Patents Examined by Benjamin L Lebron
  • Patent number: 11840502
    Abstract: The present disclosure provides a system for efficiently preparing taurine, including: a solution storage unit configured to store a solution containing alkali metal taurinate, the solution being prepared by an ethylene oxide process; an ion exchange unit including at least one ion exchange resin column each configured to be activated by a first activation manner or a second activation manner independently, the first activation manner using sulfurous acid for activation to obtain alkali metal bisulfate and taurine, and the second activation manner using sulfuric acid for activation to obtain alkali metal sulfate and taurine; and a dispensing unit connected to the solution storage unit and the ion exchange unit respectively, and configured to adjust an amount of a solution conveyed from the solution storage unit to each of the at least one ion exchange resin column in the ion exchange unit.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: December 12, 2023
    Assignee: HUBEI GRAND LIFE SCIENCE AND TECHNOLOGY CO., LTD.
    Inventors: Huajun Sun, Min Tan, Xiaojing Yan, Ruyong Jiang, Hongbo Peng, Jiale Tang, Chen Guo, Xingxing Wang, Zhiqiang Qian
  • Patent number: 11839836
    Abstract: Chromatography column components are described. One component, a chromatography plug, can include a body, the body including: a first surface; a second surface opposing the first surface; a passage through the body extending from an opening in the first surface to an opening in the second surface; and a circumferential surface extending from the first surface to the second surface; a plurality of ridges, located on the first surface, wherein each of the plurality of ridges having a first end and an opposed second end, and the first end of each of the plurality of ridges being closer to one another than the second ends of each of the plurality of ridges. In some instances, a bridge can be located between the first ends, the bridge extending into the body. A porous partition can be located on or in the plug.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: December 12, 2023
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Pascal Wijnant, John Tipton, Christopher Ward
  • Patent number: 11837756
    Abstract: An ion filter for a fuel-cell stack, which is configured for overcoming restrictions related to hydraulic head on the ion filter in a fuel-cell system and has a simplified structure, may include a manifold unit of diverging a coolant introduced from an outside; and an ion filter unit connected to the manifold unit to receive the coolant from the manifold unit and including a cartridge assembly having an ion filter resin.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: December 5, 2023
    Assignees: Hyundai Motor Company, Kia Corporation, Mahle Donghyun Filter Systems Co., Ltd.
    Inventors: Hyun Ju Ji, Hun Woo Park, Sun Ae Park, Hwan Choi
  • Patent number: 11827541
    Abstract: The present embodiments generally relate to the treatment of produced water comprising one or more water soluble polymers, wherein such treatment comprises: adding to the produced water at least one iron complex; and degrading at least a portion of the one or more water soluble polymers. This treatment may result in a reduction of the viscosity of said produced water and/or the degradation of the water soluble polymers which are contained therein.
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: November 28, 2023
    Assignee: KEMIRA OYJ
    Inventors: Iris Porat, Miguel Pelaez, Mehrdad Hesampour, Yuping Luo, William Morris, Luciana Bava
  • Patent number: 11819779
    Abstract: A chromatographic separation method for separating plural components contained in a liquid to be separated by a chromatography, with a separating device 1 including plural filling portions 10 filled with a separating agent for separating the plural components contained in the liquid to be separated, a supply portion 20 provided in each of the plural filling portions 10 to supply the liquid to be separated or an eluent for extracting any component contained in the liquid to be separated to the filling portion 10, and an extraction portion 30 to extract any component contained in the liquid to be separated from the filling portion 10, the method including: an upward supplying and extracting step of extracting any component contained in the liquid to be separated from an upward stream extraction portion while supplying the eluent to at least one filling portion 10 from an upward stream supply portion by an upward stream.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: November 21, 2023
    Assignee: Mitsubishi Chemical Aqua Solutions Co., Ltd.
    Inventors: Keiji Iwamoto, Makoto Yasumoto, Toshihiko Uratsuji
  • Patent number: 11820679
    Abstract: Disclosed are an energy self-sufficient high-efficiency photothermal evaporative nano-particle porous membrane and application thereof, including: dissolving polymer A in solvent B to obtain solution A; dripping solution A into solvent C to obtain a polymer A nano hydrogel dispersion; evenly mixing polymer A nano hydrogel dispersion and nano particle dispersion of photothermal conversion material D to obtain a co-blended dispersion; performing suction-filtering to the co-blended dispersion on a surface of a solvent-resistant membrane E to form an A-D co-blended membrane; and performing suction-filtering to a solvent F using the A-D co-blended membrane, followed by drying to obtain a high-efficiency photothermal evaporative nano-particle porous membrane.
