Patents Examined by Brian-Yong Kwon
  • Punctal plugs and methods of delivering therapeutic agents
    Patent number: 8753666
    Abstract: The present invention concerns implantable ocular devices for the sustained release of medication to the eye, and methods for manufacturing and using such devices. In one embodiment, the present invention provides a device comprising: (a) a body comprising a matrix of a prostaglandin and a silicone; (b) a parylene coating on the outer surface of the body; and (c) one or more pores extending from the outer surface of the parylene coating to the outer surface of the body.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: June 17, 2014
    Assignee: Alcon Research, Ltd.
    Inventors: Theron R. Rodstrom, Larry Smith, II, Youqin Tian, David Allen Marsh, Alan L. Weiner, Shivalik Bakshi
  • Transparent cosmetic or dermatological formulation
    Patent number: 8747821
    Abstract: The invention relates to a clear, cosmetic and dermatological formulation having reduced stickiness, comprising at least one antiperspirant active ingredient and/or deodorant active ingredient, at least one ?-hydroxycarboxylic acid and water.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: June 10, 2014
    Assignee: Beiersdorf AG
    Inventors: Ulrike Schulz, Gordon Christ
  • Dosage form with improved release of cefuroximaxetil
    Patent number: 8747900
    Abstract: The invention relates to a pharmaceutical composition comprising cefuroximaxetil and at least one carrageenan selected from the group consisting of ?-carrageenan, ?-carrageenan and -carrageenan. The invention furthermore relates to pellets, to a multiparticulate, pharmaceutical dosage form and to a novel crystalline modification of cefuroximaxetil.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: June 10, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Iris Ziegler, Andreas Fischer
  • Nanoparticulate compositions for diagnostic imaging
    Patent number: 8728440
    Abstract: The present invention provides a trialkoxysilanes having structure I wherein R1 and R2 are independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; and X? represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: May 20, 2014
    Assignee: General Electric Company
    Inventors: Matthew David Butts, Peter John Bonitatibus, Jr., Robert Edgar Colborn, Andrew Soliz Torres
  • X-ray visible drug delivery device
    Patent number: 8722037
    Abstract: The subject invention provides an X-ray visible drug delivery device for subdermal administration of a contraceptive or hormone replacement therapy.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: May 13, 2014
    Assignee: Meck Sharp & Dohme B.V.
    Inventors: Harm Veenstra, Wouter De Graaff
  • Tabletting process
    Patent number: 8715724
    Abstract: A process for producing a compressed solid dosage form containing an active ingredient. The process includes a step of preparing core elements containing the active ingredient. Optionally the core elements are coated with a pharmaceutically acceptable coating layer to form coated pellets. The core elements or pellets are treated with an anti-static agent and compressed with suitable excipients to form the compressed solid dosage form. Preferred anti static agents are starch, microcrystalline cellulose, kaolin, bentonite, silicates, silicon dioxide, cellulose, stearic acid, sodium stearyl fumarate and glyceryl behenate.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: May 6, 2014
    Assignee: Mayne Pharma International Pty Ltd
    Inventor: Stefan Lukas
  • Carbide-derived-carbon-based oxygen carriers
    Patent number: 8697128
    Abstract: An oxygen delivery system is disclosed. The basis of the oxygen deliver system is a carbide-derived carbon (CDC). The CDC can be tuned to carry O2 directly (CDC OC), or hemoglobin can be adsorbed to provide a hemoglobin-based oxygen carrier (CDC HBOC). The delivery system allows the use of a variety of hemoglobins which differ in their oxygen dissociation profiles, including variant and mutant hemoglobins from other species. The delivery system is biocompatible and stable, and is able to irreversibly bind and hold large amounts of functional hemoglobin variants. The CDC HBOC and CDC OC provide a safe and effective blood substitute for combat casualty care, as well as being useful for oxygen delivery in other contexts.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: April 15, 2014
    Assignee: BAE Systems Information and Electronic Sytems Integration Inc.
