Patents Examined by C. Azpuru
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Patent number: 4981960Abstract: A modified cellulose for biocompatible dialysis membranes having a structure represented by the formula ##STR1## wherein Cell is cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH.sub.3 and/or C.sub.2 H.sub.5 and/or C.sub.3 H.sub.7, X denotes specified functional groups, R" is H or R, Z corresponds to the following groups of atoms: SR", SO.sub.3 H and salts thereof, SO-R, SONR".sub.2, SO.sub.2 -R, SO.sub.2 NR".sub.2, SO.sub.2 H and salts thereof, F, Cl, Br, I, NR".sub.2, PR".sub.2, PO.sub.3 H.sub.2 and salts thereof, PO.sub.2 H(OR), PO(OR).sub.2, PO.sub.2 HR" and salts thereof, POR"(OR) and POR".sub.2, x+t=0.75 to 2.85, t=0 to 2.85, x=0 to 2.85, and z=0.01 to 0.45. A process for preparation of the cellulose derivatives is also disclosed.Type: GrantFiled: February 27, 1989Date of Patent: January 1, 1991Assignee: Akzo N.V.Inventor: Michael Diamantoglou
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Patent number: 4981958Abstract: A method for the dry cationization of starch is disclosed by means of reaction with alkylene epoxides in an alkaline medium in the presence of water.Type: GrantFiled: August 2, 1988Date of Patent: January 1, 1991Assignee: Degussa AktiengesellschaftInventors: Reinhard Stober, Wolfgang Fischer, Michael Huss, Reimund Pieter
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Patent number: 4977192Abstract: A granular polymer composition having increased water absorption and desorption capability, resistance to photogradation and increased life span, comprising a water-insoluble but swellable cross-linked polymer material formed of at least one polymer and/or copolymer prepared from at least one unsaturated ethylene monomer having at least one carboxylic, amide, sulfuric, sulfonic, phosphoric, phosphonic, or hydroxyl functional group and at least one powdered mineral charge well dispersed in and intimately bonded to said polymer as a result of its introduction into the mixture of monomers of the same type or of a different type before their polymerization into said polymer or copolymer.Type: GrantFiled: April 28, 1988Date of Patent: December 11, 1990Assignees: Coatex S.A., Conservatome S.A.Inventors: Pierre Martineu, Christiane Saunier, Jacky Rousset, Christian Jacquemet
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Patent number: 4977252Abstract: Modified starches useful for emulsifying industrial products, especially foods and beverages containing flavor oils, are prepared by enzymatic degradation of the 1,4-alpha-D-glucosidic linkages from the non-reducing ends of a starch molecule, preferably employing beta-amylase, which may be carried out before or after the preparation of a starch derivative containing a hydrophobic group or both hydrophilic and hydrophobic substituent groups. The enzymatic degradation provides a starch emulsifier whose emulsions are characterized by improved shelf stability, which emulsifier may be used as a replacement for gum arabic and in other industrial applications.Type: GrantFiled: August 18, 1988Date of Patent: December 11, 1990Assignee: National Starch and Chemical Investment Holding CorporationInventor: Chung-Wai Chiu
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Patent number: 4954652Abstract: N-acetyl-para-aminophenol is prepared by subjecting 4-hydroxyacetophenone oxime to a Beckmann rearrangement in the presence of a thionyl chloride catalyst and an alkyl alkanoate as the reaction solvent. An integrated process is disclosed wherein 4-hydroxyacetophenone is reacted with a hydroxyl amine salt and a base to obtain the ketoxime of the ketone, e.g., 4-hydroxyacetophenone oxime, extracting the ketoxime product from the reaction with alkanoate ester and subjecting the ketoxime dissolved in the ester to a Beckmann rearrangement in the presence of a thionyl chloride catalyst.Type: GrantFiled: July 12, 1988Date of Patent: September 4, 1990Assignee: Hoechst Celanese CorporationInventors: John R. Fritch, Olan S Fruchey, Theodore Horlenko
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Patent number: 4950699Abstract: A composition and formulation for use in covering and healing of wounds to the body, the formulation consisting of a mixture of a tissue compatible, water-based acrylic adhesive and collagen. The formulation comprises from between about 0.1% and 10% of collagen (dry basis), with the adhesive component preferably containing about 50% solids, balance water.Type: GrantFiled: May 11, 1989Date of Patent: August 21, 1990Assignee: Genetic Laboratories, Inc.Inventor: Daniel G. Holman
