Patents Examined by Carlos A. Azpuru
  • Patent number: 10849989
    Abstract: A process for the preparation of a composite comprising a carrier particle and a plurality of drug nanoparticles. The process comprises providing a suspension of drug nanoparticles in the presence of a carrier particle, the carrier particle having an external surface that is functionalised with a surface treatment agent. The process simplifies isolation of drug nanoparticles from suspension.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: December 1, 2020
    Assignee: University of Limerick
    Inventors: Sarah Hudson, Teresa Tierney, Ake Rasmuson, Katalin Bodnar
  • Patent number: 10849843
    Abstract: A cosmetic ink composition comprises a particulate material, a (meth)acrylic acid homopolymer or salt thereof, and a rheology modifier. The particulate material can have a Particle Size Distribution D50 of about 100 nm to about 2,000 nm. The (meth)acrylic acid homopolymer or salt thereof can have a weight average molecular weight of less than about 20,000 daltons. The rheology modifier can be selected from the group consisting of alkali swellable emulsion polymers, hydrophobically modified alkali swellable emulsion polymers, and combinations thereof. The cosmetic ink composition can have a first dynamic viscosity of greater than about 1,100 cP at a shear rate of 0.1 sec?1 measured at 25° C. and a second dynamic viscosity of less than about 100 cP at a shear rate of 1,000 sec?1 measured at 25° C.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: December 1, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Janette Villalobos Lingoes, Thomas Elliot Rabe, Matthew Joseph Linser, Ajay Suthar
  • Patent number: 10849927
    Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: December 1, 2020
    Assignee: HOWARD UNIVERSITY
    Inventors: James W. Mitchell, Dazhi Yang
  • Patent number: 10849848
    Abstract: Compositions comprising electro-activated aqueous solutions and methods for the prevention and treatment of dysfunctional cardiovascular conditions are provided.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: December 1, 2020
    Assignee: REVEN PHARMACEUTICALS INC.
    Inventors: Henk Van Wyk, Mariette Van Wyk, Trace Krebs, Peter Lange, Brian Denomme, Michael A. Volk
  • Patent number: 10842754
    Abstract: Non-viral delivery platforms are provided for facilitating transport of molecules across cell membranes. In some forms, DNA nanoshells capable of transporting cargo molecules are formed, and may be formed in order to surround a variety of materials for a variety of purposes.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: November 24, 2020
    Assignee: HOWARD UNIVERSITY
    Inventor: Preethi Chandran
  • Patent number: 10842755
    Abstract: A nanoparticle suitable for delivery of an active agent across the blood-brain barrier is provided. As such, the nanoparticle can target brain tissue so that the active agent can be delivered across the blood-brain barrier to the target brain tissue. The nanoparticle includes a core that includes a core material such as a polymer or inorganic material as well as an active agent; and a shell comprising a membrane derived from a brain metastatic cancer cell, wherein the brain metastatic cancer cell facilitates transport of the nanoparticle across a blood-brain barrier. Also disclosed are methods of forming the nanoparticle and methods of using the nanoparticle.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: November 24, 2020
    Assignee: University of South Carolina
    Inventor: Peisheng Xu
  • Patent number: 10835556
    Abstract: Described herein are hydrolyzed tetravalent salts and formulations thereof that can be used to inhibit a biofilm. Also described herein are uses of the hydrolyzed tetravalent salts and formulations thereof to inhibit a biofilm and/or treat biofilm infection.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: November 17, 2020
    Assignee: Board of Trustees of the University of Illinois
    Inventor: Russell Pesavento
  • Patent number: 10828265
    Abstract: Melts or ionic liquids containing amorphous propranolol, topical formulations and patches for transdermal drug delivery, and methods of making and using thereof are described herein. The melts or ionic liquids may be in a topical drug delivery formulation or patch to be applied to the skin. The drug delivery formulation or patch contains a sufficient amount of the amorphous propranolol to deliver a therapeutically effective amount of the amorphous propranolol to the patient in need of treatment, such as for the treatment or amelioration of infantile hemangioma. The formulations have a low viscosity and reduced skin irritation compared to the crystalline propranolol free base (PFB). The melts or ionic liquids can be formed by a salt metathesis reaction.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: November 10, 2020
    Assignee: The Regents of the University of California
    Inventors: Kazuhiro Aoyagi, Michael Zakrewsky, Samir Mitragotri
  • Patent number: 10830767
    Abstract: A method of making at least one nanocomposite for surface enhanced Raman spectroscopy (SERS) detection of a target of interest includes forming at least one gold nanorod; coating a silver layer on an outer surface of the gold nanorod; assembling a Raman reporter molecule layer on the coated silver layer, wherein the Raman reporter molecule layer comprises Raman reporter molecules that are detectable by the SERS; coating a thiolated polyethylene glycol (PEG) layer on the assembled Raman reporter molecule layer; and conjugating the coated thiolated PEG layer with molecules of an antibody to make the at least one nanocomposite.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: November 10, 2020
    Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Alexandru S. Biris, Zeid Nima, Yang Xu
  • Patent number: 10814112
    Abstract: A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: October 27, 2020
