Abstract: The present invention provides a process for preparing halogenated sulfones by reacting a halogenating agent with a salt of a hydroxysulfone. The halogenated sulfones are useful as an intermediate for vitamin A or its carboxylic acid esters employed as medicines or feed additives.
Abstract: The invention relates to new 4-benzoyl-3-hydroxy-5-oxo-3-cyclohexenecarboxylic acid derivatives of general formula I ##STR1## in which A, B, R.sup.1, R.sup.2, R.sup.2 and R.sup.3 have the meanings given in the description, and their use as plant growth regulants.
Type:
Grant
Filed:
December 16, 1988
Date of Patent:
July 24, 1990
Assignee:
Schering Aktiengesellschaft
Inventors:
Alfred Angermann, Helga Franke, Gerhard Johann
Abstract: Substituted quinoxalyl-imidazolidine-2,4-diones, processes for their preparation, their use as medicaments and pharmaceutical preparations 5-Quinoxalyl-imidazolidine-2,4-diones of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings given, and physiologically tolerated salts thereof and processes for their preparation are described. The compounds inhibit aldose reductase and can be used as medicaments.
Type:
Grant
Filed:
April 22, 1988
Date of Patent:
July 24, 1990
Assignee:
Hoechst Aktiengesellschaft
Inventors:
Heiner Glombik, Roland Utz, Hans-Jochen Lang, Karl Geisen, Friedrich E. Beyhl
Abstract: The 3-aminoazetidine, its salts, new intermediates of formula ##STR1## wherein X' represents hydrogen or a protecting group and both X" represent hydrogen or, together with the nitrogen atom, a phthalimido group, X' and both X" not being hydrogen at the same time; a process for the preparation of the 3-aminoazetidine, starting from a 1-protected 3-sulfonyloxyazetidine by reaction with the potassium phthalimide and transformation of the above mentioned intermediates.
Abstract: Cyanine dyes, particularly indocyanine dyes, having at least 7 carbon atoms in the polymethine chain which may possess a fused cyclopentene or cyclohexene ring in the form of a tri-iodide salt exhibit a substantial reduction in the propensity to associate compared to dyes having the identical cation but different anion. The tri-iodide salts are particularly useful as sensitizers in organic photoconductor systems.
Type:
Grant
Filed:
July 24, 1989
Date of Patent:
July 24, 1990
Assignee:
Minnesota Mining and Manufacturing Company
Abstract: (1H-azol-1-ylmethyl)substituted benzotriazole derivatives, compositions containing the same, and methods of treating estrogen dependent disorders.
Type:
Grant
Filed:
September 28, 1989
Date of Patent:
July 24, 1990
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Alfons H. M. Raeymaekers, Eddy J. E. Freyne, Josephu L. H. Van Gelder, Marc G. Venet
Abstract: Organic halogen compounds in which one or more halogen atoms are covalently bonded to the carbon are subjected to reductive dehalogenation by reaction with a hydrocarbon in the presence of carbon at elevated temperatures with formation of a hydrogen halide, by a process in which the dehalogenation is carried out in the presence of iron powder or an iron compound as a cocatalyst, at from 100.degree. to 450.degree. C.
Type:
Grant
Filed:
May 2, 1988
Date of Patent:
July 24, 1990
Assignee:
BASF Aktiengesellschaft
Inventors:
Toni Dockner, Manfred Sauerwald, Herbert Krug, Matthias Irgang
Abstract: The invention provides a process for producing vitamin A or its carboxylic acid ester by treating inexpensive and readily available industrial starting materials with potassium hydroxide which is widely employed industrially and is inexpensive.
Abstract: Novel cephem compounds of the general formula: ##STR1## wherein R.sup.1 is a lower alkyl group, and salts and esters thereof, showing excellent and balanced antibacterial activity against a broad spectrum of bacteria, especially by rectal administration, and their production and use as antimicrobial agents are described.
Abstract: This invention relates to a process for the preparation of insecticidally active compounds and to novel styrene derivatives useful as intermediates therein.
Abstract: The present invention provides 1-Hydroxy-3-(N-methyl-N-propylamino)propane-1,1-diphosphonic acid of formula ##STR1## wherein R is hydrogen or C.sub.1 -C.sub.4 alkyl and the pharmacologically acceptable salts thereof.The present invention also provides processes for the preparation of a diphosphonic acid of formula I and pharmaceutical compositions containing it for the treatment of diseases of the calcium metabolism.
Abstract: The use of compositions containing bis- or oligo-bis-guanides, alcohols, hydrogen peroxide, carboxylic acids, and water, applied externally, provides for the effective control of eggs of the threadworm Enterobius vermicularis on the skin.