    Inventor: Robert A. Burton
  • Pegylated interleukin-10
    Patent number: 8697045
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: April 15, 2014
    Assignee: Merck Sharp & Dohme Corporation
    Inventors: Seoju Lee, David C. Wylie, Susan Cannon-Carlson
  • Peeling capsules
    Patent number: 8691249
    Abstract: A cosmetic peeling preparation which comprises a plurality of capsules. A capsule comprises a casing and a filling. The casing material is solid at 25° C. and selected from cosmetically conventional lipids, waxes, emulsifiers, natural polymers, synthetic polymers, and mixtures thereof. The filling comprises an oil or lipid mixture having a viscosity at 25° C. of from 3 to 50,000 mPas and one or more solid substances having an abrasive effect.
    Type: Grant
    Filed: September 15, 2007
    Date of Patent: April 8, 2014
    Assignee: Beiersdorf AG
    Inventors: Jessica Schaefer, Silke Weyland
  • Pharmaceutical composition for preventing or treating rheumatoid arthritis, containing rebamipide
    Patent number: 8691842
    Abstract: The present invention provides a pharmaceutical composition for preventing or treating rheumatoid arthritis comprising rebamipide as an active ingredient and a pharmaceutically acceptable carrier. The pharmaceutical composition may be for oral administration, for example an oral solid dosage form of a tablet or capsule form. The pharmaceutical composition may be formulated into a unit dosage form suitable for orally administering rebamipide in a dose ranging from 0.5 to 50 mg/kg, preferably from 0.6 to 6 mg/kg.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: April 8, 2014
    Assignees: Catholic University Industry Academic Cooperation Foundation, Hanlim Pharmaceutical Co., Ltd.
    Inventors: Jun-Ki Min, Mi-La Cho, Yun-Ju Woo, Hye-Jwa Oh, Joo-Yeon Jhun, Geun-Hyeog Lee, Se-Wan Park, Jin-Ha Park, Eun-Young Kwak
  • Polycondensate, composition, treatment process, and preparation process
    Patent number: 8691193
    Abstract: Polycondensate, composition containing it, especially a nail varnish composition, and process for preparation. The polycondensate may be obtained by reacting: a polyol comprising 3 to 6 hydroxyl groups; a saturated or unsaturated non-aromatic monocarboxylic acid; an aromatic monocarboxylic acid containing 7 to 11 carbon atoms; and a saturated or unsaturated, or even aromatic, linear, branched and/or cyclic polycarboxylic acid, comprising at least two carboxylic groups COOH; and/or a cyclic anhydride of such a polycarboxylic acid.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: April 8, 2014
    Assignee: L'Oreal
    Inventors: Ivan Rodriguez, Roland Ramin, Pascal Giustiniani, Gerard Malle, Philippe Ilekti
  • Composition, system, and method for modulating release kinetics in implantable drug delivery devices by modifying drug solubility
    Patent number: 8673336
    Abstract: An implantable drug delivery device loaded with a beneficial agent is provided, wherein the beneficial agent is in two different forms, a first form having a higher solubility and a second form having a lower solubility, and wherein the two different forms are present in a proportion which is selected to achieve a desired release rate.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: March 18, 2014
    Assignee: Innovational Holdings LLC
    Inventors: Theodore L. Parker, Stephen Hunter Diaz, John F. Shanley, Diane Mai Huong Dang, Thai Minh Nguyen
  • Demand-release bioactive composition for implantable medical devices
    Patent number: 8673339
    Abstract: A biostable polymeric substrate of an implantable medical device unit includes a demand-release bioactive composition including one or more bioactive agents covalently bound to surface-modifying end groups of the substrate. Certain cellular activities, in proximity to the polymeric substrate, release substances reacting with the end groups such that the end groups release the one or more bioactive agents, which modify the certain cellular activities.
    Type: Grant
    Filed: March 11, 2003
    Date of Patent: March 18, 2014
    Assignee: Medtronic, Inc.
