Abstract: The present disclosure provides oral, chewable dosage forms that are suitable for delivery of one or more active ingredients to a consumer, particularly a human individual. The dosage forms can be configured as multicomponent compositions formed of: a first component including a gummy composition; a second component that is a particulate material or is a pre-formed solid unit or plurality of pre-formed solid units; and an active ingredient. The second component can be, for example, in the form of a pharmaceutically acceptable oral dosage unit, such as a tablet, a caplet, a soft shell capsule, a hard shell capsule, a microcapsule, or a pastille.

Abstract: There is provided a solid pharmaceutical composition for delivering by oral administration a pharmaceutically active binding polypeptide to a region of the intestinal tract comprising a compressed core, wherein the compressed core comprises a pharmaceutically active binding polypeptide and wherein the compressed core is coated with a pH sensitive enteric coating.

Abstract: The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.

Abstract: Cold atmospheric plasma is an emerging technology in the treatment of cancer. Meanwhile, different types of self-organized pattern (SOP) phenomenon have been reported in a wide of range of plasmas. In this paper, we describe the application of SOP plasma to two breast cancer cells MDA-MB-231 and MCF-7. Specifically, the effect of SOP plasma on reactive oxygen and nitrogen species (RONS) were investigated. SOP plasma-generated RONS displayed significantly decreased cancer cell viability in both breast cancer cell lines; significantly inhibiting cell proliferation via while inducing apoptosis. SOP plasma induced DNA damage, activating the ATM/ATR kinase signaling cascade. ATR phosphorylates the checkpoint effector kinase Chk-1 activating ?-H2AX resulting in cell cycle arrest and ATM induced apoptosis.

Abstract: Various embodiments of modified-release multiparticulates (in bead or granule from) are described. The modified-release multiparticulates can comprise a core including a pharmaceutical and/or probiotic agent, optionally with additional excipients or binders to aid in creation of the core, one or more functional coatings disposed on the core and configured to provide a modified-release profile of the pharmaceutical and/or probiotic agent when given orally, and a coating of hypromellose acetate succinate (HPMCAS) disposed on the one or more functional coatings and configured to impart multiparticulate stability in aqueous acidic media. Suspensions including the modified-release multiparticulates are also described.

Abstract: The present disclosure relates to pharmaceutical formulations of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid and methods of use thereof.

Abstract: A method for manufacturing plasma-activated saline for treatment of cancer cells. The method comprises the steps of immersing a cathode in saline solution in a container, positioning an anode at a fixed distance from a surface of said saline solution in said container and applying electrical energy to said anode for a fixed period of time, wherein said fixed distance and said fixed period of time are selected to cause a plasma self-organized pattern at a surface of said saline solution with an atmospheric discharge between said anode and said cathode.

Abstract: A glycerin-in-oil deodorant composition is disclosed that contains a continuous phase comprising one or more oils, silicones, esters and/or waxes; a discontinuous phase comprising glycerin and water; an antimicrobial agent; a moisture-absorption agent; an odor neutralizing agent; and an emulsifier.

Abstract: The present invention includes acidifying film coating compositions containing a polymer and an acidic component for use on orally-ingestible substrates such as tablets and the like. The acidifying coating compositions can be applied as an aqueous dispersion to an enteric-coated substrate to increase the disintegration resistance to aqueous media of up to pH 5.0. In preferred aspects, the acidic component is citric acid, lactic acid, stearic acid or mixtures thereof. Methods of preparing the dry film coatings, methods of preparing corresponding aqueous dispersions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.

Abstract: The present invention provides a water-soluble or water-dispersible polymers. The water -soluble or water-dispersible polymer comprise a first monomer having hydrogen bonding/complexing properties to polyphenols, a second monomer having detergent properties, and a third monomer having hydrogen bonding/complexing properties to polyphenols, wherein the first monomer and the third monomer are the same or different. The present invention also provides oral care compositions comprising the water-soluble or water-dispersible polymers. The present invention also provides methods of cleaning, Whitening arid polishing natural teeth and dental prosthesis and of preventing, reducing or removing surface deposited stains from teeth by administering the oral care compositions. The water-soluble or water-dispersible polymer has a structure: wherein x, y, z, mole %, n, R1, and R2 are defined herein.

Abstract: Provided is a beauty care pack including a release film and a beauty care sheet which is separably attached to the release film, wherein the beauty care sheet comprises: a support; a fiber layer which is laminated on the support and in which water-soluble polymers are formed in the form of a nanofiber web; a moisturizing layer which is laminated on the fiber layer and consists of the water-soluble polymers and moisturizing materials; and a beauty care layer which is laminated on the moisturizing layer and in which the water-soluble polymers and functional materials are formed in the form of a nanofiber web, such that active ingredients are absorbed into the skin while being dissolved by moisture.

