Patents Examined by Bao-Thuy L. Nguyen
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Patent number: 7915051Abstract: According to the biosensor and the blood component analytical method of the present invention, in a biosensor that is made of a single layer or plural layers of a porous material as shown in FIG. 1, having a reagent holding part and utilizing chromatography, a cell shrinkage reagent is carried on at least part of the reagent holding part, or at least part of a chromatographically developed part that is upstream of the reagent holding part. According to the biosensor having the above-mentioned structure and the blood component analytical method, even when whole blood is a sample, a high-accuracy blood component analysis cart be performed easily and quickly with less cost.Type: GrantFiled: December 5, 2007Date of Patent: March 29, 2011Assignee: Panasonic CorporationInventors: Mie Takahashi, Masataka Nadaoka, Hirotaka Tanaka, Fumihisa Kitawaki
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Patent number: 7910381Abstract: A chromatographic specific binding assay strip device, comprising: a non-permeable platform strip; a permeable membrane testing strip positioned on top of said non-permeable platform strip, with the testing strip comprising at least one capture reagent site containing a capture reagent for at least one specific analyte, a sample receiving pad positioned on top of and at a proximal end of the non-permeable platform strip, with the sample receiving pad having contact with a proximal end of said permeable membrane testing strip, a reservoir pad positioned on top of and at a distal end of said non-permeable membrane testing strip, with the reservoir pad having contact with a proximal end of said permeable membrane test strip; a supporting strip attached to and extending from the proximal end of said non-permeable platform strip; and a conjugate pad positioned on said supporting strip, said conjugate pad comprising a semi-permeable membrane containing a colorant conjugate.Type: GrantFiled: March 5, 2008Date of Patent: March 22, 2011Assignee: BioAssay WorksInventors: Glen Ford, Leslie Kirkegaard
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Patent number: 7901949Abstract: The present invention provides an assay kit for detecting an analyte of interest in a sample. The kit comprises a) a reporter species; b) a labelled species having first and second binding regions, wherein the first binding region is capable of binding to the analyte of interest and the second binding region is capable of binding to the reporter species; c) an immobilised species capable of binding to the first binding region of the labelled species; and d) immobilised capture reagent capable of binding to the reporter species. The arrangement is such that the sample is contacted with the labelled species, is then contacted with the immobilised species and is subsequently contacted with the immobilised capture reagent, the reporter species being added prior to exposure of the sample to the immobilised capture reagent. If no analyte is present in the sample, the labelled species becomes bound to the immobilised species and is therefore unable to bind to the immobilised capture reagent.Type: GrantFiled: June 12, 2006Date of Patent: March 8, 2011Assignee: Alere Switzerland GmbHInventor: Balbir Raj
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Patent number: 7897360Abstract: A lateral flow assay device for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The lateral flow assay device utilizes a molecular substrate to facilitate the detection of an enzyme or enzyme inhibitor via detection of the substrate and/or a product formed in an enzyme-catalyzed reaction of the substrate. In one embodiment, for example, upon contacting a molecular substrate, an enzyme catalyzes a reaction with the molecular substrate and forms a product. The lateral flow assay device also includes a detectable substance that may generate a detectable signal for determining the presence or amount of enzyme in a test sample. For example, the detectable substance may be directly or indirectly attached to a specific binding member that has affinity for the product. Following the enzyme catalyzed reaction, the product may bind the detectable substance which may, in turn, generate the detectable signal.Type: GrantFiled: December 15, 2006Date of Patent: March 1, 2011Assignee: Kimberly-Clark Worldwide, Inc.Inventor: Xuedong Song
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Patent number: 7892757Abstract: An immunochemical method for the accurate measurement of the quantity of cytochrome c in a body fluid, in particular, blood, and a kit for the measurement. The quantity of cytochrome c can be measured accurately without being affected by any interfering substrate by reacting an antibody with cytochrome c in a buffer solution in an acidic range.Type: GrantFiled: April 17, 2006Date of Patent: February 22, 2011Assignee: Eisai R&D Management Co., Ltd.Inventor: Muneo Aoyama
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Patent number: 7888057Abstract: A method of immunologically analyzing plasmin-digested products of stabilized fibrin, characterized by using a combination of a monoclonal antibody (a) which does not react with stabilized fibrin, fibrinogen, and plasmin-digested products of fibrinogen, but reacts with a neoantigen which is newly exposed in a D domain by digesting stabilized fibrin with plasmin, and a monoclonal antibody (b) which recognizes a site different from that recognized by the monoclonal antibody (a), and specifically reacts with plasmin-digested products of stabilized fibrin, wherein one of the monoclonal antibodies (a) and (b) is carried on a magnetic particle, and the other is labeled with an enzyme, and a chemiluminescent substrate is used as a substrate for the enzyme, is disclosed.Type: GrantFiled: April 27, 2006Date of Patent: February 15, 2011Assignee: Mitsubishi Chemical Medience CorporationInventor: Takeshi Matsuya
