Abstract: Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes providing a first intravascular device having a distal portion with a concave side, inserting the first device into the vascular lumen, positioning the distal portion in the vascular wall, and orienting the concave side of the distal portion toward the vascular lumen.

Abstract: A drug injection device comprising: a cartridge configured to hold a volume of a drug; one or more processors configured to operate in at least an enabled state and a sleep state, wherein the one or more processors are configured to control an operation of the drug injection device while the one or more processors are in the enabled state; a member disposed in the cartridge, the member including at least two conductive surfaces electrically connected to the one or more processors; and a drive mechanism including a conductive element spaced from the at least two conductive surfaces, wherein the one or more processors are configured to enter the enabled state from the sleep state when the conductive element makes electrical contact with the at least two conductive surfaces.

Abstract: A catheter that includes an inner layer forming the inner surface of a tubular catheter main body having a lumen, an outer layer forming the outer surface of the catheter main body, and multiple reinforcements embedded between the inner surface and the outer surface. The inner diameter of the catheter main body is D1, the outer diameter is D2, the wall thickness is T1, a thickness of each reinforcement is T2, an effective width of each reinforcement is W, and a total number of the multiple reinforcements is N. The catheter satisfies Expressions (1), (2), and (3): 0.050 mm?T1?0.100 mm??Expression (1) T2/T1?0.25??Expression (2) 60,000?(D1×D2×W×N)/(T12×T2)<1,000,000??Expression (3).

Abstract: Implementations of the present disclosure are directed to an injection device including: a reservoir including a wall defining a proximal end, a distal end and a tubular side, a plunger rod configured to be movable within the reservoir in a direction from the distal end to the proximal end, a radio frequency (RF) antenna attached to the tubular side and configured to receive an interrogation signal from an external device, and a resonating assembly configured to receive the interrogation signal from the RF antenna and to generate a modulated RF signal having a frequency associated with a position of the plunger rod.

Abstract: A fastening unit, in particular a fastening unit for modules which are intended to supply a user of a breathing mask or breathing hood with breathable air, and to such modules. The fastening unit is designed to secure one module relative to another module, and has a first component part for assembly with the other module and a second component part for assembly with the module. The second component part is rotatable, by means of the first component part, about a predetermined angle relative to the first component part; and first and second subcomponents within the region of the defined angle can engage with each other in a plurality of positions.

Abstract: A glucose control system employs adaptation of a glucose target (set-point) control variable in controlling delivery of insulin to a subject to maintain euglycemia. The glucose target adapts based on trends in actual glucose level (e.g., measured blood glucose in the subject), and/or computed doses of a counter-regulatory agent such as glucagon. An adaptation region with upper and lower bounds for the glucose target may be imposed. Generally the disclosed techniques can provide for robust and safe glucose level control. Adaptation may be based on computed doses of a counter-regulatory agent whether or not such agent is actually delivered to the subject, and may be used for example to adjust operation in a bihormonal system during periods in which the counter-regulatory agent is not available for delivery.

Abstract: A method includes measuring a fluid pressure of fluid in a fluid supply line of an infusion pump. The fluid pressure includes a motor pressure and a patient pressure. The method also includes determining the patient pressure. The determining includes removing, by an adaptive filter, to remove the motor pressure from the measured fluid pressure. The removing includes generating a predicted motor pressure based on the current of the motor, generating an error signal based on a comparison between the predicted motor pressure and the measured fluid pressure, and removing the motor pressure from the measured fluid pressure when an error value indicative of the error signal is less than an error threshold. The method also includes adjusting, based on the patient pressure, a setting of the infusion pump. Related methods and articles of manufacture, including apparatuses and computer program products, are also disclosed.

Abstract: A catheter assembly includes a catheter hub defining an interior cavity and a catheter tube extending distally thereof. A rigid actuator is positioned to extend proximally in the interior cavity and support a seal member positioned thereon in the interior cavity. The seal member includes a central membrane, a distal portion, and a proximal portion. An hourglass shaped actuator cavity is formed in the distal portion and receives a barbed end of the actuator. The outer surface of the seal member is in partial circumferential engagement with the catheter hub to define an air path that allows fluid communication between areas of the interior cavity distal and proximal of the seal member. The seal member may be configured for multi-use and include a biasing member that moves the seal member to force the membrane back over the actuator to close the membrane.

Abstract: An aspiration thrombectomy system for use with a vacuum source and an aspiration catheter includes a connection tubing configured to selectively connect the aspiration catheter to the vacuum source via a controllable vacuum valve. A distal pressures sensor is configured to detect pressure at the distal end within the connection tubing. An automatic controller may operate the vacuum valve to generate fluid pressure change in the connection tubing, and detect pressure profiles in the connection tubing correlated with the generated pressure changes via the distal pressure sensor. The automatic controller may determine one or more system states in the aspiration catheter or connection tubing based on the detected pressure profiles, and may operate the vacuum valve based on the determination of system state.

Abstract: Aspects herein relate to a low-friction septum for providing a leak-resistant seal for use in a vascular access device. In an embodiment, a device for vascular access hemostasis is included having an enclosure defining a cavity and configured to at least partially receive a medical device. The device can include a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The device can include a barrel in structural communication with the second seal portion, the second seal portion including a septum seal. The second seal portion can define two or more discrete portions, each separated by one or more split lines. The discrete portions can include a mating surface to interface with mating surfaces of other discrete portions. The mating surface can include a surface topology including raised portions and depressions. Other embodiments are also included herein.