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Mark Thomas Fulmer, David A. Armbruster, Robert Frigg, Elliott A. Gruskin, Sean Hamilton Kerr
  • Patent number: 10813857
    Abstract: A cosmetic ink composition comprises a particulate material, a polymeric dispersant having a weight average molecular weight of less than about 20,000 daltons, and a polymeric rheology modifier. The particulate material can have a Particle Size Distribution D50 of about 100 nm to about 2,000 nm. The cosmetic ink composition can undergo controlled syneresis, forming a weak colloidal gel phase and a particle-lean, low viscosity phase, which can be printed without interventions such as agitation, mixing, or re-circulation to homogenize the composition.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: October 27, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Janette Villalobos Lingoes, Thomas Elliot Rabe, Jeremy Chang, Ajay Suthar
  • Patent number: 10799450
    Abstract: The present invention relates to a tableted chewing gum composition for oral administration of cannabinoids, the composition comprising a plurality of particles, including a first population of particles comprising water-insoluble gum base and a second population of particles comprising water-soluble chewing gum ingredients, and the composition constituting at least two layers, wherein a first layer of the composition comprises water-insoluble gum base and a second layer of the composition, which is cohered to and adjacent to the first layer, comprises water-soluble chewing gum ingredients, the second layer being free of water-insoluble gum base, and wherein the composition comprises one or more cannabinoids.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: October 13, 2020
    Assignee: MedCan Pharma A/S
    Inventors: Heidi Ziegler Bruun, Dorthe Schackinger Boesen, Ane Eriksen
  • Patent number: 10786570
    Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: September 29, 2020
    Assignee: The Rockefeller University
    Inventors: Jeffrey Friedman, Sarah Stanley
  • Patent number: 10786465
    Abstract: A composition comprising a nanoparticle, wherein the nanoparticle comprises a polymer/copolymer conjugated to a moiety is disclosed. A method of forming a nanostructure includes stirring poly(lactide-co-glycolide (PLGA) and 11-Ethyl-3-(dimethylaminopropyl) carbodiimide (EDC) in CH2Cl2 to create a PLGA mixture, n-boc-ethyelenediamine and N,N-Diisopropylethylamine (DIEA) are added to the PLGA mixture to create a reaction mixture. The reaction mixture is then precipitated in cold diethyl ether to form a purified polymer, which is then dried. The dried and purified polymer is then reconstituted in CH2Cl2:TFA solution and stirred under inert conditions. The product of the reconstituting step is evaporated to form a clear viscous residue that is dissolved in CH2Cl2 and then precipitated in cold ether to form a polymer. These functional polymers can encapsulate a variety of bioactives forming nanosystems improving the performance of bioactives.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: September 29, 2020
    Assignee: The Texas A&M University System
    Inventors: Naga Venkata Ravi Kumar Majeti, Raghu Ganugula, Meenakshi Arora, Prabhjot Saini
  • Patent number: 10786581
    Abstract: Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: September 29, 2020
    Assignee: Incept, LLC
    Inventors: Patrick Campbell, Amarpreet S. Sawhney
  • Patent number: 10780060
    Abstract: The invention provides devices and methods for adjusting particle size in nanoemulsions of fluorocarbons and perfluorocarbons (e.g., perfluoropentane and perfluorohexane) via sonication (e.g., ultrasonication).
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: September 22, 2020
    Assignee: NuvOx Pharma LLC
    Inventors: Evan C. Unger, Edmund Marinelli
  • Patent number: 10780168
    Abstract: The invention relates to pharmaceutical compositions in liquid form comprising pradofloxacin in an aqueous solution and citric acid or thioglycerol as antioxidants.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: September 22, 2020
    Assignee: BAYER ANIMAL HEALTH GMBH
    Inventors: Iris Heep, Patrick Billian
  • Patent number: 10772985
    Abstract: The invention relates to a device for adsorbing odours comprising an absorbent layer and an adsorbent layer, said adsorbent layer being provided with a material permeable to volatile organic compounds (VOCs) and an adsorbent particulate filler comprising at least one spice. Such a device is particularly useful for adsorbing and masking body odours.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: September 15, 2020
    Assignees: Institut Corie, Ecole Superieore De Physique Et De Chimie Industrielle (ESPCI), Cole Nationale Superieore De Chime De Paris (ENSCP), Centre National De La Recherche Scientifique, Cemag Care
    Inventors: Aurélie Thuleau, Isabelle Fromantin, Vincent Semetey, José Dugay, Jean-François Le Meur
  • Patent number: 10772840
    Abstract: Pharmaceutical compositions and methods are provided to treat headache, headache-associated symptoms, photophobia, or adverse effects associated with the headache. Also provided herein are small smooth particulates comprising a 5HT1B/1D receptor agonist. Compositions for oral administration are described herein wherein the compositions comprise a combination of active agents, such as a 5HT1B/1D receptor agonist and one or more antiemetics.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: September 15, 2020
    Assignee: CHARLESTON LABORATORIES, INC.
    Inventors: Paul Bosse, John Ameling, William Kozarek, Bernard Schachtel, John Higgins
  • Patent number: 10765744
    Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MC-NC)), methods of making micelles, methods of using micelles, and the like.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: September 8, 2020
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Carlos Rinaldi, Sun Hao, Brent S. Sumerlin