Patents Examined by Brian J. Sines
  • Patent number: 11517864
    Abstract: Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: December 6, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Weitz, Mark Romanowsky, Adam R. Abate
  • Patent number: 11506610
    Abstract: Various embodiments disclosed relate to a substrate. The present disclosure provides a substrate for use in both surface enhanced Raman spectroscopy and surface enhanced infrared spectroscopy. The substrate includes a flexible polymeric membrane, a plurality of metal oxide nanoparticles disposed on the polymeric membrane, and a plurality of metallic nanoparticles directly disposed on a portion of the plurality of metal oxide nanoparticles. The plurality of metal oxide nanoparticles are configured to work synergistically with metal nanoparticles upon exposure of the substrate surface to at least one of visible light or infrared radiation.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: November 22, 2022
    Assignee: University of Massachusetts
    Inventors: Lili He, Chen Tan
  • Patent number: 11504690
    Abstract: An integrated circuit includes two or more rows of heating elements, two or more columns of heating elements, and a plurality of sensing areas. Each sensing area is between two adjacent rows of the rows of heating elements and between two adjacent columns of the columns of heating elements and includes a bio-sensing device and a temperature-sensing device.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: November 22, 2022
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.
    Inventors: Tung-Tsun Chen, Yi-Shao Liu, Jui-Cheng Huang, Chin-Hua Wen, Felix Ying-Kit Tsui, Yung-Chow Peng
  • Patent number: 11498044
    Abstract: An integrated circuit includes two or more rows of heating elements, two or more columns of heating elements, and a plurality of sensing circuits. Each sensing circuit is between two adjacent rows of the rows of heating elements and between two adjacent columns of the columns of heating elements, in a same silicon layer as the rows of heating elements and the columns of heating elements, and configured to generate a bio-sensing signal and a temperature-sensing signal.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: November 15, 2022
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.
    Inventors: Tung-Tsun Chen, Yi-Shao Liu, Jui-Cheng Huang, Chin-Hua Wen, Felix Ying-Kit Tsui, Yung-Chow Peng
  • Patent number: 11499131
    Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: November 15, 2022
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Donald E. Ingber, Daniel Levner, Guy Thompson, II, Jose Fernandez-Alcon, Christopher David Hinojosa
  • Patent number: 11491477
    Abstract: The present disclosure provides better aspiration and dispensing by a common innovative mechanism by (i) offsetting the diameter of a bottom piston (tube) with a slightly narrower top piston (rod) when the two are swept together by O-rings to give extremely fine resolution, thereby eliminating the need for any filamentous piston and sealing means, (ii) letting the bottom tube be swept alone without offset to give high flow (iii) using a tapered top rod with thick-walled compliant O-ring seals to increase the resolution multiplier another order or magnitude, (iv) an at-the-ready interpiston space for contact-free blowoff, including viscous samples, (v) dead space filler mandrels and an integrated small valve to reduce or eliminate interpiston and disposable tip space prior to aspiration, and (vi) a mechanism for storing energy during disposable tip pickup to shoot dispensed samples contact-free down into long tubes.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: November 8, 2022
    Inventor: Henry Donald Schwartz
  • Patent number: 11491455
    Abstract: An integrated circuit includes an interconnection structure, first and second sensing pixels over the interconnection structure, and an isolation layer over the first and second sensing pixels. Each of the first and second sensing pixels includes a bio-sensing device, a temperature-sensing device, one or more heating elements adjacent to the bio-sensing device and the temperature-sensing device, and a sensing film over the bio-sensing device. The isolation layer includes a first opening configured to expose the sensing film of the first sensing pixel without exposing the sensing film of the second sensing pixel and a second opening configured to expose the sensing film of the second sensing pixel without exposing the sensing film of the first sensing pixel.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: November 8, 2022
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.
    Inventors: Tung-Tsun Chen, Yi-Shao Liu, Jui-Cheng Huang, Chin-Hua Wen, Felix Ying-Kit Tsui, Yung-Chow Peng
  • Patent number: 11478794
    Abstract: A micro channel structure includes a substrate, a supporting layer, a valve layer, a second insulation layer, a vibration layer and a bonding-pad layer. A flow channel is formed on the substrate. A conductive part and a movable part are formed on the supporting layer and the valve layer, respectively. A first chamber is formed at the interior of a base part and communicates to the hollow aperture. A supporting part is formed on the second insulation layer. A second chamber is formed at the interior of the supporting layer and communicates to the first chamber through the hollow aperture. A suspension part is formed on the vibration layer. By providing driving power sources having different phases to the bonding-pad layer, the suspension part moves upwardly and downwardly, and a relative displacement is generated between the movable part and the conductive part, to achieve fluid transportation.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: October 25, 2022
    Assignee: MICRO JET TECHNOLOGY CO., LTD.
