Abstract: The invention relates to containers or bags for chromatographic media and methods of packing chromatography columns using such containers. The bags may be used for storing and/or transporting chromatographic media and can be inserted directly into the chamber of a chromatography column in readiness for use.

Abstract: Open tubular capillary columns for liquid and ion chromatography, based upon an ionically impermeable polyolefin capillary having a bore with a sulfonate-group- or amine-group-functionalized internal surface. The capillary columns may include a coating of ion exchanging nanoparticles electrostatically bound to the functionalized internal surface. The capillary columns may be made by exposing the interior surface to a sulfonating reagent comprising chlorosulfonic acid (ClSO3H), preferably from 85 wt % to 95 wt % chlorosulfonic acid at a process temperature of 20 to 25° C. The interior surface may be subsequently exposed to an asymmetrical diamine to form a sulfonic mid-linkage to the diamine, i.e., to form a sulfonamide-linked, amine-group-functionalized internal surface. The coating may be provided by subsequently exposing the interior surface to an aqueous suspension of ion exchanging nanoparticles to electrostatically bond the ion exchanging nanoparticles to the functionalized internal surface.

Abstract: A chromatographic cassette includes a cassette including a chamber, chromatographic media disposed within the cassette chamber, a distribution network fluidly coupled to the chromatographic media and an inlet port and an outlet port coupled to the distribution network. A hyper-productive chromatography technique includes providing a scalable and stackable chromatographic cassette, loading a sample to be processed, operating the scalable chromatographic cassette having an adsorptive chromatographic bed having a volume greater than 0.5 liter by establishing a flow at a linear velocity greater than 500 cm/hr with a residence time of the loading step of less than one minute.

Abstract: The present disclosure relates to water purification compositions and the method of producing the same. Specifically, the present disclosure relates to a method of producing a water purification composition including providing a substrate having one or more functional groups that has hydroxyl, thiol, carboxyl, and/or amino group; depositing a solution of a metal salt on the substrate; depositing a solution of carboxylic acid compound on the substrate; forming a mixture wherein the metal cross-links the hydroxyl, thiol, carboxyl and/or amino groups on the surface of the substrate, and the carboxylic acid compound; and heating the mixture till the product is dry.

Abstract: The present invention relates to a pre-packed chromatography cartridge (10) suitable for flash chromatography. The chromatography cartridge (10) comprises a barrel (20) having one end sealed with a cap (40), a thread (23) arranged on the outer cylindrical surface of the barrel (20) and engaged to a mating thread (43) on the inner cylindrical surface of the cap (40). The barrel is provided with at least one protrusion (24) arranged on the outer cylindrical surface and below the thread (23) in the direction from the end sealed by the cap (40). The protrusion (24) extends essentially radially outwards from the outer cylindrical surface of the barrel (20). The cap (40) is provided with a cylindrical flange (44) arranged below the thread (43) of the cap (40). A locking member (46) is arranged on the flange (44) and extends essentially radially inwards from the inner cylindrical surface of the flange (44).

Abstract: The present invention relates chromatography cartridge comprising a barrel to be sealed with a cap utilizing a seal member such as an O-ring. The barrel comprises barrel lip on the circular top surface of the barrel. The cap comprises a seal holder and a space to accommodate the seal member. Then the cap is mounted on the barrel an interior contact surface of the cap will contact the barrel lip and force the barrel lip to shear inwards. The barrel lip and the contact surface will form a first cartridge seal. The barrel lip will in turn contact the seal member which will contact a seal surface of the cap and the seal holder to form a second cartridge seal.

Abstract: A method and microfluidic device with a porous polymer monolith in a channel of the device with capture affinity element (such as an oligonucleotide complementary to a DNA target from the KPC antibiotic resistance gene) on the monolith surface.

Abstract: A method of processing an aqueous solution, wherein the aqueous solution comprises one or more dissolved sugar, one or more dissolved sugar alcohol, or a mixture thereof, wherein the method comprises bringing the aqueous solution into contact with a collection of resin beads, wherein the resin beads comprise functional groups of structure (S1).

Abstract: Provided is an extraction method for extracting an extract from a mixture using liquefied gas that can dissolve the extract, the method facilitating extraction operations and enabling low cost operation. An extraction device that extracts a component dissolved in liquefied gas from material to be treated using continuous phase changes in the liquefied gas is characterized by being provided with: a compressor that feeds gas under pressure; a heat exchanger for generating liquefied gas by the gas flowing in a high temperature side flow path; a treatment tank into which the material to be treated is loaded and the liquefied gas flows; and a retention tank provided in series or in parallel to the flow path downstream of the high temperature side flow path in the heat exchanger.

Abstract: The present embodiments generally relate to the treatment of produced water comprising one or more water soluble polymers, wherein such treatment comprises: adding to the produced water at least one iron complex; and degrading at least a portion of the one or more water soluble polymers. This treatment may result in a reduction of the viscosity of said produced water and/or the degradation of the water soluble polymers which are contained therein.

Abstract: Systems and methods for removing heavy metals such as selenium from wastewater with zero valent iron media. Air may be introduced directly into a reaction zone of a fluidized bed reactor filled with the media to catalyze treatment.