Abstract: An improved injection port identification for injection ports implanted under the skin of a patient. The injection port has an x-ray discernable marker allowing for the determination of a pressure rating for the injection port when so implanted. A plurality of concurrent visual, RF, light emitting and sonic means for signaling the port's pressure rating are also employable to provide multiple concurrent affirmations of the port's readiness for high pressure injections.

Abstract: A surgical access system comprises a trocar, an insufflating optical obturator slidably insertable into the trocar, and a laparoscope slidably insertable into the obturator. A distal end of the obturator comprises a tip, at least a portion of which comprises a wall with a generally uniform thickness comprising a transparent material. At least one vent hole disposed at the obturator tip is fluidly connected to a gas flow channel defined by an interior surface of the obturator and the laparoscope, which is fluidly connected to an insufflation gas inlet disposed at a proximal end of the trocar. Improved optical characteristics of the trocar system permit precise and accurate visual placement thereof into a body cavity. Accordingly the access system is suitable as a first entry surgical access system. Embodiments of the trocar access are also useful for drug delivery, and/or for fluid and/or tissue aspiration.

Abstract: Medicinal fluid delivery devices and methods for advancing and retracting needles are disclosed. According to an aspect, a medicinal fluid delivery device includes a tube that defines an interior space that extends between a first and second openings. The device includes a needle including a proximal end and a distal end that substantially align in a first direction. A portion of the distal end is biased to extend in a second direction different than the first direction. A mechanism is attached to the proximal end and configured to position the distal end between a first position and a second position. In the first position, the portion of the distal end is constrained by the interior wall such that is does not extend in the second direction. In the second position, the distal end is not constrained by the interior wall such that it extends in the second direction.

Abstract: An injection nozzle for a needleless injection device includes at least one outlet conduit extending parallel to an injection axis (B). The outlet conduit(s) include a first conduit portion having a first section, a second conduit portion having a second section, the first section being larger than the second section, and a connecting portion between the first conduit portion and the second conduit portion. The connecting portion is inclined at an angle between 70° and 90° with respect to the injection axis (B).

Abstract: A system for at least partial closed-loop control of a medical condition is disclosed. The system includes at least one medical fluid pump. The medical fluid pump including a sensor for determining the volume of fluid pumped by the pump. Also, at least one continuous analyte monitor, and a controller. The controller is in communication with the medical fluid pump and the at least one continuous analyte monitor. The controller includes a processor. The processor includes instructions for delivery of medical fluid based at least on data received from the at least one continuous analyte monitor.

Abstract: A protective assembly includes a body for receiving the syringe; and a coupling device inside the body, rigidly connected to the barrel as regards to axial movement relative to the body. The coupling device includes an attaching element which can be either in an engaged state to axially fix the coupling device and the plunger rod, or in a release state in which the coupling device and the plunger rod are axially free relative to one another. The coupling device is axially movable in the body from a storage position to an injection position in which the needle extends beyond the body, and in which the attaching element can move towards the release state. The coupling device is axially movable in the body from the injection position towards a safety position, in which the needle is covered by the body.

Abstract: An apparatus includes a rigid body, a flexible sealing element, a nozzle assembly, and an electrode. The rigid body defines a channel, a reservoir, and a vent path. The reservoir is in fluid communication with the channel. The vent path is in fluid communication with the reservoir. The reservoir is configured to provide spacing between the channel and the vent path. The sealing element is positioned distal to the rigid body. The nozzle assembly includes a nozzle head and a post. The post extends distally through the channel of the rigid body. The nozzle head projects distally from a distal end of the post. The electrode is disposed within the channel of the rigid body. The reservoir extends laterally from a longitudinal axis defined by the electrode.

Abstract: Methods, devices, systems of resuscitating a patient including accessing an arterial vessel positioning a catheter into the arterial vessel advancing the catheter through the arterial vessel to position it below a vessel supplying blood to a heart and a brain expanding an expandable portion of the catheter to prevent blood from flowing past the expanded portion and infusing a substance retrograde into the artery within the arterial section between the heart and the expanded portion of the catheter.

Abstract: A medical fluid suspension generating apparatus for performing medical procedures includes a Venturi-agitating tip assembly composed of a multi-channel arrangement at a proximal first end thereof and a tip at a distal second end thereof. The apparatus also includes a compressed medical fluid unit fluidly connected to the multi-channel arrangement at a proximal first end of the Venturi-agitating tip assembly and a medical solution fluidly connected to the multi-channel arrangement at a proximal first end of the Venturi-agitating tip assembly. Pressurized sclerosant or other chemical medical solution, from the compressed medical fluid unit, and the medical solution of sclerosant or other chemical medical solution are combined within the Venturi-agitating tip assembly in a manner generating an enriched medical suspension that is ultimately dispensed from the suspension delivery apparatus to spray or wash the inner wall of a lumen.

Abstract: A sub-assembly of a medicament delivery device is presented, where the sub-assembly includes a plunger rod that is biased, a main body arranged on the plunger rod, and a coupling member movable relative to the main body, where the main body includes a first locking element, the coupling member includes a second locking element, and where the first locking element and the second locking element are configured to be releasably engaged with each other such that the coupling member is prevented from moving relative to the main body.