Abstract: A unit dosage form, such as a capsule or the like for delivering drugs into the body in a circadian release fashion, is comprising of one or more populations of propranolol-containing particles (beads, pellets, granules, etc.). Each bead population exhibits a pre-designed rapid or sustained release profile with or without a predetermined lag time of 3 to 5 hours. Such a circadian rhythm release cardiovascular drug delivery system is designed to provide a plasma concentration—time profile, which varies according to physiological need during the day, i.e., mimicking the circadian rhythm and severity/manifestation of a cardiovascular disease, predicted based on pharmaco-kinetic and pharmaco-dynamic considerations and in vitro/in vivo correlations.
Type:
Grant
Filed:
October 4, 2001
Date of Patent:
December 31, 2002
Assignee:
Eurand Pharmaceuticals Ltd.
Inventors:
Phillip J. Percel, Krishna S. Vishnupad, Gopi M. Venkatesh
Abstract: The present invention relates to a dietary supplement for the treatment of migraine headache. An extract of the feverfew plant containing parthenolide in combination with magnesium, with or without riboflavin, provided significant reduction of migraine headaches and the associated symptoms. The magnesium is present as a combination of magnesium oxide and a magnesium salt of an organic acid.
Abstract: Biocompatible hydrogels, for: scaffoldings for tissue engineering; cell encapsulation matrices; injectable bulking materials for cosmetic and functional restorations; controlled release matrices; gene delivery vehicles; immunoprotection matrices; immobilization materials; food additives; medical gels; conductive electrode gels; lubricious coatings; film forming creams; membranes; superabsorbents; hydrophilic coatings; and wound dressings. The hydrogels include: at least one water-soluble polymer/copolymer; and at least one slow and/or fast dissolving and/or releasing divalent and/or multivalent cation-containing compound. At least one of the monomers is an acid, and/or contains an acid group or a derivative thereof. Such monomer reacts with the cations to form a three-dimensional ionically crosslinked hydrogel composition.
Type:
Grant
Filed:
December 1, 1999
Date of Patent:
December 24, 2002
Assignee:
The Regents of the University of Michigan
Abstract: Polymeric micelles for encapsulation of hydrophobic molecules are provided. Methods and formulations for delivering hydrophobic molecules to a host via these micelles are also provided. Methods of stabilizing liposomes or lipid based formulations by addition of polymeric micelles are also provided.
Type:
Grant
Filed:
October 9, 2001
Date of Patent:
December 24, 2002
Assignee:
Rutgers, The State University of New Jersey
Abstract: The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that exhibit superior cohesive strength and in many instances can serve as adequate replacements for surgical means of attaching tissues, such as sutures and medical staples.
Type:
Grant
Filed:
August 28, 2000
Date of Patent:
December 17, 2002
Assignee:
Cohesion Technologies, Inc.
Inventors:
Donald G. Wallace, George H. Chu, Jacqueline Anne Schroeder
Abstract: A controlled release antihyperglycemic tablet that does not contain an expanding polymer and comprising a core containing the antihyperglycemic drug, a semipermeable membrane coating the core and at least one passageway in the membrane.
Type:
Grant
Filed:
November 1, 2001
Date of Patent:
December 17, 2002
Assignee:
Andrx Pharmaceuticals, Inc.
Inventors:
Xiu Xiu Cheng, Chih-Ming Chen, Steve Jan, Joseph Chou
Abstract: Provided are methods of inhibiting bile acid uptake from the gastrointestinal system and reducing blood serum cholesterol by administering to a mammal, such as a human, an effective amount of particles comprising amphiphilic copolymers, having a crosslinked shell domain and an interior core domain.
Type:
Grant
Filed:
June 27, 1997
Date of Patent:
December 10, 2002
Assignee:
Washington University
Inventors:
Denis Forster, Gary S. Jacob, James M. Warner
Abstract: A controlled release pharmaceutical formulation is disclosed. The formulation comprises a construct having a matrix of a material selected from the group comprising (a) a high melting point fatty acid ester, (b) an oil, (c) a polymeric cellulose derivative and (d) a mixture of any of the foregoing. Associated with the matrix is a selected medicament. Preferably, the matrix comprises at least two of the aforementioned materials or components.
Abstract: A vitamin K adduct, particularly suitable as vitamin supplement for feeds, constitued by menadione bisulfite bonded with an appropriate ion-exchange resin and exceptionally stabilized thereby. The adduct can be used as an antihemorrhagic additive for farm animal feeds. The high thermal stability of the vitamin adduct allows to use it in modern technologies for producing feeds in extruded form.
