Patents Examined by Bradley J Osinski
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Patent number: 12285584Abstract: Some embodiments disclosed herein relate to medical connectors with a housing comprising a proximal body member and a base member that form an internal cavity with a proximal abutment surface. An elastomeric seal with a collar and without a guide member is positioned within the internal cavity. A rigid, hollow elongated portion is located within the internal cavity such that in an open configuration, a tip of the elongated portion is more proximal than a proximal surface of the elastomeric seal.Type: GrantFiled: August 15, 2024Date of Patent: April 29, 2025Assignee: ICU Medical, Inc.Inventor: Thomas F. Fangrow
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Patent number: 12280241Abstract: A glucose control system employs adaptation of a glucose target (set-point) control variable in controlling delivery of insulin to a subject to maintain euglycemia. The glucose target adapts based on trends in actual glucose level (e.g., measured blood glucose in the subject), and/or computed doses of a counter-regulatory agent such as glucagon. An adaptation region with upper and lower bounds for the glucose target may be imposed. Generally the disclosed techniques can provide for robust and safe glucose level control. Adaptation may be based on computed doses of a counter-regulatory agent whether or not such agent is actually delivered to the subject, and may be used for example to adjust operation in a bihormonal system during periods in which the counter-regulatory agent is not available for delivery.Type: GrantFiled: July 18, 2023Date of Patent: April 22, 2025Assignees: Trustees of Boston University, The General Hospital CorporationInventors: Firas H. El-Khatib, Edward R. Damiano, Steven J. Russell
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Patent number: 12280222Abstract: A system for catheter-based aspiration includes an aspiration catheter having a distal portion configured for insertion within a blood vessel of a subject, the aspiration catheter including an aspiration lumen having a distal opening at the distal portion of the aspiration catheter, an injection lumen having a distal end at the distal portion of the aspiration catheter, and an orifice located at or near the distal end of the injection lumen, the orifice configured to direct liquid into the aspiration lumen at or near the distal opening of the aspiration lumen; an injector configured to pressurize the liquid within the injection lumen, such that liquid exits the orifice and enters the aspiration lumen; and a mechanical oscillator coupled to the injector and configured to cause a pulsatile pressure of the liquid as it is injected through the injection lumen.Type: GrantFiled: June 26, 2024Date of Patent: April 22, 2025Assignee: Incuvate, LLCInventors: Bradley S. Culbert, Gary D Carlson
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Patent number: 12280238Abstract: The devices and systems can allow for safe and cost-effective administration intravenous medication, for example, in psychiatric settings by mitigating ligature, disassembly, and weaponization risks associated with intravenous administration. The system may include a fluid connection device. The fluid connection device may include an internal conduit configured to deliver a medical fluid and a housing disposed in which the internal conduit is disposed. The housing may include a first rigid segment and a second rigid segment spaced from the first rigid segment. The housing may also include a first joint segment disposed between the first rigid segment and the second rigid segment and configured to bend to the predetermined bending angle with respect to the first rigid segment.Type: GrantFiled: November 20, 2020Date of Patent: April 22, 2025Assignee: Emory UniversityInventors: Nathan J. Skoller, Rush Austin Leigh, Tamera Tyra Mason, Rachael Elizabeth Price, Ian Smith
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Patent number: 12274859Abstract: A drug delivery device and a method for manufacturing the same, and more specifically, a drug delivery device that can deliver a drug to a biological tissue while minimizing damage thereto and can come into close contact with the biological tissue to be able to measure an electrical signal of or apply electrical stimulation to the biological tissue and a method for manufacturing the drug delivery device are proposed. The drug delivery device includes a substrate unit that is inserted into a human body and has a porous insertion portion having one or more discharge voids. The insertion portion is provided to be deformable to match a shape of a biological tissue while expanding and contracting as a drug is injected into and discharged from an inside of the injection portion.Type: GrantFiled: November 12, 2018Date of Patent: April 15, 2025Assignee: DAEGU GYEONGBUK INSTITUE OF SCIENCE AND TECHNOLOGYInventors: So Hee Kim, Hyun Min Moon, Nam Sun Chou
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Patent number: 12274869Abstract: Implementations of the present disclosure are directed to an injection device that includes a medicament reservoir, a stopper including a rigid core and an ultrasound probe disposed in a housing, the ultrasound probe configured to transmit an emitted ultrasound signal through the rigid core along a longitudinal direction of the rigid core into the medicament reservoir and to receive an ultrasound signal generated by reflections of the emitted ultrasound signal, the reflections including at least a reflection from a distal end of the medicament reservoir, a control component configured to be electronically coupled with the ultrasound probe and to process the ultrasound signal to generate injection device data, and an antenna configured to be electronically coupled with the control component and to transmit the injection device data to an external computing device.Type: GrantFiled: August 12, 2022Date of Patent: April 15, 2025Assignee: SanofiInventors: Bernd Kuehn, Michael Schabbach, Dietmar Hammen
