Abstract: Provided is a method for producing an antithrombotic coating material in which a high molecular weight polymer can be obtained by a solution polymerization using a radical polymerization initiator. The above-mentioned task is achieved by a method for producing an antithrombotic coating material, including steps of: preparing a methanol solution containing a monomer represented by formula (1): wherein in formula (1), R1, R2, and R3 are the same as those described in the specification, respectively; adding a radical polymerization initiator having a 10-hour half-life temperature of 60° C. or less to the methanol solution to prepare a polymerization reaction liquid; and polymerizing the monomer.
Abstract: A layer having individual elements made of an elastic material, with the length thereof exceeding the diameter thereof, which are secured on a carrier at a distance to one another, wherein the elements can be moved towards and away from one another, the elements can contact when moving towards one another, the outer surfaces of the elements provided with a surface modification, and the surface modification containing substances that can form reversible, non-covalent bonds. Also, a method for producing the layer, and the use of the layer.
Type:
Grant
Filed:
March 23, 2017
Date of Patent:
August 30, 2022
Assignee:
Universitaet Heidelberg
Inventors:
Michael Timmermann, Soeren Gutekunst, Christine Selhuber-Unkel, Eckhard Quandt
Abstract: The present invention provides for collagen and collagen like peptide based hydrogels, corneal implants, filler glue and uses thereof. The invention represents an advancement in the field of hydrogels, corneal implants, filler glue based on collagen and collagen like peptides. The invention discloses collagen and novel collagen like peptides crosslinked with DMTMM and their use in preparation of hydrogel, corneal implant and filler glue which are highly efficacious and robust as compared to existing corneal implants. Further, the invention relates to method of treating corneal defects and diseases.
Abstract: The invention discloses a composition comprising glycyrrhizin, hyaluronic acid or a salt or a derivative thereof, and a viscosizing agent. The composition therefore finds advantageous application in all those cosmetic and therapeutic indications in which glycyrrhizin is used, since the composition according to the invention significantly improves the bioavailability thereof.
Abstract: Core-shell microcapsules comprising a hydrophobic core surrounded by a shell comprising a thermosetting resin comprising moieties derived from polyisocyanates, substantially unprotonated chitosan and another amine different from chitosan, characterized in that the substantially unprotonated chitosan is delivered in the solid, powder form to the locus of the encapsulation reaction. The core-shell microcapsules are provided in the form of a slurry comprising 10 to 50 wt % of microcapsules, based on the total weight of the slurry, and the shell of the microcapsules comprises from 0.1 to 20 wt % of moieties derived from chitosan, based on the total weight of the shell.
Type:
Grant
Filed:
September 25, 2018
Date of Patent:
July 12, 2022
Assignee:
GIVAUDAN SA
Inventors:
Nelly Bulgarelli, Ian Michael Harrison, Emmanuel Aussant
Abstract: Provided is a bioink set for printing a construct that is able to carry cells, including a bioink which contains a biodegradable polyurethane and a biopolymer, and a divalent metal ion solution. The biopolymer is gelatin, agar, alginate salts, hyaluronic acid and salts thereof, chitosan, and any combination thereof. Also provided are a method of preparing a construct for carrying cells by three-dimensional printing with the bioink set, and a method of three-dimensional printing of cells by using an ink composition.
Abstract: Described herein is a novel two-component composition including acetylsalicylic acid (ASA) and which is particularly useful in providing an aqueous solution of ASA for immediate peroral administration such as to treat imminent myocardial infarction in a person in need thereof.
Abstract: The present invention provides for an oral dissolvable film that includes a rapidly dissolving binder, a film forming polymer, a moisture deterring polymer, and at least one of a first active ingredient and a second active ingredient. Also provided is a method of forming an oral dissolvable film and kits that include the oral dissolvable film. Also provided is a method of delivering one or more active ingredients to a subject that include orally administering the oral dissolvable film.
Abstract: The present invention relates to hydrogel beads having liquid crystalline structured phase. Process for preparing crystalline hydrogel beads is also an object of the invention. Perfuming compositions and consumer products comprising or consisting of said crystalline beads, in particular perfumed consumer products in the form of a personal care products or flavoured products, are also part of the invention.
Type:
Grant
Filed:
October 18, 2018
Date of Patent:
May 17, 2022
Assignee:
FIRMENICH SA
Inventors:
Vera Tchakalova, Laura Mesmin, Nathalie Thiebaut
Abstract: A unit-type polyion complex for use in delivering nucleic acid to a target site in a patient includes one or more molecules of a block copolymer having a poly(ethylene glycol) segment and a cationic poly(amino acid) segment and one or more molecules of a nucleic acid. A total quantity of positive charges derived from side chains of the cationic poly(amino acid) segment of the block copolymer in the unit-type polyion complex is not offset by a total quantity of negative charges derived from the nucleic acid. Furthermore, the nucleic acid has a strand length of 10-50 bases, the molecular weight of the poly(ethylene glycol) segment is 40×103 or more, and the block copolymer has a binding constant (Ka) for the nucleic acid of 3.0×105 or more.
Type:
Grant
Filed:
August 30, 2018
Date of Patent:
May 10, 2022
Assignees:
KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION, THE UNIVERSITY OF TOKYO
Abstract: Multifunctional compositions and methods are provided for therapeutic treatment of bacteria and cancers and for fluorescence diagnosis. Systems generate in situ reactive oxygen species such as singlet oxygen (1O2), hydroxyl radical (OH) and Juglone, and other chemotherapeutic agents. Methods provided selectively produce greater amounts of one reactive oxygen species over others. Variations are effective in aerobic, anaerobic or H2O2 rich environments and in presence of, or absence of, light. In H2O2 rich environment in absence of light, variations decompose H2O2 into O2 gas to remove excess H2O2 for elimination of hypoxic environment. Variations are formed of porphyrins, naphthalene derivatives, and metal ions, for illustration, free base tetrakis Ar substituted porphyrine core without metal or halide substitution but having hydroxyphenyl and alkyl pyridyl substituents at meso positions combined with dihydroxynaphthalene and +3 hydrated metal ions.
