Patents Examined by Brian J. Sines
  • Patent number: 11187656
    Abstract: One aspect of this disclosure relates to a method for determining a presence of at least one guest structure at a host structure. The method comprises a light-sensitive system receiving light from the host structure. The host structure hosts one or more optically active entities at at least one part of the host structure. Herein, the at least one part does not host the at least one guest structure. Furthermore, the optically active entities cause light emission from said at least one part. The method also comprises the light-sensitive system outputting a signal based on the received light. The method further comprises determining a light value based on the output signal. The light value indicates an amount of light from the host structure being incident on the light-sensitive system. The method also comprises determining on the basis of the light value at least one of a quantity and a position of the at least one guest structure at the host structure.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: November 30, 2021
    Inventors: Iddo Heller, Anna Elisabeth Christina Meijering, Gijs Jan Lodewijk Wuite, Erwin Johannes Gerard Peterman, Andreas Sebastian Biebricher
  • Patent number: 11187698
    Abstract: A living plant can function as self-powered auto-samplers and preconcentrators of an analyte within ambient groundwater, detectors of the analyte contained therein. For example, a pair of near infrared (IR) fluorescent sensors embedded within the mesophyll of the plant leaf can be used as detectors of the nitroaromatic molecules, with the first IR channel engineered through CoPhMoRe to recognize analyte via an IR fluorescent emission and the second IR channel including a functionalized nanostructure that acts as an invariant reference signal.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: November 30, 2021
    Inventors: Michael S. Strano, Juan Pablo Giraldo Gomez, Seongyeon Kwak, Min Hao Wong
  • Patent number: 11186480
    Abstract: An exemplary method includes forming a sacrificial layer along sidewalls of an array of trenches that are indented into a substrate, depositing a fill layer over the sacrificial layer, and then creating an array of gaps between the fill layer and the substrate by removing the sacrificial layer along the sidewalls of the trenches, while maintaining a structural connection between the substrate and the fill layer at the floors of the trenches. The method further includes covering the substrate, the fill layer, and the gaps with a cap layer that seal fluid-tight against the substrate and the fill layer. The method further includes indenting a first reservoir and a second reservoir through the cap layer, and into the substrate and the fill layer, across the lengths of the array of gaps, so that the array of gaps connects the first reservoir in fluid communication with the second reservoir.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: November 30, 2021
    Assignee: International Business Machines Corporation
    Inventors: Joshua T. Smith, Stacey Gifford, Sung-Cheol Kim, Benjamin Wunsch
  • Patent number: 11173488
    Abstract: Microfluidic systems and methods are described for capturing magnetic target entities bound to one or more magnetic beads. The systems include a well array device that includes a substrate with a surface that has a plurality of wells arranged in one or more arrays on the surface. A first array of wells is arranged adjacent to a first location on the surface. A second and subsequent arrays, if present, are arranged sequentially on the surface at second and subsequent locations. When a liquid sample is added onto the substrate and caused to flow, the liquid sample will flow across the first array first and then flow across the second and subsequent arrays in sequential order. The wells in the first array each have a size that permits entry of only one target entity into the well and each well in the first array has approximately the same size.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: November 16, 2021
    Assignee: Purdue Research Foundation
    Inventors: Cagri A. Savran, Chun-Li Chang, Wanfeng Huang, Onur Gur, Rohil Jain
  • Patent number: 11161113
    Abstract: A microchannel (1) having a spiral geometry structured with asymmetrical curls (2) that enables separation of metastasis cancer cells rarely found in blood from the blood cells and enrichment thereof, which forces the particles or the cells to focus quicker and where high-quality particle focusing in a wider flow rate range can be performed.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: November 2, 2021
    Inventors: Levent Trabzon, Samir Jaber, Utku Mustafa Sonmez
  • Patent number: 11162902
    Abstract: Nanoarchitectures comprised of subwavelength metal nanosphere oligomers with uniform narrow gap spacings for plasmonic and metamaterial devices are described, as well as methods of fabrication thereof, a biosensor system based thereon, and methods of detection of pathogenic or other organisms (e.g., bacteria) using the same.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: November 2, 2021
