Abstract: A composition for treating or preventing inflammatory-related conditions includes as an active principle a carrier which exhibits a plurality of a scavenger structure capable of mitigating the activity of a mediator of inflammatory-related conditions. The scavenger structure includes a nucleophilic center complying with the formula X1(—R?—)(—R?)mHn where: a) X1 is a single-bonded heteroatom selected amongst N, O and S and exhibits a free electron pair; b) m is 0 or 1 and n is 1 or 2; c) —R?— is a bivalent organic group providing attachment to the carrier via one of its free valences and to X1 at the other free valence; and d) R?— is a monovalent organic group attached to the X1 via its free valence. A method for treating or preventing inflammatory-related conditions in an individual suffering from such conditions includes: providing the composition; and contacting the mediator within or separate from the individual.
Type:
Grant
Filed:
February 25, 2016
Date of Patent:
May 8, 2018
Assignee:
PVAC MEDICAL TECHNOLOGIES LTD.
Inventors:
Tim Bowden, Kristoffer Bergman, Thomas Engstrand, Lennart Soderberg
Abstract: An oral care composition containing a stannous ion source, a zinc ion source, a polyphosphate, and a thickening agent. The thickening agent contains polyvinylpyrrolidone, a polysaccharide gum and carboxymethyl cellulose. The compositions have excellent rheology properties.
Type:
Grant
Filed:
June 20, 2014
Date of Patent:
May 8, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Kavita Vemishetti, Linh Fruge, Michael Prencipe
Abstract: The invention pertains to thermosensitive liposomes encapsulating nanoparticles. In certain embodiments, the thermosensitive liposomes of the invention disrupt when heated at gel-to-liquid crystalline phase transition temperature (Tm) or above Tm, wherein the liposome comprises a thermosensitive lipidic membrane encapsulating nanoparticles. The nanoparticles used in the invention comprise an inorganic core the largest dimension of which is less than about 100 nm that is fully coated with an agent responsible for the presence of an electrostatic charge below ?20 mV or above +20 mV at the surface of the nanoparticle, the electrostatic charge being determined by zeta potential measurements in an aqueous medium between pH 6 and 8, for a concentration of nanoparticles in suspension in the aqueous medium varying between 0.2 and 8 g/L. The invention also relates to pharmaceutical and diagnostic compositions comprising the thermosensitive liposomes as well as to their uses.
Abstract: A composition for imparting anti-aging benefits onto skin containing: (a) an aqueous phase containing: (i) from about 0.5% to 10% by weight, of at least one water-soluble active ingredient; and (ii) water; and (b) an oil phase containing: (iii) at least one emulsifying crosslinked siloxane elastomer; (iv) from about 0.1% to 1% by weight, of at least one oil-soluble active ingredient; (v) wax; and (vi) oil; all weights based on the total weight of the composition.
Type:
Grant
Filed:
February 4, 2015
Date of Patent:
April 24, 2018
Assignee:
L'Oreal
Inventors:
Catherine Chiou, Carlos Crissien, Raul M. Diaz, Angelike A. Galdi
Abstract: One aspect of the invention is a polymer material comprising a capsule coated with PDA. In certain embodiments, the capsule encapsulates a functional agent. The encapsulated functional agent may be an indicating agent, healing agent, protecting agent, pharmaceutical drug, food additive, or a combination thereof.
Type:
Grant
Filed:
May 26, 2016
Date of Patent:
April 17, 2018
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Scott R. White, Nancy R. Sottos, Sen Kang, Marta B. Baginska
Abstract: The present invention provides a vesicle, a conjugate, a composition comprising the vesicle or the conjugate, for use in delivering a drug to the brain, and a method for administering the same. The composition of the present invention is a composition for administration to a subject according to a dosing regimen, comprising a carrier for drug delivery, wherein the dosing regimen comprises administering the composition to a subject who has been fasted or caused to have hypoglycemia and inducing an increase in blood glucose level in the subject, and the carrier is modified at the outer surface thereof with a GLUT1 ligand.