Abstract: Compositions and methods for reshaping keratin-rich substrates while forming adherent flexible films contain emulsified or soluble mixtures of silanols and hemiaminals or the reaction products of silanols and hemiaminals including silylated hemiaminals. A method for treating split-ends in hair is also described.
Type:
Grant
Filed:
March 9, 2020
Date of Patent:
May 3, 2022
Assignee:
GELEST, INC.
Inventors:
Barry C. Arkles, Jonathan D. Goff, Alison Ane Phillips, Kerry Campbell Demella
Abstract: The invention is directed to a seed coating composition containing a polymeric binder, a filler and a fibrous material. The seed coating composition can be formed by combining an aqueous composition pre-blend which contains a polymeric binder with a powder pre-blend which contains a filler and a fibrous material. The polymeric binder preferably contains polyvinylpyrrolidone, the filler preferably contains talc and the fibrous material preferably contains cellulose fibers.
Type:
Grant
Filed:
November 17, 2017
Date of Patent:
April 19, 2022
Assignee:
INCOTEC HOLDING B.V.
Inventors:
Tyler Alan Reece, Ryan Thomas Latham, Gerard Henry Denny
Abstract: Aspects of the present disclosure include compositions having a plurality of individual polymeric nanowires. Individual polymeric nanowires according to embodiments include a bioactive compound. Methods for preparing and methods for administering the subject compositions of individual polymeric nanowires to a subject are also described. Kits having one or more components for practicing the subject methods are also provided.
Type:
Grant
Filed:
October 4, 2017
Date of Patent:
March 22, 2022
Assignee:
The Regents of the University of California
Abstract: The invention relates to methods for producing a polymeric scaffold for use in tissue engineering applications or soft tissue surgery, as well as to the produced scaffolds and an associated kit. The method features a first fast drying step of applying a mechanical compression on a polymeric gel layer and a second slow drying step of the gel up to reach a polymer mass fraction of at least 60% w/w in the final scaffold. The method allows the production of scaffolds with high regeneration and healing properties of a grafted tissue via host cell invasion and colonization, and a good suturability. These goals are achieved through the formation within the scaffold of a non-uniform architecture creating softer and stiffer areas, which is maintained even upon re-swelling of the scaffold upon hydration of the final dried product.
Type:
Grant
Filed:
March 29, 2017
Date of Patent:
March 8, 2022
Assignee:
Regenosca SA
Inventors:
Peter Frey, Jeffrey A. Hubbell, Hans M. Larsson, Elif Vardar, Eva-Maria Balet, Ganesh Vythilingam, Kalitha Pinnagoda
Abstract: Crosslinked biodegradable block polyurethane copolymers prepared from a plurality of biodegradable polymers or oligomers linked together via urethane bonds and crosslinked via a citrate ester are disclosed. Such copolymers can include folic acid and fabricated into medical devices such as a nerve growth conduit and locally deliver folic acid to a site of injury such as a PNS injury site.
Type:
Grant
Filed:
November 29, 2016
Date of Patent:
March 8, 2022
Assignees:
Aleo BME, Inc., The Penn State Research Foundation
Abstract: The present invention relates to a composition for articular cavity injection comprising a nucleic acid and chitosan. More specifically, in the present invention, it was confirmed that the sol-gel transition occurred depending on the temperature in the composition for articular cavity injection prepared through the mixing of the nucleic acid and chitosan, the proteoglycan biosynthesis of the cartilage tissue was increased by the injection of the composition and the cartilage regeneration effect was exhibited, and the pain was alleviated and the walking speed and stride which are the joint motilities were improved. Therefore, development of a therapeutic agent for arthritis having an excellent therapeutic effect using the composition for articular cavity injection comprising the nucleic acid and chitosan of the present invention is expected.
Abstract: A biocompatible textile and methods for its use and fabrication are disclosed. The textile may be fabricated from electrospun fibers forming windings on a mandrel, in which the windings form openings having a mesh size between adjacent windings. The textile may also be fabricated by the addition of solvent-soluble particles incorporated into the textile while the windings are formed. Such particles may be removed by exposing the textile to a solvent, thereby dissolving them. Disclosed are also replacements for animal organs composed of material including at least one layer of an electrospun fiber textile having a mesh size. Such replacements for animal organs may include biocompatible textiles treated with a surface treatment process.
Abstract: The invention relates to the use of polyether modified short-chain siloxanes in agriculture in order to increase agronomic yield, a method for irrigation, and a kit containing at least one polyether modified short-chain siloxane, and an irrigation system.
Type:
Grant
Filed:
March 2, 2017
Date of Patent:
February 1, 2022
Assignee:
Evonik Operations GmbH
Inventors:
René Hänsel, Daniela Kruse, Ewald Sieverding, Carsten Riedl, Jordi Samso Ludwig
Abstract: Novel rapamycin analogs and uses thereof are disclosed herein. The rapamycin analogs of the present disclosure show increased mTORC1 specificity and lowered mTORC2 specificity relative to rapamycin.
Type:
Grant
Filed:
September 17, 2020
Date of Patent:
January 25, 2022
Assignee:
Aeovian Pharmaceuticals, Inc.
Inventors:
Stelios T. Tzannis, Ian J. Massey, Alexandre Froidbise, Guillaume Eppe