Patents Examined by Bin Shen
  • Patent number: 11059757
    Abstract: The process for producing organic molecules from fermentable biomass includes a step of anaerobic fermentation (5) producing volatile fatty acids (6), these precursors being transformed into final organic molecules by non-fermentation means. It also includes at least the following steps: a) extracting (9) at least one portion of the volatile fatty acids from the fermentation medium in such a way that the production of fermentation metabolites by the microorganisms (M) is not affected, and introducing a portion of the liquid phase (11) containing microorganisms from the extraction (9), b) synthesizing (13) organic molecules from the fermentation metabolites or from the volatile fatty acids extracted in step a)-c) continuing steps a) to b) until the final molecules are obtained, in terms of amount and quality. The invention also relates to an installation for implementing the process.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: July 13, 2021
    Assignee: AFYREN
    Inventors: Régis Nouaille, Jérémy Pessiot
  • Patent number: 11059050
    Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: July 13, 2021
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Joo Hun Kang, Donald E. Ingber, Michael Super
  • Patent number: 11052117
    Abstract: The present invention relates to administration of sweet whey protein (SWP) for promoting the enteric neuronal development in infants, especially preterm, low birth, very low and extremely low birth weight infants as well as in young children up until the age of six. Administration of the SWP according to the invention prevents and treats disorders associated with an immature or impaired enteric nervous system. The disorders are, notably, dysfunctional gastrointestinal motility manifested as slow intestinal transit, intestinal discomfort, hard stools, constipation and/or gastrointestinal reflux, gut barrier dysfunction, food intolerance or necrotizing enterocolitis.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: July 6, 2021
    Assignee: Societe des Produits Nestle S.A.
    Inventor: Magali Faure
  • Patent number: 11046983
    Abstract: In a method and an apparatus for an enzymatic hydrolysis in which plant based raw material is hydrolysed by means of enzymes in at least one enzymatic hydrolysis stage. A plant based feed (1) is fed to the enzymatic hydrolysis stage (2) in which the plant based feed is hydrolysed. A liquid fraction (3) comprising carbohydrates is separated from a solid fraction (4) in a solid-liquid separation stage (11). At least a part (5) of the solid fraction (4) comprising enzymes is recirculated to the plant based feed (1) of the enzymatic hydrolysis stage (2) or to the enzymatic hydrolysis stage (2), and a rest part (6) of the solid fraction (4) is recovered. Further, the invention relates to the liquid fraction and the solid fraction and their use.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: June 29, 2021
    Assignee: UPM-KYMMENE CORPORATION
    Inventors: Juha Tamper, Sami Turunen
  • Patent number: 11034923
    Abstract: A corn-to-ethanol production process is disclosed. The process includes the steps of dry-milling corn kernels to form a corn flour; combining the corn flour with water to form a mash; extracting corn oil from the mash; fermenting the mash thereby producing beer and carbon dioxide; distilling the beer to produce ethanol and whole stillage; and processing the whole stillage to produce wet distiller's grains with solubles (WDGS) and/or dried distiller's grains with solubles (DDGS). The step of extracting corn oil from the mash includes the sub steps of: optionally wet-milling the mash; separating the mash to produce a light phase and a heavy phase; adding an alkanesulfonic acid to the light phase; extracting corn oil from the light phase; and combining the light phase having the corn oil extracted therefrom with the heavy phase to reform the mash.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: June 15, 2021
    Assignee: BASF SE
    Inventors: Kenneth L. Zack, Joseph P. Borst, Anthony Newton
  • Patent number: 11034992
    Abstract: Disclosed herein are methods, assays, compositions and kits for the detection and measurement of UDPglucose in biological samples. The methods, assays, compositions and kits are suitable for use with equipment that is readily available in a clinical laboratory, and permit rapid and reproducible detection and measurement of UDP-glucose at physiologically relevant levels in biological samples.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: June 15, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Sylvie Breton, Rachel Liberman, Leileata M. Russo
  • Patent number: 11028425
    Abstract: Methods and compositions for screening or diagnosis of liver disease are provided. The results may also indicate course and efficacy of treatment. The composition includes an activity sensor and a reporter releasably attached to the activity sensor. The method includes detecting the presence and/or amount of a reporter. The reporter is released from an activity sensor in the presence of diseased liver tissue but remains attached to the activity sensor in healthy tissue. The presence and/or amount of the reporter are used to characterize the liver disease. The liver disease may be nonalcoholic steatohepatitis (NASH) and results may further indicate staging of NASH.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: June 8, 2021
    Assignee: GLYMPSE BIO, INC.