    Assignee: The Regents of the University of California
    Inventors: Regina Ragan, Filippo Capolino, William Thrift
  • Patent number: 11156623
    Abstract: Provided herein are methods to determine the safety of quercetin compositions regarding contaminants that can result from the degradation of quercetin, such as by storage of solid form quercetin compositions in an air atmosphere. The contaminants include protocatechuic acid, 2,4,6-trihydroxybenzoic acid, and 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoic acid. Provided herein are also methods which reduce degradation of solid form quercetin compositions and reduce the formation of such toxic compounds. The provided methods increase the shelf life and patient safety of quercetin compositions.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 26, 2021
    Inventors: Sergii Fesenko, Alexander Shneider, Vladimir Gabai
  • Patent number: 11148136
    Abstract: Methods and apparatus for driving flow in a microfluidic arrangement are provided. In one disclosed arrangement, the microfluidic arrangement comprises a first liquid held predominantly by surface tension in a shape defining a microfluidic pattern on a surface of a substrate. The microfluidic pattern comprises at least an elongate conduit and a first reservoir. The area of contact between the substrate and a portion of the first liquid that forms the elongate conduit defines a conduit footprint. The area of contact between the substrate and a portion of the first liquid that forms the first reservoir defines a first reservoir footprint. The size and shape of each of the conduit footprint and the first reservoir footprint are such that a maximum Laplace pressure supportable by the first liquid in the elongate conduit without any change in the conduit footprint is higher than a maximum Laplace pressure supportable by the first liquid in the first reservoir without any change in the first reservoir footprint.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: October 19, 2021
    Inventors: Edmond Walsh, Alexander Feuerborn, Peter Richard Cook
  • Patent number: 11150185
    Abstract: The present technology is directed to the nanoparticles for use as molecular environmental sensors. The nanoparticles comprise a photoluminescence core and a plurality of ligands bound to the core and forming a quencher permeable ligand shell. The ligands comprise a reactive or charged moiety capable of being modulated between a first stand and a second state, and the proportion of ligands in each state determine the permeability of the ligand shell to a photoluminescence quencher.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: October 19, 2021
    Assignee: Northwestern University
    Inventors: Chen He, David J. Weinberg, Emily A. Weiss, Jeremiah Yoonsung Kim, Chen Wang, Andrew Lee
  • Patent number: 11150240
    Abstract: The present disclosure relates to, inter alia, devices, systems, and methods for use in the magnetic separation of biological entities from fluid samples. This device includes a magnetic separation chamber configured to receive a fluid sample for magnetic separation, where the magnetic separation chamber includes at least two magnets mounted on the surface or in the wall of the magnetic separation chamber. The device also includes a force provider configured to move the magnetic separation chamber in a side-to-side motion to mix and/or magnetize the fluid sample. In one embodiment, the magnetic separation chamber is in a form of a sleeve and comprises a substantially central channel for loading a vessel containing the fluid sample therein. The systems and methods of the present disclosure involve the use of this device to separate biological entities from fluid samples.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: October 19, 2021
    Inventors: Sasank Vemulapati, David Erickson
  • Patent number: 11125695
    Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: September 21, 2021
    Inventors: Hans-Peter Josel, Herbert Andres, Michaela Windfuhr, Oliver Larbolette, Stefan Quint
  • Patent number: 11123729
    Abstract: Apparatus for controlling motion of liquid droplets. A set of electrode pads is arranged to define one or more tracks over which liquid droplets may be induced to move over a sequence of 5 the electrode pads. A surface over the electrode pads is dielectric, smooth, and slippery to the droplets. In some cases, the smooth surface is formed as a thin layer of a second liquid that is immiscible with the liquid of the droplets. The surface has wetting affinity to the liquid that can be individually varied in a controlled manner by application of voltage to respective electrode pads. A control is designed to alter the wetting characteristic of varying-wettability portions of 10 the surface over respective electrode pads to effect induced motion of the droplets over the surface. The apparatus is designed with the smooth hydrophobic surface open, with no overlying or facing electrode or plate above the droplets.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: September 21, 2021
    Assignee: VOLTA LABS, INC.
