Abstract: The invention features formulations for the local delivery of therapeutically effective doses of curcumin to treat head and neck disorders and upper aerodigestive disorders. Also disclosed are use of the formulations for delivery of other phytochemicals, or the combination of phytochemicals for the treatment of said disorders. Furthermore, these formulations can be used to deliver the recommended daily allowance of vitamins and/or minerals to children or adults.
Type:
Grant
Filed:
June 3, 2020
Date of Patent:
February 8, 2022
Inventors:
Cherie Ann Nathan, James Douglas Boudreaux
Abstract: The present invention relates to mixtures comprising: i) at least one lipid and/or at least one oil; and ii) an alkyl ammonium EDTA salt; wherein the mixture has a water content in the range of 0 to 1.0 wt %. The invention further relates to mixtures which are pre-formulations, methods of treatment comprising administration of such pre-formulations, to pre-filled administration devices and kits containing the formulations, to the use of an alkylammonium EDTA salt to reduce the decomposition of the lipid components and/or any active agent contained within the pre-formulation, and to alkyl ammonium EDTA salts as described herein.
Type:
Grant
Filed:
September 26, 2017
Date of Patent:
February 8, 2022
Assignee:
CAMURUS AB
Inventors:
Justas Barauskas, Catalin Nistor, Markus Johnsson
Abstract: The present invention provides a nanocomposite hydrogel and a preparation method thereof, and relates to the field of nanocomposite materials. The nanocomposite hydrogel is prepared by mixing completely gelatinized short amylose with an aqueous gelatin solution having a mass concentration of 8%-14%, and then cooling. The present invention utilizes the nanoparticles formed by in-situ self-assembly of the short amylose in the aqueous gelatin solution as a reinforcing agent, and the nanoparticles are uniformly distributed in the hydrogel to form a stable crystallization system, such that the prepared nanocomposite hydrogel exhibits optimal mechanical properties in terms of viscoelasticity, hardness, compressive stress, etc. The preparation process of the present invention is green and environmentally friendly, simple and efficient, and can be widely applied to the fields of food, cosmetics and medicine.
Type:
Grant
Filed:
November 8, 2018
Date of Patent:
January 4, 2022
Assignee:
Qingdao Agricultural University
Inventors:
Qingjie Sun, Liu Xiong, Shengju Ge, Hao Lu, Man Li, Mei Zhao
Abstract: The disclosure relates to compositions for treating keratinous substrates, such as the hair, comprising at least one monoamine and at least one carboxylic acid, as well as systems and methods for treating keratinous substrates with the compositions.
Type:
Grant
Filed:
November 24, 2016
Date of Patent:
January 4, 2022
Assignee:
L'OREAL
Inventors:
Kimberly Christine Dreher, Gérard Provot, Dariusz Danielski, Fabien Pascal Boulineau, Caroline Rahmouna Françoise Goget, Anthony Potin, Allison Chin, Michael Degeorge, Mara Applebaum, Mary Abraam Soliman, Ashley Ann Figatner, Megan Pauker, Emmanuel Appiah-Amponsah
Abstract: The present invention relates to a method for solubilizing poorly water-soluble organic cosmetic agents, to the solubilisate and cosmetic preparations produced by this method and respective uses of the solubilisate in cosmetic preparations. A phosphatidylcholine-based solubilization method is disclosed.
Type:
Grant
Filed:
June 28, 2018
Date of Patent:
December 28, 2021
Assignee:
ATHENION AG
Inventors:
Ingo Saar, Wolfgang Brysch, Jörg von Wegerer
Abstract: A method of preparing a reconstitutable implantable bone putty includes combining a bone matrix derived from human bone and gelatin particulates derived from human tissue at a concentration of the bone matrix by dry weight of 20 to 60 percent to form the reconstitutable implantable bone putty. Preparing the gelatin particulates includes supplying a gelatin precursor of bone or soft tissue from a human, treating the gelatin precursor with phosphoric acid to generate a gelatin-acid mixture, neutralizing the gelatin-acid mixture with an alkali to a pH between 6 and 8 to allow a gelatin-rich solution and a waste solution to separate, removing residual salts from the gelatin-rich solution to obtain purified gelatin, drying the purified gelatin, and reducing the purified gelatin to particulates having a largest dimension less than 300 ?m. A method of preparing an implantable bone putty includes adding a reconstitution media to the reconstitutable implantable bone putty.
Type:
Grant
Filed:
July 9, 2019
Date of Patent:
December 28, 2021
Assignee:
Community Blood Center
Inventors:
Felicia C. T. Gooden, Robert D. Hoskins, Shawn A. Hunter
Abstract: The invention relates to an antimicrobial mixture containing 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and chlorphenesin, and also to a cosmetic composition containing such a mixture. Use in caring for, making up and cleansing keratin materials.
Abstract: The present invention relates to an asymmetric structure moisturizing mask pack comprising a polylactide. More specifically, the present invention relates to a porous membrane mask pack prepared from copolymers of polylactide and polyvinyl alcohol, wherein the skin contact surface of the mask pack is hydrophilic and the back surface thereof is hydrophobic.
Abstract: Provided is a gel-type oil-in-water emulsion composition containing components A to F, in which A: at least one liquid oil which is selected from the group consisting of a hydrocarbon oil, an aliphatic ester and a silicone oil and a content of which is equal to or greater than 15% by mass with respect to a total amount of the gel-type oil-in-water emulsion composition; B: at least one nonionic surfactant which is selected from the group consisting of a saturated fatty acid glyceryl and a saturated fatty acid polyglyceryl and which has a Hydrophilic-Lipophilic Balance of equal to or smaller than 7; C: a sucrose saturated fatty acid ester; D: an ionic surfactant which has a saturated fatty acid residue as a hydrophobic group and a glutamic acid residue as a hydrophilic group; E: at least one surfactant having an unsaturated fatty acid residue; and F: water.
