Patents Examined by Caralynne Helm
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Patent number: 9622985Abstract: The present invention provides a patch or patch preparation in which the anchoring property of a pressure-sensitive adhesive layer to a support is improved with no adverse effects on its pressure-sensitive adhesive properties such as adhesion, pressure-sensitive adhesiveness, and a cohesive strength. A support of the present invention is for a patch or patches preparation, and comprises a base material containing a plastic film and an undercoat agent layer laminated on the base material. The undercoat layer contains porous inorganic particles having an average particle diameter of from 1 ?m to 15 ?m. A patch and patch preparation of the present invention comprises the support and a pressure-sensitive adhesive layer placed on one surface of the support to be adjacent to the undercoat agent layer.Type: GrantFiled: September 20, 2013Date of Patent: April 18, 2017Assignee: NITTO DENKO CORPORATIONInventors: Naoko Urushihara, Satoshi Ameyama
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Patent number: 9616128Abstract: Disclosed herein are injectable compositions containing high concentration of paracetamol or its pharmaceutically acceptable salts wherein the concentration of paracetamol or its pharmaceutically acceptable salt is >150 mg/ml in a judiciously tailored solvent system comprising glycofurol, ethanol, water or a solvent system comprising glycofurol, ethanol, polyethylene glycol, water. The viscosity of the said injectables is <28 cps. Further disclosed is the process for preparing the said injectables. The injectables can be administered by intramuscular route, intravenous route or as intravenous infusion after diluting in one of the routinely used intravenous fluids, infusion solutions of antibacterial, antifungal and amoebicidal drugs and along with anxiolytics (Midazolam injection) or narcotic analgesics (Fentanyl Citrate injection etc) as they remain stable, clear and transparent at least for 6 hours after dilution.Type: GrantFiled: June 29, 2011Date of Patent: April 11, 2017Assignee: Troikaa Pharmaceuticals LtdInventors: Ketan R. Patel, Milan R. Patel, Prakashchandra J. Shah
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Patent number: 9610242Abstract: A water-based composition containing oil soluble components may include an anhydrous concentrate and a hydration component, which may be stored in separate vessels prior to mixing. The anhydrous concentrate may be combined with the hydration component to create a consumer product such as a topical cream. The anhydrous concentrate may include a preparation that includes a liquid dispersion polymer, an inverting surfactant and a binding agent, and also may include lipid-soluble vitamins, antioxidants and the like. The hydration component may include water and a preservative system, and also may include water-soluble vitamins, antioxidants and the like. Two forms (i.e. lipid-soluble and water-soluble) of a given ingredient (such as vitamin C) may be provided in the concentrate and the hydration component, respectively. A third vessel may be used for mixing the concentrate with the hydrator and/or dispensing the concentrate, the hydrator and/or the consumer product.Type: GrantFiled: August 21, 2015Date of Patent: April 4, 2017Assignee: Concept Labs, Inc.Inventors: Zoe Weisman, Jose Torres
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Patent number: 9592324Abstract: A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.Type: GrantFiled: October 30, 2007Date of Patent: March 14, 2017Assignee: ATRIUM MEDICAL CORPORATIONInventors: Steve A. Herweck, Joseph Ferraro, Paul Martakos, Theodore Karwoski, Anthony Richard Horton
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Patent number: 9572909Abstract: Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.Type: GrantFiled: September 14, 2010Date of Patent: February 21, 2017Assignee: Virginia Commonwealth UniversityInventors: David Simpson, Gary Bowlin, Raymond Colello, Woon Chow, Balendu Shekhar Jha
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Patent number: 9561309Abstract: A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.Type: GrantFiled: May 27, 2004Date of Patent: February 7, 2017Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Thierry Glauser, Eugene Michal, Charles Claude, Stephen D. Pacetti
