Patents Examined by Bin Shen
  • Patent number: 10813981
    Abstract: Disclosed herein are methods and compositions useful in the treatment and/or prevention of a disease or indication associated with accumulation of a bisretinoid, for example A2E. In many embodiments, the disclosed methods and compositions are useful in treating an eye disease, for example macular degeneration.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: October 27, 2020
    Assignee: Syracuse University
    Inventors: Kelsey Moody, Robert P. Doyle
  • Patent number: 10801053
    Abstract: Process for producing a rhamnolipid produced by Pseudomonas or Enterobacter using andiroba or murumuru seed waste, pertaining to the sector of compounds containing monosaccharide radicals, consists of producing rhamnolipids by a biotechnological process using andiroba or murumuru seed waste, following oil extraction, as a substrate for a Pseudomonas aeruginosa, Enterobacter hormaechei or Enterobacter buriae line cultivated in a bioreactor with a non-dispersive aeration system for reducing foam, producing a rhamnolipid content of 10.5 g/L for Pseudomonas aeruginosa bacteria, in bioreactors carried out in a stirred tank with non-dispersive aeration using microporous membranes, particularly of silicone tubes, which allow oxygen to be supplied by diffusion.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: October 13, 2020
    Assignees: Natura Cosmeticos S/A, Instituto de Pesquisas Tecnologicas do Estado de Sao Paulo S.A.-IPT
    Inventors: Noemi Jacques Vieira, Cintia Rosa Ferrari, Gabriela da Silva Bicalho, Patricia Leo, Alfredo Eduardo Maiorano, Eliza Mami Ota, Maria Filomena de A. Rodrigues, Rosa Mitiko Saito Matsubara
  • Patent number: 10800689
    Abstract: The invention discloses a magnetic nanoparticle microbial composite material with a core-shell structure and a preparation method thereof as well as application of the magnetic nanoparticle microbial composite material in azo dye treatment. The preparation method comprises the following steps: putting ferroferric oxide into an ethanol solution with ferric trichloride and trimesic acid; carrying out layer-by-layer self-assembly and ultrasonic condition reaction in sequence to prepare modified ferroferric oxide nanoparticles; then loading the modified composite material on the surfaces of microorganisms. The composite material prepared by the preparation method disclosed by the invention has the advantages of high adsorption effects and capability of carrying out local enrichment on the dye; meanwhile, magnetic separation can be performed, and thereby the azo dye can be removed efficiently.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: October 13, 2020
    Assignee: SOOCHOW UNIVERSITY
    Inventors: Jianmei Lu, Dongyun Chen
  • Patent number: 10792396
    Abstract: A hybrid tissue engineered heart valve leaflet including a polyurethane core, such as a polycarbonate-based thermoplastic polyurethane like carbothane. The polyurethane core is enclosed within one or more layer of a patient's cells and collagen. Also disclosed are hybrid tissue engineered heart valves, including a frame; and at least two leaflets attached thereto in a configuration of a heart valve, wherein the leaflets are hybrid tissue engineered heart valve leaflets, and methods of making a hybrid tissue engineered heart valve for deployment in a patient.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: October 6, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Arash Kheradvar, Ramin Zareian
  • Patent number: 10793832
    Abstract: A method for producing pancreatic endocrine cells, the method including introducing one or more genes of a GLIS family or one or more gene products thereof and a Neurogenin3 gene or one or more gene products thereof into somatic cells.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: October 6, 2020
    Assignee: Juntendo Educational Foundation
    Inventors: Masahito Matsumoto, Yasushi Okazaki, Izumi Sugahara
  • Patent number: 10792314
    Abstract: Provided herein are methods and compositions related to Bifidobacterium animalis ssp. lactis useful as therapeutic agents.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: October 6, 2020
    Assignee: Evelo Biosciences, Inc.
