of a plurality of micromagnets, the micromagnet array comprising a first capture region, a second focusing region, and, a third detection region, the focusing region comprising a converging and/or diverging micromagnet array region. Also provided is a method for separating and detecting at least one target analyte in a sample.
    Type: Grant
    Filed: July 4, 2016
    Date of Patent: March 15, 2022
    Assignee: University College Dublin, National University of Ireland, Dublin
    Inventors: Devrim Kilinc, Peng Li, Gil Lee, Dhruv Ghandi, Stefano Rampini
  • Patent number: 11255809
    Abstract: The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of splitting a droplet is provided, the method including providing a droplet microactuator including a droplet including one or more beads and immobilizing at least one of the one or more beads. The method further includes conducting one or more droplet operations to divide the droplet to yield a set of droplets including a droplet including the one or more immobilized beads and a droplet substantially lacking the one or more immobilized beads.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: February 22, 2022
    Assignees: Advanced Liquid Logic, Inc., Duke University
    Inventors: Vamsee K. Pamula, Vijay Srinivasan, Michael G. Pollack, Richard B. Fair
  • Patent number: 11221331
    Abstract: In an embodiment, an immunochemistry analysing system includes a source of paramagnetic particles, a source of fluid, a cuvette configured to receive the paramagnetic particles and the fluid, a pipette configured to (i) translate so that at least a portion of the pipette is located within the cuvette and (ii) dispense at least one of the paramagnetic particles and the fluid into the cuvette so that the paramagnetic particles and the fluid can be mixed within the cuvette, a motor configured to move the pipette while located in the cuvette, and a control unit configured to vary a motor drive of the motor to cause the pipette to mix the fluid with the paramagnetic particles within the cuvette.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: January 11, 2022
    Assignee: Hycor Biomedical, LLC
    Inventors: Mark Van Cleve, Taylor Reid, Gerold Firl, Yohei Yamamuro, Nathaniel Hague
  • Patent number: 11219897
    Abstract: Provided are a chip for separating or aligning fine particles, a device for separating or aligning fine particles including two or more chips for separating or aligning fine particles, and a method for separating or aligning fine particles using the chip for separating or aligning fine particles or the device for separating or aligning fine particles. The chip for separating or aligning fine particles includes: (i) a passage part in which a space where a fluid including fine particles which are capable of flowing is integrally formed and which has an inclined groove formed on one surface thereof; (ii) an inlet part which is positioned on one end of the passage part and into which the fluid is introduced; and (iii) a fine particle discharge part which is positioned on one side surface of the passage part, wherein one or more inclined grooves are formed to be inclined at an angle greater than 0° and less than 90° with respect to a line which is perpendicular to both side surfaces of the passage part.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: January 11, 2022
    Assignee: CURIOSIS CO., LTD.
    Inventors: Seung Jeong Song, Ho Young Yun
  • Patent number: 11207086
    Abstract: A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: December 28, 2021
    Assignee: VAXXAS PTY LIMITED
    Inventor: Mark Anthony Fernance Kendall
  • Patent number: 11181482
    Abstract: A mobile phone-based system for ELISA (MELISA). The MELISA system can perform all steps of ELISA procedure and output hormone concentration values. The system includes a heater that keeps the temperature required for sample incubation, illumination system for sample image capturing, and a digital camera system. All components are enclosed in a dark box to create optimal light conditions for image capturing. After sample images are captured, they are digitally processed, and hormone concentration values are reported based on colorimetric data from the samples. The system can be used to complete all steps of the assay, including incubation and reading. It is lightweight, can be fabricated at low cost, is portable, and can transfer test results via mobile phone. MELISA can be calibrated for accurate measurements of progesterone and has demonstrated successful measurements with the calibrated system.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: November 23, 2021
    Assignee: University of South Florida
    Inventors: Anna Pyayt, Arsenii Zhdanov, Jordan Keefe, Luis Franco-Waite
  • Patent number: 11162946
    Abstract: Methods, devices, and systems for analyzing biological samples are provided. A biological sample may be analyzed for the presence of an analyte by an initial assay, and the performance of, or method of performance of, a subsequent assay may be contingent upon the results of the initial assay. For example, the following may be contingent on the results of a prior assay: whether or not a subsequent assay is performed; which subsequent assay is performed; the method of performing a subsequent assay; the order of performance of a sequence of subsequent assays; the steps, or order of steps, performed in a subsequent assay; the timing of the performance of a subsequent assay; the choice of a reagent used in a subsequent assay; the detection method used in a subsequent assay; and other particulars of assays may be contingent on the results of a prior assay.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: November 2, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Daniel Young, Elizabeth A. Holmes
  • Patent number: 11156542
    Abstract: A surface acoustic wave (SAW) performs a rapid, label-free detection of biological species. Biosensing and detection of multiple analytes multiplexed by an array of sensing lanes is configured to enable bio-amplification using engineered DNA encoded libraries as the probe through a phage display procedure to enhance specificity, capture statistics for the detection, screening and analyzing of the analyte in vitro. A biochemical formulation minimizes the limit of detection (LOD) at a threshold magnitude on the order of a femtomolar concentration. Additional enhancement of the apparatus is achieved by use of an analog front end to amplify biochemical events.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: October 26, 2021
    Assignee: Autonomous Medical Devices Inc.
