Abstract: Disclosed herein are a novel polymer, a thermosensitive carrier prepared using the same and use thereof. The novel polymer is essentially composed of a PEO-PPO-PEO block copolymer and silane.
Type:
Grant
Filed:
September 19, 2016
Date of Patent:
October 2, 2018
Assignee:
INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.
Abstract: The invention relates to a method for ionic gelation on solids for encapsulating water-insoluble solids. The method uses negatively charged macromolecules and soluble salts of polyvalent cations as shell-forming materials having a high adsorption on the surface of the solid when subjected to thermal treatment. The shell-forming material represents at least 10% of the weight of the dry microcapsule obtained. The obtained microcapsule can be redispersed in water and treated by altering the environment thereof in order to be used as an encapsulating medium for water-soluble compounds and they can also be used as active ingredients and/or excipients in the production of pharmaceutical or nutraceutical compositions.
Abstract: Methods and compositions regarding nested nanoparticles comprising polymer nanoparticles encased in a cyclodextrin shell to facilitate sequence-specific drug release.
Type:
Grant
Filed:
May 2, 2016
Date of Patent:
September 18, 2018
Assignee:
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Abstract: The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
Abstract: The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
Abstract: A method is provided which provides shine to hair comprising spraying a leave-on composition to hair with a particle size in the range of from about 0.01 ?m to about 10 ?m, wherein the resulting film at the dried hair is in the range of from about 100 nm to about 500 nm and more than 25% of the hair fibers are covered. The oil-in water polysiloxane emulsion shows a viscosity of less than 7 Pa*s and a pH value from about 4 to about 8. The emulsion comprises about 0.1% to about 10% by weight of a non-volatile polysiloxane fluid and from about 0.003% to about 0.6% by weight of a rheology modifier, wherein less than 0.015 g of the non-volatile polysiloxane fluid are applied per gram hair.
Type:
Grant
Filed:
October 28, 2016
Date of Patent:
September 11, 2018
Assignee:
The Procter & Gamble Company
Inventors:
Michael Lee Vatter, Kelly Rose Kroger Lyons, Timothy Woodrow Coffindaffer, Mikah Coffindaffer, Simran Preet Kaur, Timothy James Felts, Scott Edward Smith, Samuel Wolfe Stofel
Abstract: In some embodiments, a composition and/or method may include a toxin binding system formulated for safe and effective mixture into various feed rations which are fed to monogastric and ruminant animals such as poultry, swine, cows, cattle, and fish, among others. The toxin binding system includes novel combinations of one or more of an organoclay, an activated hydrated sodium calcium aluminosilicate clay, and a synthetic hectorite clay. In some embodiments, the binding composition may include organoclay, bentonite, hectorite, Leonardite, and/or any combination thereof. The toxin binding complex may effectively bind mycotoxins, endotoxins and some pesticides in the animal's digestive system, preventing their absorption and the consequent damages to the animal. This binding action includes the T-2 toxin, which can start their damaging action in the animal's mouth, hence, offering protection from oral lesions.
Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
Abstract: A vitamin supplement composition that includes a complex with enhanced bioavailability having a vitamin B complex, wherein the vitamin B complex includes: (a) a first vitamin, wherein the first vitamin comprises a form of vitamin B6; (b) a second vitamin, wherein the second vitamin comprises a form of vitamin B9; (c) a third vitamin, wherein the third vitamin comprises a form of vitamin B12; and (d) wherein the first vitamin, the second vitamin, and the third vitamin cooperate synergistically to enhance bioavailability of the same. The present invention further includes a method of administering a vitamin supplement composition to an individual having, for example, known or unknown MTHFR CT polymorphism.
Abstract: An infant food formulation having a vitamin complex with enhanced bioavailability, including a protein; a carbohydrate; a fat; and a vitamin B complex, wherein the vitamin B complex includes a vitamer of vitamin B6, a vitamer of vitamin B9, and a vitamer of vitamin B12.
Abstract: A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone.
Type:
Grant
Filed:
April 26, 2016
Date of Patent:
July 24, 2018
Assignee:
206 Ortho, Inc.
Inventors:
Jeffrey A. D'Agostino, Andrew J. Carter, Arthur Watterson, Joseph P. Lane
Abstract: The present invention relates to a risperidone sustained release delivery system for treatment of medical conditions relating delusional psychosis, schizophrenia, bipolar disorder, psychotic depression, obsessive-compulsion disorder, Tourette syndrome, and autistic spectrum disorders. The sustained release delivery system includes a flowable composition containing risperidone, a metabolite, or a prodrug thereof and an implant containing risperidone, a metabolite, or a prodrug thereof. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid, and risperidone, a metabolite, or a prodrug thereof.
Type:
Grant
Filed:
February 13, 2008
Date of Patent:
July 3, 2018
Assignee:
Indivior UK Limited
Inventors:
Eric Dadey, Qi Li, Christopher Lindemann
Abstract: Aniline copolymers and the synthesis thereof for use as antimicrobial (antibacterial, antifungal or antiviral material) material of for the manufacture of antimicrobial objects, suitable for use in the health, food, packaging, water, paint, wood, textile, poultry, glass, paper, rubber, ceramic, seafood, sports, plastic and agricultural industries. The copolymer may be for example (A): where for example R3?H5—CO2H, —CO2Me, or —CO2Et. R is typically H or a C1-C6 alkyl, x is an integer between 1 and 0 and m indicates the degree of polymerization. Preferred copolymers are copolymers of aniline with 3-aminobenzoic acid, 2-aminobenzoic acid and ethyl 3-aminobenzoate.
Type:
Grant
Filed:
April 29, 2016
Date of Patent:
June 12, 2018
Inventors:
Marija Gizdavic-Nikolaidis, Allan J. Easteal, Srdjan Stepanovic
Abstract: A skin care composition is described comprising water-soluble dye polymer comprising polymer backbone having negatively charged reactive dye substituent covalently bound thereto; and cosmetically acceptable carrier. The dye polymer is present in amount of 0.00001 to 0.1% in terms of reactive dye substituent by weight of the skin care composition. The composition is useful for providing cosmetic benefits such as skin lightening, evening skin tone and masking blemishes.
Type:
Grant
Filed:
March 10, 2015
Date of Patent:
May 29, 2018
Assignee:
Conopce, Inc.
Inventors:
Stephen Norman Batchelor, Peter Fairley, Naresh Dhirajlal Ghatlia, Adam John Limer, Xuezhi Tang, Jian-Rong Zhang
Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.
Type:
Grant
Filed:
February 20, 2017
Date of Patent:
April 24, 2018
Assignees:
International Business Machines Corporation, Agency For Science, Technology And Research
Inventors:
Mareva B. Fevre, James L. Hedrick, Victor W. L. Ng, Robert J. Ono, Shrinivas Venkataraman, Yi Yan Yang
Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
Type:
Grant
Filed:
March 10, 2016
Date of Patent:
April 17, 2018
Assignee:
Intezyne Technologies, Inc.
Inventors:
Kevin Sill, Tomas Vojkovsky, Adam Carie, Joseph Edward Semple, Hooshmand Sheshbaradaran
Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
Type:
Grant
Filed:
September 28, 2016
Date of Patent:
April 17, 2018
Assignee:
Intezyne Technologies, Inc.
Inventors:
Kevin Sill, Joseph Edward Semple, Tomas Vojkovsky
Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
Type:
Grant
Filed:
November 3, 2016
Date of Patent:
March 20, 2018
Assignee:
Durect Corporation
Inventors:
Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton, Roger Fu, Michael S. Zamloot