Abstract: Freeze-dried pharmaceutical preparation containing antibacterial quinolinecarboxylic acid derivatives are provided. These preparations are characterized by their stability against light and heat and have rapid solubility.

Abstract: 8,10-Dideazatetrahydrofolic acid derivatives of the formula: ##STR1## where R.sub.1 and R.sub.2 are selected from hydrogen and alkyl having from one to about eight carbon atoms and the carboxylates and acid addition salts thereof, showing strong inhibition of L1210 murine leukemia cells in culture, modest inhibition of glycinamide ribotide transformylase and aminoimidazole carboxamide ribotide transferase, and insignificant inhibition of dihydrofolate reductase and thymidylate synthase enzymes.

Abstract: A suspension type aerosol inhalations containing (a) 0.015 to 5.00% (w/w) of a pyrido[1,2-a]pyrimidine compound of the formula: ##STR1## where R is a n-propyl or allyl group, A is a tetrazolyl or carboxyl group, and n is a whole number of 0 to 2, and (b) 0.015 to 5.00% (w/w) of a fatty acid ester.

Abstract: A particulate carrier, including a hydrophilic, non-liquid core, a first layer or ring of lipid nature bonded to the core by covalent bonds and a second layer or outer shell of amphiphilic compounds bonded to the first lipid by hydrophobic interactions.

Abstract: A cosmetic preparation having germicidal properties is set forth, which contains 5-hydroxy-1,4-naphthoquinone as such, in the form of plant parts or in the form of a extract obtained from the plant parts. Preferable cosmetic preparations are preparations for oral and dental care, deodorants and a foot powder.The use of 5-hydroxy-1,4-naphthoquinone as a germicidal agent for cosmetic preparations either as such or in the form of plant parts or an extract obtained from the plant parts is also described.

Abstract: The invention provides a modified protease such that a protease is coupled to a polysaccharide via a triazine ring. This modified protease is considerably stable, safe and active as compared with the conventional modified proteases and immobilized proteases. Therefore, cosmetic products containing this modified protease are less liable to undergo aging, easier to use and improved in effect on the skin.

Abstract: An apatite coated article comprising a substrate having thereon an apatite layer which is formed by flame spraying apatite powder at from about 2,000.degree. to 4,000.degree. C., and a process for producing such an apatite coated article.

Abstract: There are described pharmaceutical compositions comprising aqueous solutions of 7 c l r - ,2,3,4-tetrahydro-2-methyl-3-2-methylphenyl)-4-oxo-6-quinazolinesulfonamid e. ethanol and a cosolvent selected from propylene glycol or polyethylene glycols suitable for parenteral administration to a patent suffering from refractory edema.

Abstract: Compounds of formula (I): ##STR1## [in which: Y represents a group of formula ##STR2## the dotted line is a double of single bond; R.sup.1 is hydrogen, alkyl or aryl; R.sup.2 is hydrogen or halogen; R.sup.3 is alkyl or cycloalkyl; R.sup.4 is hydrogen, alkyl, hydroxy or halogen; and R.sup.6 is hydrogen, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or aralkyl;]and pharmaceutically acceptable salts thereof are valuable in the treatment of cachexia. Certain of these compounds are novel.

Abstract: A substrate for medical devices and a process for making the substrate is provided, the substrate having on at least part of its surface a blood-compatible surface produced by coupling a physiologically active substance to the surface. The physiologically active substance is one having an inhibitory effect on the formation of blood clots and/or is capable of breaking down blood clots formed. The physiologically active substance is bonded to a polyacid, and the polyacid is attached to the surface by a covalent bond.

Abstract: Microbially-stable liquid pharmaceutical suspensions for oral administration comprising a bismuth-containing pharmaceutical agent, benzoic acid, sorbic acid, a suspension system and water, and wherein said compositions have a pH within the range of from about 3.0 to about 5.5. These compositions are efficacious, and have good aesthetics and good storage stability.

Abstract: A corrosion resistant, water expandable composition comprising:(A) 100 parts by weight of at least one material selected from the group consisting of rubbers, thermoplastic resins and mixtures thereof;(B) 10-200 parts by weight of a water-absorbable material; and(C) 5-30 parts by weight of a corrosion inhibitor is disclosed.

