Abstract: The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.

Abstract: Described herein are compositions comprising a MMP-13 inhibitor, and methods of using the same.

Abstract: The present invention relates to a vaginal suppository comprising an inert vehicle and lactic acid or a salt thereof for the treatment and/or prophylaxis of disorders in the urogenital tract. It also relates to the use of such a suppository for the production of a medicament for the treatment and/or prophylaxis of disorders in the urogenital tract as well as to a method for the treatment and/or prophylaxis of disorders in the urogenital tract.

Abstract: Swellable, coated sutures have a swellable polymeric coating and a fibrous component, wherein the coating is formed of an absorbable or non-absorbable polymer, while the fibrous component is formed of a synthetic absorbable or non-absorbable monofilament yarn, synthetic absorbable or non-absorbable braided multifilament yarn, braided silk multifilament yarn or combinations thereof. In certain instances, the coating is used as a carrier for the controlled delivery of different types of bioactive agents, including those having antimicrobial, anti-inflammatory, anesthetic, tissue growth-promoting, and antineoplastic activities.

Abstract: Methods for producing a mono- or multilayer composite are provided in which one or several layers are applied onto a carrier material by coating, the coated mono- or multilayer composite is dried and rolled up, and the installation is subsequently cleaned. The air circuit in the drying oven is entirely set to fresh air supply, and the drying oven is configured to be cleaned in a controlled manner. All components of the drying oven that come into contact with the product do not have to be removed during cleaning, but can be cleaned-in-place using technology integrated into the drying oven. The drying oven Outer housing is designed so that it can be lifted upwardly. All assembly parts in the drying oven interior are designed to eliminate disassembling for cleaning purposes. Transport rollers within the drying oven are designed as hollow shafts and provided with spraying nozzles.

Abstract: The invention relates to a treatment solution for treating wounds, preferably for liquid wound treatment of acute and chronic wounds, made of an aqueous solution including zinc, iron, and acid, wherein the per liter proportion of zinc is 10 to 100 mg, the proportion of iron is 6.5 to 60 mg, and the proportion of acid is selected such that the pH value of the treatment solution is 2.5 to 3.5.

Abstract: The present disclosure generally relates to a personal care composition containing a carrier, an oil phase having at least one terpene alcohol component, an at least partially fluorinated compound, and a stabilizer. In an exemplary aspect, the at least partially fluorinated compound is stable within the composition of the present disclosure with the introduction of an oil phase having at least one terpene alcohol component to stabilize the at least partially fluorinated compound. Thus, the composition provides an initial foaming action and longer term skin benefits provided by an oil phase contacting a terpene alcohol component. A stabilizing component may also be included to provide further stability to the composition.

Abstract: A method of treating burns, preferably second and third degree burns, by administration of an oxidative reduction potential (ORP) water solution that is stable for at least twenty-four hours is provided.

Abstract: Aqueous compositions, methods of manufacturing such aqueous compositions, and methods of removing reducing and/or suppressing malodors using such aqueous compositions are described. These compositions utilize a combination of hydrogen peroxide, a source of copper II, nonionic surfactant and alcohol to provide a highly effective and stable malodor removing, reducing and/or suppressing composition. The compositions are particularly useful as aerosol compositions for effective malodor removal, reduction and/or suppression in particular malodors from open sites such as landfill and in closed domestic environments such as the home. Also described is a stabilized hydrogen peroxide solution, which is stable on the addition of copper (II) salts.

Abstract: The invention relates to the use of polymeric particles for boosting the UV absorption of an UV filter in an UV-sunscreen composition, wherein the polymeric particles comprise at least one polymeric particle comprising at least one chromophore having an UV absorption maximum at ?max?275 nm covalently bound thereto.