Abstract: A scleral plug which releases a drug accurately in a specified amount. The scleral plug is formed from a blend of a high-molecular weight polylactic acid having a molecular weight of 40,000 or higher and a low-molecular weight polylactic acid having a molecular weight of 40,000 or lower, and contains a drug for treating or preventing a vitreoretinal disease. The high-molecular weight polylactic acid and the low-molecular weight polylactic acid are in a blending ratio of preferably 90/10 to 50/50, more preferably 90/10 to 70/30, and most preferably 80/20. The molecular weight of the high-molecular weight polylactic acid is preferably 40,000 to 200,000. The molecular weight of the low-molecular weight polylactic acid is preferably 3,000 to 40,000, and more preferably 5,000 to 20,000. The drug is, for example, an antiulcer agent, an antiviral agent, an anti-inflammatory agent, an antifungal agent or an antimicrobial.
Type:
Grant
Filed:
December 30, 1999
Date of Patent:
December 3, 2002
Assignee:
Santen Pharmaceutical Co., Ltd.
Inventors:
Yuichiro Ogura, Noriyuki Kunou, Atsutoshi Ota
Abstract: A composition and method for making a silicone composition is provided which comprises at least one polysiloxane or silicone resin, at least one linker, and at least one molecular hook wherein the molecular hook comprises a heterocyclic trimethylpyrimidinium compound.
Type:
Grant
Filed:
July 14, 2000
Date of Patent:
December 3, 2002
Assignee:
General Electric Company
Inventors:
Matthew David Butts, Susan Adams Nye, Christopher Michael Byrne, Alan Roy Katritzky, Jon Walter Merkert
Abstract: Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are provided. Also provided are methods of producing polymeric drug delivery systems via these polyanhydride linkers as well as methods of administering low molecular weight drugs to a host via the polymeric drug delivery systems.
Type:
Grant
Filed:
July 27, 2000
Date of Patent:
November 26, 2002
Assignee:
Rutgers, The State University of New Jersey
Abstract: The present invention relates to antimicrobial compositions including pharmaceutical compositions and treatment regimens for preventing or treating a microbial infection in a mammal, such as a human, by administering to the mammal, a therapeutically effective amount of a polymer and a therapeutically effective amount of an antibacterial agent.
Abstract: There is provided according to the present invention a process for preparing crystalline particles, especially particles of a pharmaceutical or carrier substance suitable for inhalation therapy, in addition to apparatus for the preparation of such particles.
Type:
Grant
Filed:
July 7, 1999
Date of Patent:
November 19, 2002
Assignee:
SmithKline Beecham Corporation
Inventors:
Hardev Singh, Andrew Theophilus, Robert William Lancaster
Abstract: A liquid composition for oral administration comprising a pharmaceutically active medicament coated with a taste masking effective amount of a polymer blend of (a) dimethylaminoethyl methacrylate and neutral methacrylic acid ester (MM/MAE) and (b) a cellulose ester, in an aqueous vehicle, wherein the polymer weight ratio of the cellulose ester to the MM/MAE is about 40:60 to about 90:10, preferably about 60:40. The liquid composition utilizes a “reverse enteric coating” which is soluble in the acid pH's of the stomach, generally about 1.0 to 4.0, but relatively insoluble at the non-acidic pH's of the mouth. The coatings provide for rapid release and absorption of the drug, which is generally desirable in the case of liquid dosage forms.
Abstract: The invention provides a pretreatment method and primer that is applied directly to the hard tissue. The invention has particular utility for adhering to or coating sclerotic dentin and cervical enamel or for adhering to or coating hard tissue in a high humidity environment. The primer enables formation of extremely strong bonds to dentin. The method comprises the steps of:
(a) applying to the hard tissue adhesively effective amounts of an acid and a water-dispersible film former comprising a polymer and
(b) hardening the film former.
Primer compositions are provided for use in this method, comprising a mixture of an acid and a film former comprising a polymer prior to hardening, the mixture being in the form of a film atop the hard tissue.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
November 19, 2002
Assignee:
3M Innovative Properties Company
Inventors:
Steven M. Aasen, F. Andrew Ubel, III, Joel D. Oxman, Sumita B. Mitra, Jon W. Fundingsland
Abstract: A method for producing a sustained-release preparation, which comprises dispersing a physiologically active polypeptide into an organic solvent solution of a biodegradable polymer and removing the organic solvent, wherein the polypeptide is a powder obtained by lyophilizing an aqueous solution of the polypeptide which solution has a water-miscible organic solvent and/or a volatile salt; which improves the ease of handling of the physiologically active polypeptide powder in the process for producing the preparation; which makes it possible to industrially produce the sustained-release preparation in large scale; which provides a sustained-release preparation showing high and stable concentration of the active component in blood in long term, low initial release ratio of the physiologically active polypeptide, and high entrapment ratio of the polypeptide into the sustained-release preparation.
Abstract: A composition containing nicotine and an uncrosslinked, water-insoluble vinylpyrrolidone copolymer is applied on the skin of patients in the form of a gel, ointment, solution, suspension or film which slowly releases nicotine and creates levels of the drug in the blood to reduce nicotine-craving in smokers, thereby assisting in smoking-cessation programs.
Abstract: The present invention relates to an antibacterial aqueous solution comprising a complex of an anionic surfactant, a polycationic antibacterial agent and water.