Abstract: The present invention discloses the taste masking of drugs by wet granulating the drug with a microcrystaline cellulose compositions then spheronizing the granulation into spheres having a smooth uniform surface and a particle size in the range of 1 to 1000 microns.

Abstract: The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation of the device being of a predetermined length of time. The delivery of the agent formulation from the dispensing device is continued until essentially all of the active agent formulation is delivered as a result of the fluid inhibition into a fluid flow path in the housing of the device and the expansion of an expansion agent in the active agent delivery chamber.

Abstract: A topically applied aphrodisiac dispersed in a manually applied vehicle which substantially increases tissue sensation. The principal ingredient is benzalkonium chloride in a water soluble gel which includes sorbitol, glycerin, hydroxethylcellulose and propylene glycol.

Abstract: A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir comprising the effective agent; a first coating layer, which is permeable to the passage of the effective agent; a second coating layer, which is essentially impermeable to the passage of the effective agent; and a third coating layer, which is permeable to the passage of the effective agent. The first coating layer covers at least a portion of the inner core.

Abstract: The in vivo catalytic dismutation of hydrogen peroxide by pseudocatalase such as a transition metal bicarbonate complex is increased by the addition of a chelating agent, preferably ethylenediaminetetraacetic acid (EDTA), citic acid, 2,6-pyridinedicarboxylic acid, or a salt thereof Further, the stability of a topical composition comprising a transition metal bicarbonate complex is improved by storing the composition under carbon dioxide, preferably under pressure in aerosol form.

Abstract: This invention relates to personal lubricant compositions that are at least between three and eighteen times more lubricious than the compositions known previously. The compositions of this invention contain one or more polyhydric alcohols, one or more water-soluble polymers derived from cellulose, water and, optionally, preservatives and alkali metal or alkaline earth metal bases. The compositions of this invention can provide a vehicle for delivering medicaments for contraception and for the treatment and prevention of disease. This invention also relates to methods of using the personal lubricant compositions of this invention.

Abstract: A single bead drug delivery system suitable for oral administration with multiply layered drug and polymer compartments can provide a two-step release of active agent to facilitate an immediate yet sustained drug delivery over a 24 hour period following oral administration with minimized variance between peak and trough levels of therapeutic drug amounts.

Abstract: Disclosed is a topical composition for relieving pain in a person in need of such relief, consisting essentially of an effective amount of a combination of at least one corticoid analgesic, at least one arylpropionic acid type analgesic, and at least one p-aminobenzoic acid ester type local anesthetic; an amount effective in enhancing the effectiveness in relieving pain of the combination of capsaicin, and an amount effective to increase the transmission thereof of through the skin of at least one phospholipid and at least one polyoxyethylenepolyoxypropylene copolymer.

Abstract: A phthalate-free long-lasting nail polish enamel composition consisting essentially of a film-forming agent, solvents, one or more colorants, one or more suspending agents, adhesion promoters and plasticizers selected from the group consisting essentially of the adipates, pentaerythrityl tetrabenzoate, 2,2,4-trimethyl-1,3-pentanediol diisobutyrate, pentaerythrityl tetraacetate and mixtures thereof. Preferably, the nail composition is free of any toluene-containing components as well.

Abstract: A composition comprising at least one non-steroidal antiinflammatory drug, their salts, their chirally pure forms, isomers and derivatives, analogues and adducts thereof and two drugs pitofenone hydrochloride and fenpiverinium bromide in a pharmaceutically acceptable combination.

Abstract: S,S'-ethylidene dithioacetate is used as a flavoring ingredient for giving the edible products in which it is incorporated not only a sulphurous but also a green, fruity, rich and even meaty quality. It has been particularly successfully used in grapefruit and other fruit flavorings. It can also be used in the preparation of perfuming compostions.

Abstract: Controlled release pharmaceutical compositions for the oral administration of nifedipine are disclosed which comprise an amorphous coprecipitate of nifedipine and polyvinylpyrrolidone with suitable excipients. The release rate may be varied from 8 to 24 hours by varying the amounts of the cellulose derivative, the carboxypolymethylene and the lactose.