    Inventors: Yehoshua Shachar, Roger Kornberg
  • Patent number: 11150460
    Abstract: Disclosed is a cell culture microscopy slide comprising an optically transparent generally flat supporting surface (20) including upper and lower opposed substrate surfaces (27,28). A peripheral frame (40) surrounds the substrate (20), the frame (40) having a lower frame surface (44) and an upper frame surface (42). The lower frame surface (44) and the lower substrate surface (28) are generally flush. The upper frame surface (42) lies above the upper substrate surface (27), to form a well (32), and the upper and lower frame surfaces (42,44) are continuously flat and generally parallel. The substrate is preferably glass having a thickness of 1.7 mm.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: October 19, 2021
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventors: Paul C. Goodwin, Jeremy R. Cooper, Steven A. Reese, Kathryn Buckanan, Jeffrey D. Bert, James T. Newberry
  • Patent number: 11149059
    Abstract: The present disclosure relates to a sensitive, multidimensional chromatography method for extraction, detection, and quantification of non-conjugated cytotoxic agents and associated linker molecules used in cysteine based antibody-drug-conjugate production.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: October 19, 2021
    Assignee: Waters Technologies Corporation
    Inventor: Robert Birdsall
  • Patent number: 11143647
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: October 12, 2021
    Assignee: Labrador Diagnostics, LLC
    Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
  • Patent number: 11137391
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: October 5, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
  • Patent number: 11130989
    Abstract: An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a polymer layer comprising brush molecules formed on the linking layer; and (d) optionally but preferably, a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) coupled to the brush molecules. The polymer layer is preferably formed by the process of surface-initiated polymerization (SIP) of monomeric units thereon. Preferably, each of the monomeric units comprises a monomer (for example, a vinyl monomer) core group having at least one protein-resistant head group coupled thereto, to thereby form the brush molecule on the surface portion. Methods of using the articles are also described.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: September 28, 2021
    Assignee: DUKE UNIVERSITY
    Inventor: Ashutosh Chilkoti
  • Patent number: 11131670
    Abstract: A device for determining presence or absence of infection due to an infectious agent is described. The device comprises a sample receiving zone configured to receive a liquid sample from a subject suspected of having an infection due to an infectious agent, the sample receiving zone positioned to distribute the sample along a first fluid flow path to a first label zone and along a second fluid flow path to a second label zone. Test lines in each fluid flow path capture a mobile detectable species as an indicator of presence or absence of the infectious agent. The device also comprises a reference line positioned in the one of the fluid flow paths. The bidirectional fluid flow paths emanate from a common sample zone and provide an efficient approach to detection and differentiate two species as indicators of the same infectious agent or as indicators of two different infectious agents.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: September 28, 2021
    Assignee: Quidel Corporation
    Inventors: Robert Reed, Irene Sinn, Robert Weiller, Jason McClure
  • Patent number: 11130994
    Abstract: The illustrated embodiments of the invention include an automated method of assaying a viral and antibody analyte in a sample in a portable, handheld microfluidic reader having a SAW detector with a minimal mass sensitivity limitation. The automated method includes the steps of automatically performing the assay with the SAW detector with enhanced sensitivity as in Optikus I, but also includes the steps of automatically disposing a second portion of the sample on a microarray, selectively automatically probing the second portion of the sample for antibodies corresponding to the at least one selected virus using the microarray, and automatically reading the microarray using a fluorescent camera to identify antibodies in the second portion of the sample.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: September 28, 2021
    Assignee: Autonomous Medical Devices Inc.
    Inventors: Josh Shachar, Philip Felgner, Marc Madou
  • Patent number: 11112404
    Abstract: Disclosed is a method for obtaining information of a test substance, the method including: forming a complex by causing a capture substance to bind to a test substance in a specimen; selectively collecting at least the complex from the specimen; immobilizing the complex collected from the specimen, onto a base plate; and obtaining information regarding a structure of the test substance from the complex immobilized on the base plate.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: September 7, 2021
    Assignee: SYSMEX CORPORATION
    Inventors: Kenji Akama, Toshihiro Watanabe, Masaya Okada, Kazuto Yamashita, Akshay Ganguly, Shigeki Iwanaga
  • Patent number: 11099178
    Abstract: The present invention relates to a device and a method for detecting substances which are present in biological or chemical samples, each substance producing an optically detectable signal upon reaction with a reagent. The device further comprises a sample carrier with at least two receptacles for receiving samples and is characterized in that at least part of the receptacle is equipped to receive at least 2 reagents each, and in that a camera for recording an image which shows at least one receptacle filled with at least two reagents for the detection of different substances, and an evaluation device for evaluating the samples which device is designed such as to evaluate each image by analyzing the signals in the image.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: August 24, 2021
    Inventor: Torsten Matthias
  • Patent number: 11099179
    Abstract: The present invention relates to a device and a method for detecting substances which are present in biological or chemical samples, each substance producing an optically detectable signal upon reaction with a reagent. The device further comprises a sample carrier with at least two receptacles for receiving samples and is characterized in that at least part of the receptacle is equipped to receive at least 2 reagents each, and in that a camera for recording an image which shows at least one receptacle filled with at least two reagents for the detection of different substances, and an evaluation device for evaluating the samples which device is designed such as to evaluate each image by analyzing the signals in the image.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: August 24, 2021
    Inventor: Torsten Matthias
  • Patent number: 11092593
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: August 17, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
  • Patent number: 11073470
    Abstract: Provided herein is a biosensor for conformation and secondary structure analysis, notably for the direct non-invasive qualitative secondary structure analysis of a single selected protein within a complex mixture, as e.g. a body fluid, by vibrational spectroscopic methods. For the analysis it is not required that the selected substance be isolated, concentrated, or pretreated by a special preparative procedure.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: July 27, 2021
    Assignee: Betasense GMBH
    Inventors: Klaus Gerwert, Jens Wiltfang, Julian Ollesch, Andreas Nabers, Jonas Schartner, Carsten Kötting