Abstract: Hyperhalogens, a new class of highly electronegative species, are now invented. A hyperhalogen is a superhalogen-containing composition in which the electron affinity (EA) of the hyperhalogen is even larger than that of the superhalogens they are composed of. Novel production methods are provided in which highly electronegative species are produced by surrounding a central metal atom by superhalogen moieties.
Abstract: The present invention relates to liquid oral pharmaceutical compositions of lanthanum and its pharmaceutically acceptable salts thereof. The present invention further relates to preparation of liquid oral pharmaceutical compositions of lanthanum and its salts and also provides use of such compositions in treating hyperphosphatemia in patients.
Type:
Grant
Filed:
January 17, 2012
Date of Patent:
August 2, 2016
Assignee:
PANACEA BIOTEC LIMITED
Inventors:
Rajesh Jain, Sarabjit Singh, Paramjit Singh, Pirthi Pal Singh
Abstract: A treatment system and method includes use of a chemical facilitator to provide a result-effective event against one or more negative therapeutic effects related to exposing to a light output a skin portion including a condition treatable in whole or in part with light. In one exemplary embodiment for skin treatment including tattoo removal, perfluorodecalin is used to inhibit or resolve whitening, for example to speed a laser therapy session.
Abstract: Effective treatments of dystonia and/or post-stroke spasticity for extended periods of time are provided. Through the administration of an effective amount of clonidine at or near a target site, one can relieve dystonia and/or post-stroke spasticity caused by diverse sources. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least five days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
Abstract: The invention provides method for sequestering or trapping L-lactate in or near a tumor cell comprising contacting an isolated polymer of D-lactic acid (PDLA) or an equivalent, derivative or analog thereof with the tumor cell so that the PDLA binds L-lactate in or near the cell and thereby sequestering or trapping L-lactate in or near the tumor cells.
Type:
Grant
Filed:
October 21, 2014
Date of Patent:
July 5, 2016
Assignee:
The United States of America as represented by the Department of Veterans Affairs
Abstract: A treatment system and method includes use of a chemical facilitator to provide a result-effective event against one or more negative therapeutic effects related to exposing to a light output a skin portion including a condition treatable in whole or in part with light. In one exemplary embodiment for skin treatment including tattoo removal, perfluorodecalin is used to inhibit or resolve whitening, for example to speed a laser therapy session.
Abstract: The present invention relates generally to nail polish formulations for application to natural or artificial finger- or toenails, where the nail polish formulation comprises grapefruit seed extract that imparts antifungal and other antimicrobial properties.
Abstract: The present invention relates to a stable fixed dose aqueous pharmaceutical composition (e.g., contained in a container) for nasal administration to a human, comprising mometasone or its salt, olopatadine or its salt. The composition may further include a hydrocolloid. The invention also relates to a process for preparing the pharmaceutical composition, and the use of the pharmaceutical composition in the treatment of rhinitis in a subject.
Abstract: It is an object of the present invention to provide a hair cosmetic achieving a hair-setting property without causing flaking and further having an excellent hair-rearranging property and non-stickiness. The hair cosmetic of the present invention includes the following components (A) to (D): (A) a (meth)acrylic silicone-based graft copolymer; (B) at least one film-forming polymer selected from nonionic, amphoteric, and cationic polymers; (C) a monohydric lower alcohol; and (D) at least one selected from polyalkylene glycols and sugar alcohols, wherein the component (A) and the component (B) preferably have a content ratio (A):(B) within a mass ratio range of 1:10 to 2:1; and the hair cosmetic preferably has a viscosity at 25° C. of 1000 mPa·s or less.
Abstract: A cleansing composition comprising at least 5% of a surfactant, at least about 25% water, a cyclodextrin complex comprising a perfume, wherein 80% of the plurality of perfume raw materials comprise a FDV of at least 0.69.
