Abstract: To obtain improved bio-affinity and high bone attachment in an implant body, a method of manufacture for the implant body, and a dental implant. The implant body is fixed in a contact configuration to bone, and includes the base material formed from zirconia, and a surface layer formed on the surface of the base material and having a lower hardness than the base material. Therefore, in addition to having superior mechanical strength due to the zirconia base material, the soft and flexible surface layer functions as a buffer layer to mitigate the difference in the degree of hardness between the bone and the base material, and therefore the soft surface further improves the bone adhesion characteristics.

Abstract: This invention relates to regenerable antimicrobial coatings with long-lasting efficacy for use in medical applications including implants, medical instruments or devices, and hospital equipment. The same coatings would also have broad utility in the consumer, industrial, and institutional markets. The coating technology would be based on sequestration of hydrogen peroxide (HP) by zinc oxide binders incorporated into the coatings.

Abstract: Provided is a method for fabricating a microchip for nucleic acid amplification reaction that is capable of simple and highly accurate analysis. Provided is a method for fabricating a microchip for nucleic acid amplification reaction, the method including a solidification step of drying a reagent solution including at least a part of substances required for a nucleic acid amplification reaction, and a containment step of arranging the reagent solution including the solidified substance in wells that serve as a reaction site for a nucleic acid amplification reaction. In the microchip for nucleic acid amplification reaction fabricated by the fabrication method, since substances required for the nucleic acid amplification reaction are contained by being solidified, non-specific amplification is suppressed in a nucleic acid amplification reaction, which enables highly accurate analysis.

Abstract: A method of forming an implant to be implanted into living bone is disclosed. The method comprises the act of roughening at least a portion of the implant surface to produce a microscale roughened surface. The method further comprises forming a nanoscale roughened surface on the microscale roughened surface. The method further comprises the act of depositing discrete nanoparticles on the nanoscale roughened surface though a one-step process of exposing the roughened surface to a solution including the nanoparticles. The nanoparticles comprise a material having a property that promotes osseointegration.

Abstract: Embodiments described herein generally relate to a method for deposition of a biofunctionalizing material, such as for the production of a biomedical device. The method can include positioning a substrate on a substrate support, the substrate having a plurality of wells formed therein. A printing mask is positioned over the substrate, the printing mask having a plurality of mask openings, the plurality of mask openings corresponding to the plurality of wells. A biofunctionalizing material is then deposited through the printing mask and into the wells, the biofunctionalizing material being guided by the plurality of mask openings, the biofunctionalizing material forming a layer over a bottom surface of the plurality of wells.

Abstract: An automated apparatus and method for coating medical devices such as an intravascular stent, are disclosed in the method, a 2-D image of a stent is processed to determine (1) paths along the stent skeletal elements by which a stent secured to a rotating support element can be traversed by a dispenser head whose relative motion with respect to the support element is along the support-element axis, such that some or all of the stent skeletal elements will be traversed (2) the relative speeds of the dispenser head and support element as the dispenser head travels along the paths, and (3), and positions of the dispenser head with respect to a centerline of the stent elements as the dispenser head travels along such paths The rotational speed of the support and relative linear speed of the dispenser are controlled to achieve the desired coating thickness and coating coverage on the upper surfaces, and optionally, the side surfaces, of the stem elements.

Abstract: A processing liquid is supplied onto a substrate rotated by a spin chuck in a coating processing unit so that a film of the processing liquid is formed, and a rinse liquid is supplied to a peripheral edge of the substrate so that a processing liquid on the peripheral edge of the substrate is removed. An edge cut width between a position of an outer peripheral portion of the substrate rotated by the spin chuck in an edge exposure unit and a position of an outer peripheral portion of a film on the substrate is detected. Based on the detected edge cut width, a positional deviation of the center of the substrate held in the spin chuck from a rotation center of the spin chuck in the coating processing unit is determined while a supply state of the rinse liquid by an edge rinse nozzle is determined.

Abstract: Provided in one embodiment is a method for producing a composition, comprising: heating a first material comprising an amorphous alloy to a first temperature; and contacting the first material with a second material comprising at least one fiber to form a composition comprising the first material and the second material; wherein the first temperature is higher than or equal to a glass transition temperature (Tg) of the amorphous alloy.

Abstract: An implantable micro-miniature device is disclosed. The device comprises a thin hermetic insulating coating and at least one thin polymer or metal secondary coating over the hermetic insulating layer in order to protect the insulating layer from the erosive action of body fluids or the like. In one embodiment the insulating layer is ion beam assisted deposited (IBAD) alumina and the secondary coating is a parylene polymer. The device may be a small electronic device such as a silicon integrated circuit chip. The thickness of the insulating layer may be ten microns or less and the thickness of the secondary layer may be between about 0.1 and about 15 microns.