Abstract: A composition is described that includes lipid microcapsules and at least one dispersed active principle. A method is also described for preparing the composition. Also described, is the use of the composition in the treatment of dermatological diseases.
Type:
Grant
Filed:
May 27, 2016
Date of Patent:
December 14, 2021
Assignee:
GALDERMA RESEARCH AND DEVELOPMENT
Inventors:
Carole Dubayle, Claire Mallard, Nicolas Atrux-Tallau
Abstract: An external patch that contains rupatadine as a second-generation antihistamine, has excellent plaster physical properties, good adhesion to applied skin, and good transdermal absorption of rupatadine as an active ingredient is provided. The external patch containing rupatadine uses an acrylic adhesive as an adhesive base. Specifically, the external patch containing rupatadine uses an acrylic adhesive as an adhesive base and further contains an organic acid having 2 to 7 carbon atoms as a solubilizer, a fatty acid ester as a softener, and/or a surfactant.
Type:
Grant
Filed:
April 18, 2018
Date of Patent:
November 23, 2021
Assignees:
TEIKOKU SEIYAKU CO., LTD., J.URIACH Y COMPANIA S.A.
Abstract: The present invention provides a patch comprising a backing layer and an adhesive agent layer, wherein the adhesive agent layer is non-aqueous, the adhesive agent layer contains nonylic acid vanillylamide, terpene-based resin, rosin-based resin, styrene-isoprene-styrene block copolymer, and liquid paraffin, a mass ratio of a content of the terpene-based resin to a content of the rosin-based resin ((content of the terpene-based resin)/(content of the rosin-based resin)) in the adhesive agent layer is 0.45 to 1.3, and a mass ratio of a content of the styrene-isoprene-styrene block copolymer to a content of the liquid paraffin ((content of the styrene-isoprene-styrene block copolymer)/(content of the liquid paraffin)) in the adhesive agent layer is 0.45 to 1.2.
Abstract: A composition and a method of washing urushiol off the surface of human skin. The composition includes a first solely C12 surfactant and a second solely C12 surfactant that are each in a non-buffered composition and the composition is free of each of the following: (1) any nonylphenol ethoxylate, (2) any pharmaceutically active drug or prodrug, or (3) any salt that affects the functional characteristics of either of the solely C12 surfactants.
Abstract: To provide a transparent solid composition having a high ultraviolet ray blocking effect, as well as superior moldability and stability. A transparent solid composition includes: (a) 12-hydroxystearic acid in an amount within a range from 1 to 15% by mass; (b) an oil having a refractive index within a range from 1.5 to 1.7; (c) an oil having a refractive index of 1.3 or greater and less than 1.5; and (d) one type or two or more types of an ultraviolet ray absorbing agent in an amount within a range from 5 to 50% by mass. The refractive index of the transparent solid composition is within a range from 1.47 to 1.55.
Abstract: The present invention relates to an aqueous cosmetic powder composition especially designed for styling hair comprising water, hydrophobic colloidal silica and a water soluble non-ionic polyol having at least three hydroxyl groups and is solid at ambient temperature.
Abstract: A dispersion process of adapalene gel preparation, including the following steps: pulverizing adapalene raw material to D50 not more than 10 ?m and D90 not more than 30 ?m by dry detection; adding methyl p-hydroxybenzoate, 1,2-propanediol, carbomer 980 and disodium edetate in water, heating and stirring consistently to obtain a matrix in a uniform jelly; adding poloxamer 188, propylene glycol and ethylene glycol phenyl ether in water, stirring and heating to prepare a mixed solution; adding adapalene in the mixed solution prepared, emulsifying at a high speed, then adding to the matrix for thorough stirring; and then adding a triethanolamine aqueous solution for homogenization and stirring. The preparation prepared has good emulsifying and dispersing effect of adapalene, can be expanded on a large scale, and the industrial promotion prospect is good.
Type:
Grant
Filed:
December 21, 2018
Date of Patent:
July 13, 2021
Assignee:
ZHAOKE (GUANGZHOU) OPHTHALMIC DRUG COMPANY LIMITED
Inventors:
Jing Liu, Gang Li, Xiaoyi Li, Xiangrong Dai, Lei Yin, Juan Ling
Abstract: Disclosed are novel active substance combinations comprising specific heterocyclic trifluorobutenyls and previously known fungicidal agents. Said active substance combinations have a very good synergistic fungicidal, nematicidal, insecticidal, and/or acaricidal effect.
Type:
Grant
Filed:
August 2, 2019
Date of Patent:
June 8, 2021
Assignee:
ADAMA MAKHTESHIM LTD.
Inventors:
Wolfram Andersch, Ulrike Wachendorff-Neumann, Anton Kraus
Abstract: Phase-inverted capsules of a prodrug of budesonide are provided for treatment of bowel diseases.
Type:
Grant
Filed:
October 3, 2019
Date of Patent:
May 25, 2021
Assignee:
UNIVERSITY OF NIZWA
Inventors:
Anil K. Philip, Betty Annie Samuel, Hamna Naseer Al Senani, Afaf Mohammed Weli, Ahmed-Sulaiman Fadhil Al Harrasi, Ahmed bin Khalfan Al Rawahi
Abstract: A method of treating a subject for smoking cessation including periodically administering to the subject a pharmaceutically effective amount of cefdinir to treat the subject. Cefdinir for use in treating a subject for smoking cessation. A pharmaceutical composition including a pharmaceutically effective amount of cefdinir for use in treating a subject for smoking cessation.