Patents Examined by Bao-Thuy L. Nguyen
  • Patent number: 7998754
    Abstract: The invention concerns a diagnostic kit for simultaneous assay of antibiotics of different classes. The kit contains a single reaction mixture containing at least one first labelled receptor, specific of recognition of ?-lactams, a second labelled receptor, specifically and competitively identifying a tetracycline and a biotinylated nucleic acid fragment, an antisulfamide antibody and a labelled sulfamide analogue; and a recovery system in the form of a solid support comprising a nitrocellulose membrane whereon are fixed in three separate testing zones, respectively an antibiotic with ?-lactam nucleus, an avidin and an antibody capable of specifically identifying the antisulfamide antibody, so that the labelling intensity detected on the recovery system at the three testing zones results independently from a competitive recognition of each antibiotic by its labelled receptor.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: August 16, 2011
    Assignee: Unisensor S.A.
    Inventor: Benoit Granier
  • Patent number: 7998753
    Abstract: It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of the developing directions.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: August 16, 2011
    Assignee: Fujifilm Corporation
    Inventors: Hiroyuki Chiku, Junichi Katada, Hideyuki Karaki, Hiroki Terada
  • Patent number: 7993935
    Abstract: A test strip for immunochromatography comprising a sample receiving member, a label holding member, and a chromatography membrane is described. The chromatography membrane has a first detection zone and a second detection zone. The second detection zone is formed by utilizing a blocking material and the second substance. A method for producing above the test strip is also described.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: August 9, 2011
    Assignee: Sysmex Corporation
    Inventors: Haruki Yamaguchi, Takehiro Hasegawa, Takeshi Imoarai
  • Patent number: 7989217
    Abstract: The subject invention is an immunoassay for the semi-quantitative test kit for determination of human chrionic gonadtropin (hCG) in fluid sample (such as urine) as an aid in the diagnosis of a certain stage of pregnancy. The test device includes five strips having each having a dipping end or sample ends where sample can be applied. Results are indicated by coloration of two bands across a clear area of the strips, one band being coated with a reagent such as hCG antigens and the other with a reagent such as goat/rabbit polyclonal antibody gold conjugate. The combination of color indications on the bands provides the test results.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: August 2, 2011
    Assignee: AmeriTek USA, Inc.
    Inventors: Hsiao-Ching Yee, Kuo-Ching Yee, Hsian-Pei Yee
  • Patent number: 7989219
    Abstract: A capturing molecule having an association containing a plurality of polypeptide chains that specifically bind to different sites of a target substance, characterized in that each of the polypeptide chains has a domain having a hypervariable loop structure at a binding site binding to the target substance and an association portion for forming the association, and the polypeptide chains are associated via the association portions present in the polypeptide chains.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: August 2, 2011
    Assignee: Canon Kabushiki Kaisha
    Inventors: Hidenori Shiotsuka, Satoru Hatakeyama, Tsuyoshi Nomoto, Masaru Kaieda, Junta Yamamichi
  • Patent number: 7972872
    Abstract: This invention provides an immunochromatography detection apparatus exhibiting excellent convenience, sensitivity, and specificity, a detection method therefore, a kit using the same, and a method for producing such apparatus and kit, by constructing a solid-phase support, on which the conditions for the reaction wherein an analyte specifically binds to a labeled reagent containing a ligand that specifically binds to the analyte and those for the reaction wherein a capture reagent specifically binds to a complex of the analyte and the labeled reagent in the immunochromatography detection method are continuously optimized, and the pretreated specimens are optimized for such reactions.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: July 5, 2011
    Assignee: Denka Seiken Co., Ltd.
    Inventors: Ryo Shida, Hiromi Ito
  • Patent number: 7972837
    Abstract: Dipstick tests for detecting analyte are described. In a preferred embodiment, a multiple biotinylated antibody capable of binding analyte is bound to an anti-biotin antibody labeled with colloidal gold and wicked up the dipstick with test solution thought to contain analyte. Complex formed between analyte, biotinylated anti-analyte antibody, and colloidal gold labeled anti-biotin antibody is captured at a capture zone of the dipstick. Presence of colloidal gold label at the capture zone indicates the presence of analyte in the test solution. The sensitivity of analyte detection using such methods is an order of magnitude higher than for comparable methods in which biotinylated anti-analyte antibody bound to analyte is wicked up the dipstick in a first step, and a colloidal gold labeled anti-biotin antibody is wicked up the dipstick in a separate step. Kits for performing the tests of the invention are also described.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: July 5, 2011
    Assignee: Diagnostics for the Real World, Ltd.