    Inventors: Sangeeta Bhatia, Gabriel Kwong, Eric Huang, Sirshendu Roopom Banerjee, Andrew Warren, Sophie Cazanave
  • Patent number: 10995318
    Abstract: Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: May 4, 2021
    Assignee: Ossium Health, Inc.
    Inventors: Erik John Woods, Brian H. Johnstone, Dongsheng Gu, Aubrey Marie Sherry, Kelsey Gwen Musall, John R. Woods, James Hardin, Alan Hooks
  • Patent number: 10993969
    Abstract: This document provides methods and materials for treating nerve injuries and/or neurological disorders. For example, compositions including an amnion tissue preparation and/or a stem cell preparation as well as methods for using such compositions to treat a nerve injuries and/or neurological disorders are provided.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: May 4, 2021
    Inventor: Gary M. Petrucci
  • Patent number: 10982254
    Abstract: The present invention relates, in part, to methods and kits for rapidly determining antimicrobial susceptibility of microorganisms.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: April 20, 2021
    Assignee: SeLux Diagnostics, Inc.
    Inventors: Eric Stern, Aleksandar Vacic, Benjamin Spears, Alec Flyer, Kelly Flentie
  • Patent number: 10982185
    Abstract: Novel strains of Pseudomonas fluorescens are disclosed. Several novel mutated strains of Pseudomonads are engineered by repetitive culturing of a parent strain under stressed conditions. Various enriched populations are screened and ranked based on relative performance indices including viable cell yield during growth, efficacy in suppression of dry rot disease, cell growth recovery after dry storage and resistance to switchgrass hydrolysate.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: April 20, 2021
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Patricia J. Slininger, David A. Schisler, Maureen A. Shea Andersh
  • Patent number: 10982252
    Abstract: Bacterial systems for analyzing ubiquitination of proteins is disclosed herein. Kits for analyzing the ubiquitination and methods for carrying out the analysis are also disclosed.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: April 20, 2021
    Assignee: Technology Innovation Momentum Fund (Israel) Limited Partnership
    Inventor: Gali Prag
  • Patent number: 10974026
    Abstract: Tissue transfer devices suitable for transfer of tissues include a cannula, a plurality of tissue separating members outwardly extendable from the cannula, a tissue reservoir disposed in fluid communication with the cannula and a pump disposed in fluid communication with the tissue reservoir.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: April 13, 2021
    Assignee: Surgistem Technologies LLC
    Inventor: Simeon Wall, Jr.
  • Patent number: 10968470
    Abstract: The application provides a method for preparing rubusoside comprising steps of raw material crushing, flash extraction, double centrifugations, macroporous resin purification, desorption, enzymatic hydrolysis, organic film decoloring, concentration, crystallization and drying. The application optimizes the quality control of key process such as extraction, separation, purification and decolorization, and can obtain the rubusoside product with purity more than 99%, and the product is white, no bitterness, less solvent residue, no pesticide residue, and stable quality.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: April 6, 2021
    Assignee: Guilin Layn Natural Ingredients Corp.