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Patent number: 9555000Abstract: The invention concerns a storage stable pharmaceutical preparation comprising oxycodone and naloxone for use in pain therapy, with the active compounds being released from the preparation in a sustained, invariant and independent manner.Type: GrantFiled: June 16, 2014Date of Patent: January 31, 2017Assignee: Purdue Pharma L.P.Inventors: Bianca Brögmann, Silke Mühlau, Christof Spitzley
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Patent number: 9555010Abstract: The present invention provides a patch or patch preparation in which the anchoring property of a pressure-sensitive adhesive layer to a support is improved with no adverse effects on its pressure-sensitive adhesive properties such as adhesion, pressure-sensitive adhesiveness, and a cohesive strength. A support of the present invention is for a patch or patches preparation, and comprises a base material containing a plastic film and an undercoat agent layer laminated on the base material. The undercoat layer contains porous inorganic particles having an average particle diameter of from 1 ?m to 15 ?m. A patch and patch preparation of the present invention comprises the support and a pressure-sensitive adhesive layer placed on one surface of the support to be adjacent to the undercoat agent layer.Type: GrantFiled: September 20, 2013Date of Patent: January 31, 2017Assignee: NITTO DENKO CORPORATIONInventors: Naoko Urushihara, Satoshi Ameyama
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Patent number: 9555011Abstract: The present invention includes compositions and methods of making an activated polymeric nanoparticle for targeted drug delivery that includes a biocompatible polymer and an amphiphilic stabilizing agent non-covalently associated with a spacer compound that includes at least one electrophile that selectively reacts with any nucleophilic on a targeting agent and places the targeting agent on the exterior surface of a biodegradable nanoshell, wherein an active agent is loaded with the nanoshell.Type: GrantFiled: April 7, 2015Date of Patent: January 31, 2017Assignee: University of North Texas Health Science Center at Fort WorthInventors: Arthur R. C. Braden, Jamboor K. Vishwanatha
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Patent number: 9540471Abstract: Disclosed is a nitric oxide-releasing polyvinylpyrrolidone-based polymer derived from N-vinylpyrrolidone monomer and at least one nitric oxide releasing N2O2? group, in which the N2O2? group is attached to a 2 pyrrolidinone group or a group derived therefrom in the N-vinylpyrrolidone monomer, and the polymer is optionally in combination with a substrate. The NO-releasing polymer can be part of a medical device or pharmaceutical composition and is useful for treating a biological disorder, such as healing a wound, restenosis, and/or promoting angiogenesis.Type: GrantFiled: July 17, 2013Date of Patent: January 10, 2017Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Joseph A. Hrabie, Larry K. Keefer
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Patent number: 9492594Abstract: A coating for an expandable portion of a catheter comprising a hydrophobic matrix and a dispersed phase is disclosed. The dispersed phase comprises a plurality of micro-reservoirs dispersed in the hydrophobic matrix, wherein the plurality of micro-reservoirs comprises a first active agent and a first biodegradable or bioerodable polymer. A coating formulation and a method for forming the coating are also disclosed. A catheter comprising the coating on the expandable portion and a method for treating a condition are also provided.Type: GrantFiled: July 18, 2014Date of Patent: November 15, 2016Assignee: M.A. Med Alliance SAInventors: Michael Thomas Ahlering, Ronald Kenichi Yamamoto, Robert John Elicker, Tien Thuy Nguyen, John Edwin Shulze, Jelle Jurjen Zoethout
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Patent number: 9488409Abstract: The present invention relates to methods by which to produce sheet-like, wafer-like or film-like forms of drugs, confectionery, other food, cosmetics and the like for oral application or intake. The present invention is more particularly directed to the thermal treatment of carrier materials used in the production of such sheet-like, wafer-like or film-like forms. The thermal treatment removes contaminating or undesired substances from the carrier material.Type: GrantFiled: August 16, 2013Date of Patent: November 8, 2016Assignee: LTS Lohmann Therapie-Systeme AGInventors: Detlev Neuland, Wolfgang Schaefer, Peter Schwarz
