Patents Examined by C. Sayala
  • Patent number: 5200096
    Abstract: Corrosion inhibitor additives are added directly to an aqueous acid solution used in acidizing subterranean formations. The additives comprise a bismuth compound, a quaternary compound, and a surfactant. The corrosion inhibitor is free of toxic Sb and acetylenic compounds.
    Type: Grant
    Filed: September 27, 1991
    Date of Patent: April 6, 1993
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Dennis A. Williams, Phyllis K. Holifield, James R. Looney, Lee A. McDougall
  • Patent number: 5200169
    Abstract: Vinyl radiohalogenated small molecules as shown in formulas I and II: ##STR1## wherein *X is radiohalogen, C.dbd.C is a double bonded set of sp.sup.2 hybridized carbon atoms, and substituents R.sub.1, and R.sub.2 are as defined in the specification. Y is a substituent containing any of the groups described for R.sub.1 and R.sub.2, except that Y cannot be hydrogen, and bearing a functional group suitable for binding to protein under conditions that preserve the biological activity of the protein. The compounds of formulas I and II can be coupled to proteins such as monoclonal antibodies to provide reagents for diagnostic and therapeutic applications. Also metalated precursors of compounds I and II, as well as radiopharmaceutical reagent kits containing any of the subject small molecules.
    Type: Grant
    Filed: July 5, 1989
    Date of Patent: April 6, 1993
    Assignee: NeoRx Corporation
    Inventors: Daniel S. Wilbur, Stephen W. Hadley
  • Patent number: 5192615
    Abstract: An encapsulated breaker chemical composition used in a fracturing process in the protection of an oil or gas stimulation operation which comprises: a breaker chemical; and a pinhole free coating of a neutralized sulfonated elastomeric polymer of about 2 to about 80 microns thick deposited onto the surface of the breaker chemical, wherein said neutralized sulfonated polymer encapsulates the breaker chemical, wherein the neutralized sulfonated polymer is permeable to the breaker chemical and the neutralized sulfonated polymer is non-reactive to the breaker chemical.
    Type: Grant
    Filed: January 3, 1992
    Date of Patent: March 9, 1993
    Assignee: Exxon Research & Engineering Company
    Inventors: Lee A. McDougall, John C. Newlove, Pacifico V. Manalastas, Evelyn N. Drake
  • Patent number: 5192526
    Abstract: The process of the present invention includes preparing a first aqueous solution of rhenium in the form of radioactive perrhenate, wherein the concentration of rhenium in said solution is within the range of about 5.times.10.sup.-6 M to about 2.times.10.sup.-3 M, and then reducing and complexing the radioactive perrhenate by mixing a second solution or lyophilized solid with the first solution. The second solution or lyophilized solid comprises a ligand which complexes with the radioactive perrhenate and a reductant wherein the reductant is present in the second solution at a concentration in the range of about 0.005M to about 0.020M and the ligand is present in the second solution at a concentration in the range of about 0.01M and about 0.15M. The pH of the resultant solution is within the range of about 1.5 to about 5.5.
    Type: Grant
    Filed: March 21, 1991
    Date of Patent: March 9, 1993
    Assignee: Mallinckrodt Medical, Inc.
    Inventor: David W. Pipes
  • Patent number: 5190741
    Type: Grant
    Filed: August 6, 1991
    Date of Patent: March 2, 1993
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Cis Bio International
    Inventors: Marie-France Moreau, Josette Michelot, Annie J. Veyre, Jean-Claude Madelmont, Denise Godeneche, Pierre Lebarre, Daniel Parry, Gaston Meyniel
  • Patent number: 5187011
    Abstract: An encapsulated breaker chemical composition used in an oil or gas stimulation operation which comprises: a breaker chemical; and a pinhole free coating of an ionically and covalently crosslinked neutralized sulfonated elastomeric polymer of about 2 to about 80 microns thick deposited onto the surface of the breaker chemical, wherein said polymer encapsulates the breaker chemical, wherein the polymer is permeable to the breaker chemical and the polymer is non-reactive to the breaker chemical.
    Type: Grant
    Filed: January 9, 1992
    Date of Patent: February 16, 1993
    Assignee: Exxon Research and Engineering Company
    Inventors: Pacifico V. Manalastas, Evelyn N. Drake, Edward N. Kresge, Warren A. Thaler, Lee A. McDougall, John C. Newlove, Vijay Swarup, Albert J. Geiger
  • Patent number: 5183581
    Abstract: A process, based on the Nitrogen Generating System/Emulsion in the presence of organic solvents, which is useful for the dewaxing of producing formations, is disclosed. The heat generation with the nitrogen reaction system and organic solvents gives rise to a thermo-chemical, synergistic system for long lasting removal of paraffinic damage, oil production rates being restored and even increased. The process is relatively easy to implement and of low cost.