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Patent number: 7888002Abstract: It is an object of the present invention to provide a method for simply mixing two or more types of liquids in a porous carrier.Type: GrantFiled: September 29, 2008Date of Patent: February 15, 2011Assignee: Fujifilm CorporationInventors: Junichi Katada, Akira Wakabayashi
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Patent number: 7888040Abstract: The present invention provides immunoassays which are highly specific for detection in biological samples of methamphetamine and other drugs of abuse of the methamphetamine group such as ecstasy and other ecstasy class drugs. More particularly, competitive assays are provided comprising: (a) contacting said sample with (i) a pseudoephedrine/carrier conjugate in which pseudoephedrine is linked via its hydroxyl group to the carrier and (ii) an antibody which is capable of binding both one or more drugs of the methamphetamine group and said conjugate; and (b) determining whether the binding of said antibody to said conjugate is reduced by the presence of said sample, a reduction in binding being indicative that the sample contains a methamphetamine group drug.Type: GrantFiled: June 10, 2005Date of Patent: February 15, 2011Assignee: Concateno UK LimitedInventor: Ahmed Mohammed Taki Jehanli
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Patent number: 7879597Abstract: The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the first flow path for a sample, and a test site with immobilized antigens or antibodies or other ligand binding molecules such as aptamers, nucleic acids, etc. located at the junction of the first and second sorbent materials for identifying one or more ligands. The first and second sorbent strips touch each other at the test site location. The test cell may be used to test for pregnancy, HIV (including different HIV antigens or peptides), tuberculosis, prion, urin-analysis/drug, cardiac markers, cancer markers, Chagas, Chlamydia, dental bacteria (SM/LC), influenza A, influenza B, adenovirus, rotavirus, strep A, other bacteria or viruses, etc., and veterinary applications such as CPV, FIV, FeLV, heartworm, etc., although it is not limited to those applications.Type: GrantFiled: March 10, 2006Date of Patent: February 1, 2011Assignee: Chembio Diagnostic Systems, Inc.Inventor: Javanbakhsh Esfandiari
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Patent number: 7879624Abstract: Disclosed is an assay device for determining the presence and/or extent of one or more analytes in liquid sample containing a) first and second assays each comprising a flow-path having a detection zone for immobilising a labelled binding reagent, wherein detection of a labelled binding reagent at one or both detection zones is indicative of the presence and/or extent of one or more analytes; b) a shared reference zone; c) one or more light sources to illuminate the detection zones and the reference zone; d) one or more photodetectors to detect light from the detection zones and the reference zone, which photodetector/s generate a signal, the magnitude of which signal is related to the amount of light detected; and e) signal processing means for processing signals from the photodetector/s.Type: GrantFiled: August 27, 2008Date of Patent: February 1, 2011Assignee: Alere Switzerland GmbHInventor: Stephen Paul Sharrock
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Patent number: 7875465Abstract: A capturing molecule having not less than two domains specifically binding to different sites of a target substance, wherein the not less than two domains comprise (1) a first domain having a hypervariable loop structure at a binding site to the target substance, and (2) a second domain having no hypervariable loop structure at a binding site to the target substance.Type: GrantFiled: May 29, 2006Date of Patent: January 25, 2011Assignee: Canon Kabushiki KaishaInventors: Hidenori Shiotsuka, Satoru Hatakeyama, Tsuyoshi Nomoto, Masaru Kaieda, Junta Yamamichi
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Patent number: 7875433Abstract: Methods for measuring the relative amount of two or more analytes of interest in a fluid sample, as well as kits useful in the methods, are disclosed. The methods involve assays that utilize a solid phase apparatus with a membrane having an application point and at least two sample capture zones having sample capture reagents; analyte binding particles or analyte coated particles; and assessment of a ratio of such particles arrested in capture zones, wherein the ratio is equal to, or inversely equal to, the relative amounts of the analytes of interest in the fluid sample.Type: GrantFiled: February 15, 2008Date of Patent: January 25, 2011Assignee: Response Biomedical CorporationInventor: Paul C. Harris
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Patent number: 7871781Abstract: Lateral flow assay devices and methods for detecting an analyte in a sample which comprises a plurality of nonspecific binding pair members are adapted for two step determinations.Type: GrantFiled: May 23, 2006Date of Patent: January 18, 2011Assignee: Phadia ABInventors: Gerd Rundström, Per Matsson, Paul Christopher