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Patent number: 12274853Abstract: The present invention relates to a system consisting of one or more instruments, which provides a simple method for detaching a connector cap from the connector as this is the juncture utilized to administer fluids into the body via an IV peripherally inserted central catheter, commonly know as a PICC or PIC line. This device enables one to avoid potential breakage of the PICC line connector cap, which can occur utilizing current procedures. The system is put into place whereby the portion of the instrument associated with the fixed end of the PICC line (that which is implanted in the patient) is slid over the PICC line connector and held stationary, while the portion of the accompanying instrument associated with the free end of the PICC line is secured around the connector cap and rotated counterclockwise until the connector cap assembly is loose enough to be separated without further aid.Type: GrantFiled: December 2, 2020Date of Patent: April 15, 2025Inventor: Atilla Kennedy Bognar
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Patent number: 12268831Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: GrantFiled: April 25, 2022Date of Patent: April 8, 2025Assignee: Rani Therapeutics, LLCInventor: Mir Imran
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Patent number: 12263244Abstract: Implantable devices and methods for delivery of lidocaine or other drugs to a patient are provided. In one embodiment, the device includes a first drug portion which has a first drug housing which contains a first drug formulation in a solid form which includes a pharmaceutically acceptable salt of lidocaine; and a second drug portion which includes a second drug housing which contains a second drug formulation which includes lidocaine base. In another embodiment, the device includes a drug reservoir component which has an elastic tube having at least one lumen bounded by a porous sidewall having an open-cell structure, a closed-cell structure, or a combination thereof; and a drug formulation contained within the at least one lumen, wherein the device is deformable between a low-profile deployment shape and a relatively expanded retention shape.Type: GrantFiled: September 9, 2021Date of Patent: April 1, 2025Assignee: TARIS Biomedical LLCInventors: Heejin Lee, Michael J. Cima, Karen Daniel, Cheryl Larrivee-Elkins
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Patent number: 12257398Abstract: A medical device, comprising a hub or housing having a push tab including a main portion extending radially from an upper surface of the hub or housing, and at least one anti-rotation feature for resisting rotation of the hub or housing. A cannula is directly or indirectly connected to the hub or housing. The medical device may be a catheter, the cannula may be a catheter tube, and the hub or housing may be a catheter hub or an introducer needle tip shield for the catheter.Type: GrantFiled: December 20, 2022Date of Patent: March 25, 2025Assignee: BECTON, DICKINSON AND COMPANYInventors: Stephen Bornhoft, Marty Stout, Carl Ellis
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Patent number: 12257406Abstract: A catheter system may include a catheter hub, a septum disposed within the catheter hub, a catheter tube extending from the catheter hub, a needle hub, and an introducer needle secured within the needle hub. The catheter hub may include a push tab and one or more ribs, which may extend outwardly from an upper surface of the catheter hub. The ribs may be shorter in height than the push tab and/or may be generally parallel to the push tab. The introducer needle may include a flashback notch. In response to insertion of the introducer needle into vasculature, blood may flow into the introducer needle, through the flashback notch, and into a flashback chamber disposed between the septum and the catheter tube. The flashback chamber may be disposed distal to the push tab and the ribs, which may improve visualization of the flashback chamber by a user.Type: GrantFiled: November 29, 2021Date of Patent: March 25, 2025Assignee: Becton, Dickinson and CompanyInventors: Michael Garrison, Bart D. Peterson, Ralph L. Sonderegger, Jonathan Karl Burkholz, Thomas Solosko, Stephen T. Bornhoft, Marty Stout, Carl Ellis
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Patent number: 12257414Abstract: A cap is described for connection to a medical connector, the cap includes a housing having a top wall and sidewall forming a cavity, and an integrally formed protrusion. The protrusion includes an inner thread on an inner surface, the inner thread being sufficient to interlock with a mating feature of a female needleless connector. The inner surface of the protrusion defines a second cavity. The outer surface of the sidewall of the protrusion is tapered and adapted to engage a male luer connector in a press-fit connection. The second cavity configured to define a chamber to contain an absorbent material and disinfectant or antimicrobial agent. The cap may also include a peel seal to prevent the disinfectant or the antimicrobial agent from exiting the second cavity. An exterior sidewall surface of the housing may include a plurality of grip members.Type: GrantFiled: November 22, 2022Date of Patent: March 25, 2025Assignee: Becton, Dickinson and CompanyInventor: Kevin M. Ryan
