Abstract: The invention concerns di- and tri-esters derived from alkanoic, (cycloalkyl)alkanoic, benzoic or phenylalkanoic acids with N-(acylaminoalkyl)-dihydroxyphenylethanolamines, and pharmaceutically acceptable salts thereof; processes for their preparation and manufacture; and pharmaceutical compositions thereof. The esters are useful for the topical treatment of an area of inflammation affecting the skin of a warm-blooded animal. Representative esters of the invention are 1-[3,4-bis(pivaloyloxy)phenyl]-2-[2-(2-phenylacetamido)ethylamino]-ethanol , 1-[3,4-bis(pivaloyloxy)phenyl]-2-[1,1-dimethyl-2-(2-phenoxyacetamido)ethy lamino]-ethanol, and the hydrochlorides and hydrobromides thereof.

Abstract: Hydroxy carboxylic acids minimize the formation of color bodies in processes for preparing and purifying alkylsaccharides when the temperature exceeds about 100.degree. C.

Abstract: The present invention provides 3'"-dehydrocardenolide tridigitoxoside oximes of the general formula: ##STR1## in which R.sub.1 is a hydrogen atom or an alkyl radical containing up to 3 carbon atoms, R.sub.2 is a hydrogen atom or a lower acyl or alkyl radical and R.sub.3 represents two hydrogen atoms, the group ##STR2## or the oximino group .dbd.NOR.sub.1, wherein R.sub.1 has the above-given meaning.The present invention also provides a process for the preparation of these oximes, as well as pharmaceutical compostions containing them which are useful for the treatment of cardiac insufficiency.

Abstract: New antibacterial compounds, DC--45--A.sub.1 and DC--45--A.sub.2 are produced by fermentation of a microorganism belonging to the genus Streptomyces. The antibiotics are accumulated in the culture liquor and are isolated therefrom. These compounds are also prepared by acid hydrolysis of known compounds, DC--45--A or DC--45--B.sub.2. DC--45--A.sub.2 is also prepared by acid hydrolysis of DC--45--A.sub.1.

Abstract: Nitrosourea derivatives are provided which possess a high level of inhibitory activity against leukemia and tumors and which are therefore useful for pharmaceutical purposes. The compounds have the structure represented by formulae (I), (II) and (III): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.4 may be the same or different and each represent a hydrogen atom or an alkyl, aryl, aralkyl, alkanoyl or a heterocyclic group; R.sup.3 represents the residual group on the .alpha.-carbon atom of an .alpha.-amino acid; n represents 2 or 3; X represents a halogen atom selected from chlorine, fluorine and bromine; and Ac represents an alkanoyl group.

Abstract: A delivery device is disclosed for delivering a beneficial drug to a biological environment of use. The device comprises a hydrogel reservoir containing tiny pills. The tiny pills comprise a wall surrounding a drug core.

Abstract: Substituted spiro 2H-1-benzopyran-2,3'-(3H)-naphtho(2,1-b)pyrans particularly suitable for use as precursors to stable colored pyrylium salts are disclosed.

Abstract: Substituted spiropyrans particularly suitable for use as precursors to stable pyrylium salts are disclosed.