Abstract: Compounds of the formula The compounds are useful in the treatment of bacterial infections.

Abstract: The present invention provides new methods isolating taxanes and other metabolites from taxane-producing plant materials.

Abstract: A new class of stable dioxetanes bears a polycyclic stabilizing group and aryloxy moiety, the oxygen atom of which is provided with a protective group which can be removed by an enzymatic or chemical trigger admixed with the dioxetane. The polycyclic stabilizing group is preferably spiroadamantane. The group further bears an alkoxy, aryloxy, aralkyloxy or cycloalkyloxy moiety which is partially or completely substituted with halogens, particularly fluorine and chlorine. Proper selection of electron active groups on the stabilizing moiety, the aryl group and the OR group yields enhanced enzyme kinetics, superior light intensity and excellent detection sensitivity in various assays.

Abstract: The present invention provides a compound of formula ##STR1## wherein R.sup.1a is --H or --OR.sup.7a in which R.sup.7a is a hydroxy protecting group;R.sup.2a is --H, halo, or --OR.sup.8a in which R.sup.8a is a hydroxy protecting group;R.sup.6 is --H or a hydroxy protecting group which can be selectively removed;R.sup.11 is non-existent or .dbd.O; andZ is --O-- or --S--;or a pharmaceutically acceptable salt thereof.

Abstract: The instant invention provides novel benzo[b]thiophene compounds, intermediates, compositions, pharmaceutical formulations, and methods of use.

Abstract: A compound of the formula I: ##STR1## wherein Ar represents an aryl radical;R.sub.1 represents a hydrogen atom, an aroyl radical, or a radical of the formula R.sub.4 --O--CO;R.sub.2 and R.sub.3 together form a 5- or 6-membered saturated heterocycle;G.sub.1 represents an acetyl radical or a protecting group of the hydroxyl functional group; andG.sub.2 represents a protecting group of the hydroxyl functional group.

Abstract: An integrated process is provided for the production of propylene oxide from propane wherein propane is dehydrogenated to propylene and hydrogen and the resulting propylene, propane, and hydrogen mixture together with added oxygen is reacted over a palladium on titanium silicilite catalyst to form propylene oxide, the molar ratio of oxygen to hydrogen in the reaction feed being at least about 2/1.

Abstract: The present invention relates to novel oxazolidinecarboxylic acids. These oxazolidinecarboxylic acids are useful intermediates for the esterification of taxane synthons to provide taxanes esterified with an isoserine residue.

Abstract: A chemical compound having the formula: wherein R is an alkyl group and M.sup.+ counterion is an alkali metal, and a process of making the same.

Abstract: 4-Cyano-4-deformylsordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops.

Abstract: A high yield and high purity method for obtaining taxane analogues from a source containing taxanes. The method employs a polymeric resin membrane for separating the analogues under low pressure without the use of complex and expensive separation/purification steps currently provided in the art.

Abstract: This invention provides oxazolidine protected taxol analogs of the Formula: ##STR1## which are useful intermediates to make various taxol analogues.

Abstract: The present invention is directed compositions of the formula: ##STR1## wherein: D is a residue of biologically active moiety;X is an electron withdrawing group;Y and Y' are independently O or S;(n) is zero (0) or a positive integer, preferably from 1 to about 12;wherein: R.sub.1 and R.sub.2 are independently selected from the group consisting of H, C.sub.1-6 alkyls, aryls, substituted aryls, aralkyls, heteroalkyls, substituted heteroalkyls and substituted C.sub.1-6 alkyls;wherein: R.sub.3 is a substantially non-antigenic polymer, C.sub.1-12 straight or branched alkyl or substituted allyl, C.sub.5-8 cycloalkyl or substituted cycloalkyl, carboxyalkyl, carboalkoxy alkyl, dialkylaminoalkyl, phenylalkyl, phenylaryl or ##STR2## wherein: R.sub.4 and R.sub.5 are independently selected from the group consisting of H, C.sub.1-6 alkyls, aryls, substituted aryls, aralkyls, heteroalkyls, substituted heteroalkyls, and substituted C.sub.1-6 alkyls or jointly form a cyclic C.sub.5 -C.sub.7 ring.

Abstract: A process and catalyst for the direct oxidation of an olefin having three or more carbon atoms, such as propylene, by oxygen to an olefin oxide, such as propylene oxide. The process involves contacting the olefin with oxygen under reaction conditions in the presence of hydrogen and a catalyst. The catalyst comprises gold on a support of titanium dispersed on silica. The titanium phase is disorganized and substantially free of crystalline titanium dioxide, as determined by analytical methods, such as, high resolution transmission electron microscopy and Raman spectroscopy. Selectivity to olefin oxide is high at good conversions of the olefin. The time between catalyst regenerations is long, and the catalyst is readily regenerated.

Abstract: The present invention relates to a novel process for preparing dialkoxy derivatives of the taxoid family by direct alkylation of the two positions 7 and 10 of deacetylbaccatin or derivatives thereof which are esterified in position 13.

Abstract: A process for the preparation of butyrolactones of the formula I ##STR1## where the substituents R.sup.1 and R.sup.2 are hydrogen, alkyl or hydroxyalkyl groups, or aryl and trialkylsilyl groups, if appropriate carrying inert: substituents, is described in which an alkyne of the formula IIR.sup.1 --C.tbd.C--R.sup.2 IIwhere the substituents have the meanings indicated above, is reacted under reducing conditions at elevated pressure and elevated temperature with carbon monoxide CO and hydrogen in the presence of a transition metal catalyst or with carbon monoxide and water in the presence of a transition metal catalyst.

Abstract: Novel taxoids of general formula (I), wherein R is a substituted alkyl radical or an alkenyl, alkynyl, cycloalkyl, optionally substituted cycloalkenyl or phenyl radical, or an aromatic 5- or 6-membered heterocyclic radical; and Z is a hydrogen atom or a radical of general formula (II), wherein R.sub.1 is an optionally substituted benzoyl, thenoyl or furoyl radical or a radical R.sub.2 --O--CO, where R.sub.2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl, or heterocycl radical, and R.sub.3 is an aromatic heterocyclic, alkyl, alkenyl, alkynyl cycloalkyl, phenyl or naphthyl radical. The novel products of general formula (I), wherein Z is a radical of general formula (II), have remarkable antitumoral activity.

Abstract: A process for dehydrogenating 1,4-butanediol to .gamma.-butyrolactone in the gas phase in the presence of a copper-containing catalyst, wherein the catalyst contains 4-40% by weight of copper and 0-5% by weight of Na.sub.2 O, based on the total weight of the catalyst, on a carrier consisting of 80-100% by weight of SiO.sub.2 and 0-20% by weight of CaO.

Abstract: The present invention provides new sources of taxanes and other metabolites from members of the order Coniferales that are not in the genus Taxus.

Abstract: The compounds of Formula I ##STR1## are useful as iumnunosuppressive agents.