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Patent number: 4931282Abstract: A pressure-sensitive medical sealant composition comprising (a) a crosslinked, swellable polymeric matrix made from an N-vinyl lactam monomer and a multi-ethylenically unsaturated compound, wherein the ethylenic groups are vinyl groups, allyl groups or methallyl groups, which groups are bonded to nitrogen or oxygen atoms; (b) a plasticizer; and (c) an antimicrobial. The medical sealant is highly moisture vapor transmissive and is capable of incorporating large concentrations of iodine. The composition can be used in a variety of medical applications including as a teat plug, a wound or burn dressing, or as a sealant to seal junctions between medical instruments penetrating the skin and the skin. A method of preparing the medical sealant composition in a caulkable form is also disclosed.Type: GrantFiled: November 25, 1987Date of Patent: June 5, 1990Assignee: Minnesota Mining and Manufacturing CompanyInventors: Robert A. Asmus, Daniel C. Duan
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Patent number: 4929649Abstract: The binder serves to produce foundry moulds and comprises a solution (preferably an aqueous solution) of aldehyde reactive phenol substances and gaseous acetals (preferably dimethyl formal) as reaction partners and strong acids, e.g. sulphuric acid and sulphonic acids as a catalyst. The acetal is in this system hydrolysed by the acid, the basic aldehyde being formed, which will react with the aldehyde reactive phenol substance accompanied by cross-linking. The acid serves thereby simultaneously as a cross-linking catalyst. In principle, it is possible to regard as "aldehyde reactive phenol substances" any phenolic compounds which can in the acid range cross-link more or less spontaneously with aldehydes. Preferably, these are resorcinol or resorcinol products, e.g. resorcinol pitch or precondensates formed with a shortfall of aldehyde, e.g. based on resorcinol formaldehyde, phenol resorcinol formaldehyde or resorcinol melamine formaldehyde.To produce foundry moulds, a granular basic moulding material, e.g.Type: GrantFiled: July 13, 1988Date of Patent: May 29, 1990Assignee: Huttenes-Albertus Chemische Werke GmbHInventors: Marek Torbus, Franz Jerman, Gerard Ladegourdie, Dirk Lingemann, Willi Seiss, Aleksandar Vujevic
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Patent number: 4925919Abstract: Interleukin 2 (IL 2; T-cell growth factor), produced with and without costimulation by Burkitt's lymphoma line Daudi, is highly purified approximately over 37,000-fold to apparent homogeneity from lymphocyte-conditioned medium derived from normal human blood cells by (NH.sub.4).sub.2 SO.sub.4 -precipitation, ion-exchange chromatogrThis invention was made with support in part under Grants CA 08748, CA 22507, CA 25608, CA 20194, CA 21525, CA31525, P01-CA-20194, AI 18 321-01, CA 23766 and CA 33050 awarded by the National Cancer Institute, National Institute of Health, DHEW. The government has certain rights in this invention.Type: GrantFiled: June 10, 1988Date of Patent: May 15, 1990Inventors: Roland Mertelsmann, Karl Welte, Salvatore Venuta
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Patent number: 4918180Abstract: A process for reducing the dust content of cellulose ethers comprises reacting the cellulose ether with an aggregating agent comprising (1) a polypropylene glycol or a propoxylated alcohol and (2) an ethylene oxide/propylene oxide copolymer.Type: GrantFiled: November 23, 1988Date of Patent: April 17, 1990Assignee: Union Carbide Chemicals and Plastics Company, Inc.Inventor: Serge Huybrechts
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Patent number: 4912209Abstract: This invention presents starch-based alkaline corrugating adhesives having improved green bond strength due to the use of undried starch as the raw starch component in the adhesive. Such adhesives can be used in corrugation processes at much higher corrugator running speeds than the conventionally employed adhesives.Type: GrantFiled: June 15, 1988Date of Patent: March 27, 1990Assignee: National Starch and Chemical CorporationInventors: Craig Leake, Michael Foran, Jeffrey G. Atkinson
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Patent number: 4908434Abstract: Interleukin 2 (IL 2; T-cell growth factor), produced with and without costimulation by Burkitt's lymphoma line Daudi, is highly purified approximately over 37,000-fold to apparent homogeneity from lymphocyte-conditioned medium derived from normal humaThis invention was made with support in part under Grants CA 08748, CA 22507, CA 25608, CA 20194, CA 21525, CA 31525, P01-CA-20194, AI 18 321-01, CA 23766 and CA 33050 awarded by the National Cancer Institute, National Institute of Health, DHEW. The government has certain rights in this invention.Type: GrantFiled: June 10, 1988Date of Patent: March 13, 1990Assignee: Sloan-Kettering institute for Cancer ResearchInventors: Roland Mertelsmann, Karl Welte, Salvatore Venuta
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Patent number: 4894397Abstract: An improved process for pruducing stabilized, core-shell latex emulsions is disclosed. In a process which comprises preparing a hydrophilic polymer and contacting the hydrophilic polymer with a hydrophobic monomer for producing an inverted core-shell latex emulsion, the improvement comprises the additional step of adjusting the pH of the inverted core-shell latex emulsion to dissolve the hydrophilic polymer, thereby to produce a stabilized, core-shell latex emulsion.Type: GrantFiled: April 21, 1988Date of Patent: January 16, 1990Assignee: S. C. Johnson & Son, Inc.Inventors: Lee W. Morgan, Richard J. Esser, Dennis P. Jensen
