Abstract: The invention relates to liquid pharmaceutical formulations for oral administration with the modified release of amoxicillin, said formulations consisting of suspensions of coated particles of amoxicillin (microcapsules). According to the invention, the microcapsules constituting the disperse phase of the suspension are designed to allow the modified release of the amoxicillin according to a profile that does not change during the storage of the liquid suspension. To do this the inventors propose the selection of a specific coating composition for the microcapsules which consists of at least four components that allow these microcapsules to be stored in water without modifying their properties of modified release of the amoxicillin, this liquid phase furthermore being saturated with amoxicillin.

Abstract: A delivery agent for delivering a biologically active agent to a warm-blooded animal includes a hydrophobic moiety covalently bonded to a hydrophilic moiety. The hydrophobic moiety can include bile acids, sterols, or hydrophobic small molecules. The hydrophilic moiety can include ?-amino acids, dipeptides or tripeptides, or hydrophilic small molecules. An illustrative delivery agent is N?-deoxycholyl-L-lysine-methylester. The delivery agent and the biologically active agent are mixed together to form a complex, which is then administered to the animal. These complexes are particularly useful for oral administration of biologically active agents, but other routes of administration may be used.

Abstract: The invention concerns liquid pharmaceutical formulations, for oral delivery, with modified release of active principle(s) excluding amoxicillin and consisting of suspensions of coated particles of active principles (microcapsules). The microcapsules constituting the dispersed phase of the suspension are designed, according to the invention, to enable modified release of the active principle(s), in accordance with a profile which remains unaltered during the shelf life of the liquid suspension. Therefor, the invention consists in selecting a coating composition specific to the microcapsules consisting of at least four components enabling preservation of said microcapsules in water without altering their properties of modified release of the active principle, said liquid phase being furthermore saturated with active principle(s).

Abstract: A particulate fiber composition containing at least one first dietary fiber, coated by an insoluble dietary fiber or a dietary fiber with low solubility, serving to prevent dissolution of the fiber composition in the oral cavity and during passage through the esophagus. The fiber composition has one or several inserted additional layers of at least one second dietary fiber between the at least one first dietary fiber and the coating of the insoluble dietary fiber/dietary fiber of low solubility. The different properties of solubility and fermentability of the fibers are utilized for the production of multilayer particles. The dietary fiber composition can be used as a supplement applied in pharmaceuticals and food products where high fiber content and small calorie content is given a high priority. Furthermore, the dietary fiber supplement can be applied for replacement of part of the sugar in sugar coatings of generally known cereals.

Abstract: Methods are provide for producing flowable compositions, e.g. pastes, that set into calcium phosphate products. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a solution of a soluble silicate, e.g. sodium silicate, and the combined liquids and solids are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g. bone defects.

Abstract: An object of the present invention is to provide a practical ophthalmic lens which has an effect of effectively retaining and sustainedly releasing a drug and has form stability before and after release of the drug, wherein the ionic polymer gel having sustained drug releasability can regulate the amount of the drug included therein, depending on the efficacy of the drug used, and storing solution for a practical ophthalmic lens.

Abstract: The present invention is directed to a homogeneous, thermoreversible gel film comprising a film forming amount of kappa-2 carrageenan, and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent; and processes for the preparation thereof. The present invention is also directed to soft capsules and solid forms containing the gel film, as well as processes for the preparation thereof.

Abstract: The present invention provides curable materials, medical devices incorporating such materials, wherein the curable materials are capable of releasing hydrolyzable leaving agents upon hydrolysis that can form agents (e.g., pharmaceutically active agents), and methods of making and using such materials and devices.

Abstract: The present invention provides a medical device comprising a release region and a therapeutic agent disposed within or beneath the release region, and the release region includes a copolymer comprising a low Tg block and at least one graft copolymer endblock having a main chain and a plurality of side chains.

Abstract: Implantable or insertable medical devices comprising a surface region that is modified by covalently coupling a molecular species (or a combination of molecular species) to the same. The molecular species are selected such that the resulting modified surface region has critical surface energy between 20 and 30 dynes/cm. In certain embodiments, the covalently coupled molecular species comprise one or more methyl groups. An advantage of the present invention is that novel medical devices are provided, which have a surface with a critical surface energy value that has been shown to display enhanced biocompatibility, including enhanced thromboresistance, relative to other surfaces.

Abstract: The present invention relates to a topical cosmetic composition that has improved non-oily feel comprising: (a) a hybrid silicone composite powder having a spherical shape with particle diameter ranging from 2 to 10 ?m, of which each particle has a composite structures consisting of two interpenetrating polymer networks of polydimethylsiloxane (PMS) and polymethylsilsesquioxane (PMSQ). These two interpenetrating polymer networks are joined together by physical entanglements instead of chemical bonds; (b) a volatile cosmetic fluid; (c) a silicone fluid with viscosity ranging from 2 to 350 cSt; (d) an oil base consisting of an oil, wax, oil gelling agent or the mixture thereof; (e) a surface active agent; (f) a cosmetic pigment; and (g) an optional aqueous gel containing glycerin, glycols and an aqueous thickening agent. The cosmetic composition provides an improved skin sensory feel and a superior matte finish, and is useful for skin treatment, makeup and personal hygiene products.