Patents Examined by Anton H. Sutto
  • Patent number: 4946863
    Abstract: The present invention relates to 3-aminomethyl derivatives of indane, dihydrobenzofurane, dihydrobenzothiophene, and indoline, acid addition salts thereof, isomers thereof, methods of preparation, pharmaceutical compositions and method of treating CNS-disorders such as schizophrenia, Parkinson's disease, depression, anxiety, migraine and senile dementia, or in the cure of cardiovascular diseases, by administering such a derivative.
    Type: Grant
    Filed: January 18, 1989
    Date of Patent: August 7, 1990
    Assignee: H. Lundbeck A/S
    Inventors: Klaus P. Boegesoe, Jens K. Perregaard
  • Patent number: 4943574
    Abstract: (1H-azol-1-ylmethyl)substituted benzotriazole derivatives, compositions containing the same, and methods of treating estrogen dependent disorders.
    Type: Grant
    Filed: September 28, 1989
    Date of Patent: July 24, 1990
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Alfons H. M. Raeymaekers, Eddy J. E. Freyne, Josephu L. H. Van Gelder, Marc G. Venet
  • Patent number: 4943671
    Abstract: Organic halogen compounds in which one or more halogen atoms are covalently bonded to the carbon are subjected to reductive dehalogenation by reaction with a hydrocarbon in the presence of carbon at elevated temperatures with formation of a hydrogen halide, by a process in which the dehalogenation is carried out in the presence of iron powder or an iron compound as a cocatalyst, at from 100.degree. to 450.degree. C.
    Type: Grant
    Filed: May 2, 1988
    Date of Patent: July 24, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Toni Dockner, Manfred Sauerwald, Herbert Krug, Matthias Irgang
  • Patent number: 4943638
    Abstract: Cyanine dyes, particularly indocyanine dyes, having at least 7 carbon atoms in the polymethine chain which may possess a fused cyclopentene or cyclohexene ring in the form of a tri-iodide salt exhibit a substantial reduction in the propensity to associate compared to dyes having the identical cation but different anion. The tri-iodide salts are particularly useful as sensitizers in organic photoconductor systems.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: July 24, 1990
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: David E. Brown, Louis M. Leichter
  • Patent number: 4943641
    Abstract: The 3-aminoazetidine, its salts, new intermediates of formula ##STR1## wherein X' represents hydrogen or a protecting group and both X" represent hydrogen or, together with the nitrogen atom, a phthalimido group, X' and both X" not being hydrogen at the same time; a process for the preparation of the 3-aminoazetidine, starting from a 1-protected 3-sulfonyloxyazetidine by reaction with the potassium phthalimide and transformation of the above mentioned intermediates.
    Type: Grant
    Filed: February 17, 1989
    Date of Patent: July 24, 1990
    Assignee: Sanofi
    Inventors: Dino Nisato, Marco Frigerio
  • Patent number: 4943576
    Abstract: Substituted quinoxalyl-imidazolidine-2,4-diones, processes for their preparation, their use as medicaments and pharmaceutical preparations 5-Quinoxalyl-imidazolidine-2,4-diones of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings given, and physiologically tolerated salts thereof and processes for their preparation are described. The compounds inhibit aldose reductase and can be used as medicaments.
    Type: Grant
    Filed: April 22, 1988
    Date of Patent: July 24, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heiner Glombik, Roland Utz, Hans-Jochen Lang, Karl Geisen, Friedrich E. Beyhl
  • Patent number: 4943310
    Abstract: The invention relates to new 4-benzoyl-3-hydroxy-5-oxo-3-cyclohexenecarboxylic acid derivatives of general formula I ##STR1## in which A, B, R.sup.1, R.sup.2, R.sup.2 and R.sup.3 have the meanings given in the description, and their use as plant growth regulants.
    Type: Grant
    Filed: December 16, 1988
    Date of Patent: July 24, 1990
    Assignee: Schering Aktiengesellschaft
    Inventors: Alfred Angermann, Helga Franke, Gerhard Johann
  • Patent number: 4942262
    Abstract: The invention provides a process for producing vitamin A or its carboxylic acid ester by treating inexpensive and readily available industrial starting materials with potassium hydroxide which is widely employed industrially and is inexpensive.
    Type: Grant
    Filed: June 20, 1989
    Date of Patent: July 17, 1990
    Assignee: Kuraray Company Ltd.
