Patents Examined by Ba K. Trinh
  • Process for the oxidation of organic compounds in the presence of bis- and tris- (.mu.-oxo)-dimanganese complex salts as catalyst
    Patent number: 6008387
    Abstract: Disclosed and claimed are oxidation reactions involving, as a catalyst, a bis- and/or tris-(.mu.-oxo)-dimanganese complex salt of the formula I[LMn(.mu.-O).sub.a (.mu.-OAc).sub.b MnL].sup.x A.sub.y (I)Ac is a C.sub.2 -C.sub.8 -acyl group,a is 1, 2 or 3,b is 0 when a is 2 or 3 or b is 2 when a is 1,x indicates the number of positive charges and is 2 or 3,A is a singly or doubly negatively charged anion,y is the number of anions A required to balance the positive charges andL is a ligand, such as N,N-bis(2-pyridylmethyl)-N-methylamine or N,N,N',N'-tetrakis(2-pyridyl(methyl)-N-methylamine or N.sub.1 N.sub.1 N.sub.1, N.sup.1 -tetrakis(2-pyridylmethyl)-1,2-ethylenediamine.
    Type: Grant
    Filed: January 2, 1997
    Date of Patent: December 28, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ahmed Tafesh, Matthias Beller
  • (2R,3S,24S)-2,3-diacetoxy-22,23-epoxy -24-ethyl-.beta.-homo-7-oxa-5.alpha.-cholestan-6-one and a process for preparing the same
    Patent number: 6008380
    Abstract: The present invention relates to a novel compound namely (2R,3S,24S)-2,3-diacetoxy-22,23-epoxy-24-ethyl-.beta.-homo-7-oxa-5.alpha.- cholestan-6-one and a process for the preparation thereof. The said compound is represented by the structural formula ##STR1## The said compound is a crucial intermediate in the synthesis of honobrassinolide having molecular formula C.sub.29 H.sub.50 O.sub.6.
    Type: Grant
    Filed: March 30, 1998
    Date of Patent: December 28, 1999
    Assignee: Council of Scientific & Industrial Research
    Inventors: Braja Gopal Hazra, Padmakar Laxman Joshi, Tirunahari Pavan Kumar
  • Process for the purification of taxoids
    Patent number: 6008385
    Abstract: A method for purifying taxoids (Taxotere, 10-deacetylbaccatin III) by centrifugal partition chromatography.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: December 28, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Andre Durand, Alain Gerbaud, Rodolphe Margraff
  • Tricyclic and tetracyclic taxanes
    Patent number: 6005120
    Abstract: The synthesis of taxol and other tricyclic and tetracyclic taxanes.
    Type: Grant
    Filed: January 2, 1997
    Date of Patent: December 21, 1999
    Assignee: Florida State University
    Inventors: Robert A. Holton, Carmen Somoza, Hyeong Baik Kim, Mitsuru Shindo, Ronald J. Biediger, P. Douglas Boatman, Chase Smith, Feng Liang, Krishna Murthi
  • Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
    Patent number: 6005138
    Abstract: Taxane derivatives having a 3' butenyl substituted C13 side chain.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: December 21, 1999
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai, Hossain Nadizadeh
  • Triptolide derivatives useful in the treatment of autoimmune diseases
    Patent number: 6004999
    Abstract: The present invention relates to novel triptolide derivatives and a method of treating a patient suffering from an autoimmune disease comprising administering to a patient an effective amount of the novel triptolide derivatives.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: December 21, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Michel J. Jung, Mahinda Wickramaratne, Michael Hepperle
  • Epoxidation process
    Patent number: 6005123
    Abstract: The selectivity of an olefin epoxidation catalized by a noble metal-modified titanium or vanadium zeolite is greatly enhanced by the addition of a phosphorus, sulfur, selenium or arsenic compound to the reaction mixture. The epoxidation utilizes hydrogen and oxygen in addition to the olefin.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: December 21, 1999
    Assignee: Arco Chemical Technology, L.P.