Abstract: The present invention provides a hair styling composition comprising (a) 1% to 10% by weight of at least one polymer comprising, as polymerized units, one or more monomers having at least one acid-functional group; (b) 99% to 90% by weight of a solvent mixture comprising: (i) 5% to 100% by weight of at least one volatile organic solvent; (ii) 95% to 0% by weight of water, and (iii) 0% to 80% by weight of at least one propellant; and (c) a neutralizer, wherein the mole ratio of said neutralizer to the acid-functional groups on said polymer (a) is from 0:1 to 1.2:1, and the neutralizer comprises: (i) 10% to 30% neutralization of the acid group of the polymer by tetrabutylammonium hydroxide, and (ii) 90% to 70% neutralization of the acid group of the polymer by aminomethyl propanol. More particularly, the polymer (a) may comprise, as polymerized units, (i) 30% to 75% by weight of one or more monomer that has refractive index of 1.

Abstract: The present invention is directed to compositions and methods of delivery of CoQ that is reduced in the presence of lipoic acid and, optionally a fatty acid and/or optionally in a monoterpene. The compositions that include the reduced CoQ can be formulated in soft gel capsules.

Abstract: Layered pharmaceutical composition suitable for oral use in the treatment of diseases where absorption takes place over a large part of the gastrointestinal tract. The composition comprising A) a solid inner layer comprising i) an active substance, and ii) one or more disintegrants/exploding agents, one of more effervescent agents or a mixture thereof.

Abstract: A polymer emulsion for use in a cosmetic composition includes an olefin copolymer; a copolymer of an acidic monomer to include acrylic acid, methacrylic acid or other unsaturated, carboxyl containing monomer; optionally, at least one stabilizing emulsifier; optionally, a resin selected from a group consisting of an acrylic resin and styrene-acrylic resin, said resin having an average molecular weight from about 500 to about 15,000 daltons; and, optionally, a polymer selected from a group consisting of oxidized polyethylene polymers and oxidized polypropylene polymers, said polymer modified with cationic end-groups such as tallow alkyl amines.

Abstract: [Summary] An external preparation formulation superior in the transdermal absorbability has been desired as a new administration route of aripiprazole. Transdermal absorption of aripiprazole has been enabled for the first time by appropriately combining aripiprazole and an organic acid (particularly fatty acid with low lipophilicity). That is, it has been found that more superior transdermal absorbability can be achieved by forming a salt by using a compound showing lipophilicity within the range of ?1.5-2, such as fatty acid and the like. It has been further found that the transdermal absorbability is remarkable improved by appropriately selecting the solvent composition. As a result, since a new dosage form of aripiprazole other than oral preparation has been developed, a new transdermal absorption preparation of aripiprazole can be provided.

Abstract: The present invention is directed to implants and the modification of the surface of implants using amino acid or polypeptide functionalized rosette nanotubes.

Abstract: The present invention includes methods for treating Meibomian gland dysfunctions. The invention also includes methods for improving tear lipid composition, for treating abnormal Meibomian gland secretion and for normalizing Meibomian gland secretions.

Abstract: A patch containing a support and an adhesive layer formed on at least one surface of the support, wherein the adhesive layer contains an elastomer obtained by crosslinking a polymer having a butadiene skeleton in the presence of organic peroxide, wherein the patch has good adhesion property and maintain this quality for a long time.

Abstract: Process for manufacturing 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate comprising step (i): (i) reacting 1-amino-1,3,3,5,5-pentamethylcyclohexane with methane sulfonic acid in a solvent or a mixture of two or more solvents selected from anisole, cumene, pentane, hexane, heptane, isooctane, methyl acetate, propyl acetate, isopropyl acetate, n-butyl acetate, isobutyl acetate, methyl ethyl ketone, methyl isopropylketone, methyl isobutyl ketone, dimethyl sulphoxide, tetrahydrofuran, methyltetrahydrofuran, 1,1-diethoxypropane, 1,1-dimethoxymethane, and 2,2-dimethoxypropane.

Abstract: The present subject matter provides a nail patch comprising a backing layer and a pressure-sensitive adhesive layer disposed on at least one side of the backing layer, wherein the pressure-sensitive adhesive layer comprises a pressure-sensitive adhesive base, terbinafine and/or a pharmacologically acceptable salt thereof, and sodium acetate and/or sorbitan monolaurate as a solubilizer.