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Patent number: 12257416Abstract: This present disclosure relates to fluid therapy based on sodium excretion, and associated systems, devices, and methods. Exemplary methods can include receiving a sodium excretion input for the patient; receiving a urine output rate; determining an adjusted urine output rate based on the sodium excretion input and the urine output rate; and providing fluid therapy based on the adjusted urine output rate. By determining the amount and/or rate of the infused diuretic and/or hydration fluid based on a patient's actual sodium excretion levels, embodiments of the present technology can optimize and/or customize all or a subset of a diuretic therapy to an individual patient's physiology.Type: GrantFiled: September 12, 2024Date of Patent: March 25, 2025Assignee: Reprieve Cardiovascular, Inc.Inventors: Andrew V. Halpert, Antony Jonathan Fields, Jeffrey Testani
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Patent number: 12251128Abstract: Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes inserting an intramural crossing device into the vascular lumen, positioning at least the distal tip of the crossing device in the vascular wall, advancing an orienting device over the crossing device such that an orienting element of the orienting device resides in the vascular wall, inserting a reentry device, and re-entering the true vascular lumen.Type: GrantFiled: February 8, 2023Date of Patent: March 18, 2025Assignee: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Chad J. Kugler, Robert E. Atkinson, Matthew J. Olson
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Patent number: 12251499Abstract: A syringe includes a syringe body, a syringe cone having a distal opening, and a connection arranged in the region of the syringe cone, wherein the syringe body includes a first material and the connection includes a second material, and wherein the first material is different from the second material and the second material is a softer material than the first material.Type: GrantFiled: September 28, 2022Date of Patent: March 18, 2025Assignee: SCHOTT Pharma Schweiz AGInventors: Judith Auerbach, Bastian Fischer, Helena Derksen
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Patent number: 12239819Abstract: A apparatus and method to treat patients with acute decompensated heart failure (ADHF), heart failure or another fluid overload condition, that includes: administrating a diuretic to the patient to increase urine output of the patient; monitoring a rate or amount of urine output by the patient after administration of the diuretic; infusing a hydration liquid into the patient to induce an increase in the urine output; and adjusting the rate or amount of the hydration liquid infused into the patient to achieve a target fluid loss in the patient.Type: GrantFiled: May 16, 2019Date of Patent: March 4, 2025Assignee: Reprieve Cardiovascular, Inc.Inventors: Howard R. Levin, Andrew Halpert, Zoar Engelman, Mark Gelfand
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Patent number: 12239797Abstract: A catheter (1) comprises a jacket (20, 33) and defining a lumen, and extends distally towards a tip (30, 31). The catheter has a helical support (20) within the jacket for at least some of the length of the jacket. The catheter distal end has a plurality of portions of different configurations for different bending and/or pushability characteristics. These may be according to different helical supports and the manner in which they are interwoven, and/or different liners with lap joints. There may be a hydrophilic coating.Type: GrantFiled: June 17, 2020Date of Patent: March 4, 2025Assignee: Perfuze LimitedInventors: Liam Mullins, Dara Finneran, Evin Donnelly, Eoghan Thornton, Kieran Connolly
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Patent number: 12239460Abstract: In general, systems and methods for controlling operation of drug administration devices using surgical hubs are provided.Type: GrantFiled: October 13, 2020Date of Patent: March 4, 2025Assignee: Janssen Pharmaceuticals, Inc.Inventors: Jason L. Harris, Gregory J. Bakos, Frederick E. Shelton, IV, Steven Vesole, Peter Krulevitch, Kevin L. Houser
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Patent number: 12232751Abstract: An aspiration thrombectomy system for use with a vacuum source and an aspiration catheter includes an aspiration catheter, connection tubing configured to act as a common conduit for fluid communication between the aspiration catheter and a vacuum source, controllable valves operable to selectively open and close to control fluid flow, pressure sensors associated with the aspiration catheter or the connection tubing, and an automatic controller configured to operate the valves in a first operational state to generate fluid pressure changes, detect pressure levels in the system, wherein changes in the detected pressure levels are correlated with the generated fluid pressure changes, determine system states based on system state scores determined based on the detected pressure levels, the system state scores indicating a measure of occlusion in the aspiration catheter or the connection tubing, and operate the valves in a second operational state based on the determined system states.Type: GrantFiled: August 3, 2023Date of Patent: February 25, 2025Assignee: Penumbra, Inc.Inventors: Cheng Yong Timothy Thio, Lincoln Herbert Davidson, Scott Teigen, Corey Teigen
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Patent number: 12226621Abstract: A drug delivery device and cartridge wherein the cartridge includes a movable use indicator that indicates whether the cartridge has been opened and/or used.Type: GrantFiled: May 12, 2022Date of Patent: February 18, 2025Assignee: Fresenius Kabi Deutschland GmbHInventors: Sharon D. West, Jason Zerweck