Abstract: The invention describes one or more compositions for causing an increase in thermogenesis in mammals, comprising at least caffeine, hordenine and ?-phenylethylamine and optionally the addition of B vitamins. The caffeine is often provided from green coffee bean extracts and normally comprises from 0.0001 g to 0.30 g of caffeine from 0.00001 g to 0.1 g of hordenine from barley and from 0.00001 g to 1.0 g ?-phenylethylamine from cocoa beans. The present invention finally provides a method that may cause a simultaneous and synergistic increase in central nervous system activity assisted by the addition of vitamin B as well as thermogenesis in mammals prior to physical exercise, the method comprising providing a composition comprising a source of caffeine, hordenine and ?-phenylethylamine.

Abstract: The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.

Abstract: In some embodiments, a composition and/or method may include a rodenticide binding system formulated for safe and effective mixture into various feed rations which are fed to monogastric and ruminant animals such as poultry, swine, cows, cattle, and fish, among others. The rodenticide binding system includes novel combinations of one or more of an organoclay, an activated hydrated sodium calcium aluminosilicate clay, and a synthetic hectorite clay. In some embodiments, the binding composition may include organoclay, bentonite, hectorite, Leonardite, and/or any combination thereof. The toxin binding complex may effectively bind some pesticides (e.g., rodenticides) in the animal's digestive system, preventing their absorption and the consequent damages to the animal.

Abstract: The invention relates to a process for the preparation of a product comprising one or more nanoparticles of calcium phosphate (CaP-NP) with negative surface charge having a ?-potential in the range from ?41.0 mV to ?27.0 mV comprising the steps of: a) maintaining a mixture having a pH in the range from 7 to 10 and comprising an aqueous solution of calcium, an aqueous solution of phosphate and a solution of citrate ions at a temperature in the range from 20° C. to 40° C. for a time in the range from 30 seconds to 10 minutes; b) removing non-reacted ions from the solution of step a), thus obtaining a suspension of one or more nanoparticles of calcium phosphate (CaP-NP); c) recovering the product of one or more nanoparticles of calcium phosphate (CaP-NP) from the suspension of step b). In an advantageous embodiment, the process of the invention provides, in the mixture of step a), also an aqueous solution of one or more therapeutic/diagnostic compounds.

Abstract: Mesoporous oxide nanoparticles, compositions comprising such nanoparticle, and methods of making and using such nanoparticles. The nanoparticles (e.g., compositions comprising the nanoparticles) have an average size of less than 15 nm and a narrow size distribution. The nanoparticles can be used in imaging applications and delivery of molecular cargo (e.g., a drug) to an individual.

Abstract: Provided is an aqueous gelling agent composition, including: compound (A) represented by the general formula (1); and compound (B) represented by the general formula (2), wherein a mass ratio of compound (A) to compound (B), (A): (B), is from 95:5 to 85:15: where R1, R2, R8, R9, R10, R11, R15, and R16 each independently represent a hydrocarbon group having 4 to 20 carbon atoms, R3, R5, R7, R12, and R14 each independently represent a divalent hydrocarbon group having 2 to 4 carbon atoms, R4, R6, and R13 each independently represent a divalent hydrocarbon group having 3 to 16 carbon atoms, a, e, j, and m each independently represent a number of 10 to 100, d represents a number of 100 to 500, and g represents a number of 1 to 10.

Abstract: A method of treating the skin or hair on a dog containing an effective amount of an ectoparasiticide previously applied to the skin or hair, comprising applying a quantity of a cleansing composition directly to the skin or hair, wherein the treatment does not result in reducing the efficacy of the ectoparasiticide against adult fleas (C. felis) or adult ticks (R. sanguineus) below 90% efficacy for at least a month after application of the ectoparasiticide; wherein the cleansing composition comprises about 1-3% glycerin; about 2-4% silicone copolyol esters, water and is essentially free of surfactant.

Abstract: Composites comprising a metal carbonate and organic agent included within a crystal lattice of the metal carbonate are disclosed. Process of preparing the composites is also disclosed. Uses of the composites, in medicine, are also disclosed.

Abstract: Antibacterial compositions comprising at least one unsaturated fatty acid or a pharmaceutically acceptable salt thereof; at least one alpha-hydroxy acid or a pharmaceutically acceptable salt thereof; and at least one amino alcohol. The compositions have broad-spectrum antibacterial activity, including on pathogens displaying multi-drug resistance.