    Inventors: Jun Zhao, Yunfei Song, Wenguo Yang, Linfeng Zhang, Meiying Yang, Yuyu Li
  • Patent number: 10968466
    Abstract: The present invention relates to a process for preparing aminobenzoic acid or an aminobenzoic acid conversion product, comprising the steps of: (I) providing an aqueous solution of aminobenzoic acid using a fermentation process; (II) adsorbing aminobenzoic acid; (III) desorbing aminobenzoic acid at a pH in the range from ?0.8 to 3.0, preferably ?0.5 to 3.0, more preferably 0.1 to 3.0, very preferably 0.5 to 2.5, very exceptionally preferably 1.0 to 2.0; (IV) obtaining the aminobenzoic acid from the desorbate obtained in step (III); (V) optionally further converting the aminobenzoic acid obtained in step (IV) to an aminobenzoic acid conversion product.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: April 6, 2021
    Assignee: Covestro Deutschland AG
    Inventors: Gernot Jäger, Ivonne Görtz, Giulio Lolli, Amgad Salah Moussa, Thomas Hamedinger
  • Patent number: 10960033
    Abstract: The present invention relates to the use of at least one lactic acid bacterium, or a composition comprising thereof or conditioned thereby, for increasing or maintaining a Faecalibacterium prausnitzii population.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: March 30, 2021
    Assignee: COMPAGNIE GERVAIS DANONE
    Inventors: Muriel Derrien, Mathilde Lebas, Peggy Garault
  • Patent number: 10961497
    Abstract: A method for concentrating, in order to favour the subsequent extraction process of intracellular lipids, a cell suspension containing a biomass of oleaginous yeasts fermented in fermentation broth under conditions that allow the intracellular accumulation of lipids, where the biomass contains significant quantities of mucilaginous material. The method includes: a) cultivating the oleaginous yeasts in a fermentation broth to obtain a cell suspension containing the mucilaginous biomass; b) subjecting the cell suspension obtained from a) to heat treatment, at a temperature between 95° C. and 120° C. and to acid treatment, to obtain a treated cell suspension containing the mucilaginous biomass containing intact oleaginous yeast cells; and c) concentrating the treated cell suspension obtained from b), by removing at least part of the fermentation broth to obtain a concentrated cell suspension.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: March 30, 2021
    Assignee: ENI S.p.A.
    Inventors: Rossella Bortolo, Daniele Bianchi, Mario Baldassarre
  • Patent number: 10962453
    Abstract: A signal of fluorescence emitted from a fluorescent particle of a pathological specimen can be increased in sensitivity and be stabilized, thereby resulting in an enhancement in retrieval accuracy of information from a fluorescence image. A pathological specimen including a tissue section subjected to a treatment (immunostaining/FISH staining treatment) for fluorescence-labeling of an objective biomaterial with a fluorescent particle observable in a dark field, based on an immunostaining or FISH method; a packed layer with which the tissue section is covered; and a protection layer with which the packed layer is covered; wherein the refractive indexes of the fluorescent particle, the packed layer and the protection layer (measurement wavelength: 589 nm; measurement temperature: 20° C.; in all) satisfy the conditions of Expressions (1) and (2): |n1?n2|?0.20??Expression (1) |n2?n3|?0.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: March 30, 2021
    Assignee: Konica Minolta, Inc.
    Inventor: Yasuhiro Watanabe
  • Patent number: 10961464
    Abstract: A process for producing BTX and alcohols from biomass, comprising at least a) catalytic pyrolysis of said biomass in a fluidized-bed reactor producing a gaseous pyrolysis effluent; b) separation of said gaseous pyrolysis effluent into at least one BTX fraction and a gaseous effluent comprising at least carbon monoxide and carbon dioxide, c) recycling at least part of said gaseous effluent comprising at least carbon monoxide and carbon dioxide into the reactor of said step a), d) purging said gaseous effluent recycled according to step c) to produce a purge effluent, e) sending at least part of said purge effluent from step d) into a fermentation step producing a liquid fermentation stream comprising at least one stream comprising at least one oxygenated compound chosen from alcohols, diols, acid alcohols, carboxylic acids, aldehydes, ketones and esters, alone or as a mixture.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: March 30, 2021
    Assignee: IFP Energies nouvelles
    Inventors: Frederic Feugnet, Nicolas Lopes Ferreira, Slavik Kasztelan
  • Patent number: 10947496
    Abstract: A molding system for forming an inoculated lignocellulose based medium into a fungal molded shape, the molding system comprising a vessel within which environmental conditions are regulated, the vessel comprising an inoculated lignocellulose based medium capable of supporting growth of saprophytic fungi without any secondary organisms displacing the process through infection a secondary organic material layered near the top and bottom of the inoculated lignocellulose based medium, a hard mold containing the flexible vessel; and a compressive system for applying a primary compressive pressure of at least 10 PSI to the lignocellulose based medium such that it takes on a fungal molded shape.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: March 16, 2021
    Assignee: MycoWorks, Inc.
    Inventor: Philip Ross