    Type: Grant
    Filed: April 13, 1992
    Date of Patent: February 2, 1993
    Assignee: Petroleo Brasileiro S.A.
    Inventors: Carlos N. Khalil, Regis K. Romeu, Andre Rabinovitz
  • Patent number: 5182370
    Abstract: Comounds having the formula ##STR1## wherein: a is 2 or 3; b is an integer from 0 to 4;Me.sup.(a+) is an ion of an element of atomic number from 57 to 70 or an ion of a transition metal of atomic number 21-29, 42 or 44;E.sup.(b+) is one or more physiologically biocompatible cation of an inorganic or an organic base or amino acid, said cation representing a total positive charge of b units;S is the group --A--O--R wherein:A is --(CH.sub.2).sub.m --; --CH.sub.2 --C(CH.sub.3).sub.2 --; m is an integer from 1 to 5; R is H; linear or branched alkyl of 1 to 8 carbon atoms, said carbon atoms being unsubstituted or substituted by one or more hyroxy group; aralkyl of 1 to 4 aliphatic carbon atoms; phenyl or phenyl substituted by halogen, amino, hydroxy or trifluoromethyl; (poly)-oxa-alkyl of 1 to 10 oxygen atoms and from 3 to 30 carbon atoms;R.sub.1 is R.sub.2 or --CH.sub.2 COOZ; --CH(CH.sub.3)COOZ; --(CH.sub.2).sub.n --N(CH.sub.2 COOZ).sub.
    Type: Grant
    Filed: December 13, 1989
    Date of Patent: January 26, 1993
    Assignee: Bracco Industria Chimica S.p.A.
    Inventors: Ernst Felder, Luciano Fumagalli, Fulvio Uggeri, Giorgio Vittadini
  • Patent number: 5175343
    Abstract: Protein conjugated chelated metal radionuclides are provided for use in vivo. Intermediates are provided for preparing the polypeptide compositions efficiently.
    Type: Grant
    Filed: June 19, 1987
    Date of Patent: December 29, 1992
    Assignee: NeoRx Corporation
    Inventors: Alan R. Fritzberg, Sudhakar Kasina, Ananthachari Srinivasan, Daniel S. Wilbur
  • Patent number: 5171460
    Abstract: While many materials have been used to inhibit scale formation previously, none have been fully satisfactory to prevent scale formation and precipitation of totally dissolved solids (TDS) in fluids used in well drilling, completion and workovers when the fluids contain divalent metal cations and when the formation contains carbon dioxide. Since many wells are completed into such formations, a continuing search has been directed to an improved method for preventing the formation of such scale. According to the present invention, metal carbonate scale formation and TDS precipitation in a well penetrating a subterranean formation wherein a fluid containing calcium, magnesium, barium or zinc is used in the presence of carbon dioxide is prevented by maintaining the fluid at a pH from about 2 to about 9 and adding from about 1 to about 5000 parts per million of a phosphonomethylated oxyalkyleneamine material having a molecular weight from about 150 to about 3000 to the fluid.
    Type: Grant
    Filed: May 29, 1991
    Date of Patent: December 15, 1992
    Assignee: Atlantic Richfield Company
    Inventor: David R. Underdown
  • Patent number: 5169560
    Abstract: A method and composition for foam control in non-aqueous systems utilizing sulfonate or phosphinate compounds. The method is especially well adapted for use in oil distillation units and coking of crude oil residues.
    Type: Grant
    Filed: September 17, 1990
    Date of Patent: December 8, 1992
    Assignee: Betz Laboratories, Inc.
    Inventor: Paul R. Hart
  • Patent number: 5167947
    Abstract: The present invention provides a pharmaceutical composition for enhancing gastrointestinal tract absorption of a radioprotective drug comprising a therapeutically effective dosage amount of a bioactive polar radioprotective agent, such as ethiofos, its active metabolites, and pharmaceutically acceptable salts thereof and a chelating agent selected from the group consisting of EDTA, EGTA, citrate and therapeutically acceptable salts thereof.A method for enhancing the rate of gastrointestinal absorption of radioprotective agents is also provided.
    Type: Grant
    Filed: October 26, 1989
    Date of Patent: December 1, 1992
    Assignee: Southwest Research Institute
    Inventor: Richard Geary
  • Patent number: 5167948
    Abstract: The invention relates to a diagnostic or radiotherapeutic composition, comprising a hydrogen containing compound in addition to a pharmaceutically acceptable formulation means and optionally an inactive carrier and/or one or more auxiliary substances, wherein the hydrogen containing compound comprises at least one deuterium atom. The invention further relates to a compound to be used for said composition and to a kit for preparing a radio-diagnostic composition.
