Abstract: A catheter pump includes a cannula and an impeller system. The cannula has an inlet zone with a first maximum outer diameter, an outlet zone with a second maximum outer diameter and a blood flow channel extending between the inlet zone and the outlet zone. The first maximum outer diameter is greater than the second maximum outer diameter, and the impeller system has a rotatable impeller body operable to convey blood from the inlet zone to the outlet zone. The impeller body may be axially spaced from the cannula in a separated position.

Abstract: The embodiments described herein relate generally to medical devices that measure vital signs, and more particularly to wearable wireless devices that collect multiple simultaneous vital signs, and systems and methods for compressing the sensor data into a matrix representation to facilitate collecting, transmitting, processing, and displaying vital sign data.

Abstract: An apparatus and method to enable clinicians to verify needle or catheter location within an anatomic site by relying upon combined sensing of two signals, such as a pressure signal and a heart rate pulse signal, in which the detection of a correlation between both signals is identified to confirm location of the needle or catheter.

Abstract: A controller for an implantable blood pump, the implantable blood pump having an impeller. The controller includes processing circuitry configured to reduce a speed of the impeller from a set speed to a first reduced speed if a first predetermined amount of time of detected suction events occurs during a first time interval and increase the speed of the impeller from the first reduced speed if a second predetermined amount of time or less of detected suction events occur during a second time interval and a third predetermined amount of time or less of detected suction events.

Abstract: A phototherapy system having sensor(s) for detecting parameters associated with light generation by a light source and circuitry for modulating the light source based on the detected parameters. Also, a phototherapy system having a light guide interfacing with a light source at a connection point, an ambient light sensor, a connector light sensor for detecting (at the connection point) ambient light received by a light emitting pad that is directed into the light guide, and circuitry for determining whether the light guide is correctly connected to the light source based on a difference between the output of the ambient light source and the connector light sensor. Further, a phototherapy system including a light emitting pad having an identification tag and circuitry that modulates a light source based on the identification tag. Additionally, a phototherapy system including a casing encapsulating multiple light emitters and a light emitting pad.

Abstract: A cardiovascular health assessment score, representing a working tissue flow and indicating the dependence on central and peripheral control mechanisms, is generated by an evaluation system and used to support a variety of individualized medicine and health applications. One or more of the individualized medicine and health applications may be implemented as part of the evaluation system and incorporate the cardiovascular health assessment.

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.

Abstract: The invention relates to a system and a method for providing an exacerbation risk score for a respiratory disease of a patient. The system measures a heart signal and/or a blood circulation signal of a patient and detects cough events and sneeze events in the measurement data. The cough events and sneeze events are indicative for an onset of a contagion and/or an allergy, which can rapidly exacerbate a respiratory disease of the patient. Thus, the system is configured for providing unobtrusively an exacerbation risk score to the patient and/or to a physician.

Abstract: An efficient nanoscale semiconducting optoelectronic system, containing a P/N acceptor donor organic hetrojunction which is optimized for neuronal stimulation—an organic electrolytic photocapacitor. The devices comprise a thin (80 nm) trilayer of metal and p-n semiconducting organic nanocrystals. When illuminated in physiological solution, these metal-semiconductor devices charge up, transducing light pulses into localized displacement currents that are strong enough to electrically stimulate neurons with safe light intensities.

Abstract: The present disclosure relates to a novel epidermal paper-based electronic devices (EPEDs), and the methods of making and using the epidermal paper-based electronic devices. The epidermal paper-based electronic devices comprise an electrically conductive layer; and a paper layer with a first hydrophilic side and a second omniphobic side, wherein the electrically conductive layer is attached to the first hydrophilic side of the paper layer.

Abstract: Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. Wherein, when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer and the heated energy-absorbing material of the scleral shield conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region.

Abstract: Apparatuses and methods for treating neurological disorders by electro-stimulation. The apparatus may include a neural input signal acquisition module having a front-end block configured to amplify the potential difference of its input signals (V1a, V2a) and to filter a stimulus artifact and may include a multi-stage fully-differential switched capacitor circuit (e.g., an integrated circuit) configured for discrete-time signal processing.