    Inventors: Kenneth B. Stokes, Michael J. Ebert, Christopher M. Hobot
  • Method for producing gamma-aminobutyric acid and food produced thereby
    Patent number: 8673324
    Abstract: The embodiment of invention provides a method for producing ?-aminobutyric acid, including the steps of providing a medium including Saccharomyces cerevisiae, adding an extract of Rhinacanthus nasutus into the medium and fermentating Saccharomyces cerevisiae in the medium added with the extract of Rhinacanthus nasutus to produce ?-aminobutyric acid.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: March 18, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Ching-Hui Chang, Tsai-Mei Wu
  • Sodium channel blocker delivery system with scleral lens
    Patent number: 8673340
    Abstract: A scleral lens is provided with a sodium channel blocker or a sodium channel modulator disposed in the pre-corneal tear film between the scleral lens and the cornea. This system can be used to deliver sodium channel blockers or a sodium channel modulators not currently used because of poor bioavailability. Methods of using this sodium channel blocker delivery system or a sodium channel modulator delivery system are also disclosed.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: March 18, 2014
    Assignee: Boston Foundation for Sight
    Inventor: Perry Rosenthal
  • Compositions and methods for treating keratinous substrates
    Patent number: 8658140
    Abstract: The disclosure relates to compositions and methods of using the compositions to treat keratinous substrates. The compositions provide a water resistant and non-transferable protective barrier on the substrate. The compositions contain at least one polyamine, at least one acid, at least one water-insoluble ingredient, solvent and optionally at least one auxiliary ingredient. The methods for treating keratinous substrates involve contacting the keratinous substrates with the compositions of the disclosure.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: February 25, 2014
    Assignee: L'Oreal
    Inventors: Nghi Van Nguyen, David W. Cannell, Sawa Hashimoto, Cynthia Espino
  • Actives-comprising polymer networks, processes for producing them, and their use
    Patent number: 8653004
    Abstract: Process for producing actives-comprising polymeric networks from oligomers containing (meth)acrylate groups, optionally from further monomers, and from actives, the polymeric networks obtainable by the process, and the use of the networks for various purposes, more particularly for protecting materials or in crop protection.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: February 18, 2014
    Assignee: BASF SE
    Inventors: Alexandre Terrenoire, Hartmut Leininger, James Bullock, Mohammed Shoaib Qureshi, Hans-Werner Schmidt, Reiner Giesa, Meik Ranft, Oscar Lafuente Cerda
  • 2,4-disubstituted pyridines as perfuming ingredients
    Patent number: 8652452
    Abstract: The present invention relates to the field of perfumery. More particularly, it concerns the use as perfuming ingredients of a 2,4-dialkyl-pyridine of formula (I): in the form of any one of its stereoisomers or a mixture thereof, wherein R1 represents a C1-3 alkyl group; R2 represents a C4-9 linear alkyl group; and the compound has between 10 and 15 carbon atoms. These compounds are useful for imparting odors of the green and/or pyrazine type. The present invention concerns the use of such compounds in the perfumery industry as well as the compositions or articles containing them.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: February 18, 2014
    Assignee: Firmenich SA
    Inventors: Estelle Delort, Kirk F. Eidman
  • Rapamycin formulations and methods of their use
    Patent number: 8637070
    Abstract: Described herein are liquid rapamycin formulations. Described herein are methods of treating or preventing diseases or conditions, such as choroidal neovascularization, wet AMD and dry AMD, and preventing transition of dry AMD to wet AMD, using the liquid rapamycin formulations described herein.
    Type: Grant
    Filed: February 9, 2006
    Date of Patent: January 28, 2014
    Assignee: Santen Pharmaceutical Co., Ltd.
    Inventors: Sreenivasu Mudumba, Philippe J M Dor, Thierry Nivaggioli, David A. Weber, Sidiq Farooq
  • Use of a copolymer in the form of a solubiliser for a poorly water-soluble compound
    Patent number: 8632763
    Abstract: The use of copolymers obtained by free-radical polymerization of a mixture of i) 30 to 80% by weight of N-vinyllactam, ii) 10 to 50% by weight of vinyl acetate, and iii) 10 to 50% by weight of a polyether, with the proviso that the total of components i), ii) and iii) equals 100% by weight, as solubilizers for slightly water-soluble substances.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: January 21, 2014
    Assignee: BASF SE
    Inventors: Nathalie Bouillo, Marianna Pierobon, Ralf Widmaier, Rainer Dobrawa, Kathrin Meyer-Böhm, Ronald Frans-Maria Lange