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Patent number: 4867976Abstract: A method for treatment of acquired immuno-deficiency syndrome (AIDS) which comprises administering a therapeutically effective amount of liposomes containing a toxin which specifically inhibits the protein synthesis in cells to a patient with AIDS.Type: GrantFiled: July 2, 1987Date of Patent: September 19, 1989Assignee: Sumitomo Chemical Company, LimitedInventors: Shigeharu Ueda, Kazuyoshi Ikuta, Shiro Kato, Tsuyoshi Uchida
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Patent number: 4859733Abstract: A method is disclosed for the reduction of the extractability of trialkanolamines from polyolefins containing such compounds e.g. as a result of the use of trialkanolamines as catalyst deactivators in processes for the polymerization of olefins. Zinc oxide and/or zeolite molecular sieves are incorporated into the polyolefin, either during the process for the manufacture of the polyolefin or subsequent to such manufacture. Zinc oxide may be used in amount of 0.01-4 parts by weight and zeolite molecular sieves in amounts of 0.05-1 parts by weight, per 100 parts of polyolefin. The resultant compositions may be more acceptable for use in the fabrication of articles intended for the packaging of e.g. foodstuffs.Type: GrantFiled: August 4, 1988Date of Patent: August 22, 1989Assignee: Du Pont Canada Inc.Inventors: David J. Mitchell, Vaclav G. Zboril
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Patent number: 4857578Abstract: A water repellent coating for wood substrates is presented. The coating comprises a highly dispersed mixture of polytetrafluoroethylene, alkyd resin and microcrystalline wax. Dispersion of the polytetrafluoroethylene and microcrystalline wax as discrete particles prevents delamination of successive coats while providing intercoat adhesion. Also presented is a process for the preparation of water repellent wood coatings that prohibits microcrystalline wax breakdown.Type: GrantFiled: July 29, 1988Date of Patent: August 15, 1989Assignee: Rust-Oleum CorporationInventor: Robert M. Hall
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Patent number: 4842856Abstract: Parenteral solutions comprising(a) a sparingly soluble medicament active compound,(b) a solvent consisting of(i) 5-100 M/V % of an organic solvent or of a mixture of organic solvents and(ii) 0-95 W/V % of water,(c) A 0.5-30 W/V % strength aqueous solution of a human serum protein and customary auxiliaries and/or excipients, 1 to 40,000 parts by weight, preferably 25 to 30,000 parts by weight of solvent (b) and 1 to 1,000,000 parts by weight, preferably 50 to 40,000 parts by weight, of human serum protein solution (c) being present per part by weight of medicament active compound.The sparingly soluble medicament active compounds which can be used have a solubility in water of between 1 .mu.g and 10 g, preferably between 10 .mu.g and 1 g per liter of water. Examples of such medicaments are dihydropyridine compounds and pyrazolones, and muzolimine.Type: GrantFiled: January 11, 1988Date of Patent: June 27, 1989Assignee: Bayer AktiengesellschaftInventors: Wolfgang Hoederath, Hans J. Ahr, Klaus Buhner, Ahmed Hegasy, Manfred Winter
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Patent number: 4839376Abstract: 2-Pyrazoline derivatives of the formula (A): ##STR1## where R.sup.1 is a pyridyl, a pyrazyl or an alkoxy group; and R.sup.2 is a hydrogen atom, an alkyl, a pyridyl, a furyl, phenyl or a substituted phenyl group, and to a process for producing the same. Therapeutic agents for treating cerebrovascular diseases containing, as the active ingredient, a 2-pyrazoline derivative represented by the formula (G): ##STR2## where R.sup.3 is a hydrogen atom, an alkyl, acetyl, an alkoxycarbonyl, an amino, benzoyl, a substituted benzoyl, a pyridylcarbonyl, a furylcarbonyl, a thienylcarbonyl, a pyrazylcarbonyl, an N-substituted carbamoyl, an N-substituted thiocarbamoyl, or carboxy group; and R.sup.4 is a hydrogen atom, an alkyl, a pyridyl, a thienyl, a furyl, cyclohexyl, phenyl or a substituted phenyl group or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 15, 1988Date of Patent: June 13, 1989Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Hiroyuki Yamashita, Makoto Odate, Hajime Iizuka, Hiroshi Kawazura, Yoshio Shiga, Hiroshi Namekawa
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Patent number: 4814437Abstract: A new method for preparation of sulfated polysaccharides by means of pyridine-chlorosulfonic acid reagents. The polysaccharide is before sulfation treated with a reducing agent, e.g. sodium borohydride.Type: GrantFiled: February 25, 1988Date of Patent: March 21, 1989Assignee: Pharmacia ABInventors: Anthony N. de Belder, Leif G. Ahrgren, Tomas Malson