Abstract: An object of the present invention is to provide a composition which is excellent in plant disease control effect without causing significant injury to the plants. A liquid composition comprising mefentrifluconazole, a Nonionic Surfactant (NIS), and water, wherein the weight ratio of mefentrifluconazole to the NIS is in the range of 1:0.1 to 1:10.
Abstract: The present invention relates to a disintegrant free pharmaceutical composition comprising apremilast or pharmaceutically acceptable salts thereof and one or more pharmaceutically acceptable excipients. Particularly the present invention relates to disintegrant free immediate release dosage form comprising apremilast or pharmaceutically acceptable salts thereof and one or more pharmaceutically acceptable excipients. It further relates to process of preparing such composition and its use in psoriatic arthritis and psoriasis.
Abstract: This disclosure relates to treatments for reducing the side effects associated with treatment of a medication or drug, such as a chemotherapy medication, being experienced by a patient. This may be accomplished by administering to a patient taking the medication, a buffered aqueous liquid having a pH of about 10 to about 11.5, wherein the buffered aqueous liquid comprises sodium bicarbonate, sodium carbonate, and trisodium phosphate.
Abstract: Compositions and methods for the treatment of vasospasm are provided comprising applying an amount of a semi-solid vasoactive prostaglandin composition to the affected tissue. Also provided are methods of improving microcirculation in a replanted body part.
Type:
Grant
Filed:
March 30, 2018
Date of Patent:
February 15, 2022
Assignee:
NEXMED HOLDINGS, INC.
Inventors:
Tian Wen, Liu Liu, Mingqi Lu, Jieshan Bai, Y. Joseph Mo
Abstract: Compositions and methods for combination therapy are provided. The compositions comprise a multiple unit dosage form having both a therapeutic agent and a nutritional supplement. The combination therapy is useful for restoring a nutrient depletion associated with a particular disease state. Additionally, the combination therapy can prevent or attenuate the depletion of a nutrient caused, in whole or in part, by the co-administrated therapeutic drug. Methods of manufacturing the formulations are likewise described.
Abstract: Provided are a hydrogel composition with high viscoelasticity and a bioink composition including the hydrogel composition. The hydrogel composition according to an embodiment is composed of natural biocompatible substances and thus is not toxic, but has high viscosity, resulting in high mechanical stability or long persistence. Thus, the hydrogel composition may be usefully utilized as a bioink composition for bioprinting, a support in tissue engineering, or a soft tissue filler.
Type:
Grant
Filed:
October 19, 2018
Date of Patent:
February 8, 2022
Assignee:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Sang Heon Kim, Joo Young Lee, Seung Ja Oh
Abstract: The present invention relates to a pharmaceutical combination comprising a CDK inhibitor and at least one antioxidant enzyme inhibitor for use in the treatment of cancer. The present invention also relates to a method for the treatment of cancer comprising administering to a subject in need thereof, a therapeutically effective amount of a CDK inhibitor and a therapeutically effective amount of at least one antioxidant enzyme inhibitor. The pharmaceutical combination of the present invention exhibits synergistic effect when used in the treatment of cancer.
Abstract: The application describes a cosmetic agent for temporarily reshaping keratin fibres, in particular human hair, comprising a film former and a cosmetic carrier, wherein the film former comprises at least one neutralization product of chitosan with at least one organic acid and at least one non-ionic propylene oxide-modified starch, which cosmetic agent is also substantially free of a fully synthetic film former.
Type:
Grant
Filed:
December 14, 2018
Date of Patent:
February 1, 2022
Assignee:
HENKEL AG & CO. KGAA
Inventors:
Thorsten Knappe, Marie Meisel, Laura Meunier
Abstract: The present invention relates to oral solid dosage forms comprising a plasma kallikrein inhibitor, in particular a solid form (Form 1) of the compound of Formula A. Also provided are methods of preparing oral solid dosage forms comprising the compound of Formula A using Form 1 of the compound of Formula A.
Type:
Grant
Filed:
November 28, 2018
Date of Patent:
February 1, 2022
Assignee:
KalVista Pharmaceuticals Limited
Inventors:
John Herman Collett, Gary Paul Cook, Jamie Joseph Farrar, Michael John Frodsham, Michael Bryan Roe, Richard Simon Todd, Robert Neil Ward
Abstract: In some embodiments, the present invention provides methods for making resorbable ear tubes including the steps of providing a silk fibroin solution, and forming a silk ear tube from the silk fibroin solution, wherein the silk ear tube is less than 2 mm in length and has an outer diameter of less than 1.5 mm, and wherein the silk ear tube is resorbable. In some embodiments, the present invention also provides methods for treating otitis media including the step of introducing a silk ear tube into the ear canal of a subject, wherein the silk ear tube is less than 2 mm in length and has an outer diameter of less than 1.5 mm, and wherein the silk ear tube is resorbed by the subject.