Type:
Grant
Filed:
October 28, 2014
Date of Patent:
June 14, 2016
Assignee:
The Procter & Gamble Company
Inventors:
Timothy Alan Scavone, Jianjun Justin Li, Marc Adam Flickinger, Jonathan Robert Cetti
Abstract: A submicron protein sphere and method to intravenously treat a patient requiring blood component transfusion. The submicron protein spheres have a size ranging from 1.0 micron to less than 0.1 micron and a molecular weight ranging from 780 billion Daltons to less than 0.8 billion Daltons. The protein spheres have no biologically active molecules added or bound to the protein spheres prior to administering to the patient. The protein used to construct the spheres can be human serum albumin from natural sources or recombinant DNA-derived serum albumin, or other proteins such as gelatin or synthetic polypeptides. However, the protein spheres can bind the various clotting factors including fibrinogen after the spheres have entered the blood stream, binding the necessary additional biologically active molecules supplied in vivo from the patient's own blood, and possibly in vitro.
Abstract: Provided are a cross-bridged tetraaza macrocyclic compound of a novel structure that can be used, for example, as a contrast agent for diagnostic imaging or a radiopharmaceutical and a method for preparing the same. The disclosed tetraaza macrocyclic compound is able to form a stable metal complex at a lower temperature and allows easy conjugation with a bioactive substance or a chemically active substance, when compared to the existing cross-bridged tetraaza macrocyclic compounds.
Type:
Grant
Filed:
March 12, 2015
Date of Patent:
May 31, 2016
Assignee:
Kyungpook National University Industry-Academic Cooperation Foundation
Abstract: The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.
Type:
Grant
Filed:
December 11, 2013
Date of Patent:
May 24, 2016
Assignee:
Novartis AG
Inventors:
John Dallas Pruitt, Lynn Cook Winterton
Abstract: The present invention relates to a solid composition containing ivabradine or a pharmaceutically acceptable salt thereof. Further, the invention relates to a method for the preparation of such a composition as well as a pharmaceutical product comprising such a composition.
Abstract: The present invention relates to the cosmetic use of at least one C4-C16 glycol with a hydrocarbon-chain and/or of a hydroxylated ester resulting from the esterification of polyol and/or of C4-C16 carboxylic acid(s), in a composition for caring for and/or making up the skin and/or the lips, as an agent for reinforcing the natural flesh tint of the skin and/or the lips and/or the natural volume of the lips.
Abstract: Methods of treating a subject for a cardiac arrhythmia are provided. Aspects of the methods include thoracoscopically producing a cardiac Cox maze III set of lesions in cardiac tissue of the subject in a manner sufficient to treat the subject for the cardiac arrhythmia.
Abstract: The disclosure provides compounds useful as insect repellents and compositions comprising such repellents. The disclosure further provides insect traps and method for identifying ligands and cognates for biological molecules.
Type:
Grant
Filed:
November 13, 2014
Date of Patent:
April 12, 2016
Assignee:
The Regents of the University of California
Abstract: The invention is directed to compositions and methods of their use as effective biocidal agents for water streams. The composition comprises a halogen source, halogen stabilizers containing a sulfur bearing species and ammonium salts/urea, and an alkali. The sulfur bearing species includes sulfamic acid or its salt equivalent. By having optimized mixing ratio of halogen to stabilizer and that of ammonium salts to sulfamic acid or sulfamate, a synergistic effect occurs which both increases the efficacy of the composition as a biocide and it avoids adverse impacts on other chemicals that are present in the water stream. Best of all the composition is easy to form and easy to introduce into a water stream of concern. Its introduction can be as simple as mixing two containers of reagent prior to introduction to the water process stream.
Type:
Grant
Filed:
November 4, 2011
Date of Patent:
February 23, 2016
Assignee:
NALCO COMPANY
Inventors:
Wen Li Tu, Laura E. Rice, Andrew J. Cooper, Elisa M. Luth, Yu-mei Lu, Jian Kun Shen
Abstract: The present invention encompasses biocompatible reactants, biocompatible product hydrogels, methods of use thereof, and methods of synthesis thereof using a novel crosslinking mechanism between a first reactant compound including an N-Hydroxysuccinimide (NHS) ester group and a second reactant compound including a N-terminal cysteine amine group. In certain embodiments, one or more of the reactant compounds may be a macromonomer.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
February 16, 2016
Assignee:
Northwestern University
Inventors:
Phillip B. Messersmith, Devin G. Barrett, Iossif A. Strehin