    Inventors: Ralph M. Dessau, Andrew P. Kahn, Roger A. Grey
  • Method for preparing 4, 10-diacetoxy-2.alpha.-benzoyloxy-5.beta., 20-Epoxy-1, 7.beta.-dihydroxy-9-oxo-tax-11-en-13.alpha.-yl(2R,3S)-3-benzoylamino-2-h ydroxy-3-phenylpropionate trihydrate
    Patent number: 6002022
    Abstract: A process for the preparation of 4,10-diacetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1,7.beta.-dihydroxy-9- oxo-tax-11-en-13.alpha.-yl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropionate trihydrate by crystallization from a water/alcohol solution.
    Type: Grant
    Filed: July 24, 1997
    Date of Patent: December 14, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Rene Authelin, Eric Didier, Franck Leveiller, Isabelle Taillepied
  • Fluorinated vinyl oxiranes
    Patent number: 6002052
    Abstract: A compound having the formula: ##STR1## wherein: R is fluorine, hydrogen, an unsubstituted or substituted aliphatic or unsubstituted or substituted aromatic radical;R.sub.1 is an unsubstituted or substituted aliphatic radical, or unsubstituted or substituted aromatic radical; andR.sub.2 is hydrogen, an unsubstituted or substituted aliphatic radical, or unsubstituted or substituted aromatic radical.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: December 14, 1999
    Assignee: AlliedSignal Inc.
    Inventor: Michael Van Der Puy
  • Method for the purification of taxanes
    Patent number: 6002025
    Abstract: Taxanes are purified by chromatographic separation using a phenylalkyl chromatographic resin, wherein the alkyl portion of the phenylalkyl is a C.sub.4 -C.sub.10 moiety. Taxanes such as paclitaxel, 10-deacetyltaxol, 7-epi-taxol, cephalomannine, baccatin III, baccatin V, 7-epi-DAB, 10-deactylbaccatin III ("DAB") and 9-dihydro-13-acetylbaccatin III ("DHB") and others may be purified. In accordance with the invention, taxanes are separated from each other and from other impurities common to crude taxane samples.
    Type: Grant
    Filed: February 24, 1999
    Date of Patent: December 14, 1999
    Assignee: BCM Developement Inc.
    Inventors: Michel Page, Marie-Josee Perron
  • Process for the catalytic preparation of 3-isochromanones from phthalans
    Patent number: 6002020
    Abstract: Good yields and selectivities are achieved in a process for preparing an isochroman-3-one of the formula (I) ##STR1## by reacting a 1,3-dihydroisobenzofuran of the formula (II) ##STR2## with carbon monoxide at a CO pressure of from 0.1 to 20 MPa in the presence of an ionic halide, a palladium catalyst and a dipolar aprotic solvent.
    Type: Grant
    Filed: January 27, 1999
    Date of Patent: December 14, 1999
    Assignee: Clariant GmbH
    Inventors: Holger Geissler, Daniel Decker, Peter Gross
  • C10 tricyclic taxanes
    Patent number: 5998656
    Abstract: Taxane derivatives having alternative C10 substituents.
    Type: Grant
    Filed: December 4, 1997
    Date of Patent: December 7, 1999
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai
  • Process for producing a .beta.-lactone derivative
    Patent number: 5998635
    Abstract: The present invention provides a process for producing a .beta.-lactone derivative by reacting an aldehyde represented by formula (1):RCHO (1)wherein R represents a C1-C15 alkyl group which may be substituted by an aryl group, a C2-C15 alkenyl group, a 5-7-membered alicyclic group, or a phenyl group which may be substituted by a C1-C4 alkyl group; and ketene in the presence of a transition metal-phosphine complex. An industrially valuable .beta.-lactone can be efficiently produced at high yield.