Abstract: An amphoteric dissociation ion exchange separation medium, the surface of which is an amphoteric dissociation covalently-modified layer. When an environmental pH value is lower than the isoelectric point, pIm, of the covalently-modified layer, the type of net charges on the surface of the covalently-modified layer is positive and the separation medium has the properties of an anion exchanger; when the environmental pH value is higher than the pIm, the type of net charges on the covalently-modified layer surface is negative and the separation medium has the properties of a cation exchanger. The separation medium has the properties of an anion exchanger and a cation exchanger at both sides of the pIm, respectively. The pH of an eluent can be adjusted to allow the separation medium surface and the target substance to have the same type of net charges, so that the target substance can be released by electrostatic repulsion.

Abstract: Techniques are described for accelerating thermal equilibrium in a chromatographic column. An apparatus comprises a chromatography column, and a plurality of temperature control units in thermal contact with the chromatography column. A method of performing liquid chromatography comprises setting an inlet of a chromatography column to a first temperature using a first temperature control unit in thermal contact with said inlet, setting an outlet of the chromatography column to a second temperature using a second temperature control unit in thermal contact with the outlet, wherein the first temperature is less than the second temperature; and injecting a sample into a liquid stream that flows through the chromatography column after the inlet is set at the first temperature and the outlet is at the second temperature.

Abstract: A sorbent cartridge device includes an ion-exchange material containing zirconium phosphate and no more than about 0.1 mg of leachable phosphate ions per about 1 g of the ion-exchange material. In one example, the cartridge also includes a phosphate-adsorbing material containing zirconium oxide. In this example, the weight ratio between zirconium phosphate and zirconium oxide in the cartridge is from about 10:1 to about 40:1. The zirconium phosphate may be alkaline zirconium phosphate prepared by a process including the following steps: (i) drying acid zirconium phosphate to obtain a dry acid zirconium phosphate; (ii) combining the dry acid zirconium phosphate with an aqueous solution to obtain an aqueous slurry; and (iii) combining the slurry with an alkali hydroxide to obtain the alkaline zirconium phosphate. During step (ii), any free phosphate ions in the dry acid zirconium phosphate leach out into the aqueous phase of the slurry.

Abstract: The invention provides methods for quantifying a non-ionic surfactant in a composition comprising a polypeptide and the non-ionic surfactant, where the quantification exhibits reduced interference between the non-ionic surfactant and the polypeptide. Also provided are methods where the composition further includes N-acetyl tryptophan, and the quantification exhibits reduced interference between the non-ionic surfactant, the polypeptide, and N-acetyl tryptophan.

Abstract: The invention relates to a method for the chromatographic purification of at least one cannabinoid compound, wherein the method comprises a main purification stage comprising the steps of: injecting an initial mixture comprising the at least one cannabinoid compound and one or more additional compounds onto a main stationary phase comprising silica particles, the silica particles comprising amino and/or diol groups; performing an elution with an elution solution, and collecting one or more elution fractions; and optionally, washing the main stationary phase with a washing solution and collecting one or more washing fractions; at least one of the elution fractions or washing fractions containing the at least one cannabinoid compound purified from the one or more additional compounds.

Abstract: A system and method of applied radial technology chromatography using a plurality of beads is disclosed, with each bead comprising one or more pores therein having a diameter of about 250 ? to about 5000 ?, and each bead having an average radius between about 100 ?m to about 250 ?m. Also disclosed are processes for selecting beads for use in a radial flow chromatography column, and for purifying an unclarified feed stream using a radial flow chromatography column.

Abstract: A variable fluidic restrictor of a liquid chromatography system including a stator body, the stator body include a plurality of fluidic channels located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element, wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element coupled to the stator body is provided. Furthermore, an associated method is also provided.

Abstract: There is provided an integrated system for liquid separation, such as LC, CE, affinity chromatography, and ion exchange chromatography, comprising a column and end-fittings embedded in a plastic material, such as a thermoplastic polymer. The system may further comprise an electrospray emitter directly connected with the outlet of the column, wherein a substantial part of the emitter is covered with the polymer material. There is also provided a method by which a separation column along with the accompanying end fittings for connection with adjacent liquid conduits is embedded in a polymer matrix. This configuration e.g. ensures that the factory-made, correct attachment of the fittings to the column is preserved (since the matrix prevents further user intervention, accidental or otherwise). Accordingly, the responsibility for the correct attachment of the fittings is shifted from the end user to the manufacturer.

Abstract: A method for separating ionic species from an analyte solution to form a fractionated sample, the method comprising contacting the analyte solution with an ion-exchanger that is selectively permeable to ionic species of either a positive or negative charge, contacting an opposing side of the ion-exchanger with a draw solution, wherein the draw solution comprises adsorber particles dispersed in a liquid carrier, establishing a concentration gradient across the ion-exchanger to allow at least some ionic species from the analyte solution to permeate through the ion-exchanger to the draw solution, adsorbing ionic species that permeate from the analyte solution onto the adsorber particles, separating adsorber particles having the ionic species adsorbed thereto from at least part of the draw solution, and eluting the ionic species from the separated adsorber particles to form a fractionated analyte sample comprising eluted ionic species.