    Inventors: Hao-Jan Mou, Rong-Ho Yu, Cheng-Ming Chang, Hsien-Chung Tai, Wen-Hsiung Liao, Chi-Feng Huang, Yung-Lung Han, Chun-Yi Kuo
  • Patent number: 11480559
    Abstract: A method for analyzing thrombogenic capacity or blood coagulation capacity, the method comprising adding calcium, a blood coagulation factor XII (FXII) inhibitor, and a kallikrein inhibitor to blood collected with a blood collection tube containing sodium citrate, to allow initiation of blood coagulation reaction, is provided. Preferably, heparin, heparan sulfate, and tissue factor are further added to the blood, and thrombogenic capacity or blood coagulation capacity is analyzed.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: October 25, 2022
    Assignee: FUJIMORI KOGYO CO., LTD.
    Inventors: Kazuya Hosokawa, Tomoko Wada, Hisayo Kaneko, Takaaki Hasegawa, Tomoka Nagasato
  • Patent number: 11480778
    Abstract: Disclosed in one aspect is a method for performing a complete blood count (CBC) on a sample of whole blood by metering a predetermined amount of the whole blood and mixing it with a predetermined amount of diluent and stain and transferring a portion thereof to an imaging chamber of fixed dimensions and utilizing an automated microscope with digital camera and cell counting and recognition software to count every white blood cell and red blood corpuscle and platelet in the sample diluent/stain mixture to determine the number of red cells, white cells, and platelets per unit volume, and analyzing the white cells with cell recognition software to classify them.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: October 25, 2022
    Assignee: Medica Corporation
    Inventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Donald Barry, Jr., Dirk Osterloh, Chen Yi, Tyler Cote
  • Patent number: 11471887
    Abstract: A microfluidic device comprising a plurality of microreactors is provided. Each microreactor includes at least a first inlet and a second inlet for supplying a first fluid and a second fluid, respectively, to said microreactor and at least one waste channel for draining fluid from said microreactor. The device further comprises a shared first microfluidic supply system for supplying a first fluid to the first inlets of the plurality of microreactors, a shared second microfluidic supply system for supplying a second fluid to the second inlets of the plurality of microreactors. At least one of said inlets to each microreactor comprises at least one valve-less fluidic resistance element having a fluidic resistance that is substantially larger than the fluidic resistance of the corresponding shared microfluidic supply system. A chemical reaction sequencer apparatus including the microfluidic device and a method for supplying reagents to a plurality of microreactors are also provided.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: October 18, 2022
    Assignee: IMEC VZW
    Inventors: Peter Peumans, Benjamin Jones, Nicolas Vergauwe
  • Patent number: 11471789
    Abstract: A chromatograph is provided for identifying components of a mixture. Components are identified by different rates of adsorption and/or desorption with a material phase. In one embodiment, an electrical lead is connected to the material phase for supplying an electrical charge to the material phase. The electrical charge alters the rate of adsorption/desorption of the components with the material phase. In another embodiment, the material phase is disposed between two conductors with electrical leads connected to each of the conductors. A charge differential between the two conductors alters the rate of adsorption and/or desorption of components with the material phase.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: October 18, 2022
    Assignee: ABB Schweiz AG
    Inventors: Nolan W. Nicholas, Thomas Morgan
  • Patent number: 11465145
    Abstract: A collection device for a biological sample to capture target compounds such as viruses or other pathogens or particles for testing from within the sample and move the captured target compound to a separate chamber for subsequent processing. The collection device can include an openable substance blister including capture particles located in a cup interior. Capture particles can attract and bind the target compounds from the sample. An extraction tube extracts any nucleic acid from the target compound for storage or subsequent amplification and testing to confirm presence of known microorganisms. The extraction tube can comprise a heat-deformable material and can be connected to a microfluidic cartridge for further processing of nucleic acid including, amplification and detection. The microfluidic cartridge includes valves and a plurality of chambers for amplification.