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Patent number: 9474712Abstract: Embodiments of a system including a remotely controlled reaction device and associated controller are described. Methods of use and control of the device are also disclosed. According to various embodiments, a reaction device is placed in an environment in order to perform a chemical reaction in an environment. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.Type: GrantFiled: November 9, 2005Date of Patent: October 25, 2016Assignee: Gearbox, LLCInventors: Leroy E. Hood, Muriel Y. Ishikawa, Edward K. Y. Jung, Robert Langer, Clarence T. Tegreene, Lowell L. Wood, Jr., Victoria Y. H. Wood
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Patent number: 9474719Abstract: In one aspect, the present invention is concerned with a treatment where it is desired that an active agent is designed to be released in a pulse at a time point some time after administration of the active agent. The present invention is particularly suited to administering an agent which may be released while a subject is sleeping. As well as treating certain conditions by a particular regime, the invention also provides novel formulations for a delayed, followed by a pulsed release of drug.Type: GrantFiled: March 4, 2011Date of Patent: October 25, 2016Assignee: UNIVERSITY OF STRATHCLYDEInventors: Alexander Mullen, Howard Stevens, Sarah Eccleston
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Patent number: 9468706Abstract: A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a drug eluting stent comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.Type: GrantFiled: March 20, 2015Date of Patent: October 18, 2016Assignee: Abbott Cardiovascular Systems Inc.Inventors: Thierry Glauser, Stephen Dirk Pacetti, Syed Faiyaz Ahmed Hossainy, Ni Ding
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Patent number: 9433576Abstract: The invention relates to respirable dry particles that contain one or more divalent metal cations, such as calcium, in an amount of less than 3% by weight, and to dry powders that contain the respirable particles. The dry particles can further contain an active agent, or can be used as carrier particles to deliver an active agent.Type: GrantFiled: September 29, 2011Date of Patent: September 6, 2016Assignee: Pulmatrix, Inc.Inventors: Michael M. Lipp, Jean C. Sung
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Patent number: 9427423Abstract: The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.Type: GrantFiled: March 10, 2009Date of Patent: August 30, 2016Assignee: ATRIUM MEDICAL CORPORATIONInventors: Thomas M. Swanick, Joseph Ferraro, Lisa Rogers, Paul Martakos
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Patent number: 9408800Abstract: A cosmetic composition, comprising the following components (A), (B), (C), and (D): (A) from 0.01 to 50% by mass of a fluorine-modified silicone having a polysiloxane unit represented by the following formulae (1) and (2): wherein, Rf represents a perfluoroalkyl group having 6 carbon atoms; R1, R2, and R3 each represent a hydrocarbon group having 1 to 6 carbon atoms; m represents a number of from 2 to 6; n represents a number of from 1 to 6; p represents a number of from 3 to 50; s represents a number of from 1 to 5; and a ratio between p and s satisfies 0.66?p/(p+s)?0.9, (B) from 0.01 to 40% by mass of a powder having been subjected to a surface treatment with tridecafluoro octyltriethoxysilane, (C) from 0.01 to 20% by mass of a fine zinc oxide particle having a specific surface area of from 10 to 100 m2/g, with the proviso that the component (B) is excluded from the component (C), and (D) from 0.Type: GrantFiled: February 25, 2013Date of Patent: August 9, 2016Assignee: KAO CORPORATIONInventors: Hirohisa Suzuki, Yoshiaki Matsui, Takashi Kodate
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Patent number: 9381144Abstract: The invention relates to cosmetic formulations. In one embodiment, the present invention relates to cosmetic formulations for use on the skin (e.g., the skin of the face).Type: GrantFiled: December 8, 2012Date of Patent: July 5, 2016Inventor: Bethany L. Hilt
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Patent number: 9375449Abstract: A composition containing a plurality of water-soluble nanoclusters ranging from 2 nm to 500 nm in diameter. Each of the nanoclusters contains one or more metal cations, one or more anions, and one or more water-soluble ligands. Also disclosed is a method of using the composition for treating various disorders such as anemia, heartburn, and diabetes.Type: GrantFiled: November 18, 2010Date of Patent: June 28, 2016Assignee: LG Bionano, LLCInventor: Chien-Chin Wu