Type:
Grant
Filed:
April 1, 2021
Date of Patent:
January 25, 2022
Assignees:
Tufts University, Massachusetts Eye and Ear Infirmary, The General Hospital Corporation
Inventors:
David Kaplan, Michael Whalen, Christopher Hartnick
Abstract: This invention relates to an antimicrobial cleansing composition, especially one which provides synergistic anti-dandruff efficacy. This is achieved through a judicious combination of anti-dandruff agent zinc pyrithione and thymol in a composition comprising synthetic anionic surfactant.
Abstract: Provided are formulations and related methods, for coating or impregnating a medical device, as well as a coated or impregnated medical device, for example, a device that is a catheter or cannula, where a different formulation may be used for interior surface of device and for exterior surface of the device.
Type:
Grant
Filed:
February 10, 2020
Date of Patent:
January 11, 2022
Assignee:
ARROW INTERNATIONAL LLC
Inventors:
Kamma Giare-Patel, Nisha Gupta, Greg Etter, Kevin Sechrist, Molly Stewart, Igor Tentler, Al Williams
Abstract: The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
Abstract: Aqueous compositions and methods using the compositions for preventing or minimizing live body weight loss in livestock animals subjected to a prolonged period of feed deprivation, e.g., such as during the period before slaughter or during a period surrounding transportation from one location to another location (e.g., before, during and/or after), and/or for minimizing carcass weight loss or carcass yield loss, and/or meat quality deterioration and/or for preventing or minimizing deterioration of the well-being or health of livestock animals subjected to a prolonged period of feed deprivation, e.g., such as during the period before slaughter or during a period surrounding transportation from one location to another location (e.g., before, during and/or after).
Type:
Grant
Filed:
June 7, 2017
Date of Patent:
December 28, 2021
Assignee:
Nutreco Nederland B.V.
Inventors:
Javier Martin-Tereso Lopez, Isabela Pena Carvalho De Carvalho
Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.
Type:
Grant
Filed:
November 1, 2019
Date of Patent:
December 28, 2021
Assignee:
206 ORTHO, INC.
Inventors:
Jeffrey A. D'Agostino, Robert S. Whitehouse, Arthur Watterson, Werner Blank, Charles Hegedus, Sandip Agarwal, Elizabeth Nelson
Abstract: In one embodiment, the present invention provides a personal care composition, comprising: (i) a compound of Formula (1) at a concentration from 0.0001 wt % to 20 wt % of the composition; wherein R is selected from the group consisting of C15-C23 conjugated dienes, C15-C23 hydroxylated mono unsaturated alkenes, and C15-C23 hydroxylated alkanes; wherein R1 is selected from the group consisting of H, C1-C4 alkyl, —CH2OH, —CH2(CH3)—OH, —[CH2]4—NH2, —CH2—CO2H, —[CH2]2—CO2H, wherein R3 is —CO2H; —CH2CO2H; —CH2CH2CO2H; and (ii) a cosmetically acceptable carrier.
Abstract: An aqueous formulation for treating insects and fungal diseases on plants includes effective amounts of an HOCl-containing electrolyzed oxygenated aqueous solution, one or both of a food grade diatomaceous earth and a clinoptilolite zeolite, and one or more of a sodium magnesium fluorosilicate and a bentonite clay. The formulation, which is non-toxic to humans and pets, can be sprayed on the plants to kill insects and fungi and has a long dwell time to improve the effectiveness of the components of the formulation against insects and fungi. In particular, the formulation will kill bacteria, virus, mold, fungi, and may be used on food crops. The formulation also may be used as a plant and foliar cleaner and/or the formulation can be used to treat skin of a person to improve skin health.
Abstract: A pharmaceutical composition for treating infertility in a female subject substantially consists of local anesthetic of amide type such as lidocaine, human albumin, viscosity controlling agent selected from recombinant hyaluronic acid and combination of recombinant hyaluronic acid and water-soluble cellulose ether, optionally citrate, glucose, and/or amino acid, water optionally comprising one or more ions selected from the group consisting of sodium, potassium, magnesium, calcium, acetate, chloride, sulfate. Also disclosed is a method of treating infertility by administration of the composition to a female subject in need thereof.
Abstract: Cosmetic compositions capable of forming a multilayer structure after application to a keratinous material are provided, as well as methods of applying such compositions to a keratinous material. Certain cosmetic compositions comprises at least two immiscible components: Component A which comprises about 0.01% to 60% by weight with respect to the total weight of the composition of at least one silicone-containing film forming agent having at least one glass transition temperature which is lower than normal human body temperature; and Component B which comprises about 0.01% to 90% by weight with respect to the total weight of the composition of one or more silicone compounds in amounts sufficient to achieve a viscosity of about 1,000 cSt to 10,000,000 cSt, wherein the weight ratio of silicone-containing film forming agent(s) in Component A to silicone compound(s) in Component B is from about 1:50 to 50:1.