Type:
Grant
Filed:
November 21, 2014
Date of Patent:
April 10, 2018
Assignees:
THE UNIVERSITY OF TOKYO, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
Abstract: A coated balloon device for stabilizing a section of a blood vessel in a living subject is disclosed. The coating layer of the coated balloon comprises a phenolic compound having a plurality of phenolic groups connected to form a hydrophobic core with peripheral phenolic hydroxyl groups. The coating layer of the coated balloon may contain a hydrophilic polymer to facilitate the release of the phenolic compound. The balloon in general is made of a compliant polymer for atraumatic contact with the blood vessel. In some embodiments, the coating of the coated balloon device further comprises a hydrophilic undercoat layer between the balloon and the coating layer. In some embodiments, the coated balloon device further comprises a sacrificial top coating that dissolves upon delivery into the section of the blood vessel and comprises a hydrophilic composition including sugar, sugar derivatives, or a combination thereof.
Type:
Grant
Filed:
May 17, 2012
Date of Patent:
April 10, 2018
Assignee:
NECTERO MEDICAL, INC.
Inventors:
Matthew F. Ogle, Wenda C. Carlyle, Edward J. Anderson, Kishore Udipi
Abstract: In one aspect, apparatuses for providing chemical gradients are described herein. In some embodiments, an apparatus described herein comprises a conduit having a first end and a second end, one or more microchannels disposed in the conduit and extending from the first end toward the second end, and a fiber coiled around the exterior of at least one microchannel, wherein the fiber comprises an active agent that is operable to diffuse into the interior of the microchannel.
Type:
Grant
Filed:
February 18, 2014
Date of Patent:
April 3, 2018
Assignee:
Board of Regents, The University of Texas System
Inventors:
Mario I. Romero-Ortega, Parisa Lotfi, Benjamin R. Johnston, Swarupnarayan Dash, Joselito Razal, Gordon Wallace
Abstract: Provided is an oral care composition comprising a phosphate/acrylate co-polymer, zinc and an orally acceptable carrier and methods of using the same.
Type:
Grant
Filed:
December 20, 2013
Date of Patent:
April 3, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Michael Prencipe, Suzanne Jogun, Andre Michelle Morgan, Xiang Chen
Abstract: The subject of the invention is an N-sulfonic polyallylamine derivative (NSPAH) with Formula 1, wherein R is —SO3? or —H, and n is an integer from 150 to 15000; an application of the N-sulfonic polyallylamine derivative as a medicine, particularly for prevention and treatment of respiratory tract infections caused by the human metapneumovirus (hMPV), respiratory tract infections caused by the human rhinoviruses (HRV), and infections caused by the influenza A virus; as well as a pharmaceutical composition comprising the N-sulfonic polyallylamine derivative and application thereof.
Type:
Grant
Filed:
October 25, 2017
Date of Patent:
March 27, 2018
Assignee:
UNIWERSYTET JAGIELLONSKI
Inventors:
Maria Nowakowska, Krzysztof Szczubialka, Krzysztof Pyrc, Justyna Ciejka, Magdalena Wytrwal, Aleksandra Milewska
Abstract: Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical compositions contain crosslinked amine polymers and may be used, for example, to treat diseases or other metabolic conditions in which removal of protons and/or chloride ions from the gastrointestinal tract would provide physiological benefits such as normalizing serum bicarbonate concentrations and the blood pH in an animal, including a human.
Type:
Grant
Filed:
November 18, 2015
Date of Patent:
March 27, 2018
Assignee:
TRICIDA, INC.
Inventors:
Gerrit Klaerner, Eric F. Connor, Randi K. Gbur, Matthew J. Kade, Paul H. Kierstead, Jerry M. Buysse, Michael J. Cope, Kalpesh N. Biyani, Son H. Nguyen, Scott M. Tabakman
Abstract: The present disclosure relates, according to some embodiments, to molecules, including conjugated fused polycyclic molecules, that may receive excited state energy from other molecules (e.g., light-absorbing molecules) or directly from the irradiation sources. According to some embodiments, the disclosure relates to molecules, including conjugated fused polycyclic molecules, that may resolve (e.g., quench, dissipate) excited state energy, normally by way of releasing it as heat. (e.g., as heat). Conjugated fused polycyclic molecules of various structures are disclosed including Formula III: The disclosure further relates to methods of use and/or therapy using molecules of Formulas I, II, and/or III.
