Abstract: A hair treatment composition comprising a thickener which comprises a copolymer derived from the polymerization of at least a non-ionic monomer (a) and at least a cationic monomer (b).
Type:
Grant
Filed:
January 29, 2013
Date of Patent:
May 31, 2016
Assignee:
Conopco, Inc.
Inventors:
Frederic Jean-Michel Blondel, Christopher John Roberts
Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
Type:
Grant
Filed:
May 13, 2009
Date of Patent:
May 17, 2016
Assignees:
University of Washington, PhaseRx, Inc.
Inventors:
Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Craig L. Duvall, Danielle Benoit, Robert W. Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
Abstract: Provided is an emulsion composition comprising the following ingredients (A), (B), (C), (D), (E), and (F): (A) glyceryl monofatty acid ester derived from a linear-chain fatty acid having 10 to 24 carbon atoms; (B) a higher alcohol having 10 to 24 carbon atoms; (C) a ceramide; (D) an anionic surfactant; (E) a polar oil selected from branched fatty acid esters having an IOB of from 0.2 to 0.85 and having a hydroxyl group or an amino group; and (F) water, wherein the mass ratio of the total content of ingredients (A), (B), and (C) and ingredient (D) in terms of acid to the content of ingredient (E), ((A)+(B)+(C)+(D))/(E), is from 1.2 to 25.
Abstract: A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
Type:
Grant
Filed:
January 21, 2015
Date of Patent:
May 10, 2016
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education
Inventors:
Mohammed S. El-Kurdi, Yi Hong, Lorenzo Soletti, John J. Stankus, David A. Vorp, William R. Wagner
Abstract: A system and method for optimizing the systemic delivery of growth-arresting lipid-derived bioactive drugs or gene therapy agents to an animal or human in need of such agents utilizing nanoscale assembly systems, such as liposomes, resorbable and non-aggregating nanoparticle dispersions, metal or semiconductor nanoparticles, or polymeric materials such as dendrimers or hydrogels, each of which exhibit improved lipid solubility, cell permeability, an increased circulation half life and pharmacokinetic profile with improved tumor or vascular targeting.
Type:
Grant
Filed:
November 9, 2012
Date of Patent:
May 3, 2016
Assignee:
The Penn State Research Foundation
Inventors:
Mark Kester, Thomas Stover, Tao Lowe, James H. Adair, Young Shin Kim
Abstract: The present invention provides an implantable device having a biosoluble coating comprising a polyelectrolyte and a counterion and the methods of making and using the same.
Type:
Grant
Filed:
February 17, 2015
Date of Patent:
May 3, 2016
Assignee:
Abbott Cardiovascular Systems Inc.
Inventors:
Syed F. A. Hossainy, O. Mikael Trollsas, Lothar W. Kleiner
Abstract: Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
Type:
Grant
Filed:
October 19, 2009
Date of Patent:
March 8, 2016
Assignee:
Atrium Medical Corporation
Inventors:
Thomas M. Swanick, Joe Bienkiewicz, Joseph Ferraro, Paul Martakos, Keith M. Faucher, Alicia Dale
Abstract: Medical devices, and in particular implantable medical devices, may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
Abstract: Medical devices, and in particular implantable medical devices, may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
Abstract: A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
Type:
Grant
Filed:
January 30, 2008
Date of Patent:
January 19, 2016
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education
Inventors:
Mohammed S. El-Kurdl, Yi Hong, Lorenzo Soletti, John J. Stankus, David A. Vorp, William R. Wagner
Abstract: Methods for producing silver nanoparticles are described. In one aspect, a liquid solution is prepared that contains phenazine-1-carboxylic acid. Silver metal salt is added to the solution to produce multiple silver nanoparticles.
Type:
Grant
Filed:
May 10, 2010
Date of Patent:
December 22, 2015
Inventors:
Abdulaziz A. Alkhedhairy, Javed Musarrat
Abstract: The present invention relates to implantable medical devices coated with phosphoryl choline acrylate polymer topcoat layer and their use in the treatment of vascular diseases.