    Inventors: Helen Lee, Ling Huang, Magda Anastassova Dineva, Hsiang Yun Hu
  • Patent number: 7968348
    Abstract: Provided is sampling and testing device for the detection of specific molds, allergens, viruses, bacteria, fungi, and other protein containing substances. Embodiments of the device include a sampling member slideably engaged with a base that contains a lateral flow strip adapted to detect specific analytes of interest. The sampling member defines a solvent reservoir that stores an elution solvent in a fluid-tight manner before the device is used to sample and test environmental surfaces. During slideable withdrawal of the sampling member from the base, the elution solvent stored in the reservoir is automatically released to a wick assembly of the sampling member. The wick assembly includes a wick adapted to receive, distribute, and retain the elution solvent. After a user samples an environmental surface for an analyte of interest with the elution solvent wetted wick, the sampling member is returned to the base where the wick contacts the lateral flow strip contained in the base.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: June 28, 2011
    Assignee: The Clorox Company
    Inventors: Brendi M. Cumberland, Maha El-Sayed, Alan J. Fujii, Scott D Manske, Elias A. Shaheen
  • Patent number: 7964370
    Abstract: An analytical strip and a detecting method using the analytical strip are provided. The analytical strip includes a substrate having a channel thereon. The channel has a first region, a second region and a third region, which are connected sequentially. A first antibody is localized in the first region. A saccharide and a peroxidase are localized in the first or second region. A second antibody for recognizing a different epitope of an identical antigen with the first antibody is immobilized in the second region. An optical substrate and a substrate reagent including a saccharide oxidase are localized in the third region.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: June 21, 2011
    Assignee: Actherm Inc
    Inventors: Yi-Jen Wu, Wen-Pin Hsieh, Chih-Wei Hsieh
  • Patent number: 7955791
    Abstract: A test strip and method for detecting an analyte present in a sample.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: June 7, 2011
    Assignee: Relia Diagnostic Systems
    Inventors: Robert K. Dinello, Alan J. Polito, Stella Quan
  • Patent number: 7955866
    Abstract: Labelled silica nanoparticles for immunochromatographic reagent, comprising silica nanoparticles containing a labelled substance.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: June 7, 2011
    Assignee: The Furukawa Electric Co., Ltd.
    Inventors: Hideki Aizawa, Michio Ohkubo
  • Patent number: 7943395
    Abstract: A flow-through assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes multiple detection zones, one of which is premised on “competitive” binding of the analyte and the other is premised on “sandwich” binding of the analyte. The present inventors believe that the combination of these zones may enable the detection of an analyte over extended concentration ranges.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: May 17, 2011
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Ning Wei, Rameshbabu Boga
  • Patent number: 7939342
    Abstract: A diagnostic test kit that employs a lateral flow assay device and a plurality of assay reagents for detecting a test analyte within a test sample is disclosed. The assay reagents include detection probes that are capable of producing a detection signal representing the presence or quantity of the test analyte in the test sample. To further enhance detection accuracy, calibration probes are also used that are capable of producing a calibration signal representing the presence or quantity of a calibration analyte. The calibration signal may be utilized to calibrate the detection signal.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: May 10, 2011
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Xuedong Song, Chibueze Obi Chidebelu-Eze, Rosann Marie Matthews Kaylor
  • Patent number: 7935541
    Abstract: An object of the present invention is to overcome the problem of nonspecific adsorption of a labeled antibody on the detection site and to provide an immunochromatography method by which the false positive signal can be suppressed, and wherein the detection sensitivity is high and the highly reliable measurement can be performed.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: May 3, 2011
    Assignee: Fujifilm Corporation
    Inventor: Hiroyuki Chiku
  • Patent number: 7935538
    Abstract: A lateral flow assay device for detecting the presence or quantity of an analyte in a test sample is provided. The device comprises a chromatographic medium that defines a detection zone, wherein a crosslinked network is non-diffusively immobilized within the detection zone. The crosslinked network contains a small molecule indicator that is configured to undergo a detectable color change in the presence of the analyte.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: May 3, 2011
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Xuedong Song, Curtis Sayre, Shawn R. Feaster, Julie Villanueva
  • Patent number: 7935497
    Abstract: A method of detecting a protease in a sample. The method comprises providing an analyte degradable by the protease. The analyte is contacted with the sample. The degradation products of the analyte or the residual undegraded analyte is detected in a binding assay.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: May 3, 2011
    Assignee: Mologic Ltd
    Inventors: Paul James Davis, Mark James Davis, Mark Burnapp
  • Patent number: 7932099
    Abstract: The present invention is directed to methods and apparatus for detection of one or more analytes. Analytes include agents or components of infectious agents such as pathogenic virus, as well as enzymes, proteins and biomarkers.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: April 26, 2011
    Assignee: Nexus DX, Inc.
    Inventors: Richard Laswell Egan, Graham Peter Lidgard, David Dickson Booker, Christopher Johann Johnson
  • Patent number: 7927865
    Abstract: Diagnostic in-vitro devices for use in the assaying of biological fluids are provided which include cover plates or backing strips which exhibit hydrophilic properties to assist in transport of the biological fluid or retention of same within the device. Exemplary diagnostic devices include lateral flow devices, microfluidic devices and microtiter plates. The devices may also be comprised of low fluorescent material in order to facilitate any diagnostic determination by use of fluorescent emissions. Hydrophilic properties may be imparted to the cover plates or backing strips by physical or chemical treatment thereof. The cover plates or backing strips may exhibit heat sealable or pressure sensitive properties.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: April 19, 2011
    Assignee: Adhesives Research, Inc.
    Inventors: William Meathrel, Herbert M. Hand, Sr., Li-Hung Su
  • Patent number: 7927828
    Abstract: Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an antibody that specifically binds to an antigenic site on venom present in the sample. Binding is then detected. The invention is illustrated by examples showing diagnosis of brown recluse spider bite, distinguishing it from other diagnoses with which it is often confused. This extremely sensitive test can detect venom antigens down to about 20 picograms even after the sample has been shipped and stored for periods of up to three weeks during the summer.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: April 19, 2011
    Assignee: Spidertech, a division of Stoecker & associates, LLC
    Inventors: William V. Stoecker, Hernan F. Gomez, Jonathan A. Green, David L. McGlasson
  • Patent number: 7919331
    Abstract: The invention describes immunochromatographic protocols in which one or more analytes, such as a bacteria or virus, can be assayed utilizing a “sandwich” complex.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: April 5, 2011
    Assignee: Silver Lake Research Corporation
    Inventor: Mark S. Geisberg