    Inventors: Toshiki Mori, Shigeaki Suzuki, Takashi Onishi
  • Patent number: 4942159
    Abstract: Novel cephem compounds of the general formula: ##STR1## wherein R.sup.1 is a lower alkyl group, and salts and esters thereof, showing excellent and balanced antibacterial activity against a broad spectrum of bacteria, especially by rectal administration, and their production and use as antimicrobial agents are described.
    Type: Grant
    Filed: August 24, 1988
    Date of Patent: July 17, 1990
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Shoji Kishimoto, Kiminori Tomimatsu, Akio Miyake
  • Patent number: 4942157
    Abstract: The present invention provides 1-Hydroxy-3-(N-methyl-N-propylamino)propane-1,1-diphosphonic acid of formula ##STR1## wherein R is hydrogen or C.sub.1 -C.sub.4 alkyl and the pharmacologically acceptable salts thereof.The present invention also provides processes for the preparation of a diphosphonic acid of formula I and pharmaceutical compositions containing it for the treatment of diseases of the calcium metabolism.
    Type: Grant
    Filed: July 9, 1987
    Date of Patent: July 17, 1990
    Assignee: Boehringer Mannheim GmbH
    Inventors: Rudi Gall, Elmar Bosies
  • Patent number: 4942264
    Abstract: This invention relates to a process for the preparation of insecticidally active compounds and to novel styrene derivatives useful as intermediates therein.
    Type: Grant
    Filed: February 12, 1988
    Date of Patent: July 17, 1990
    Assignee: Imperial Chemical Industries PLC
    Inventors: Michael J. Bushell, Ralph A. Raphael
  • Patent number: 4942253
    Abstract: Polyhydroxy-substituted benz, phenylacet and mandelamidines, amidates, amidoximes and hydroxyamidoximes--ribonucleotide reductase inhibitors, and free radical scavengers.
    Type: Grant
    Filed: September 15, 1986
    Date of Patent: July 17, 1990
    Inventors: Bartholomeus van't Riet, Howard L. Elford, Galen L. Wampler
  • Patent number: 4942041
    Abstract: The use of compositions containing bis- or oligo-bis-guanides, alcohols, hydrogen peroxide, carboxylic acids, and water, applied externally, provides for the effective control of eggs of the threadworm Enterobius vermicularis on the skin.
    Type: Grant
    Filed: December 20, 1988
    Date of Patent: July 17, 1990
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Walter Guhl, Klaus Bansemir
  • Patent number: 4940699
    Abstract: The present invention relates to an O,O-diethyl O-1-(N-methoxyimino)ethyl thiophosphonate and O,O-diethyl O-1-(N-methoxyimino)-propyl thiophosphate useful to control pests living in soil. Said compounds have an excellent activity in controlling pests living in soil such as southern corn rootworm, cupreous chafer etc.
    Type: Grant
    Filed: April 28, 1989
    Date of Patent: July 10, 1990
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Yoshikazu Itoh, Makoto Hatakoshi, Mitsuru Sasaki
  • Patent number: 4940716
    Abstract: Diuretic and saluretic tetrahydro-isoquinoline derivatives of the Formula (I) ##STR1## wherein R stands for hydrogen or chlorine,R.sup.1 and R.sup.2 are hydrogen, methoxy or ethoxy, andR.sup.3 and R.sup.4 are hydrogen or methyl,and a process for the preparation thereof as well as pharmaceutical compositions containing as active ingredients isoquinoline derivatives of the Formula (I). The compounds of Formula I are prepared by reacting a 2-amino-tetrahydro-isoquinoline derivative of the Formula (II) ##STR2## with a carboxylic acid derivative of the Formula (III) ##STR3## wherein x stands for chlorine, --OH, --OCH.sub.2 CN, --OCH.sub.3, --OC.sub.2 H.sub.5, --OCOOCH.sub.3 or --OCOOC.sub.2 H.sub.5R.sup.5 and R.sup.6 stand for hydrogen or together from CHN(CH.sub.3).sub.2 and in case of the Formula (Ia) ##STR4## splitting off the protective group in alkaline medium.
    Type: Grant
    Filed: December 29, 1988
    Date of Patent: July 10, 1990
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt
    Inventors: Endre Palosi, Dezso Korbonits, Erzsebet Molnar nee Bako, Ida Szyoboda nee Kanzel, Laszlo Harsing, Gyorgy Simon, Vera Gergely, Peter Kormoczi, Katalin Marmarosi nee Keliner, Sandor Virag
  • Patent number: 4940797
    Abstract: A process is described for the improved synthesis of the optically pure C.sub.10 -C.sub.18 fragment of the macrolide structure of the immunosuppressant FK-506. This compound is also useful as an intermediate for preparing FK-506 derivatives.