Abstract: A coating for implantable medical devices and a method for fabricating thereof are disclosed. The coating includes a mixture of a hydrophobic polymer and a polymeric hydrophilic additive, wherein the hydrophobic polymer and the hydrophilic additive form a physically entangled or interpenetrating system.
Abstract: Medical implant devices are prepared from a polymeric material and a release agent, where the device is a molded, reservoir implant, and the release agent has a molecular weight (MW) of at least 1000. The release agent may be a non-ionic surfactant such as Brij 35, polyoxyetheylene(20)sorbitan trioleate, Tween 20, Tween 80, vitamin E TPGS, and a mixture of any two or more thereof. Hydrated implants may have a surface area of about 500 mm2 or greater.
Type:
Grant
Filed:
April 25, 2008
Date of Patent:
September 1, 2015
Assignee:
ENDO PHARMACEUTICALS SOLUTIONS INC.
Inventors:
Petr Kuzma, Stephanie Decker, Harry Quandt
Abstract: A biocidal composition comprising 2,2-dibromomalonamide and a metal selected from silver, copper, and mixtures thereof, and its use for the control of microorganisms in aqueous and water-containing systems.
Type:
Grant
Filed:
August 3, 2011
Date of Patent:
June 23, 2015
Assignees:
Rohm and Haas Company, Dow Global Technologies LLC
Inventors:
Freddie L. Singleton, Tirthankar Ghosh, Kimberly S. Cagle
Abstract: A method for manufacturing a stationary state of polymer crystallinity of an active substance charged polylactide matrix for a stent, comprising the steps of: preparing the active substance charged polylactide matrix containing (a) a polylactide in amorphous or semicrystalline modification or with amorphous domains, and (b) at least one active substance on a surface or in a cavity of the stent communicating with the surface; and heating of the active substance charged polylactide matrix to a temperature ranging from TG-20° C. to TS-10° C., where TG represents a glass transition temperature and TS a melting temperature of the crystallites of the polylactide.
Abstract: The present invention provides an assembly for the preparation of a medical device having a porous coating comprising hydrogen peroxide. Particularly interesting medical devices are catheters (such as urinary catheters), endoscopes, laryngoscopes, tubes for feeding, tubes for drainage, guide wires, condoms, urisheaths, barrier coatings e.g. for gloves, stents and other implants, extra corporeal blood conduits, membranes e.g. for dialysis, blood filters, devices for circulatory assistance, dressings for wound care, and ostomy bags. The coating is in particular a hydrophilic coating formed from cross-linked polyvinylpyrrolidone. In one embodiment, the assembly holds a dry catheter element in one compartment of a package and an aqueous hydrogen peroxide solution in another compartment. The solution may also comprise stabilizers, e.g. chelators, and osmolality increasing agents.
Type:
Grant
Filed:
February 26, 2004
Date of Patent:
May 12, 2015
Assignee:
Coloplast A/S
Inventors:
Bo Rud Nielsen, Soren Kristiansen, Bo Kjellman Bruun, Martin Sidenius
Abstract: A system and method for optimizing the systemic delivery of growth-arresting lipid-derived bioactive drugs or gene therapy agents to an animal or human in need of such agents utilizing nanoscale assembly systems, such as liposomes, resorbable and non-aggregating nanoparticle dispersions, metal or semiconductor nanoparticles, or polymeric materials such as dendrimers or hydrogels, each of which exhibit improved lipid solubility, cell permeability, an increased circulation half life and pharmacokinetic profile with improved tumor or vascular targeting.
Type:
Grant
Filed:
April 26, 2004
Date of Patent:
May 12, 2015
Assignee:
The Penn State Research Foundation
Inventors:
Mark Kester, Thomas Stover, Tao Lowe, James H. Adair, Young Shin Kim