    Type: Grant
    Filed: November 21, 1989
    Date of Patent: December 1, 1992
    Assignee: Mallinckrodt Medical, Inc.
    Inventor: Martin Wenzel
  • Patent number: 5166324
    Abstract: A compound of the formula MX.sub.n L.sub.m wherein M is a metal atom selected from the group consisting of thorium, plutonium, neptunium or americium, X is a halide atom, n is an integer selected from the group of three or four, L is a coordinating ligand selected from the group consisting of aprotic Lewis bases having an oxygen-, nitrogen-, sulfur-, or phosphorus-donor, and m is an integer selected from the group of three or four for monodentate ligands or is the integer two for bidentate ligands, where the sum of n+m equals seven or eight for monodentate ligands or five or six for bidentate ligands, a compound of the formula MX.sub.n wherein M, X, and n are as previously defined, and a process of preparing such actinide metal compounds including admixing the actinide metal in an aprotic Lewis base as a coordinating solvent in the presence of a halogen-containing oxidant, are provided.
    Type: Grant
    Filed: February 7, 1991
    Date of Patent: November 24, 1992
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Larry R. Avens, Bill D. Zwick, Alfred P. Sattelberger, David L. Clark, John G. Watkin
  • Patent number: 5164099
    Abstract: Encapsulations comprised of a breaker enclosed within a membrane are utilized to break fluids used to fracture subterranean formations. The membrane of the encapsulation is permeable to at least one fluid in the subterranean formation or injected with the breaker such that the breaker diffuses through the membrane into the fracturing fluid. Thus, controlled amounts of breaker are released into the fracturing fluid.
    Type: Grant
    Filed: December 6, 1990
    Date of Patent: November 17, 1992
    Assignee: The Western Company of North America
    Inventors: D. V. Satya Gupta, Aidan P. Cooney
  • Patent number: 5164175
    Abstract: The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ specific substance, or an organ-specific substance which has been pretreated or coupled to a complexing agent for technetium-99m, is mixed with [99m]-pertechnetate and a complex-stabilized reducing agent.
    Type: Grant
    Filed: April 3, 1991
    Date of Patent: November 17, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Karl-Heinz Bremer, Ludwig Kuhlmann, Alexander Schwarz, Axel Steinstrasser
  • Patent number: 5164176
    Abstract: Chelating compounds of specific structure are useful for radiolabeling targeting proteins such as antibodies. The radiolabeled antibodies, or catabolites thereof, demonstrate improved biodistribution properties, including reduced localization within the intestines.
    Type: Grant
    Filed: September 5, 1990
    Date of Patent: November 17, 1992
    Assignee: NeoRx Corporation
    Inventors: Linda M. Gustavson, Ananthachari Srinivasan, Sudhakar Kasina, Alan R. Fritzberg
  • Patent number: 5162109
    Abstract: A diagnostic composition suitable for administration to a warm-blooded animal, which comprises a MRI-effective amount of a zwitterionic complex of a paramagnetic ion having a cyclic or open chain structure and a pharmaceutically acceptable carrier and a method for performing a MRI diagnostic procedure using the same.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: November 10, 1992
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Raghavan Rajagopalan, Donald R. VanDeripe
  • Patent number: 5160445
    Abstract: A cross-linking system using boron alpha-hydroxy carboxylic acid salts is shown for use in a water based well treating fluid. The cross-linker will gel the water based fluid usually after a delay at a relatively neutral pH. The cross-linker is provided as a concentrated stable solution containing borate ion as boric acid in a concentration of from less than 1% up to 25% by weight. The cross-linking solution additionally may contain from 1% to 10% of EDTA and/or Glycerine, however, without these additives the cross-linking solution is stable through temperature changes and freeze-and-thaw cycles. Water based fracturing fluid is shown using galactomannan guar polymers, hydroxypropyl guar polymers or derivatives thereof.
    Type: Grant
    Filed: May 24, 1991
    Date of Patent: November 3, 1992
    Assignee: Zirconium Technology Corporation
    Inventor: Sharif Sharif
  • Patent number: 5154913
    Abstract: Novel, substituted benzamides in radioiodinated form are useful in radiopharmaceutical compositions in nuclear medicine as imaging agents to detect, visualize, and analyze the distribution and function of the dopamine D-2 receptor in the mammalian brain. The substituted benzamides and their racemic mixtures or their optically resolved enantiomers can be made by reacting a trialyltin substituted benzamide with an acid in the presence of radioactive iodine, generated by in situ oxidation of an appropriate iodide nuclide salt.
    Type: Grant
    Filed: May 28, 1991
    Date of Patent: October 13, 1992
    Assignee: Vanderbilt University
    Inventors: Tomas de Paulis, Robert M. Kessler, Howard E. Smith, Aaron Janowsky, Jeffrey A. Clanton