Abstract: Provided is a drug carrier comprising particles of at least one pure active compound which is insoluble, only sparingly soluble or moderately soluble in water, aqueous media and/or organic solvents, wherein said active ingredient is solid at room temperature and has an average diameter, determined by photon correlation spectroscopy (PCS) of 10 nm to 1,000 nm, the proportion of particles larger than 5 .mu.m in the total population being less than 0.1% (number distribution determined with a Coulter counter), and, when introduced into water, aqueous media and/or organic solvents, the active compound has an increased saturation solubility and an increased rate of dissolution compared with powders of the active compound prepared using an ultrasonic probe, a ball mill or a pearl mill, the solid particles having been comminuted, without prior conversion into a melt, by using cavitation or shearing and impact forces with introduction of a high amount of energy.

Abstract: A pharmaceutical preparation for topical treatment of skin disorders, particularly psoriasis, comprising the ingredients of a latex extracted from the leaves of the Wrightia tinctoria R Br. plant, urea, and polyethylene glycol. The pharmaceutical preparation is also a hydrophilic ointment that is capable of delivering the active drugs without being greasy or irritating to the skin.

Abstract: The invention provides a new water soluble lubricant combination which facilitates the production of tablets. The combination of glyceryl behenate and fumaric acid is useful as a lubricant, particularly in tablet compositions containing ingredients where rapid dissolution in an aqueous environment is desired for activity or desired for aesthetic purposes. This lubricant combination has fewer limitations and improved functionality in comparison to standard lubricants presently known. In addition, the lubricants provided may be used with known hydrophobic lubricants to decrease the amount of the hydrophobic lubricant required for lubrication.

Abstract: Disclosed are antiperspirant cream compositions with improved dry skin feel. These antiperspirant compositions have a penetration force value of from about 20 gram.multidot.force to about 500 gram.multidot.force, and comprise (a) from about 20% to about 80% by weight of a volatile silicone material; (b) from about 5% to about 35% of a particulate antiperspirant active; (c) from about 0.1% to about 20% by weight of a gellant material comprising glyceryl tribehenate and other triglycerides wherein at least about 75% of the esterified fatty acid moieties of said other triglycerides have from about 18 to about 36 carbon atoms, and the molar ratio of glyceryl tribehenate to said other triglycerides is from about 20:1 to about 1:1; and (d) from about 0.1% to about 5% by weight of a drying agent selected from the group consisting of bentonite clays, hectonite clays, colloidal silicas, talc, microthene, and mixtures thereof. The compositions preferably further comprise a residue masking material.

Abstract: A bone-forming graft that includes a bone morphogenetic protein (BMP) carried on a composite porous body. The composite porous body has a porous frame of a bioabsorbable hydrophilic material and a surface layer of a bioabsorbable polymer material. In particular, the present invention relates to a bone-forming graft in which the bioabsorbable hydrophilic material is one or more compounds selected from a group consisting of gelatin, hyaluronic acid, a hyaluronic acid derivative, collagen, a collagen derivative, chitosan, a chitosan derivative, and triethanolamine alginate. The bioabsorbable polymeric material is one or more compounds selected from a group consisting of a polylactic acid, a copolymer of a polylactic acid and a polyglycolic acid, and a copolymer of poly?bis(p-carboxyphenoxy)propane!anhydride and sebacic acid. The graft has excellent formability and workability and has an internal structure suitable for in vivo bone formation.

Abstract: This first aid spray is different from any other first aid spray. It has an indefinite shelf life, is safe for the environment, and is unaffected by heat or cold. It doesn't use conventional methods to accomplish its objectives of relieving pain and, reducing swelling, and allowing the skin to neutralize.

Abstract: A candy product includes a ring forming an annular handle, and having an outer diameter of at least 5 cm. A candy holder attached to the handle and adapted for carrying a lump of candy to be consumed by a child. The holder forms a paddle to pacify the child upon removal of the candy from the holder.

Abstract: A composition for treating acne and related skin conditions which contains salicylic acid and aloe vera which is improved by the addition of an effective amount of a methylxanthine. Preferably, the methylxanthine is derived from mate extract. A method for treating acne with the composition is also provided.