    Type: Grant
    Filed: August 26, 2021
    Date of Patent: October 11, 2022
    Inventors: Orion Scott, Christopher Birch, Daniel Mills, Brian Root, James Landers, Jingyi Li, Matthew Yeung, David Saul, David Vigil, Andrew Guy, Stan Wada, Betina De Gorordo, Steward Dodman, Tom Moran, Stuart Knowles, Fernando Dias, Rick Gardner
  • Patent number: 11464829
    Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: October 11, 2022
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Vasile Bogdan Neculaes, Andrew Soliz Torres, Antonio Caiafa, Brian Dun-Lan Lee, Allen Lawrence Garner
  • Patent number: 11460464
    Abstract: It can sometimes be difficult to quantify the amount of polymer present in a subterranean treatment fluid, particularly at a job site. Methods for analyzing a treatment fluid for a polymer can comprise: receiving a sample of a treatment fluid comprising a nitrogen-containing polymer; placing the sample of the treatment fluid and an aqueous base in an oilfield retort; heating the sample of the treatment fluid and the aqueous base together in the oilfield retort at least until the nitrogen-containing polymer has been substantially hydrolyzed to one or more volatile nitrogen compounds; distilling the one or more volatile nitrogen compounds from the oilfield retort; and determining a quantity of the nitrogen-containing polymer in the sample of the treatment fluid based upon a quantity of the one or more volatile nitrogen compounds distilled from the oilfield retort. Analyses of other nitrogen-containing compounds may take place similarly.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: October 4, 2022
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Zhao Deng, Jay Paul Deville, Philip Wayne Livanec
  • Patent number: 11453001
    Abstract: Techniques regarding one or more microfluidic chips with integrated electronic sensors are provided. For example, one or more embodiments described herein can regard an apparatus that can comprise a conductive plug of a reference electrode structure, the conductive plug extending from within a microfluidic channel to within a reference fluid holding chamber that is in fluid isolation from the microfluidic channel.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: September 27, 2022
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Sufi Zafar, Yuksel Temiz, Emmanuel Delamarche
  • Patent number: 11453003
    Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
    Type: Grant
    Filed: December 14, 2021
    Date of Patent: September 27, 2022
    Assignee: ILLUMINA, INC.
    Inventors: Ali Agah, Aathavan Karunakaran, Tarun Khurana, Stanley Hong, Merek Siu, Arvin Emadi, Craig Ciesla
  • Patent number: 11448583
    Abstract: In some embodiments, a process and system are provided for generating a user interface for classification of a sample image of a cell that includes receiving a sample image of a sample particle from a biological sample and selecting reference images that each portray a reference particle of a biological sample. The reference images can be ordered based on similarity and the reference images can be selected based on the order. The first selected reference image can be aligned with the sample image and expanded such that the adjacent edges of the reference image and sample image are the same. The expanded image can be dynamically filled. The sample image and the expanded reference image can be displayed in a user interface.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: September 20, 2022
    Assignee: Beckman Coulter, Inc.
    Inventors: Jun Yang, Jon Tindel
  • Patent number: 11446630
    Abstract: An integrated circuit includes a plurality of sensing pixels, each sensing pixel including a sensing film portion, a bio-sensing device configured to generate a first signal responsive to an electrical characteristic of the sensing film portion, a first switching device coupled between the bio-sensing device and a first signal path, a temperature-sensing device configured to generate a second signal responsive to a temperature of the sensing film portion, and a second switching device coupled between the temperature-sensing device and a second signal path.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: September 20, 2022
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.
    Inventors: Tung-Tsun Chen, Yi-Shao Liu, Jui-Cheng Huang, Chin-Hua Wen, Felix Ying-Kit Tsui, Yung-Chow Peng
  • Patent number: 11446664
    Abstract: Extracting and concentrating particles from a first fluid sample includes: providing the first fluid sample to a fluid exchange module of a microfluidic device, providing a second fluid sample to the fluid exchange module, in which the first fluid sample and the second fluid sample are provided under conditions such that particle-free portions of the first fluid sample are shifted, and an inertial lift force causes the particles in the first fluid sample to cross streamlines and transfer into the second fluid sample; passing the second fluid sample containing the transferred particles to a particle concentration module under conditions such that particle-free portions of the second fluid sample are shifted, and such that the particles within the second fluid sample are focused to a streamline within the particle concentration module.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: September 20, 2022
    Assignee: The General Hospital Corporation
    Inventors: Ravi Kapur, Kyle C. Smith, Mehmet Toner