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: December 7, 1999
    Assignee: Takasago International Corporation
    Inventors: Sotaro Miyano, Tetsutaro Hattori, Yutaka Suzuki, Shuichi Oi, Takashi Miura, Tsutomu Hashimoto
  • Substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives
    Patent number: 5994397
    Abstract: Substituted tetrahydrofuran analogs of prostagladins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: November 30, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Robert D. Selliah, Peter G. Klimko
  • C7 tricyclic taxanes
    Patent number: 5994576
    Abstract: Taxane derivatives having alternative C7 substituents.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: November 30, 1999
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai
  • Process for recovering high boiling solvents from a photolithographic waste stream comprising less than 10 percent by weight monomeric units
    Patent number: 5994597
    Abstract: A method of recovering solvents from an impure effluent stream of an industrial process. The effluent waste stream contains less than about 10 percent by weight of monomeric units that are reacted to form larger oligomers and polymers. The waste stream contains dissolved polymers, polymeric particles, and the hydrolysis, oxidation and/or other decomposition products of one of the solvents. In one embodiment, the first step involves filtering particulate matter from the waste stream. In another embodiment, the filtering step is omitted. The filtered or unfiltered waste stream is fed to a first separation stage for separation into (i) a gaseous stream of water, soluble gases, and volatile contaminants and (ii) a suspension comprising the solvent, water, semi-volatile and non-volatile contaminants, and photoresist products.
    Type: Grant
    Filed: November 6, 1998
    Date of Patent: November 30, 1999
    Assignee: International Business Machines Corporation
    Inventors: Anilkumar C. Bhatt, Jerome J. Wagner
  • Polyheterocyclic compounds
    Patent number: 5994394
    Abstract: The present invention relates to a group of polyheterocyclic compounds covered by the following formula: ##STR1## wherein each of X.sub.1, X.sub.2, X.sub.3, and X.sub.4, independently, is O, S, NH, or N(C.sub.1-6 alkyl), but one of them must be O, NH, or N(C.sub.1-6 alkyl); each of R.sub.1, R.sub.2, R.sub.5, and R.sub.6, independently, is H or a substituent (e.g., halogen, CN, NO.sub.2, or C.sub.1-4 haloalkyl), but at least one of them must be a substituent; each of R.sub.3 and R.sub.4, independently, is H, C.sub.1-6 alkyl, CHO, CH.sub.2 OH, or CH.sub.2 NH.sub.2 ; and each of m and n, independently, is 0 or 1.
    Type: Grant
    Filed: March 21, 1997
    Date of Patent: November 30, 1999
    Assignee: Industrial Technology Research Institute
    Inventors: Ching Te Chang, Yuh-Lin Yang
  • 3-oxiranyl benzoic acids and derivatives thereof
    Patent number: 5990326
    Abstract: The present invention relates to compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R is alkyl of 12 carbon atoms, alkenyl of 12 carbon atoms having from 1 to 4 --CH.dbd.CH-- groups when the carbon adjacent to R is saturated and from 1 to 2 --CH.dbd.CH-- groups when the carbon adjacent to R is unsaturated, aryl, heterocyclo, alkoxyalkyl wherein the alkyl groups have 1 to 6 carbon atoms, or aryloxyalkyl wherein the alkyl group has 1 to 6 carbon atoms R.sup.1 is hydrogen, lower alkyl, or a pharmaceutically acceptable cation. These compounds are inhibitors of leukotriene A.sub.4 (LTA.sub.4) hydrolase.
    Type: Grant
    Filed: November 16, 1992
    Date of Patent: November 23, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Stevan Wakefield Djuric, Thomas Dale Penning
  • Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
    Patent number: 5990325
    Abstract: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C9 substituent other than keto in which the C9 keto substituent of taxol, a taxol analog, baccatin III or 10-desacetyl baccatin III is selectively reduced to the corresponding hydroxy group.
    Type: Grant
    Filed: March 5, 1993
    Date of Patent: November 23, 1999
    Assignee: Florida State University
    Inventors: Robert A. Holton, Carmen Somoza, Yukio Suzuki, Mitsuru Shindo
  • Benzothiophene compounds, intermediates, compositions, and methods
    Patent number: 5986109
    Abstract: A compound of fomula XIV: ##STR1## wherein: R.sup.1a is --H or --OR.sup.7a in which R.sup.7a is a hydoxy protecting group;R.sup.2a is --H, halo, or OR.sup.8a in which R.sup.8a is a hydroxy protecting group; andR.sup.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: November 16, 1999
    Assignee: Eli Lilly and Company
    Inventors: Alan David Palkowitz, Kenneth Jeff Thrasher