Type:
Grant
Filed:
July 6, 2015
Date of Patent:
March 27, 2018
Inventors:
Craig A. Bonda, Shengkui Hu, Qing Jean Zhang, Zhihui Zhang
Abstract: Provided is a mouth rinse composition comprising a phosphate/acrylate co-polymer and an orally acceptable carrier and methods of using the same.
Abstract: The invention relates to styling agents, comprising—with respect to the weight thereof—0.1 to 20 wt % of strengthening polymer(s) and 0.1 to 5 wt % of esters of the formula (I), in which R1 stands for —H or CH3, R2 stands for a straight-chain or branched alkyl group having 7 to 15 carbon atoms, and n stands for an integer from the group 1, 2, 3, 4, 5, 6, 7, 8. Said styling agents effect significantly improved curl retention, in particular significantly improved high-humidity curl retention, thus a higher degree of curl retention even in a humid environment in addition to further improved hold and improved hair feel, such as texture and combability.
Type:
Grant
Filed:
May 24, 2016
Date of Patent:
March 20, 2018
Assignee:
Henkel AG & Co. KGaA
Inventors:
Diane Metten, Julia Bibiane Lange, Bernd Richters
Abstract: The invention is directed to an immediate release capsule which mitigates the abuse of Tapentadol or physiologically acceptable salt thereof by direct intravenous injection. The capsule comprises a tamper resistant formulation which when mixed with water and heated, results in a turbid, bubbling mixture that is not injectable with a standard insulin syringe.
Type:
Grant
Filed:
September 7, 2016
Date of Patent:
March 13, 2018
Assignee:
GRÜNENTHAL GMBH
Inventors:
Ingo Friedrich, Richard Fuhrherr, Silke Möschter, Simone Wengner
Abstract: A cosmetic composition comprising a cosmetically active ingredient in a cosmetically acceptable medium, wherein the cosmetic composition contains a silicone composition comprising (A) a hydrophobic organopolysiloxane fluid having a surface tension of from 15 to 40 mN/m and (B) a finely divided solid hydrophobic filler dispersed in the organopolysiloxane fluid (A).
Abstract: Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high ionic strength adhesive complex coacervates are introduced into the lower ionic strength application site, the fluid complex coacervate is converted to a an adhesive solid or gel as the salt concentration in the complex coacervate equilibrates to the application site salt concentration. In one embodiment, the fluid complex coacervates are designed to solidify in situ at physiological ionic strength and have numerous medical applications. In other aspects, the fluid complex coacervates can be used in aqueous environment for non-medical applications.
Abstract: The present invention relates to a consumer goods product comprising a consumer goods product ingredient and a non-crosslinked functionalized lignin oligomer, wherein the functionalized lignin oligomer: (a) has an average number of lignin monomers of from 3 to 8; (b) comprises a polyethylene glycol functional group; (c) comprises a functionalization content between 90 and 0.5% lignin (m/m), wherein the consumer goods product ingredient is an emulsifier, and wherein the lignin oligomer is in the form of an emulsion, and wherein the consumer goods product is in the form of an oral care composition or a detergent composition.
Abstract: The present invention relates to a consumer goods product comprising a consumer goods product ingredient and a lignin oligomer, wherein the lignin oligomer: (a) comprises less than 1 wt % sulphur content; (b) has a number average molecular weight (Mn) of from 800 Da to 1,800 Da; and (c) has a molar ratio of aromatic hydroxyl content to aliphatic hydroxyl content in the range of from 1.2 to 1.9, wherein the consumer goods product ingredient is an emulsifier, and wherein the lignin oligomer is in the form of an emulsion, and wherein the consumer goods product is selected from skin treatment composition, oral care treatment composition, and detergent composition.
Abstract: A consumer goods product comprising a consumer goods product ingredient and a cross-linked co-polymer of a lignin oligomer and a vinyl monomer, wherein the lignin oligomer has: (a) comprises less than 1 wt % sulphur content; (b) has a number average molecular weight (Mn) of from 800 Da to 1,800 Da; and (c) has an average number of lignin monomers of from 3 to 8.