Abstract: To provide a storage battery electrode including an active material layer with high density that contains a smaller percentage of conductive additive. To provide a storage battery having a higher capacity per unit volume of an electrode with the use of the electrode for a storage battery. A slurry that contains an active material and graphene oxide is applied to a current collector and dried to form an active material layer over the current collector, the active material layer over the current collector is rolled up together with a spacer, and a rolled electrode which includes the spacer are immersed in a reducing solution so that graphene oxide is reduced.

Abstract: A method for manufacturing a stent includes forming a stent blank from a first material, the stent blank comprising a plurality of struts and a plurality of crowns, each crown connecting at least two struts, and a plurality of slots in at least some of the plurality of struts and/or the plurality of crowns, depositing a second material over outer surfaces of the struts and the crowns and in the slots to encase the stent blank in the second material, creating at least one opening through the second material, and removing the first material to form a stent comprising the second material, the stent having a continuous lumen from one end of the stent to the other end of the stent, the continuous lumen being partitioned in portions corresponding to the locations of the slots in the stent blank. The lumen may then be filled with a therapeutic substance.

Abstract: A method of treating a textile fabric and a textile fabric having anti-microbial and durable wash properties comprising a textile substrate and one or more disinfecting agents, anti-viral agents, anti-fungal agents and emulsifying agents that are applied with one or more of an exhaust, padding, coating or spraying process and dried using a heat setting process.

Abstract: Coatings for medical devices, the coatings including albumin, the methods of forming the coatings, and the coated medical devices are disclosed. In preferred embodiments the medical device is a bioabsorbable stent. The albumin coating layer improves the thromboresistance of the device.

Abstract: The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.

Abstract: The present invention relates to a method for printing a three-dimensional structure by depositing a plurality of droplets of printing material onto a substrate, wherein the substrate comprises a main plane and wherein the droplets are deposited in such a manner that layers of printing material are generated which are inclined to the main plane of the substrate.

Abstract: A membrane electrode includes a novel sensor combining a filtering function of a membrane and a signal measuring ability of an electrode. A target material may be measured by filtration through the membrane. A small amount of target materials may be detected with high sensitivity using an amplified electrical signal by increasing electrical conductivity by reducing metal ions on the membrane, and thus the target material may be subject to quantitative analysis. In addition, only a target material selectively binding to a receptor may be filtrated by passing a sample through the membrane after a receptor material is fixed to the electrode, and thus may be used to detect an electrical signal. In addition, the sensor may measure a signal in various methods such as electrical conductivity, impedance, etc.

Abstract: A method is disclosed in which a vapor-deposited coating or layer is directly or indirectly applied to at least a portion of the internal wall of the barrel of a capped pre-assembly comprising a barrel, optionally a dispensing portion, and a cap. The cap is secured to the barrel and at least substantially isolates the distal opening of the dispensing portion from pressure conditions outside the cap. A vapor-deposited coating or layer is applied directly or indirectly to at least a portion of the internal wall of the barrel while the pre-assembly is capped. The coating or layer is applied under conditions effective to maintain communication from the barrel lumen to the exterior via the front opening, optionally further via the dispensing portion lumen if present, at the end of the applying step. The capped pre-assembly can be pressure tested easily and rapidly, for example with a test duration between 1 and 60 seconds, to determine whether it has container closure integrity.

Abstract: The present disclosure relates to the field of polymer coating. The present disclosure provides improved systems and methods for continuous polymer coating of particles (e.g., nanoparticles). The present disclosure provides for a solid hollow fiber cooling crystallization (SHFCC) technique to continuously coat the nanoparticles with polymer. In certain embodiments, the present disclosure embraces continuous coating of particles from about 1 nm to about 10 microns. A polymer solution containing a suspension of submicron particles flows in the lumen of a solid polymeric hollow fiber, and controlled cooling of the polymer solution allows for polymer nucleation on the surface of the particles, and the precipitated polymer forms a thin film around the particles (the thickness of which can be varied depending on the operating conditions). The systems, methods and assemblies of the present disclosure are easily adaptable for coating nano-sized drug particles as well.

Abstract: Medical device surfaces, for example a plastic catheter or metal guide wire, are disclosed with a lubricating coating made from Brasenia schreberi polysaccharide mucilage. The coated device surfaces may be prepared with a variety of techniques offering improved alternatives to conventional coatings.

Abstract: The invention relates to a solution to be selectively applied to individual parts of the surface of dental ceramic(s) and a process for using the solution in the dental field. More specifically the invention relates to a solution comprising a) a solvent, b) an effect agent, and c) a complexing agent. The invention also relates to a kit comprising the solution and to a method of using the solution for selectively treating of parts of the surface dental ceramic(s). The invention also relates to a application instrument suitable for applying the solution.