    Inventor: Udayan Umapathi
  • Patent number: 11117133
    Abstract: A microfluidic system which enables singular confinement of cells at the capturing stations and impedance measurements of single cells at these stations. The microfluidic system includes an inlet, a dielectrophoretic separation site, a waste outlet I, a connection pad, a hydrodynamic flow resistance. Collective measurements can also be obtained by measuring up to twenty singular cells at capturing stations simultaneously.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: September 14, 2021
    Inventors: Huseyin Kizil, Emre Altinagac
  • Patent number: 11110460
    Abstract: Provided is a microfluidic chip having an inlet/outlet structure optimized for sealing an inlet/outlet of a microfluidic chip using a UV curable sealing material, a microfluidic chip having the inlet/outlet structure, and a method of sealing the inlet/outlet of the microfluidic chip using a UV curable sealing material. It is possible to provide a semi-permanent seal with less contamination from a fluid sample or a harmful reagent, and the inlet/outlet of the microfluidic chip can be firmly sealed using simple equipment and without high-temperature/high-pressure conditions.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: September 7, 2021
    Assignee: NANOBIOSYS INC.
    Inventors: Sung Woo Kim, Seung Min Jeong, Jae Young Byun
  • Patent number: 11099145
    Abstract: Systems and methods electronic barcoding of particles. The methods comprise: performing operations by a spin coater to spin coat a single layer of particles onto a substrate; performing operations by a heat applicator to apply heat to the substrate so as to evaporate a liquid; and performing operations by at least one material depositor to transform the particles into Electronically Barcoded Particles (“EBPs”). EBPs are fabricated by: coating a portion of each said particle of the particles with a first conductive layer; depositing an insulative layer on the first conductive layer; and/or depositing a second conductive layer on the insulative layer so as to form a parallel plate capacitor on the particle. The parallel plate capacitor is tuned so that the particle has a capacitance that is different than the capacitances of other ones of the electronically barcoded particles.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: August 24, 2021
    Inventor: Mehdi Javanmard
  • Patent number: 11098300
    Abstract: The present invention relates to a method for the preparation of nanoscale nucleic acid-encircled lipid bilayers, the nanoscale nucleic acid-encircled lipid bilayers and their use.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: August 24, 2021
    Inventors: Karim Fahmy, Thorsten-Lars Schmidt, Katarina Iric
  • Patent number: 11097271
    Abstract: A microfluidic device can comprise a plurality of interconnected microfluidic elements. A plurality of actuators can be positioned abutting, immediately adjacent to, and/or attached to deformable surfaces of the microfluidic elements. The actuators can be selectively actuated and de-actuated to create directed flows of a fluidic medium in the microfluidic (or nanofluidic) device. Further, the actuators can be selectively actuated and de-actuated to create localized flows of a fluidic medium in the microfluidic device to move reagents and/or micro-objects in the microfluidic device.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: August 24, 2021
    Assignee: Berkeley Lights, Inc
    Inventors: Keith J. Breinlinger, Andrew W. McFarland, J. Tanner Nevill
  • Patent number: 11090646
    Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: August 17, 2021
    Assignees: bioMerieux, Inc., BioFire Defense, LLC
    Inventors: Christopher S. Ronsick, Kirk Ririe, Mark S. Wilson, John D. Walsh, Ryan T. Hill
  • Patent number: 11085588
    Abstract: The invention relates to the balancing of fluid streams in a dialysis system. In particular the invention relates to a cassette for conveying a first and a second fluid stream in a dialysis system, wherein the first and the second fluid streams can be medical fluid streams such as for example dialysate streams or blood streams, wherein the cassette has a sensor as a device for balancing the first and the second fluid stream, and wherein the sensor has a first channel for the first fluid stream and a second channel for the second fluid stream. The invention further relates to a dialysis system, which is configured to accommodate at least one cassette which is configured as described above. Furthermore, the present invention relates to an arrangement by which two channels for the first and the second fluid streams are formed. In addition, the invention relates to a method for construction of the two channels or the arrangement.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: August 10, 2021
    Inventors: Dejan Nikolic, Alexander Heide
  • Patent number: 11073511
    Abstract: A device (“the ExoTIC device”) for the isolation of extracellular vesicles from an extracellular vesicle-containing sample in which the sample is flowed through a membrane in a flow chamber to capture and purify the extracellular vesicles on the membrane. The extracellular vesicles may be washed and collected and utilized in any one of a number of ways including, but not limited to, identifying biomarkers of a disease, identifying the presence of a biomarker in a patient to determine whether a patient has a disease, and therapeutically treating existing diseases by re-introducing the extracellular vesicles, potentially modified, back into a body.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: July 27, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Fei Liu, Utkan Demirci, Sanjiv Sam Gambhir, Viswam S. Nair