Abstract: System and methods for controlling a laser light source of a lithotripsy device to fragment or break a target object are disclosed. An exemplary system includes a controller that can perform one or more iterations of a first process, and one or more iterations of a second process. The first process includes steps of selecting at least one variable operating parameter of a laser light source of a lithotripsy device, determining a value of each of a plurality of base settings of the at least one variable operating parameter selected and selecting one of the plurality of base settings based on signals received from the target in response to laser irradiation according to the value of each of the plurality of base settings set. The second process includes controlling the laser light source based on the one of the plurality of base settings selected.

Abstract: A light-based dental treatment system includes a handle generator having a generator housing and at least one light element configured to generate therapeutic light. The handle generator includes an alignment collet having a light passage extending along a movable interior collet profile. At least one delivery shaft assembly is selectively coupled with the handle generator. The at least one delivery shaft assembly includes a delivery shaft having proximal and distal shaft profile and a proximal light port. A distal light port of the delivery shaft is configured to deliver therapeutic light from the delivery shaft to a treatment location. The interior collet profile of the alignment collet is configured to grasp the delivery shaft and align the proximal light port with the at least one light element.

Abstract: Systems, methods, devices, and other techniques for processing an ECG recording to assess a condition of a mammal. Assessing the condition of the mammal can include screening for atrial fibrillation, and screening for atrial fibrillation can include obtaining a first neural network input, the first neural network input representing an electrocardiogram (ECG) recording of the mammal, and processing the first neural network input with a neural network to generate an atrial fibrillation prediction for the mammal.

Abstract: An annotation method, an annotation device, a storage medium, and an identification system are provided. In an annotation method according to an aspect of the present invention, a computer executes: a step of acquiring sensor data in which the outputs of a sensor are arrayed in time series; and a step for providing a plurality of labels to the acquired sensor data. The plurality of labels include a first label and a second label, wherein the first label is provided to a first time segment, and the second label is provided to a second time segment that comes after the first time segment in the time series. In addition, the first time segment and the second time segment are set to have an overlapping segment in which the first time segment and the second time segment partially overlap each other in the time series.

Abstract: Devices and methods for providing neurostimulation to a patient, particularly in trial systems assessing suitability of a permanently implanted neurostimulation, are provided herein. In one aspect, a trial neurostimulation lead includes a coiled conductor coupled to a proximal contact connector having a retention flange that withstands tensile force from tension in the lead so as to maintain the electrical connection during a trial period. In another aspect, a trial neurostimulation system includes a lead extension that includes a regression stopper between the implanted distal connector and proximal lead disposed outside the body to prevent regression of the lead through a secondary incision, thereby preventing infection and facilitating explant of the system. Methods of assembling and utilizing such leads and systems are detailed herein.

Abstract: A method for laser assisted delivery of therapeutic agents includes selectively controlling a valve connected to a first channel disposed within a first sidewall of a nozzle, applying, through the first channel, a first substance to penetrate dermis to a predetermined depth, and administering, through a second channel unconnected with the valve and disposed within a second sidewall of the nozzle, a second substance to remove debris.

Abstract: The present application provides a sensor-based surgery set and a method for determining the position of a holding device for a surgical instrument. The surgery set includes at least one holding device, an initialization station, and a number of sensors. The initialization station has a number of sensor slots, wherein each sensor is assigned to one sensor slot and wherein the initialization station is coupled to a storage unit in which initialization information is assigned to each sensor slot. A number of sensor slots are arranged on the holding device, wherein each sensor slot is assigned to one sensor slot of the initialization station. In an initialization arrangement, a specific number of sensors is in engagement with the sensor slots of the initialization station and are coupled to the storage unit for initialization and data transmission. In use, however, the sensors are in engagement with the sensor slots.

Abstract: Data regarding typing by a user may be collected and analyzed in order to assess one or more health conditions or functional states of the user. Each health condition that is assessed may be a disease or a symptom of a disease. For instance, based on the typing data, a computer may assess the presence, severity or probability of, or a change in, one or more symptoms such as: mild cognitive impairment, dementia, impairment of fine motor control, impairment of sensory-motor feedback, or behavioral impairment. A computer may calculate keystroke tensors that encode information about the typing. A computer may select or derive features from the keystroke tensors. These features may be fed into one or more machine learning algorithms, which in turn may output an assessment of a health condition or functional state of the user.