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Patent number: 7867780Abstract: The present invention provides a lateral flow format and materials and methods for using the format in a variety of applications. More particularly, the present invention provides single-layer lateral flow formats, materials and methods for detecting the presence of an analyte using a test strip comprising a dry porous medium comprising a single hydrophilic matrix. Devices are also provided as well as methods of making and using the format. The format is particularly useful for diagnosis of physiological and genetic conditions. In addition, the present invention provides methods and materials for concentrating a reagent in a porous medium.Type: GrantFiled: March 30, 2005Date of Patent: January 11, 2011Assignee: Whatman, Inc.Inventors: Kevin D. Jones, David Cox
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Patent number: 7867756Abstract: A sample analysis device is provided in which a target component to be analyzed is prevented from being contaminated by a sample itself, which can be formed in an appropriate size, and which has excellent operability. In a sample analysis device 1 in which a sample is to be held in a porous sheet 13, supporting films 11 and 12 are stuck on front and rear faces of the porous sheet 13, respectively, and a sample supply hole 14 is formed in a part of the supporting films.Type: GrantFiled: April 11, 2002Date of Patent: January 11, 2011Assignee: ARKRAY, Inc.Inventors: Konomu Hirao, Yasuhito Murata
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Patent number: 7863057Abstract: Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.Type: GrantFiled: July 8, 2008Date of Patent: January 4, 2011Assignee: Charm Sciences, Inc.Inventors: Steven J. Saul, Robert J. Markovsky, David W. Douglas
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Patent number: 7858397Abstract: The present invention relates to a method for making a test device for detecting or quantifying an analyte in a sample. This method involves contacting a membrane with a mixture including derivatized, marker-loaded liposomes, and substantially dehydrating the mixture on the membrane under vacuum pressure at a temperature of from about 4° C. to about 80° C., wherein said mixture further includes one or more sugars in an amount sufficient to promote the stability of the liposomes during dehydration and rehydration. The present invention also relates to a test device and method for detecting or quantifying an analyte in a sample. The test device includes a membrane which includes an immobilized liposome zone, wherein the immobilized liposome zone has bound thereto dehydrated, derivatized, marker-loaded liposomes dehydrated under vacuum pressure at a temperature of from about 4° C. to about 80° C.Type: GrantFiled: May 28, 2008Date of Patent: December 28, 2010Assignee: Cornell Research Foundation, Inc.Inventors: Richard A. Durst, Daniel Martorell-Pena, Sui Ti Atienza Siebert
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Patent number: 7858396Abstract: A lateral flow test strip for the analysis of a sample featuring numerous capture zones arranged in an array such that each capture zone is substantially equidistant from the sample containing area. The sample does not pass through another capture zone to reach any one of the other capture zones. The capture zones are preferably arranged in a linear array perpendicular to the flow of the sample through the lateral flow test strip. The lateral flow test strip allows for an increased number of simultaneous analyses of numerous analytes from one sample to occur on one lateral flow test strip.Type: GrantFiled: October 31, 2006Date of Patent: December 28, 2010Assignee: Orasure Technologies, Inc.Inventors: Paul L.A.M. Corstjens, Keith Kardos, R. Sam Niedbala, Hans J. Tanke, Michel Zuiderwijk, Hans H. Feindt, Vijay K. Mokkapati, Jess Aaron Kimball
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Patent number: 7846745Abstract: Device for immunochromatography comprise a test strip comprising a sample application member, a label holding member and a chromatography membrane, a first case member and a second case member. Detection kits and methods for testing an analyte substance are also described.Type: GrantFiled: June 30, 2004Date of Patent: December 7, 2010Assignee: Sysmex CorporationInventors: Noriyuki Saito, Takahiro Taya
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Patent number: 7838245Abstract: The present invention relates to the use of protachykinin and/or fragments thereof that can be isolated from body fluids, tissues or other bioiological samples and therefore, serves as a marker peptide for medical diagnosis of diseases/disorders of the central nervous system, including Alzheimer's disease, Parkinson's disease, depression and/or conditions of pain, neurological, endocrinological, cerebral, muscular, local, systemic, chronic, inflammatory diseases, infectious diseases comprising bacterial and viral infections, meningitis, sepsis, Crohn's disease, colitis ulcerosa, sickle cell anemia, ischemia, amyotrophic lateral sclerosis, arthritis comprising rheumatoid arthritis, bronchitis, hyperalgesia, asthma, intoxication comprising bacterial intoxication, immunological disorders, poly/-trauma comprising cranio-cerebral trauma, tumors/cancer, stroke, stress, atopis dermatitis, HIV, Huntington's disease, burns, schizophrenia, Hirschsprung's disease, allergies, familial dysautononmia (Riley Day syndrome),Type: GrantFiled: April 20, 2005Date of Patent: November 23, 2010Assignee: Sphingotec GmbHInventors: Andreas Bergmann, Andrea Ernst