Abstract: A 4,4'-bis(phthalimido)diphenyl sulfone compound having the formula: ##STR1## wherein X is a halogen atom, k=0 to 4, l=0 to 4, m=0 to 4 and n=0 to 4, provided k+l+m+n>1.
Abstract: Diuretic and saluretic tetrahydro-isoquinoline derivatives of the Formula (I) ##STR1## wherein R stands for hydrogen or chlorine,R.sup.1 and R.sup.2 are hydrogen, methoxy or ethoxy, andR.sup.3 and R.sup.4 are hydrogen or methyl,and a process for the preparation thereof as well as pharmaceutical compositions containing as active ingredients isoquinoline derivatives of the Formula (I). The compounds of Formula I are prepared by reacting a 2-amino-tetrahydro-isoquinoline derivative of the Formula (II) ##STR2## with a carboxylic acid derivative of the Formula (III) ##STR3## wherein x stands for chlorine, --OH, --OCH.sub.2 CN, --OCH.sub.3, --OC.sub.2 H.sub.5, --OCOOCH.sub.3 or --OCOOC.sub.2 H.sub.5R.sup.5 and R.sup.6 stand for hydrogen or together from CHN(CH.sub.3).sub.2 and in case of the Formula (Ia) ##STR4## splitting off the protective group in alkaline medium.
Type:
Grant
Filed:
December 29, 1988
Date of Patent:
July 10, 1990
Assignee:
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt
Inventors:
Endre Palosi, Dezso Korbonits, Erzsebet Molnar nee Bako, Ida Szyoboda nee Kanzel, Laszlo Harsing, Gyorgy Simon, Vera Gergely, Peter Kormoczi, Katalin Marmarosi nee Keliner, Sandor Virag
Abstract: A process is described for the improved synthesis of the optically pure C.sub.10 -C.sub.18 fragment of the macrolide structure of the immunosuppressant FK-506. This compound is also useful as an intermediate for preparing FK-506 derivatives.
Type:
Grant
Filed:
March 23, 1989
Date of Patent:
July 10, 1990
Assignee:
Merck & Co., Inc.
Inventors:
Todd K. Jones, Sander G. Mills, Richard Desmond
Abstract: The present invention relates to an O,O-diethyl O-1-(N-methoxyimino)ethyl thiophosphonate and O,O-diethyl O-1-(N-methoxyimino)-propyl thiophosphate useful to control pests living in soil. Said compounds have an excellent activity in controlling pests living in soil such as southern corn rootworm, cupreous chafer etc.
Abstract: 4-Hydroxyisoxazole derivatives corresponding to the formula: ##STR1## wherein: R represents a linear or branched alkyl or hydroxyalkyl radical with 1 to 23 carbon atoms, a linear or branched alkenyl radical with 2 to 23 carbon atoms, a phenyl radical, or a benzyl radical, andR.sub.1 represents OR.sub.2, --NHR.sub.3, or --NH--NHR.sub.4,R.sub.2 represents a hydrogen atom or an alkyl radical with 1 to 24 carbon atoms,R.sub.3 represents a hydrogen atom, an alkyl radical with 1 to 20 carbon atoms, or a ##STR2## radical, where n is 2 to 3 and r' and r" are identical or different, representing a hydrogen atom or a lower alkyl radical or forming a heterocycle when taken together such as morpholine, piperidine, or piperazine,R.sub.4 represents a hydrogen atom or a benzyl radical,and the salts of the formula (I) compounds.These derivatives are applicable to therapeutic and cosmetic fields, in particular to counteract the harmful effects of the sun.
Abstract: Disclosed are tetraalkyl enthenylidenebisphosphonates and a method for their manufacture. These compounds are suitable for use as antimicrobial agents in combating a number of pathogenic microorganisms, such as bacteria, yeasts, viruses, fungi and protozoa, when used together with a pharmaceutically-acceptable carrier. Also disclosed is a method for treating infectious diseases by administering a safe and effective amount of these tetraalkyl ethenylidenebisphosphonates.
Abstract: Novel 4-[(meth)acrylamidomethyl]-pyrazoles and -isoxazoles of the general formula ##STR1## where R is hydrogen or methyl, R.sup.1 is hydrogen, methyl or ethyl, R.sup.2 and R.sup.3 may be identical or different and are each alkyl of 1 to 6 carbon atoms or unsubstituted or substituted aryl of 6 to 20 carbon atoms, and X is oxygen or an NR.sup.4 group where R.sup.4 is hydrogen or a radical having the meanings of R.sup.2 or R.sup.3, a process for their preparation, and the use of these compounds in particular for polymerization and the preparation of homopolymers and copolymers, are described.
Type:
Grant
Filed:
June 2, 1989
Date of Patent:
July 3, 1990
Assignee:
BASF Aktiengesellschaft
Inventors:
Kaspar Bott, Bernhard Nick, Guenther Schulz