    Inventors: Peter Sandy, Jacqueline Papkoff, Maria Sizova, Brian Goodman, Humphrey Gardner, Holly Ponichtera, Hank Wu, William Caffry, Anupriya Dutta
  • Patent number: 10787639
    Abstract: Disclosed herein are systems, methods, and devices for determining plant-microbe interactions. In some embodiments, the device comprises: a root chamber configured to allow a root of a plant to grow, wherein the root chamber is connected with: an inlet channel for introducing a medium into the root chamber, an outlet channel for collecting plant exudates and metabolites, and a plant reservoir for the plant shoot of the plant to grow.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: September 29, 2020
    Assignee: The Regents of the University of California
    Inventors: Jian Gao, Trent R. Northen, Kyle M. Lewald, Lloyd T. Cornmesser, Peter F. Andeer
  • Patent number: 10786600
    Abstract: Methods of preparing a human birth tissue material are provided. A placental construct for treatment of a disease or condition is also provided. A kit including at least one placental construct and at least one structural carrier is provided. A catheter for recovering amniotic fluid is also provided.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: September 29, 2020
    Assignee: BioDLogics, LLC
    Inventor: Timothy R. Brahm
  • Patent number: 10767159
    Abstract: The invention provides an automated method for selecting a microbial strain from within a microbial strain library which can degrade or emulsify a target oil substrate. An apparatus, device or system adapted to perform the method of the invention is further provided. The use of the method of the invention in a method for preparing a microbial inoculum suitable for use to degrade or emulsify a target oil substrate; in a method of treating an oil reservoir or environmental remediation; and in a method for producing a biosurfactant-like substance is also provided.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: September 8, 2020
    Assignee: EQUINOR ENERGY AS
    Inventors: Ane Kjølhamar, Anita Skarstad, Hans-Kristian Kotlar
  • Patent number: 10767209
    Abstract: The present invention relates to a device for detecting a plant pathogen spore in soil or water. The present invention also relates to a method for detection of a plant pathogen spore. The device for detecting a plant pathogen spore in soil or water comprises a support member containing a plant pathogen chemoattractant; a filter having a plurality of pores; a culture medium containing a plant pathogen chemoattractant; and a detection means; wherein the support member is adjacent to the filter and the filter is adjacent to the culture medium.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: September 8, 2020
    Assignee: FUNGIALERT LIMITED
    Inventors: Kerry O'Donnelly Weaver, Angela De Manzanos Guinot
  • Patent number: 10767198
    Abstract: A method for producing branched aldehydes is proposed, the method comprising the following steps: (a) providing a culture of one or more fungi of the genus Conidiobolus and producing biomass containing branched carboxylic acids in free and/or bound form; (b) extracting the biomass from step (a) to produce a first intermediate containing free and/or bound carboxylic acids; (c) optionally chemically, enzymatically or microbially hydrolyzing the bound carboxylic acids from the first intermediate; (d) treating the first intermediate with a reducing agent of a chemical nature to convert the free and/or bound carboxylic acids into the corresponding alcohols and optionally separating one or more alcohols from interfering by-products and producing the chemically produced second intermediate containing these alcohols as a mixture or in enriched form; (e) treating the first intermediate with a reducing agent of a biological nature to convert the free and/or bound carboxylic acids into the corresponding aldehydes havin
    Type: Grant
    Filed: November 28, 2015
    Date of Patent: September 8, 2020
    Assignee: SYMRISE AG
    Inventors: Marco A. Fraatz, Holger Zorn, Johanna Rost, Michael Goldmann, Egon Gross, Jakob Ley, Katrin Geissler, Torsten Geissler, Michael Backes, Fabia Hentschel, Jens-Michael Hilmer
  • Patent number: 10761026
    Abstract: A method of quantitating of ions in the extracellular polymer substances area of a dental biofilm is an effective way of assessing efficacy of oral care compositions.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: September 1, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Yunming Shi, Swapna Basa, Ross Strand
  • Patent number: 10752877
    Abstract: Described herein are two bacterial strains, designated as KGS-2 and KGS-8 which have been shown to solubilize soil phosphorus and to enhance the growth of plants. In addition to promoting solubilisation of phosphate from sources such as dicalcium phosphate, manure and potassium phosphate, KGS-2 and KGS-8 also produce siderophore and indole-3-acetic acid (IAA).