    Type: Grant
    Filed: February 27, 2023
    Date of Patent: November 21, 2023
    Assignee: Institute of Eco-environmental and Soil Sciences, Guangdong Academy of Sciences
    Inventors: Bin He, Yu Ma
  • Patent number: 11813588
    Abstract: A chromatographic material including a substrate having a surface and having a polymeric layer covalently bound to the surface; the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds, each polymer molecule containing multiple first reactive groups, and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group. Preferred conditions of reacting the polymer with the substrate include elevated temperature and reduced pressure.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: November 14, 2023
    Assignee: Dionex Corporation
    Inventors: Xiaodong Liu, Xiao Cui, Xuefei Sun
  • Patent number: 11806461
    Abstract: Provided is a blood purification device including a porous molded body that has a high phosphorus adsorption capacity and that can be used safely. A blood purification device includes a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: said blood purification device satisfies the relationship B=?0.02 A+2.175±0.185 (74?A?94) when the moisture content of the porous molded body is denoted by A and the bulk density is denoted by B; and the number of fine particles having a size of 10 ?m or more is 25 or less and the number of fine particles having a size of 25 ?m or more is 3 or less in 1 mL of a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: November 7, 2023
    Assignee: ASAHI KASEI MEDICAL CO., LTD.
    Inventors: Teruhiko Oishi, Naoki Morita, Keitaro Matsuyama, Hiroshi Tajima, Toshinori Koizumi
  • Patent number: 11801505
    Abstract: A cation exchange chromatographic matrix comprising a base material, and a copolymer with one monomer unit having at least a sulfonic acid group, the copolymer being immobilized on the base material, wherein: the copolymer forms substantially no cross-linked structure, and the copolymer comprises neither acrylamide nor an acrylamide derivative as a monomer unit, or comprises acrylamide or an acrylamide derivative as a monomer unit in a range which has no substantial influence; the ratio of the mass of the copolymer to the mass of the base material is 5% or more and 200% or less; and the density of the sulfonic acid group is higher than 30 mmol/L and 200 mmol/L or lower.
    Type: Grant
    Filed: January 7, 2022
    Date of Patent: October 31, 2023
    Assignee: ASAHI KASEI MEDICAL CO., LTD.
    Inventor: Hiroki Taniguchi
  • Patent number: 11794165
    Abstract: The present disclosure provides a porous silica having an average pore diameter of at least 210 ? and a pore volume of at least 0.80 cm3g?1. The present disclosure also provides a method of producing the porous silica including gelling a liquid phase-dispersed nanoparticulate silica in the presence of either (i) a Brønsted acid and an amine group having two or more primary or secondary amine groups or (ii) an amino acid.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: October 24, 2023
    Assignee: NOURYON CHEMICALS INTERNATIONAL B.V.
    Inventors: Joakim Erik Patrik Högblom, Peter Lennart Gidlund, Börje Sigvard Persson
  • Patent number: 11786842
    Abstract: A composition includes a hybrid ligand. The hybrid ligand includes an amine group, an amide group or a sulfonamide group, and hydroxyl groups. A first method includes providing a solution containing a first polar analyte and a second polar analyte, applying the solution to a stationary phase including an immobilized hybrid ligand, applying an elution solvent to the stationary phase such that the first polar analyte and the second polar analyte pass through the stationary phase with different elution times, and collecting the first polar analyte at a first elution time and collecting the second polar analyte at a second elution time after the first elution time. A device of a packed column, a cartridge, a tube, a well plate, a membrane, or a planar thin-layer chromatography plate includes a solid support and a hybrid ligand coupled to the solid support. A second method forms an immobilized hybrid ligand.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: October 17, 2023
    Assignee: RESTEK CORPORATION
    Inventors: Xiaoning Lu, Charles Vernon Bartlett, Connor Flannery, Ahren Iver Green, Terrence Scott Reid
  • Patent number: 11782031
    Abstract: A detector for a liquid chromatograph includes a detector that detects components in liquid, and a heat exchanger that adjusts a temperature of liquid introduced into the detector, wherein the heat exchanger includes a pipe having a winding portion, and a cast in which the winding portion is embedded, the pipe is formed of resin, and the cast is formed of an alloy having a melting point lower than a continuous use temperature of the resin.
    Type: Grant
    Filed: January 14, 2022
    Date of Patent: October 10, 2023
    Assignee: Shimadzu Corporation
    Inventor: Yuki Iijima
  • Patent number: 11774413
    Abstract: A preparative liquid chromatograph includes a liquid chromatograph section, a trap section, an eluent supply section, a collector, and a flow path switching section. The flow path switching section is configured to be selectively switched to a component trap mode that connects the liquid chromatograph section and the trap section in such a way that a sample component separated in a separation column is trapped by a trap column of the trap section; and a collection mode that connects the eluent supply section and the trap section and connects the trap section and the collector in such a way that the components trapped in the trap column are eluted by an eluent from the eluent supply section and are guided to the collector.