    Type: Grant
    Filed: March 23, 1989
    Date of Patent: July 10, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Todd K. Jones, Sander G. Mills, Richard Desmond
  • Patent number: 4940575
    Abstract: 4-Hydroxyisoxazole derivatives corresponding to the formula: ##STR1## wherein: R represents a linear or branched alkyl or hydroxyalkyl radical with 1 to 23 carbon atoms, a linear or branched alkenyl radical with 2 to 23 carbon atoms, a phenyl radical, or a benzyl radical, andR.sub.1 represents OR.sub.2, --NHR.sub.3, or --NH--NHR.sub.4,R.sub.2 represents a hydrogen atom or an alkyl radical with 1 to 24 carbon atoms,R.sub.3 represents a hydrogen atom, an alkyl radical with 1 to 20 carbon atoms, or a ##STR2## radical, where n is 2 to 3 and r' and r" are identical or different, representing a hydrogen atom or a lower alkyl radical or forming a heterocycle when taken together such as morpholine, piperidine, or piperazine,R.sub.4 represents a hydrogen atom or a benzyl radical,and the salts of the formula (I) compounds.These derivatives are applicable to therapeutic and cosmetic fields, in particular to counteract the harmful effects of the sun.
    Type: Grant
    Filed: June 26, 1989
    Date of Patent: July 10, 1990
    Assignee: Societe Anonyme dite:L'Oreal
    Inventors: Alexandre Zysman, Henri Sebag
  • Patent number: 4940802
    Abstract: A 4,4'-bis(phthalimido)diphenyl sulfone compound having the formula: ##STR1## wherein X is a halogen atom, k=0 to 4, l=0 to 4, m=0 to 4 and n=0 to 4, provided k+l+m+n>1.
    Type: Grant
    Filed: December 8, 1988
    Date of Patent: July 10, 1990
    Assignee: Tosoh Corporation
    Inventors: Takao Matsuba, Masashige Kubo, Takumi Kagawa, Kiyotaka Oyama, Koji Kawabata
  • Patent number: 4939284
    Abstract: Disclosed are tetraalkyl enthenylidenebisphosphonates and a method for their manufacture. These compounds are suitable for use as antimicrobial agents in combating a number of pathogenic microorganisms, such as bacteria, yeasts, viruses, fungi and protozoa, when used together with a pharmaceutically-acceptable carrier. Also disclosed is a method for treating infectious diseases by administering a safe and effective amount of these tetraalkyl ethenylidenebisphosphonates.
    Type: Grant
    Filed: January 24, 1989
    Date of Patent: July 3, 1990
    Assignee: The Procter & Gamble Company
    Inventor: Charles R. Degenhardt
  • Patent number: 4938794
    Abstract: A cinnoline derivative having the formula (I): ##STR1## in which X is --OH, --O.sup.- M.sup.+, --OR.sup.1 or ##STR2## wherein M.sup.+ is an alkali metal cation, an alkaline earth metal cation or ##STR3## in which R.sup.4, R.sup.5 and R.sup.6 are the same or different and each is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.4 alkenyl group, a C.sub.3 -C.sub.4 alkynyl group, a C.sub.3 -C.sub.8 cycloalkyl group, a benzyl group or a phenyl group; R.sup.1 is a C.sub.1 -C.sub.9 alkyl group, a C.sub.3 -C.sub.6 alkenyl group, a C.sub.3 -C.sub.4 alkynyl group, a C.sub.1 -C.sub.3 alkoxy(C.sub.1 -C.sub.4) alkyl group, a C.sub.1 -C.sub.3 haloalkyl group, a C.sub.3 -C.sub.8 cycloalkyl group, a benzyl group or a phenyl group; and R.sup.2 and R.sup.3 are the same or different and each is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.4 alkenyl group, a C.sub.3 -C.sub.4 alkynyl group, a C.sub.3 -C.sub.8 cycloalkyl group, a benzyl group in which at most two of hydrogen atoms at the .
    Type: Grant
    Filed: December 9, 1988
    Date of Patent: July 3, 1990
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Masato Mizutani, Masao Shiroshita, Masaharu Sakaki, Nobuaki Mito, Hiroki Okuda