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: August 25, 2020
    Inventor: Stan Lozecznik
  • Patent number: 10745683
    Abstract: Disclosed herein are methods of producing hexoses from saccharides by enzymatic processes. The methods utilize fructose 6-phosphate and at least one enzymatic step to convert it to a hexose.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: August 18, 2020
    Assignee: BONUMOSE LLC
    Inventors: Daniel Joseph Wichelecki, Edwin O. Rogers
  • Patent number: 10745733
    Abstract: The present invention concerns a kit and methods for the detection of absence or presence of a ?-lactamase, for example a penicillinase, in a sample comprising or derived from a body fluid taken from a patient suffering from an infection. In some embodiments, the goal of the invention is to rapidly identify infections which can be treated effectively with a penicillin compound. The invention contributes to slowing down the occurrence of resistances to last generation antibiotics. This is achieved by using penicillin compounds for treating infections whenever this can be done efficiently. In brief, the present invention provides a tool for maximizing the use and efficiency of penicillin antibiotics. In other embodiments, the test kit of the invention can be used to detect cephalosporinases (including ESBLs) or carbapenemases.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: August 18, 2020
    Assignee: UNIVERSITE DE FRIBOURG
    Inventors: Patrice Nordmann, Laurent Poirel, Nicolas Kieffer
  • Patent number: 10745662
    Abstract: The invention relates to microbiology, and more particularly to nutrient media used for cultivating bacteria for the subsequent study thereof. A nutrient medium comprising a pancreatic digest of casein, a peptic digest of meat, a heart pancreatic digest, yeast extract, starch and water is characterized in that it additionally contains violuric acid and beef infusion, wherein the ratio of ingredients is (wt %): 0.3-1.0 pancreatic digest of casein; 0.1-1.5 peptic digest of meat; 0.1-0.9 heart pancreatic digest; 0.1-2.0 yeast extract, 0.3-0.8 starch; 0.001-0.05 violuric acid; 2.0-15 beef infusion; the remainder water. The nutrient medium can additionally contain 0.3-2.5 wt % agar-agar and/or 1-20 wt % whole or hemolyzed sheep red blood cells and/or 1-20 wt % whole or hemolyzed human red blood cells and/or 1-15 wt % horse blood serum. This provides for the simultaneous growth of the maximum possible number of bacteria present in an inoculate.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: August 18, 2020
    Assignees: Viktor Veniaminovich TETS, Georgy Viktorovich TETS
    Inventors: Viktor Veniaminovich Tets, Georgy Viktorovich Tets
  • Patent number: 10736924
    Abstract: The present invention relates to pasteurized Akkermansia muciniphila or fragments thereof for treating a metabolic disorder in a subject in need thereof. The present invention also relates to a composition, a pharmaceutical composition and a medicament comprising pasteurized Akkermansia muciniphila or fragments thereof for treating a metabolic disorder. The present invention also relates to the use of pasteurized Akkermansia muciniphila or fragments thereof for promoting weight loss in a subject in need thereof.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: August 11, 2020
    Assignees: UNIVERSITÉ CATHOLIQUE DE LOUVAIN, WAGENINGEN UNIVERSITEIT
    Inventors: Patrice Cani, Amandine Everard, Hubert Plovier, Céline Druart, Willem De Vos, Clara Belzer
  • Patent number: 10716810
    Abstract: Described are compositions of matter, protocols, and treatment means for induction of immune mediated killing in dogs suffering from cancer. The invention provides means of extracting peripheral blood from a canine patient, expanding immunocytes capable of killing cancer cells in vitro, and re-administering said immunocytes into a patient in need of therapy. In one embodiment, immunocytes expanded are T cells possessing tumor cytotoxic activity induced by stimulation of NKG2D.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: July 21, 2020
    Assignee: Zander Therapeutics, Inc.
    Inventors: Thomas Ichim, David Koos
  • Patent number: 10718002
    Abstract: A quick screening method for microbial strains includes the steps of: feeding a carrier worm with Styrofoam for a plurality of days; and sampling a digestive system of the carrier worm and placing the sampled digestive system of the carrier worm into a culture medium. The digestive system of the carrier worm includes at least one Styrofoam degrading microbial strain. The culture medium includes an emulsion formed by dissolving the Styrofoam with chloroform and adding a surfactant to the dissolved Styrofoam. A culture medium for fast culturing of the at least one microbial strain is also provided.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: July 21, 2020
    Assignee: I-SHOU UNIVERSITY
    Inventors: Hsiao-Han Liu, Zhi-Long Tang, Ting-An Kuo
  • Patent number: 10704074
    Abstract: The invention relates to a method for detecting organisms in a liquid sample, comprising the provision of a capture area including particles in a liquid medium and subjected to a hydrodynamic flow, wherein the organisms to be detected are capable of binding to these particles, the method comprising the steps of: (a) circulating the sample through the capture area; (b) circulating a growth medium through the capture area; and (c) determining the presence, nature or concentration of organisms in the capture area; said particles being retained in the capture area as a fluidized bed for at least one part of these steps. The invention also relates to a system for implementing this method.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: July 7, 2020
    Inventors: Jean-Louis Viovy, Stephanie Descroix, Laurent Malaquin, Iago Pereiro, Lucile Alexandre