    Type: Grant
    Filed: July 2, 2021
    Date of Patent: October 3, 2023
    Assignee: Shimadzu Corporation
    Inventor: Tomoyuki Yamazaki
  • Patent number: 11740210
    Abstract: Disclosed is a chromatography system (100) comprising: plural modules (1-25) including at least one pump and a column valve unit (8) connectable to plural chromatography columns; and a controller (600), the controller being operable to control the or each pump and the column valve to perform different chromatographic processes, including chromatography employing just one column, as well as chromatography employing two or more columns by selective valve opening in said unit. The system includes a housing (110) into which the plural modules (1-25) are interchangeably mountable in apertures of one generally vertical face of housing, the modules are adapted for selective fluidic interconnection by tubing substantially at said one face such that in use the modules and tubing occupy a generally vertically extending volume to minimize the footprint of the system.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: August 29, 2023
    Assignee: CYTIVA SWEDEN AB
    Inventors: Nils Stafstrom, Lars Olof Nils Rosengren, Kerstin Elisabet Erickson, Tomas Yngve Agren, Yngve L. Hareland, Tim Francois, Anita Jonsson, Jeanne Cheng, Anna Andersson
  • Patent number: 11731108
    Abstract: The subject invention pertains to proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic 1,3-dioxoisoindolin-2-yl group functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of one, two, three, four, or five atoms between the hydrophobic group and the support matrix.
    Type: Grant
    Filed: March 17, 2022
    Date of Patent: August 22, 2023
    Assignee: BIO-RAD LABORATORIES, INC.
    Inventors: Christopher Belisle, Jiali Liao, Edwin Lozano
  • Patent number: 11731062
    Abstract: A chromatography and synthesis column that includes a main tube, a plurality of lower media ports, and an internal groove. The internal groove is formed in an interior surface of the main tube and selectively provides an internal flow path between each of the internal lower media ports. This, in turn, facilitates quick and easy maintenance of the internal lower media ports and other components of the chromatography and synthesis column.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: August 22, 2023
    Assignee: Asahi Kasei Bioprocess America, Inc.
    Inventor: Michael D. Brandt
  • Patent number: 11731107
    Abstract: A system and method of applied radial technology chromatography using a plurality of beads is disclosed, with each bead comprising one or more pores therein having a diameter of about 250 ? to about 5000 ?, and each bead having an average radius between about 100 ?m to about 250 ?m. Also disclosed are processes for selecting beads for use in a radial flow chromatography column, and for purifying an unclarified feed stream using a radial flow chromatography column.
    Type: Grant
    Filed: April 7, 2022
    Date of Patent: August 22, 2023
    Assignee: emp Biotech GmbH
    Inventors: Alistair J. Hurst, Derek W. K. Levison
  • Patent number: 11733216
    Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: August 22, 2023
    Assignee: Waters Technologies Corporation
    Inventors: Michael O. Fogwill, Joseph D. Michienzi, Geoff Gerhardt, James P. Murphy
  • Patent number: 11718643
    Abstract: The invention discloses a separation matrix which comprises a plurality of separation ligands, defined by the formula R1-L1-N(R3)-L2-R, immobilized on a support, wherein R1 is a five- or six-membered, substituted or non-substituted ring structure or a hydroxyethyl or hydroxypropyl group; L1 is either a methylene group or a covalent bond; R2 is a five- or six-membered, substituted or non-substituted ring structure; L2 is either a methylene group or a covalent bond; R3 is a methyl group; and wherein if R1 is a hydroxyethyl group and L1 is a covalent bond, R2 is a substituted aromatic ring structure or a substituted or non-substituted aliphatic ring structure.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: August 8, 2023
    Assignee: Cytiva BioProcess R&D AB
    Inventors: Jean-Luc Maloisel, Gustav Rodrigo, Bjorn Noren, Virendra Kumbhar
  • Patent number: 11717770
    Abstract: A variable fluidic restrictor of a liquid chromatography system including a stator body, the stator body include a plurality of fluidic channels located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element, wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element coupled to the stator body is provided. Furthermore, an associated method is also provided.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: August 8, 2023
    Assignee: Waters Technologies Corporation
    Inventors: Zongren Shang, Stanislaw Koziol, Joseph D. Michienzi, Michael Eggertson, Keith Fadgen