Abstract: Pharmaceutical copositions comprising liposomal metalloporphyrins are provided for parenteral administration to mammals, including humans. These liposomal metalloporphyrins selectively target the spleen and markedly inhibit the heme oxygenase activity therein. A method is also provided for intravenous administration of these compositions to mammals to selectively target the spleen.

Abstract: Cellulose derivatives are disclosed which have the following formula: ##STR1## wherein Z is selected from the group consisting of alkylene, alkenylene, alkynylene, cycloalkylene or benzylene or xylylene radicals, which may or may not be substituted;X is selected from the group consisting of --H, --NR.sub.2, --N.sup.+ R.sub.3, --CN, --COOH, --SO.sub.3 H, --SO.sub.3 H, --PO(OR).sub.2, CONR.sub.2 or --Si(OR).sub.3 ;R is selected from the group consisting of hydrogen, alkyl and alkenyl groups having from 1 to 25 carbon atoms, and cycloalkyl, tolyl and phenyl groups;Y is selected from the group consisting of alkyl, alkenyl, alkynyl groups having from 1 to 36 carbon atoms, which may or may not be substituted, cycloalkyl, phenyl, tolyl and benzyl groups, ##STR2## (--CH.dbd.CH--COOH), and NHR, where R has the same meaning as in X, andm=0 to 2.5n=0.01 to 2.95,with the provision that, when m=0, n.gtoreq.1.55, if Y is an alkyl radical with 1 to 5 carbon atoms, 3-(CH.sub.2).sub.

Abstract: Methods for diagnosing, monitoring and controlling the onset and progression of certain dementias, such as AD. The onset and progression of dementia are diagnosed and monitored by following changes in the relative concentrations of two forms of albumin in either serum or CSF. The onset and progression of dementia are controlled and memory loss is impeded or the impairment of memory is improved by dietary supplementation or the administration of Mg.

Abstract: A product comprising a water soluble, high molecular weight aminoalkyl-derivative of hydroxyalkyl-cellulose. The molecular weight of said cellulose is at least 50,000 daltons. One of the methods to obtain the product comprises reacting a hydroxyalkyl cellulose in a basic aqueous medium, in the presence of halogenalkylaminohalide compounds, to obtain a hydroxyalkyl cellulose having an alkylamino group which can be used as such or further reacted in the presence of an amide reducing agent, for instance sodium cyanoborohydride and a carbohydrate residue selected from the group consisting of mono-, di-, oligo-saccharides and starch.

Abstract: A-Nor-5.alpha.-androstane compounds, such as the dipropionate and disuccinate esters of 2.alpha.,17.alpha.-diethynyl-A-Nor-5.alpha.-androstane-2.beta.,17.beta.-di ol and the corresponding 2.alpha.,17.alpha.-diol stereoisomers have an inhibitory effect on malignant cell growth and can be used to treat various carcinomas in mammals.

Abstract: A modified cellulose for biocompatible dialysis membranes having a structure represented by the formula ##STR1## wherein cell is cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH.sub.3 and/or C.sub.2 H.sub.5 and/or C.sub.3 H.sub.7, X denotes specified functional groups, R" is H or R, R"' denotes R, x+t=0.75 to 2.85, t=0 to 2.85, x=0 to 2.85, and r=0 to 1. A process for preparation of the cellulose derivatives is also disclosed.

Abstract: Silated polysaccharides having 0.0005 to 2.0 silyl molar substitution per anhydrosaccharide unit form water resistant films when cast from aqueous solution and dried in the presence of atmospheric carbon dioxide. These films are soluble in aqueous caustic. A preferred water soluble polymer is a cellulose ether with 0.005 to 1.0 silyl substitution.

Abstract: The Indian Ocean sea hare Dolabella auricularia has been found to contain a new cell growth inhibitory and antineoplastic (P388 leukemia) cyclodepsipeptide designated dolastatin 13.sup.(1) and a companion substance dehydrodolastatin 13.sup.(2). A series of high field (400 MHz) 2D-NMR experiments including sequential analyses by HMBC and NOE techniques and tandem mass spectrometry provided structural determinations. Dolastatin 13 and dehydrodolastatin 13 represent a new class of cyclodepsipeptides. Pharmaceutical preparations and therapeutic regimens employing these new cytostatic depsipeptides are disclosed.